The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform

Jimmi Hatton - One of the best experts on this subject based on the ideXlab platform.

  • Intracerebroventricular Administration of Drugs
    Pharmacotherapy, 2009
    Co-Authors: Aaron M. Cook, Katherine D Mieure, Adam Pesaturo, Robert Owen, Jimmi Hatton
    Abstract:

    Intracerebroventricular Drug Administration is a method that bypasses the blood-brain barrier and other mechanisms that limit Drug distribution into the brain, allowing high Drug concentrations to enter the central compartment. Instillation of Drugs directly into the ventricles of the brain must be done carefully and with full consideration of factors affecting the efficacy and safety of this route of Administration. These factors include the osmolarity, pH, volume, and presence of preservatives and diluents of the Drug solution being administered. Very few studies have formally investigated intraventricular therapies, and dosing recommendations may vary widely depending on the agent and the patient. Many antimicrobials have been given intraventricularly, although very few prospective studies have evaluated this strategy. There are wide variations among the reports regarding dosage regimens and the pharmacokinetics of the antimicrobials used. Guidance on appropriate formulations and their use is lacking. Clinicians should be aware of their patients' ongoing disease processes and neurologic status, as well as pertinent physiochemical properties of Drugs when formulating them for Intracerebroventricular Administration; a high index of suspicion should be maintained when monitoring patients for adverse Drug events after instillation.

Arthur J. Atkinson - One of the best experts on this subject based on the ideXlab platform.

  • Intracerebroventricular Drug Administration
    Translational and clinical pharmacology, 2017
    Co-Authors: Arthur J. Atkinson
    Abstract:

    Among the various routes of Drug Administration, perhaps the least studied is Intracerebroventricular (ICV) Administration. This route has been shown to be particularly useful in administering to the central nervous system (CNS) Drugs that do not cross the blood-brain barrier readily. As such, the ICV route is a valuable option for providing therapeutic CNS Drug concentrations to treat patients with CNS infectious and neoplastic diseases. This route of Drug Administration also has the advantage of minimizing systemic toxicity.

Aaron M. Cook - One of the best experts on this subject based on the ideXlab platform.

  • Intracerebroventricular Administration of Drugs
    Pharmacotherapy, 2009
    Co-Authors: Aaron M. Cook, Katherine D Mieure, Adam Pesaturo, Robert Owen, Jimmi Hatton
    Abstract:

    Intracerebroventricular Drug Administration is a method that bypasses the blood-brain barrier and other mechanisms that limit Drug distribution into the brain, allowing high Drug concentrations to enter the central compartment. Instillation of Drugs directly into the ventricles of the brain must be done carefully and with full consideration of factors affecting the efficacy and safety of this route of Administration. These factors include the osmolarity, pH, volume, and presence of preservatives and diluents of the Drug solution being administered. Very few studies have formally investigated intraventricular therapies, and dosing recommendations may vary widely depending on the agent and the patient. Many antimicrobials have been given intraventricularly, although very few prospective studies have evaluated this strategy. There are wide variations among the reports regarding dosage regimens and the pharmacokinetics of the antimicrobials used. Guidance on appropriate formulations and their use is lacking. Clinicians should be aware of their patients' ongoing disease processes and neurologic status, as well as pertinent physiochemical properties of Drugs when formulating them for Intracerebroventricular Administration; a high index of suspicion should be maintained when monitoring patients for adverse Drug events after instillation.

Katherine D Mieure - One of the best experts on this subject based on the ideXlab platform.

  • Intracerebroventricular Administration of Drugs
    Pharmacotherapy, 2009
    Co-Authors: Aaron M. Cook, Katherine D Mieure, Adam Pesaturo, Robert Owen, Jimmi Hatton
    Abstract:

    Intracerebroventricular Drug Administration is a method that bypasses the blood-brain barrier and other mechanisms that limit Drug distribution into the brain, allowing high Drug concentrations to enter the central compartment. Instillation of Drugs directly into the ventricles of the brain must be done carefully and with full consideration of factors affecting the efficacy and safety of this route of Administration. These factors include the osmolarity, pH, volume, and presence of preservatives and diluents of the Drug solution being administered. Very few studies have formally investigated intraventricular therapies, and dosing recommendations may vary widely depending on the agent and the patient. Many antimicrobials have been given intraventricularly, although very few prospective studies have evaluated this strategy. There are wide variations among the reports regarding dosage regimens and the pharmacokinetics of the antimicrobials used. Guidance on appropriate formulations and their use is lacking. Clinicians should be aware of their patients' ongoing disease processes and neurologic status, as well as pertinent physiochemical properties of Drugs when formulating them for Intracerebroventricular Administration; a high index of suspicion should be maintained when monitoring patients for adverse Drug events after instillation.

Adam Pesaturo - One of the best experts on this subject based on the ideXlab platform.

  • Intracerebroventricular Administration of Drugs
    Pharmacotherapy, 2009
    Co-Authors: Aaron M. Cook, Katherine D Mieure, Adam Pesaturo, Robert Owen, Jimmi Hatton
    Abstract:

    Intracerebroventricular Drug Administration is a method that bypasses the blood-brain barrier and other mechanisms that limit Drug distribution into the brain, allowing high Drug concentrations to enter the central compartment. Instillation of Drugs directly into the ventricles of the brain must be done carefully and with full consideration of factors affecting the efficacy and safety of this route of Administration. These factors include the osmolarity, pH, volume, and presence of preservatives and diluents of the Drug solution being administered. Very few studies have formally investigated intraventricular therapies, and dosing recommendations may vary widely depending on the agent and the patient. Many antimicrobials have been given intraventricularly, although very few prospective studies have evaluated this strategy. There are wide variations among the reports regarding dosage regimens and the pharmacokinetics of the antimicrobials used. Guidance on appropriate formulations and their use is lacking. Clinicians should be aware of their patients' ongoing disease processes and neurologic status, as well as pertinent physiochemical properties of Drugs when formulating them for Intracerebroventricular Administration; a high index of suspicion should be maintained when monitoring patients for adverse Drug events after instillation.