The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Raymond J Andersen - One of the best experts on this subject based on the ideXlab platform.
-
Sesterterpenoids isolated from the sponge phorbas sp activate latent hiv 1 provirus expression
Journal of Organic Chemistry, 2016Co-Authors: Meng Wang, Julie Daoust, Min Chen, Ian Tietjen, David E Williams, Mark A Brockman, Raymond J AndersenAbstract:Eight new Sesterterpenoids, alotaketals D (8) and E (9), ansellones D (10), E (11), F (12), and G (13), and anvilones A (14) and B (15), have been isolated from extracts of the marine sponge Phorbas sp. collected in Howe Sound British Columbia, and their structures have been elucidated by analysis of NMR and MS data. Ansellone F (12) contains a rare 1,2–3,4-bis-epoxydecalin substructure. Anvilones A (14) and B (15) have an unprecedented tetracylic anvilane terpenoid carbon skeleton. Using a cell culture model of latent HIV-1 infection, ansellone A (3), alotaketal D (8), and anvilone A (14) were found to induce HIV proviral gene expression similar to the control compound prostratin (1), while the known Sesterterpenoid alotaketal C (2), isolated from the same extract, was more potent and gave a stronger response than prostratin (1). Like prostratin (1), all of the Phorbas Sesterterpenoids with latency reversal agent properties appear to activate protein kinase C signaling.
-
Sesterterpenoids Isolated from the Sponge Phorbas sp. Activate Latent HIV‑1 Provirus Expression
2016Co-Authors: Meng Wang, Julie Daoust, Min Chen, David E. Williams, Ian Tietjen, Mark A Brockman, Raymond J AndersenAbstract:Eight new Sesterterpenoids, alotaketals D (8) and E (9), ansellones D (10), E (11), F (12), and G (13), and anvilones A (14) and B (15), have been isolated from extracts of the marine sponge Phorbas sp. collected in Howe Sound British Columbia, and their structures have been elucidated by analysis of NMR and MS data. Ansellone F (12) contains a rare 1,2–3,4-bis-epoxydecalin substructure. Anvilones A (14) and B (15) have an unprecedented tetracylic anvilane terpenoid carbon skeleton. Using a cell culture model of latent HIV-1 infection, ansellone A (3), alotaketal D (8), and anvilone A (14) were found to induce HIV proviral gene expression similar to the control compound prostratin (1), while the known Sesterterpenoid alotaketal C (2), isolated from the same extract, was more potent and gave a stronger response than prostratin (1). Like prostratin (1), all of the Phorbas Sesterterpenoids with latency reversal agent properties appear to activate protein kinase C signaling
-
Sesterterpenoids Isolated from a Northeastern Pacific Phorbas sp.
2013Co-Authors: Julie Daoust, Angelo Fontana, Catherine E Merchant, Timothy J Kieffer, Min Chen, Meng Wang, David E. Williams, Miguel Angel Garcia Chavez, Yan Alexander Wang, Raymond J AndersenAbstract:Four new Sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia. Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded “secoansellane” Sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells
-
ansellone a a Sesterterpenoid isolated from the nudibranch cadlina luteromarginata and the sponge phorbas sp activates the camp signaling pathway
Organic Letters, 2010Co-Authors: Julie Daoust, Angelo Fontana, Catherine E Merchant, Nicole J De Voogd, Brian O Patrick, Timothy J Kieffer, Raymond J AndersenAbstract:Ansellone A (1) has been isolated from the dorid nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It has the new “ansellane” Sesterterpenoid carbon skeleton, and it activates the cAMP signaling pathway.
-
alotaketals a and b Sesterterpenoids from the marine sponge hamigera species that activate the camp cell signaling pathway
Organic Letters, 2009Co-Authors: Roberto Forestieri, Catherine E Merchant, Nicole J De Voogd, Timothy J Kieffer, Teatulohi Matainaho, Raymond J AndersenAbstract:The new Sesterterpenoids alotaketals A (1) and B (2) have been isolated from extracts of the marine sponge Hamigera sp. collected in Papua New Guinea. Their chemical structures were elucidated by analysis of spectroscopic data. Alotaketals A and B have the unprecedented alotane carbon skeleton, and they activate the cAMP cell signaling pathway with EC50’s of 18 and 240 nM, respectively.
Xu Zhao - One of the best experts on this subject based on the ideXlab platform.
