The Experts below are selected from a list of 9273 Experts worldwide ranked by ideXlab platform
Christos V Bourantas - One of the best experts on this subject based on the ideXlab platform.
-
utility of multimodality Intravascular Imaging and the local hemodynamic forces to predict atherosclerotic disease progression
Jacc-cardiovascular Imaging, 2020Co-Authors: Christos V Bourantas, Lorenz Raber, Antonis I Sakellarios, Yashusi Ueki, Thomas Zanchin, Konstantinos C Koskinas, Kyohei Yamaji, Masanori Taniwaki, Dik Heg, Maria D RaduAbstract:Abstract Objectives This study sought to examine the utility of multimodality Intravascular Imaging and of the endothelial shear stress (ESS) distribution to predict atherosclerotic evolution. Background There is robust evidence that Intravascular ultrasound (IVUS)-derived plaque characteristics and ESS distribution can predict, with however limited accuracy, atherosclerotic evolution; nevertheless, it is yet unclear whether multimodality Imaging and ESS mapping enable more accurate prediction of coronary plaque progression. Methods A total of 44 patients admitted with a myocardial infarction that had successful revascularization and 3-vessel IVUS and optical coherence tomography (OCT) Imaging at baseline and 13-month follow-up were included in the study. The IVUS data acquired at baseline in the nonculprit vessels were fused with x-ray angiography to reconstruct coronary anatomy and in the obtained models blood flow simulation was performed and the ESS was estimated. The baseline plaque characteristics and ESS distribution were used to identify predictors of disease progression: defined as a lumen reduction and an increase in plaque burden at follow-up. Results Seventy-three vessels were included in the final analysis. Baseline ESS and the IVUS-derived but not the OCT-derived plaque characteristics were independently associated with a decrease in lumen area and an increase in plaque burden. Low ESS (odds ratio: 0.45; 95% confidence interval: 0.28 to 0.71; p Conclusions ESS and OCT-derived variables did not improve the efficacy of IVUS in predicting disease progression. Further research is required to investigate whether multimodality Imaging combined with ESS mapping will allow more reliable vulnerable plaque detection. (Comparison of Biomatrix Versus Gazelle in ST-Elevation Myocardial Infarction [STEMI] [COMFORTABLE]; NCT00962416)
-
clinical use of intracoronary Imaging part 2 acute coronary syndromes ambiguous coronary angiography findings and guiding interventional decision making an expert consensus document of the european association of percutaneous cardiovascular interventions
European Heart Journal, 2019Co-Authors: Thomas W. Johnson, Francesco Prati, Nieves Gonzalo, Christos V Bourantas, Lorenz Raber, Carlo Di Mario, Haibo Jia, Alessio Mattesini, Jose M De La Torre Hernandez, Konstantinos C KoskinasAbstract:This consensus document is the second of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary Imaging including Intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near infrared spectroscopy (NIRS)-IVUS. Beyond guidance of stent selection and optimization of deployment, invasive Imaging facilitates angiographic interpretation and may guide treatment in acute coronary syndrome. Intravascular Imaging can provide additional important diagnostic information when confronted with angiographically ambiguous lesions and allows assessment of plaque morphology enabling identification of vulnerability characteristics. This second document focuses on useful Imaging features to identify culprit and vulnerable coronary plaque, which offers the interventional cardiologist guidance on when to adopt an intracoronary Imaging-guided approach to the treatment of coronary artery disease and provides an appraisal of Intravascular Imaging-derived metrics to define the haemodynamic significance of coronary lesions.
-
state of the art role of Intravascular Imaging in the evolution of percutaneous coronary intervention a 30 year review
Eurointervention, 2017Co-Authors: Christos V Bourantas, Erhan Tenekecioglu, Maria D Radu, Lorenz Raber, Patrick W SerruysAbstract:It has been 40 years since percutaneous coronary intervention (PCI) was introduced into the clinical setting. Over these years significant advances in device technology and the invention of new therapeutic strategies have broadened its applications in the clinical arena, rendering this treatment the first-line therapy for patients with obstructive coronary artery disease. The evolution of PCI would not have been possible without Intravascular Imaging which provided unique insights about coronary artery pathology, enabled evaluation of vessel wall response following PCI and allowed meticulous evaluation of the advantages and limitations of emerging devices. This review article appraises the role of Intravascular Imaging in the evolution of PCI, summarises the findings of invasive Imaging studies that examined the efficacy of new therapies and endovascular devices, presents the evidence that supports its use in current clinical practice and discusses its future potential in PCI.
