The Experts below are selected from a list of 14013 Experts worldwide ranked by ideXlab platform
Kimmo J Hatanpaa - One of the best experts on this subject based on the ideXlab platform.
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perineural extension of cutaneous desmoplastic melanoma mimicking an Intracranial malignant peripheral nerve sheath Tumor
Journal of Neurosurgery, 2011Co-Authors: Samuel L Barnett, Michael J Wells, Bruce E Mickey, Kimmo J HatanpaaAbstract:The authors present a case illustrating the importance of obtaining a biopsy of any facial skin lesions in a patient presenting with an Intracranial Tumor involving the facial or trigeminal nerve. Conventional malignant melanoma metastasizes to the brain frequently and does not usually pose diagnostic difficulties. Direct Intracranial spread of cutaneous melanoma is rare. In our patient, desmoplastic melanoma with perineural spread to the Meckel cave mimicked a malignant peripheral nerve sheath Tumor clinically, radiographically, and histologically.
Akihide Tanimoto - One of the best experts on this subject based on the ideXlab platform.
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an autopsy case of epignathus immature teratoma of the soft palate with Intracranial extension but without brain invasion case report and literature review
Diagnostic Pathology, 2018Co-Authors: Mari Kirishima, Sohsuke Yamada, Mitsuhisa Shinya, Shun Onishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Michiyo Higashi, Akira I. Hida, Akihide TanimotoAbstract:Epignathus is a rare congenital orofacial teratoma infrequently associated with Intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such cases have been reported. While there have been some studies reporting cases of epignathus expanding directly into the cranium, others have reported no communication between an epignathus and an Intracranial Tumor. A fetus at gestational week 27 was suspected of having an epignathus with Intracranial Tumor as shown by ultrasonographic and magnetic resonance imaging. The fetus was stillborn and an autopsy was performed. An epignathus measuring 12 × 6 × 6 cm and weighing 270 g protruded from the mouth, with its base on the soft palate. An Intracranial Tumor weighing 14 g was located at the middle Intracranial fossa and connected to the epignathus through the right side of the sella turcica. The Intracranial Tumor was encapsulated, and there was no invasion into the brain. Histologically, both the epignathus and Intracranial Tumor were immature teratomas, with neural and pulmonary components that were especially immature as compared to those of the internal organs and brain tissues of the fetus. There have been several reports of epignathus and Intracranial Tumors that did not communicate; therefore, careful evaluation is needed when a fetus is suspected of having an epignathus extending into an Intracranial lesion. Our case supports the findings that an epignathus can directly expand into the cranium. Moreover, this is a rare case of an epignathus in which the Intracranial lesion was encapsulated and did not invade the brain. These rare but important findings will provide additional, potential therapeutic strategies for gynecologists, neurosurgeons, and pathologists.
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An autopsy case of epignathus (immature teratoma of the soft palate) with Intracranial extension but without brain invasion: case report and literature review
BMC, 2018Co-Authors: Mari Kirishima, Sohsuke Yamada, Mitsuhisa Shinya, Shun Onishi, Yuko Goto, Ikumi Kitazono, Tsubasa Hiraki, Michiyo Higashi, Akira I. Hida, Akihide TanimotoAbstract:Abstract Background Epignathus is a rare congenital orofacial teratoma infrequently associated with Intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such cases have been reported. While there have been some studies reporting cases of epignathus expanding directly into the cranium, others have reported no communication between an epignathus and an Intracranial Tumor. Case presentation A fetus at gestational week 27 was suspected of having an epignathus with Intracranial Tumor as shown by ultrasonographic and magnetic resonance imaging. The fetus was stillborn and an autopsy was performed. An epignathus measuring 12 × 6 × 6 cm and weighing 270 g protruded from the mouth, with its base on the soft palate. An Intracranial Tumor weighing 14 g was located at the middle Intracranial fossa and connected to the epignathus through the right side of the sella turcica. The Intracranial Tumor was encapsulated, and there was no invasion into the brain. Histologically, both the epignathus and Intracranial Tumor were immature teratomas, with neural and pulmonary components that were especially immature as compared to those of the internal organs and brain tissues of the fetus. Conclusion There have been several reports of epignathus and Intracranial Tumors that did not communicate; therefore, careful evaluation is needed when a fetus is suspected of having an epignathus extending into an Intracranial lesion. Our case supports the findings that an epignathus can directly expand into the cranium. Moreover, this is a rare case of an epignathus in which the Intracranial lesion was encapsulated and did not invade the brain. These rare but important findings will provide additional, potential therapeutic strategies for gynecologists, neurosurgeons, and pathologists
Renzhi Wang - One of the best experts on this subject based on the ideXlab platform.
