The Experts below are selected from a list of 158382 Experts worldwide ranked by ideXlab platform
Jaemoon Yang - One of the best experts on this subject based on the ideXlab platform.
-
localized surface plasmon resonance based nanobiosensor for biomarker detection of Invasive Cancer cells
Journal of Biomedical Optics, 2013Co-Authors: Yoochan Hong, Dae Sung Yoon, Jaemoon Yang, Minhee KuAbstract:In this study, we describe the development of a Cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance that enables recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on Invasive Cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of the sensing chip was confirmed using various solvents that have different refractive indexes. Subsequently, MT1-MMP–specific cleavable peptide was conjugated onto the surface of GNRs, and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed a biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from Invasive Cancer cells.
-
Molecular sensing for biomarkers of Invasive Cancer cells using localized surface plasmon resonance
Nano-Bio Sensing Imaging and Spectroscopy, 2013Co-Authors: Yoochan Hong, Jin Suck Suh, Yong-min Huh, Dae Sung Yoon, Jaemoon YangAbstract:In this study, we describe the development of Cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance (LSPR) that enabling recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on Invasive Cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of sensing chip was confirmed using various solvents that having different refractive indexes. Subsequently, MT1-MMP-specific cleavable peptide was conjugated onto surface of GNRs and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from Invasive Cancer cells.
-
Anchored Proteinase‐Targetable Optomagnetic Nanoprobes for Molecular Imaging of Invasive Cancer Cells
Angewandte Chemie (International ed. in English), 2011Co-Authors: Joseph Park, Jin Suck Suh, Jaemoon Yang, Eun-kyung Lim, Eunjung Kim, Jihye Choi, Joo Kyung Ryu, Nam Hee Kim, Jong In Yook, Yong-min HuhAbstract:Herein, we describe the development of a bimodalimaging probe enabling precise recognition of the expressionof MT1-MMP anchored on Invasive Cancer cells and itsprotease activity simultaneously. MT1-MMP may be atargetable biomarker for a specific delivery and possessesproteolytic activity for certain substrates.
Yoochan Hong - One of the best experts on this subject based on the ideXlab platform.
-
localized surface plasmon resonance based nanobiosensor for biomarker detection of Invasive Cancer cells
Journal of Biomedical Optics, 2013Co-Authors: Yoochan Hong, Dae Sung Yoon, Jaemoon Yang, Minhee KuAbstract:In this study, we describe the development of a Cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance that enables recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on Invasive Cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of the sensing chip was confirmed using various solvents that have different refractive indexes. Subsequently, MT1-MMP–specific cleavable peptide was conjugated onto the surface of GNRs, and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed a biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from Invasive Cancer cells.
-
Molecular sensing for biomarkers of Invasive Cancer cells using localized surface plasmon resonance
Nano-Bio Sensing Imaging and Spectroscopy, 2013Co-Authors: Yoochan Hong, Jin Suck Suh, Yong-min Huh, Dae Sung Yoon, Jaemoon YangAbstract:In this study, we describe the development of Cancer biomarker-sensitive nanobiosensor based on localized surface plasmon resonance (LSPR) that enabling recognition for proteolytic activity of membrane type 1 matrix metalloproteinase (MT1-MMP) anchored on Invasive Cancer cells. First of all, we prepared biomarker-detectable substrate based on gold nanorods (GNRs) using nanoparticle adsorption method. The sensitivity of sensing chip was confirmed using various solvents that having different refractive indexes. Subsequently, MT1-MMP-specific cleavable peptide was conjugated onto surface of GNRs and molecular sensing about proteolytic activity was conducted using MT1-MMP and cell lysates. Collectively, we developed biomarker detectable sensor, which allows for the effective detection of proteolytic activity about MT1-MMP extracted from Invasive Cancer cells.
Daniela Gallo - One of the best experts on this subject based on the ideXlab platform.