-
hybrid Intravascular Imaging recent advances technical considerations and current applications in the study of plaque pathophysiology
European Heart Journal, 2017Co-Authors: Christos V Bourantas, Gijs Van Soest, Sean Madden, Erhan Tenekecioglu, Yaping Zeng, Ali Fard, Farouc A Jaffer, Frank J H Gijsen, Brian K Courtney, Antonius F W Van Der SteenAbstract:Cumulative evidence from histology-based studies demonstrate that the currently available Intravascular Imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-Intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular Imaging, IVUS-NIRF, IVUS Intravascular photoacoustic Imaging and combined fluorescence lifetime-IVUS Imaging. These multimodal approaches appear able to overcome limitations of standalone Imaging and provide comprehensive visualization of plaque composition and plaque biology. The aim of this review article is to summarize the advances in hybrid Intravascular Imaging, discuss the technical challenges that should be addressed in order to have a use in the clinical arena, and present the evidence from their first applications aiming to highlight their potential value in the study of atherosclerosis.
-
oct for the identification of vulnerable plaque in acute coronary syndrome
Jacc-cardiovascular Imaging, 2015Co-Authors: Hannah Sinclair, Gary S Mintz, Christos V Bourantas, Alan Bagnall, Vijay KunadianAbstract:Abstract After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core Intravascular Imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer “vulnerability” to rupture—namely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation of plaque composition can provide insights into the pathophysiology of acute coronary syndrome and the healing that occurs thereafter. A brief summary of the principles of OCT technology and a comparison with other Intravascular Imaging modalities is presented. The review focuses on the current evidence for the use of OCT in identifying vulnerable plaques in acute coronary syndrome and its limitations.
Jagat Narula - One of the best experts on this subject based on the ideXlab platform.
-
acute coronary syndromes without coronary plaque rupture
Nature Reviews Cardiology, 2016Co-Authors: Siddak S Kanwar, Renu Virmani, Gregg W. Stone, Takashi Akasaka, Mandeep Singh, Jeffrey W Olin, Jagat NarulaAbstract:The latest advances in plaque Imaging have provided clinicians with opportunities to treat acute coronary syndrome (ACS) and provide individualized treatment recommendations based not only on clinical manifestations, angiographic characteristics, and biomarker data, but also on the findings of plaque morphology. Although a substantial proportion of ACS events originate from plaques with an intact fibrous cap (IFC), clinicians predominantly equate ACS with plaque rupture arising from thin-cap fibroatheromas. In this Review, we discuss the recent advances in our understanding of plaque morphology in ACS with IFC, reviewing contemporary data from Intravascular Imaging. We also explore whether use of such Imaging might provide a roadmap for more effective management of patients with ACS.
-
clinical classification of plaque morphology in coronary disease
Nature Reviews Cardiology, 2014Co-Authors: Fumiyuki Otsuka, Francesco Prati, Michael Joner, Renu Virmani, Jagat NarulaAbstract:In this Review, Otsuka et al. describe how optical coherence tomography (OCT)—an Intravascular Imaging modality with high resolution—can be used to define various stages of plaque progression. The authors also highlight how OCT might be used in the identification of high-risk plaques vulnerable to rupture in patients with coronary disease, to enable pre-emptive interventional treatment, and how OCT might be used in the management of acute coronary syndromes.