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targeted next generation sequencing of malignant peripheral nerve sheath Tumor of the pterygopalatine fossa with Intracranial metastatic recurrence
Medicine, 2018Co-Authors: Xinjie Bao, Xiangyi Kong, Chengxian Yang, Renzhi WangAbstract:Malignant peripheral nerve sheath Tumor (MPNST) is an uncommon neoplasm that rarely involves the head and neck region. Intracranial MPNSTs unrelated to cranial nerves are highly malignant Tumors with poor overall survival, probably because of infiltrating growth into surrounding brain tissue. The pathogenesis of MPNST remains unclear. There are no conclusive explanations for the mechanisms underlying the initiation, progression, and metastasis of MPNST. In this paper, we describe a case of MPNST in the pterygopalatine fossa with Intracranial metastatic recurrence and review related literatures. Meanwhile, targeted next-generation sequencing (NGS) revealed the presence of both a beta-catenin (CTNNB1) missense mutation p.Ser33Phe and a mediator complex subunit 12 (MED12) frameshift mutation p.Tyr1278fs in the recurrent Intracranial Tumor. Therapies that target CTNNB1 mutation, MED12 mutation, CTNNB1 activation, or Wnt pathway activation are worth future studying.
Bruce E Mickey - One of the best experts on this subject based on the ideXlab platform.
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perineural extension of cutaneous desmoplastic melanoma mimicking an Intracranial malignant peripheral nerve sheath Tumor
Journal of Neurosurgery, 2011Co-Authors: Samuel L Barnett, Michael J Wells, Bruce E Mickey, Kimmo J HatanpaaAbstract:The authors present a case illustrating the importance of obtaining a biopsy of any facial skin lesions in a patient presenting with an Intracranial Tumor involving the facial or trigeminal nerve. Conventional malignant melanoma metastasizes to the brain frequently and does not usually pose diagnostic difficulties. Direct Intracranial spread of cutaneous melanoma is rare. In our patient, desmoplastic melanoma with perineural spread to the Meckel cave mimicked a malignant peripheral nerve sheath Tumor clinically, radiographically, and histologically.
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dynamic near infrared optical imaging of 2 deoxyglucose uptake by Intracranial glioma of athymic mice
PLOS ONE, 2009Co-Authors: Heling Zhou, Bruce E Mickey, Katherine Lubyphelps, Amyn A Habib, Ralph P Mason, Dawen ZhaoAbstract:Background It is recognized that cancer cells exhibit highly elevated glucose metabolism compared to non-Tumor cells. We have applied in vivo optical imaging to study dynamic uptake of a near-infrared dye-labeled glucose analogue, 2-deoxyglucose (2-DG) by orthotopic glioma in a mouse model. Methodology and Principal Findings The orthotopic glioma model was established by surgically implanting U87-luc glioma cells into the right caudal nuclear area of nude mice. Intracranial Tumor growth was monitored longitudinally by bioluminescence imaging and MRI. When Tumor size reached >4 mm diameter, dynamic fluorescence imaging was performed after an injection of the NIR labeled 2-DG, IRDye800CW 2-DG. Real-time whole body images acquired immediately after i.v. infusion clearly visualized the near-infrared dye circulating into various internal organs sequentially. Dynamic fluorescence imaging revealed significantly higher signal intensity in the Tumor side of the brain than the contralateral normal brain 24 h after injection (Tumor/normal ratio, TNR = 2.8±0.7). Even stronger contrast was achieved by removing the scalp (TNR = 3.7±1.1) and skull (TNR = 4.2±1.1) of the mice. In contrast, a control dye, IRDye800CW carboxylate, showed little difference (1.1±0.2). Ex vivo fluorescence imaging performed on ultrathin cryosections (20 µm) of Tumor bearing whole brain revealed distinct Tumor margins. Microscopic imaging identified cytoplasmic locations of the 2-DG dye in Tumor cells. Conclusion and Significance Our results suggest that the near-infrared dye labeled 2-DG may serve as a useful fluorescence imaging probe to noninvasively assess Intracranial Tumor burden in preclinical animal models.
Samuel L Barnett - One of the best experts on this subject based on the ideXlab platform.
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perineural extension of cutaneous desmoplastic melanoma mimicking an Intracranial malignant peripheral nerve sheath Tumor
Journal of Neurosurgery, 2011Co-Authors: Samuel L Barnett, Michael J Wells, Bruce E Mickey, Kimmo J HatanpaaAbstract:The authors present a case illustrating the importance of obtaining a biopsy of any facial skin lesions in a patient presenting with an Intracranial Tumor involving the facial or trigeminal nerve. Conventional malignant melanoma metastasizes to the brain frequently and does not usually pose diagnostic difficulties. Direct Intracranial spread of cutaneous melanoma is rare. In our patient, desmoplastic melanoma with perineural spread to the Meckel cave mimicked a malignant peripheral nerve sheath Tumor clinically, radiographically, and histologically.