-
defense Sesterterpenoid lactones from leucosceptrum canum
Phytochemistry, 2013Co-Authors: Shihong Luo, Shuxi Jing, Juan Hua, Yan Liu, Xuemei Niu, Yanying Zhou, Xu ZhaoAbstract:Ten Sesterterpenoids, leucosceptroids E-N (1-10), possessing an alpha,beta-unsaturated gamma-lactone moiety, were isolated from the leaves and flowers of a woody Labiatae, Leucosceptrum canum. Their structures including relative stereochemistry were determined by comprehensive 1D and 2D NMR, MS, and in the case of 1 and 10, by single crystal X-ray diffraction analyses. This class of unique plant terpenoids was designated as leucosceptrane Sesterterpenoids (=leucosceptroids). The potent antifeedant activity of the most abundant compound, leucosceptroid G (3), and a representative compound, leucosceptroid N (10), against the generalist plant-feeding insect Helicoverpa armigera suggested that they might also be defense compounds of L. canum against insects. (c) 2012 Elsevier Ltd. All rights reserved.
-
unusual antifeedant spiro Sesterterpenoid from the flowers of leucosceptrum canum
Tetrahedron Letters, 2013Co-Authors: Shihong Luo, Juan Hua, Yan Liu, Xu ZhaoAbstract:Leucosceptroid O (1), an unusual Sesterterpenoid possessing a Spiro alpha,beta-unsaturated gamma-lactone moiety, was discovered from the flowers of a large woody Labiatae, Leucosceptrum canum. Its structure including absolute stereochemistry was determined by comprehensive NMR, MS, and single-crystal X-ray diffraction (with copper radiation) analyses. The obvious antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera suggested that it to be a new defensive Sesterterpenoid of Leucosceptrum canum. (c) 2012 Elsevier Ltd. All rights reserved.
-
new antifeedant c20 terpenoids from leucosceptrum canum
Organic Letters, 2012Co-Authors: Shihong Luo, Shuxi Jing, Juan Hua, Yan Liu, Xu ZhaoAbstract:Three novel C-20 terpenoids, norleucosceptroids A-C (1-3), were isolated from the leaves and flowers of Leucosceptrum canum (Labiatae) and were identified by comprehensive spectroscopic analysis and, in the case of 1, single-crystal X-ray diffraction. Structurally, compounds 1-3 should be categorized as pentanor-Sesterterpenoids rather than diterpenoids. Moderate antifeedant activity of 1-3 against the generalist plant-feeding insect Helicoverpa armigera was detected, suggesting that they might also be involved in the plant defense against insect herbivores.
-
glandular trichomes of leucosceptrum canum harbor defensive Sesterterpenoids
ChemInform, 2010Co-Authors: Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Shenghong LiAbstract:Leucosceptroid A (I) and leucosceptroid B (II) are found to be the major metabolites of the trichomes of L.
-
glandular trichomes of leucosceptrum canum harbor defensive Sesterterpenoids
Angewandte Chemie, 2010Co-Authors: Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Shenghong LiAbstract:Chinese Academy of Sciences (CAS) ; National Natural Science Foundation of China ; State Key Laboratory of Phytochemistry and Plant Resources in West China [P2009-ZZ01, P2008-ZZ18]; Germplasm Bank of Wild Species ; CAS Innovation Program of Kunming Institute of Botany [540806321211, 07067722K1, 07067712K1]
Zhigang She - One of the best experts on this subject based on the ideXlab platform.
-
aspterpenacids a and b two Sesterterpenoids from a mangrove endophytic fungus aspergillus terreus h010
Organic Letters, 2016Co-Authors: Zhaoming Liu, Xishan Huang, Yongcheng Lin, Dongni Chen, Yan Chen, Senhua Chen, Yayue Liu, Zhigang SheAbstract:Two new Sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.
-
asperterpenoid a a new Sesterterpenoid as an inhibitor of mycobacterium tuberculosis protein tyrosine phosphatase b from the culture of aspergillus sp 16 5c
Organic Letters, 2013Co-Authors: Xishan Huang, Hongbo Huang, Xuefeng Sun, Huarong Huang, Yongcheng Lin, Yuhua Long, Zhigang SheAbstract:Asperterpenoid A (1), a novel Sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC(50) value of 2.2 μM.
Xishan Huang - One of the best experts on this subject based on the ideXlab platform.
-
aspterpenacids a and b two Sesterterpenoids from a mangrove endophytic fungus aspergillus terreus h010
Organic Letters, 2016Co-Authors: Zhaoming Liu, Xishan Huang, Yongcheng Lin, Dongni Chen, Yan Chen, Senhua Chen, Yayue Liu, Zhigang SheAbstract:Two new Sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures were elucidated on the basis of spectroscopic methods, single-crystal X-ray diffraction analysis, and electronic circular dichroism calculations. A biogenetic pathway for 1 and 2 is proposed. Both 1 and 2 showed no significant antibacterial activity or cytotoxicity at 50 μM.