-
thinking outside the lumen fractional flow reserve versus Intravascular Imaging for major adverse cardiac event prediction
Journal of the American College of Cardiology, 2014Co-Authors: Jagat Narula, Pedro R MorenoAbstract:If you always do what you always did, you will always get what you always got —Albert Einstein [(1)][1] Four decades ago, we believed in a dogma that acute myocardial infarction (MI) resulted from near total luminal obstruction by progressive thickening of coronary atheroma. At that time,
-
intracoronary optical diagnostics current status limitations and potential
Jacc-cardiovascular Interventions, 2011Co-Authors: Harry C Lowe, Jagat Narula, James G Fujimoto, Ikkyung JangAbstract:Optical coherence tomography (OCT), is a novel Intravascular Imaging modality analogous to Intravascular ultrasound but uses light instead of sound. This review details the background, development, and status of current investigation using OCT, and discusses advantages, limitations, and likely future developments. It provides indications for possible future clinical use, and places OCT in the context of current Intravascular Imaging in what is a rapidly changing field of investigation.
-
novel combined miniature optical coherence tomography ultrasound probe for in vivo Intravascular Imaging
Journal of Biomedical Optics, 2011Co-Authors: Jiechen Yin, Kirk K. Shung, Jagat Narula, Joe Jing, Matthew Brenner, David Mukai, Sari B Mahon, Ahmad Edris, Khiet Hoang, Qifa ZhouAbstract:We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for Intravascular Imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time Imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.
Patrick W Serruys - One of the best experts on this subject based on the ideXlab platform.
-
Reliable in vivo Intravascular Imaging plaque characterization: A challenge unmet.
American Heart Journal, 2019Co-Authors: Anantharaman Ramasamy, Patrick W Serruys, Daniel A. Jones, Thomas W. Johnson, Ryo Torii, Sean Madden, Rajiv Amersey, Rob Krams, Andreas Baumbach, Anthony MathurAbstract:Intravascular Imaging has enabled in vivo assessment of coronary artery pathology and detection of plaque characteristics that are associated with increased vulnerability. Prospective invasive Imaging studies of coronary atherosclerosis have demonstrated that invasive Imaging modalities can detect lesions that are likely to progress and cause cardiovascular events and provided unique insights about atherosclerotic evolution. However, despite the undoubted value of the existing Imaging techniques in clinical and research arenas, all the available modalities have significant limitations in assessing plaque characteristics when compared with histology. Hybrid/multimodality Intravascular Imaging appears able to overcome some of the limitations of standalone Imaging; however, there are only few histology studies that examined their performance in evaluating plaque pathobiology. In this article, we review the evidence about the efficacy of standalone and multi-modality/hybrid Intravascular Imaging in assessing plaque morphology against histology, highlight the advantages and limitations of the existing Imaging techniques and discuss the future potential of emerging Imaging modalities in the study of atherosclerosis.
-
state of the art role of Intravascular Imaging in the evolution of percutaneous coronary intervention a 30 year review
Eurointervention, 2017Co-Authors: Christos V Bourantas, Erhan Tenekecioglu, Maria D Radu, Lorenz Raber, Patrick W SerruysAbstract:It has been 40 years since percutaneous coronary intervention (PCI) was introduced into the clinical setting. Over these years significant advances in device technology and the invention of new therapeutic strategies have broadened its applications in the clinical arena, rendering this treatment the first-line therapy for patients with obstructive coronary artery disease. The evolution of PCI would not have been possible without Intravascular Imaging which provided unique insights about coronary artery pathology, enabled evaluation of vessel wall response following PCI and allowed meticulous evaluation of the advantages and limitations of emerging devices. This review article appraises the role of Intravascular Imaging in the evolution of PCI, summarises the findings of invasive Imaging studies that examined the efficacy of new therapies and endovascular devices, presents the evidence that supports its use in current clinical practice and discusses its future potential in PCI.