-
changes in the expression of oestrogen receptors and e cadherin as molecular markers of progression from normal epithelium to Invasive Cancer in elderly patients with vulvar squamous cell carcinoma
Histopathology, 2011Co-Authors: Gian Franco Zannoni, Maria Grazia Prisco, Valerio Gaetano Vellone, Ilaria De Stefano, Giovanni Scambia, Daniela GalloAbstract:Zannoni G F, Prisco M G, Vellone V G, De Stefano I, Scambia G & Gallo D (2011) Histopathology58, 265–275 Changes in the expression of oestrogen receptors and E-cadherin as molecular markers of progression from normal epithelium to Invasive Cancer in elderly patients with vulvar squamous cell carcinoma Aims: The most common vulvar squamous cell carcinoma (conventional SCC) occurs in elderly women and develops following a human papillomavirus (HPV)-negative pathway. Because the highest incidence of conventional SCC is observed in patients with low oestrogen levels (postmenopausal women), the aim was to investigate whether hormonal factors could play a role in the development of Cancer. Methods and results: The expression profile of oestrogen receptor α (ERα), ERβ and progesterone receptor (PR) in a section containing both normal and tumour tissue, as well as the SCC-associated vulvar lesion, was evaluated in 34 elderly patients. Also, as recent studies have identified E-cadherin as a novel transcriptional target of oestrogen signalling, the modulation of this epithelial–mesenchymal transition (EMT) marker was studied. Finally, the expression of the proliferation marker Ki67 and of the apoptotic marker p53 was assessed. Results showed that changes in both ERα and ERβ expression characterize the transition from normal epithelium to Cancer in patients with vulvar SCC: ERα was lost in Cancer while ERβ decreased, mainly showing cytoplasmic localization. A reduction in the expression of E-cadherin was also observed in tumours, compared to normal epithelium. Conclusions: The data put the ER signalling pathway into the spotlight as a potentially important factor in vulvar carcinogenesis.
Christie Recinto - One of the best experts on this subject based on the ideXlab platform.
-
Frequency of Invasive Cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3).
Gynecologic oncology, 1999Co-Authors: Nader Husseinzadeh, Christie RecintoAbstract:Abstract Objective. The aim of this study was to determine the frequency of Invasive Cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3. Methods. Seventy-eight patients with biopsy-proven vulvar intraepithelial neoplasia 3 (VIN 3) were treated by surgical excision. Results. Sixteen patients (20.5%) were found to have invasion in the excised surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 were noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%). Conclusion. Surgical excision should be considered a preferable method in management of patients with VIN 3.
Joseph C. Larson - One of the best experts on this subject based on the ideXlab platform.
-
The Effect of Calcium plus Vitamin D on Risk for Invasive Cancer: Results of the Women's Health Initiative (WHI) Calcium Plus Vitamin D Randomized Clinical Trial
Nutrition and cancer, 2011Co-Authors: Robert L. Brunner, Rowan T. Chlebowski, Dorothy S. Lane, Jean Wactawski-wende, Bette J. Caan, Barbara B. Cochrane, Margery Gass, Elizabeth T. Jacobs, Andrea Z. Lacroix, Joseph C. LarsonAbstract:In the Women's Health Initiative (WHI) trial of calcium plus vitamin D (CaD), we examined the treatment effect on incidence and mortality for all Invasive Cancers. Postmenopausal women (N = 36,282) were randomized to 1,000 mg of elemental calcium with 400 IU vitamin D3 or placebo. Cox models estimated risk of Cancer incidence and mortality. After 7.0 yr, 1,306 Invasive Cancers were diagnosed in the supplement and 1,333 in the placebo group [hazard ratio (HR) = 0.98; CI = 0.90, 1.05, unweighted P = 0.54]. Mortality did not differ between supplement (315, annualized% = .26) and placebo [(347, 0.28%; P = 0.17; HR = 0.90 (0.77, 1.05)]. Significant treatment interactions on incident Cancer were found for family history of Cancer, personal total intake of vitamin D, smoking, and WHI dietary trial randomized group. Calcium/vitamin D supplementation did not reduce Invasive Cancer incidence or mortality. Supplementation lowered Cancer risk in the WHI healthy diet trial arm and in women without a first-degree relative with Cancer. The interactions are only suggestive given multiple testing considerations. The low vitamin D dose provided, limited adherence, and lack of serum 25(OH)D values should be considered when interpreting these findings.
