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Jean M. Schmidt - One of the best experts on this subject based on the ideXlab platform.

Guido Cimino - One of the best experts on this subject based on the ideXlab platform.

  • wistarin from the marine sponge Ircinia sp the first case of enantiomeric sesterterpenes
    Tetrahedron-asymmetry, 1999
    Co-Authors: Angelo Fontana, Issa M. I. Fakhr, Ernesto Mollo, Guido Cimino
    Abstract:

    Abstract The sestertepene (−)-wistarin has been isolated from a Red Sea sponge of the genus Ircinia . This metabolite is the enantiomer of (+)-wistarin, a tetracyclic metabolite previously isolated from the sponge Ircinia wistarii . The enantiomeric relationship was proved by comparison of the CD spectrum of (−)-wistarin with that of a synthetic sample of the (+)-isomer. A hypothetical biosynthesis of (−)-wistarin is discussed starting from a putative linear precursor.

  • (−)-Wistarin from the marine sponge Ircinia sp.: the first case of enantiomeric sesterterpenes
    Tetrahedron: Asymmetry, 1999
    Co-Authors: Angelo Fontana, Issa M. I. Fakhr, Ernesto Mollo, Guido Cimino
    Abstract:

    Abstract The sestertepene (−)-wistarin has been isolated from a Red Sea sponge of the genus Ircinia . This metabolite is the enantiomer of (+)-wistarin, a tetracyclic metabolite previously isolated from the sponge Ircinia wistarii . The enantiomeric relationship was proved by comparison of the CD spectrum of (−)-wistarin with that of a synthetic sample of the (+)-isomer. A hypothetical biosynthesis of (−)-wistarin is discussed starting from a putative linear precursor.

Pei-show Shih - One of the best experts on this subject based on the ideXlab platform.

  • irciformonins e k c22 trinorsesterterpenoids from the sponge Ircinia formosana
    Helvetica Chimica Acta, 2009
    Co-Authors: Ya-ching Shen, Yu-chi Lin, Yao-haur Kuo, Pei-show Shih, Yun-sheng Lin, Yuh-chi Kuo, Ashraf Taha Khalil
    Abstract:

    Chemical investigation of the sponge Ircinia formosana resulted in the isolation of seven new linear C22-sesterterpenoids, irciformonins E–K (1–7) in addition to irciformonin A (8), a previously isolated furanosesterterpenoid (=a furan-moiety-containing sesterterpenoid) from the same species. The structures were determined by interpretation of HR-ESI-MS and 2D-NMR spectra. The structure of irciformonin A (8) was revised. Compound 5 exhibited significant inhibition of peripheral blood mononuclear cell proliferation induced by phytohemaglutinin.

  • Irciformonins E – K, C22‐Trinorsesterterpenoids from the Sponge Ircinia formosana
    Helvetica Chimica Acta, 2009
    Co-Authors: Ya-ching Shen, Yu-chi Lin, Yao-haur Kuo, Pei-show Shih, Yun-sheng Lin, Yuh-chi Kuo, Ashraf Taha Khalil
    Abstract:

    Chemical investigation of the sponge Ircinia formosana resulted in the isolation of seven new linear C22-sesterterpenoids, irciformonins E–K (1–7) in addition to irciformonin A (8), a previously isolated furanosesterterpenoid (=a furan-moiety-containing sesterterpenoid) from the same species. The structures were determined by interpretation of HR-ESI-MS and 2D-NMR spectra. The structure of irciformonin A (8) was revised. Compound 5 exhibited significant inhibition of peripheral blood mononuclear cell proliferation induced by phytohemaglutinin.

  • Novel linear C22-sesterterpenoids from sponge Ircinia formosana
    Tetrahedron Letters, 2006
    Co-Authors: Ya-ching Shen, Yu-chi Lin, Ashraf Taha Khalil, Yao-haur Kuo, Pei-show Shih
    Abstract:

    Abstract Four unprecedented C 22 -sesterterpenes, irciformonins A–D ( 1 – 4 ), have been isolated from the marine sponge Ircinia formosana , collected off the coast of eastern Taiwan. The structures of the isolated metabolites were established on the basis of extensive spectral analysis, primarily 1- and 2D-NMR. Compounds 3 and 4 exhibited significant cytotoxicity against human colon (WiDr) tumor cells.

S. De Rosa - One of the best experts on this subject based on the ideXlab platform.

  • Lipophylic metabolites from the marine sponge Ircinia muscarum and its cell cultures
    Marine Biology, 2002
    Co-Authors: S. De Rosa, Giuseppina Tommonaro, Krasimir Slantchev, Kamen Stefanov, Simeon Popov
    Abstract:

    The composition of the lipophylic extract from the sponge Ircinia muscarum and its cell cultures developed under light and dark conditions was investigated. Lipids and their fatty acids, as well as volatile compounds and sterols, were identified. The differences between the two cell cultures did not appear to be very significant, while there were significant differences between the sponge and the cell cultures. Most of the isolated compounds were found for the first time in dictyoceratide sponges.

  • Palinurin and Fasciculatin Sulfates from Two Thyrrenean Sponges of the Genus Ircinia
    Natural Product Letters, 1997
    Co-Authors: S. De Rosa, A. De Giulio, A. Crispino, Carmine Iodice, Giuseppina Tommonaro
    Abstract:

    Abstract Together with the previously described palinurin (1a) and fasciculatin (2a), the corresponding sulfates 1b and 2b were isolated from sponges of the genus Ircinia, collected in the Thyrrenean Sea. The structural elucidation and biological activity of these compounds are reported.

  • Sulfated Furanosesterterpenes from Two Sponges of the Genus Ircinia
    Natural Product Letters, 1996
    Co-Authors: S. De Rosa, A. Milone, A. De Giulio, A. Crispino, Carmine Iodice
    Abstract:

    Abstract Together with the previously described (18R)-variabilin (1a), its 13Z-isomer 2a, ircinin 1 (3a) and ircinin 2 (4a), the corresponding sulfates 1b-4b were isolated from sponges of the genus Ircinia, collected in the Northern Adriatic Sea. The structural elucidation and biological activity of these compounds are reported.

  • Pharmacological studies on terpenoids from marine sponges: Analgesic and muscle relaxant effects
    Phytotherapy Research, 1991
    Co-Authors: R. De Pasquale, S. De Rosa, C. Circosta, Francesco Occhiuto, S. De Stefano
    Abstract:

    Some terpenoids extracted from marine sponge: triacetylated desidein (from Disidea pallescens), 2-tetraprenyl benzoquinol and 4-hydroxy-3-tetraprenylbenzoic acid (from Ircinia muscarum), 2-polyprenyl benzoquinols (from Ircinia spinosula), avarol (from Disidea avara) and furospongin-1 (from Spongia officinalis) were tested by multidimensional Irwin screening and with some tests for analgesic and muscle relaxant activity. The three prenylhydroquinols derivatives and avarol show a good analgesic activity and low toxicity.

George R. Pettit - One of the best experts on this subject based on the ideXlab platform.