-
Intravascular multimodality Imaging feasibility and role in the evaluation of coronary plaque pathology
European Journal of Echocardiography, 2017Co-Authors: Michael Michail, Patrick W Serruys, Ryo Torii, Rodrigue Stettler, Tom Crake, Erhan Tenekecioglu, Yaping Zeng, Yoshinobu Onuma, Anthony MathurAbstract:Coronary artery disease remains the leading cause of death in the developed world. Over recent years, research has been focused on the development of diagnostic Intravascular Imaging techniques that enable assessment of plaque composition and morphology, and allow identification of vulnerable, high-risk lesions. Nevertheless recent studies of coronary atherosclerosis have shown that invasive modalities have a limited accuracy in detecting lesions that will progress and cause events, whilst histology-based studies also highlighted the limitations of invasive Imaging in assessing plaque characteristics. To overcome these drawbacks, multimodality Imaging has been proposed. Although it is apparent that coronary Imaging with two or three Imaging modalities is time consuming and is associated with a risk of complications, evidence from small clinical studies demonstrated that it provides incremental information about plaque pathology and biology and underscored the need to develop dual-probe hybrid Imaging catheters that would enable complete and comprehensive assessment of plaque morphology. This paper reviews the current clinical evidence that supports the use of multimodality Intravascular Imaging in the study of atherosclerosis, summarizes the key findings of the first invasive Imaging studies that utilize hybrid dual-probe catheters, and discusses the limitations of combined Intravascular Imaging that restrict its broad application in both the clinical and research arena.
-
New insights into the coronary artery bifurcation hypothesis-generating concepts utilizing 3-dimensional optical frequency domain Imaging.
Jacc-cardiovascular Interventions, 2011Co-Authors: Vasim Farooq, Takayuki Okamura, Salvatore Brugaletta, Patrick W Serruys, Bill D. Gogas, Josep Gomez-lara, Hector M. Garcia-garcia, Robert-jan Van GeunsAbstract:Coronary artery bifurcations are a common challenging lesion subset accounting for approximately 10% to 20% of all percutaneous coronary interventions. The provisional T-stenting approach is generally recommended as the first-line management of most lesions. Carina shift is suggested to be the predominant mechanism of side-branch pinching during provisional T-stenting and has been indirectly inferred from bench work and other Intravascular Imaging modalities. Offline 3-dimensional (3D) reconstructions of patients studied in the first-in-man trial of the high-frequency (160 frames/s) Terumo optical frequency domain Imaging system were undertaken using volume-rendering software. Through a series of 3D reconstructions, several novel hypothesis-generating concepts are presented.
-
Pitfalls in Plaque Characterization by OCT: Image Artifacts in Native Coronary Arteries
JACC: Cardiovascular Imaging, 2011Co-Authors: Gijs Van Soest, Patrick W Serruys, Evelyn Regar, Thadé P. M. Goderie, Nieves Gonzalo, Senada Koljenović, Geert J.l.h. Van Leenders, Anton F. W. Van Der SteenAbstract:ONE OF THE GOALS OF Intravascular Imaging IS SPECIFIC IN VIVO IDENTIFICATION OF VULNERABLE PLAQUES, which are likely to cause acute coronary syndrome. Intravascular optical coherence tomography (OCT) is a recent technique that is used for coronary plaque characterization, and is rapidly gaining
Gary S Mintz - One of the best experts on this subject based on the ideXlab platform.
-
algorithmic approach for optical coherence tomography guided stent implantation during percutaneous coronary intervention
Interventional cardiology clinics, 2018Co-Authors: Evan Shlofmitz, Renu Virmani, Richard Shlofmitz, Keyvan Karimi Galougahi, Hussein M Rahim, Jonathan Hill, Mitsuaki Matsumura, Gary S Mintz, Akiko Maehara, Ulf LandmesserAbstract:Intravascular Imaging plays a key role in optimizing outcomes for percutaneous coronary intervention (PCI). Optical coherence tomography (OCT) utilizes a user-friendly interface and provides high-resolution images. OCT can be used as part of daily practice in all stages of a coronary intervention: baseline lesion assessment, stent selection, and stent optimization. Incorporating a standardized, algorithmic approach when using OCT allows for precision PCI.
-
intracoronary optical coherence tomography 2018 current status and future directions
Jacc-cardiovascular Interventions, 2017Co-Authors: Ziad A Ali, Richard Shlofmitz, Keyvan Karimi Galougahi, Gary S Mintz, Akiko Maehara, Ori Benyehuda, Gregg W. StoneAbstract:The advent of Intravascular Imaging has been a significant advancement in visualization of coronary arteries, particularly with optical coherence tomography (OCT) that allows for high-resolution Imaging of intraluminal and transmural coronary structures. Accumulating data support a clinical role for OCT in a multitude of clinical scenarios, including assessing the natural history of atherosclerosis and modulating effects of therapies, mechanisms of acute coronary syndromes, mechanistic insights into the effects of novel interventional devices, and optimization of percutaneous coronary intervention. In this state-of-the-art review, we provide an overview of the published data on the clinical utility of OCT, highlighting the areas that need further investigation and the current barriers for further adoption of OCT in interventional cardiology practice.