-
asperterpenols a and b new Sesterterpenoids isolated from a mangrove endophytic fungus aspergillus sp 085242
Organic Letters, 2013Co-Authors: Zeen Xiao, Xishan Huang, Huarong Huang, Changlun Shao, Yongjun Lu, Yuhua LongAbstract:Asperterpenol A (1) and asperterpenol B (2), two novel Sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 inhibit acetylcholinesterase with IC50 values of 2.3 and 3.0 μM, respectively.
-
asperterpenoid a a new Sesterterpenoid as an inhibitor of mycobacterium tuberculosis protein tyrosine phosphatase b from the culture of aspergillus sp 16 5c
Organic Letters, 2013Co-Authors: Xishan Huang, Hongbo Huang, Xuefeng Sun, Huarong Huang, Yongcheng Lin, Yuhua Long, Zhigang SheAbstract:Asperterpenoid A (1), a novel Sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC(50) value of 2.2 μM.
Julie Daoust - One of the best experts on this subject based on the ideXlab platform.
-
Sesterterpenoids isolated from the sponge phorbas sp activate latent hiv 1 provirus expression
Journal of Organic Chemistry, 2016Co-Authors: Meng Wang, Julie Daoust, Min Chen, Ian Tietjen, David E Williams, Mark A Brockman, Raymond J AndersenAbstract:Eight new Sesterterpenoids, alotaketals D (8) and E (9), ansellones D (10), E (11), F (12), and G (13), and anvilones A (14) and B (15), have been isolated from extracts of the marine sponge Phorbas sp. collected in Howe Sound British Columbia, and their structures have been elucidated by analysis of NMR and MS data. Ansellone F (12) contains a rare 1,2–3,4-bis-epoxydecalin substructure. Anvilones A (14) and B (15) have an unprecedented tetracylic anvilane terpenoid carbon skeleton. Using a cell culture model of latent HIV-1 infection, ansellone A (3), alotaketal D (8), and anvilone A (14) were found to induce HIV proviral gene expression similar to the control compound prostratin (1), while the known Sesterterpenoid alotaketal C (2), isolated from the same extract, was more potent and gave a stronger response than prostratin (1). Like prostratin (1), all of the Phorbas Sesterterpenoids with latency reversal agent properties appear to activate protein kinase C signaling.
-
Sesterterpenoids Isolated from the Sponge Phorbas sp. Activate Latent HIV‑1 Provirus Expression
2016Co-Authors: Meng Wang, Julie Daoust, Min Chen, David E. Williams, Ian Tietjen, Mark A Brockman, Raymond J AndersenAbstract:Eight new Sesterterpenoids, alotaketals D (8) and E (9), ansellones D (10), E (11), F (12), and G (13), and anvilones A (14) and B (15), have been isolated from extracts of the marine sponge Phorbas sp. collected in Howe Sound British Columbia, and their structures have been elucidated by analysis of NMR and MS data. Ansellone F (12) contains a rare 1,2–3,4-bis-epoxydecalin substructure. Anvilones A (14) and B (15) have an unprecedented tetracylic anvilane terpenoid carbon skeleton. Using a cell culture model of latent HIV-1 infection, ansellone A (3), alotaketal D (8), and anvilone A (14) were found to induce HIV proviral gene expression similar to the control compound prostratin (1), while the known Sesterterpenoid alotaketal C (2), isolated from the same extract, was more potent and gave a stronger response than prostratin (1). Like prostratin (1), all of the Phorbas Sesterterpenoids with latency reversal agent properties appear to activate protein kinase C signaling
-
Sesterterpenoids Isolated from a Northeastern Pacific Phorbas sp.
2013Co-Authors: Julie Daoust, Angelo Fontana, Catherine E Merchant, Timothy J Kieffer, Min Chen, Meng Wang, David E. Williams, Miguel Angel Garcia Chavez, Yan Alexander Wang, Raymond J AndersenAbstract:Four new Sesterterpenoids, ansellone B (4), phorbadione (5), secoepoxyansellone A (6), and alotaketal C (7), have been isolated from specimens of the sponge Phorbas sp. collected in British Columbia. Ansellone B (4) has an unprecedented heterocyclic skeleton featuring an oxocane ring, and secoepoxyansellone A (6) is the first example of the degraded “secoansellane” Sesterterpenoid carbon skeleton. Alotaketal C (7) is an activator of cAMP signaling in HEK cells
-
ansellone a a Sesterterpenoid isolated from the nudibranch cadlina luteromarginata and the sponge phorbas sp activates the camp signaling pathway
Organic Letters, 2010Co-Authors: Julie Daoust, Angelo Fontana, Catherine E Merchant, Nicole J De Voogd, Brian O Patrick, Timothy J Kieffer, Raymond J AndersenAbstract:Ansellone A (1) has been isolated from the dorid nudibranch Cadlina luteomarginata and the sponge Phorbas sp. It has the new “ansellane” Sesterterpenoid carbon skeleton, and it activates the cAMP signaling pathway.