-
multimodality Intravascular Imaging assessment of plaque erosion versus plaque rupture in patients with acute coronary syndrome
Korean Circulation Journal, 2016Co-Authors: Jee Eun Kwon, Gary S Mintz, Young Joon Hong, Wang Soo Lee, Sung Yun Lee, Ki Seok Kim, Jooyong Hahn, Kaup Sharath Kumar, Hoyoun Won, Seong Hyeop HyeonAbstract:Background and Objectives We assessed plaque erosion of culprit lesions in patients with acute coronary syndrome in real world practice.
-
Intravascular Imaging of coronary calcification and its clinical implications
Jacc-cardiovascular Imaging, 2015Co-Authors: Gary S MintzAbstract:Calcium impacts the natural history and treatment of coronary artery disease in many ways. Intravascular Imaging studies, mostly Intravascular ultrasound, but more recently studies using optical coherence tomography, have been instrumental in increasing our understanding of the relationship between calcium and coronary atherosclerosis, the predictors, the natural history of this relationship, and the impact on treatment. On one hand, stable coronary lesions are associated with more calcium than unstable lesions; and the amount of calcium may affect the success of percutaneous coronary intervention. On the other hand, calcium correlates with plaque burden; unstable lesions are associated with focal calcium deposits; and calcific nodules are one of the morphologies of vulnerable plaque. This review focuses on more than 20 years of Intravascular Imaging studies of the relationship between calcium and coronary atherosclerosis.
-
oct for the identification of vulnerable plaque in acute coronary syndrome
Jacc-cardiovascular Imaging, 2015Co-Authors: Hannah Sinclair, Gary S Mintz, Christos V Bourantas, Alan Bagnall, Vijay KunadianAbstract:Abstract After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core Intravascular Imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer “vulnerability” to rupture—namely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation of plaque composition can provide insights into the pathophysiology of acute coronary syndrome and the healing that occurs thereafter. A brief summary of the principles of OCT technology and a comparison with other Intravascular Imaging modalities is presented. The review focuses on the current evidence for the use of OCT in identifying vulnerable plaques in acute coronary syndrome and its limitations.
Ikkyung Jang - One of the best experts on this subject based on the ideXlab platform.
-
advances in Intravascular Imaging new insights into the vulnerable plaque from Imaging studies
Korean Circulation Journal, 2018Co-Authors: Taishi Yonetsu, Ikkyung JangAbstract:: The term "vulnerable plaque" denotes the plaque characteristics that are susceptible to coronary thrombosis. Previous post-mortem studies proposed 3 major mechanisms of coronary thrombosis: plaque rupture, plaque erosion, and calcified nodules. Of those, characteristics of rupture-prone plaque have been extensively studied. Pathology studies have identified the features of rupture-prone plaque including thin fibrous cap, large necrotic core, expansive vessel remodeling, inflammation, and neovascularization. Intravascular Imaging modalities have emerged as adjunctive tools of angiography to identify vulnerable plaques. Multiple devices have been introduced to catheterization laboratories to date, including Intravascular ultrasound (IVUS), virtual-histology IVUS, optical coherence tomography (OCT), coronary angioscopy, and near-infrared spectroscopy. With the use of these modalities, our understanding of vulnerable plaque has rapidly grown over the past several decades. One of the goals of Intravascular Imaging is to better predict and prevent future coronary events, for which prospective observational data is still lacking. OCT delineates microstructures of plaques, whereas IVUS visualizes macroscopic vascular structures. Specifically, plaque erosion, which has been underestimated in clinical practice, is gaining an interest due to the potential of OCT to make an in vivo diagnosis. Another potential future avenue for Intravascular Imaging is its use to guide treatment. Feasibility of tailored therapy for acute coronary syndromes (ACS) guided by OCT is under investigation. If it is proven to be effective, it may potentially lead to major shift in the management of millions of patients with ACS every year.
-
causes assessment and treatment of stent thrombosis Intravascular Imaging insights
Nature Reviews Cardiology, 2015Co-Authors: Daniel S. Ong, Ikkyung JangAbstract:Stent thrombosis is a rare, but serious, complication of percutaneous coronary intervention and is associated with severe morbidity and mortality. In addition to clinical and pathological studies, Intravascular Imaging has advanced our understanding of the mechanisms underlying stent thrombosis. In particular, Intravascular Imaging has been used to study stent underexpansion, malapposition, uncovered struts, and neoatherosclerosis as risk factors for stent thrombosis. Intravascular ultrasonography and optical coherence tomography can be used to guide stent implantation and minimize the risk of stent thrombosis. Additionally, optical coherence tomography offers the unique potential to tailor treatment of stent thrombosis to address the specific mechanism underlying the thrombotic event. Bioresorbable stent technologies have been introduced with the goal of further reducing the incidence of stent thrombosis, and Intravascular Imaging has had an integral role in the development and assessment of these new devices. In this Review, we present insights gained through Intravascular Imaging into the causes of stent thrombosis, and the potential utility of Intravascular Imaging in the optimization of stent deployment and treatment of stent thrombosis events.
-
intracoronary optical diagnostics current status limitations and potential
Jacc-cardiovascular Interventions, 2011Co-Authors: Harry C Lowe, Jagat Narula, James G Fujimoto, Ikkyung JangAbstract:Optical coherence tomography (OCT), is a novel Intravascular Imaging modality analogous to Intravascular ultrasound but uses light instead of sound. This review details the background, development, and status of current investigation using OCT, and discusses advantages, limitations, and likely future developments. It provides indications for possible future clinical use, and places OCT in the context of current Intravascular Imaging in what is a rapidly changing field of investigation.
-
expert review document on methodology terminology and clinical applications of optical coherence tomography physical principles methodology of image acquisition and clinical application for assessment of coronary arteries and atherosclerosis
European Heart Journal, 2010Co-Authors: Francesco Prati, Ikkyung Jang, Marco A. Costa, Evelyn Regar, Gary S Mintz, Takashi Akasaka, Carlo Di Mario, Eloisa Arbustini, Giulio Guagliumi, Eberhard GrubeAbstract:Optical coherence tomography (OCT) is a novel Intravascular Imaging modality, based on infrared light emission, that enables a high resolution arterial wall Imaging, in the range of 10-20 microns. This feature of OCT allows the visualization of specific components of the atherosclerotic plaques. The aim of the present Expert Review Document is to address the methodology, terminology and clinical applications of OCT for qualitative and quantitative assessment of coronary arteries and atherosclerosis.
-
characterization of human atherosclerosis by optical coherence tomography
Circulation, 2002Co-Authors: Hiroshi Yabushita, Ikkyung Jang, Brett E. Bouma, Milen Shishkov, Stuart L Houser, Thomas H Aretz, Kelly Schlendorf, Christopher R Kauffman, Dongheon Kang, Elkan F HalpernAbstract:Background— High-resolution visualization of atherosclerotic plaque morphology may be essential for identifying coronary plaques that cause acute coronary events. Optical coherence tomography (OCT) is an Intravascular Imaging modality capable of providing cross-sectional images of tissue with a resolution of 10 μm. To date, OCT Imaging has not been investigated in sufficient detail to assess its accuracy for characterizing atherosclerotic plaques. The aim of this study was to establish objective OCT image criteria for atherosclerotic plaque characterization in vitro. Methods and Results— OCT images of 357 (diseased) atherosclerotic arterial segments obtained at autopsy were correlated with histology. OCT image criteria for 3 types of plaque were formulated by analysis of a subset (n=50) of arterial segments. OCT images of fibrous plaques were characterized by homogeneous, signal-rich regions; fibrocalcific plaques by well-delineated, signal-poor regions with sharp borders; and lipid-rich plaques by signal...