The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
A C E Mccartney - One of the best experts on this subject based on the ideXlab platform.
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The composition of wide-spaced collagen in normal and diseased Descemet's membrane
Current Eye Research, 2009Co-Authors: S G Levy, Hajime Sawada, Jilly Moss, Patricia J.c. Dopping-hepenstal, A C E MccartneyAbstract:Descemet's membrane, the specialised basement membrane of the corneal endothelium, contains a form of extracellular matrix described as wide-spaced collagen. In healthy human Descemet's membrane, wide-spaced collagen forms a highly ordered array in a region called the anterior banded zone. However, in corneal endotheliopathies such as Fuchs' Endothelial dystrophy and the Iridocorneal-Endothelial Syndrome large amounts of wide-spaced collagen are deposited posterior to Descemet's membrane in a grotesque parody of the anterior banded zone termed a posterior collagenous layer. The purpose of this study was to identify the composition of the wide-spaced collagen found in the Descemet's membrane of normal and diseased human corneas.Tissue from three normal human corneas, three from patients with Fuchs' Endothelial dystrophy and five from patients with the Iridocorneal-Endothelial Syndrome was prepared for immunoelectron microscopy by freezing or embedding in Lowicryl K4M resin. Immunocytochemistry on ultrathin...
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the histopathology of the Iridocorneal Endothelial Syndrome
Cornea, 1996Co-Authors: S G Levy, Colin M. Kirkness, J Moss, Linda A Ficker, A C E MccartneyAbstract:: The Iridocorneal-Endothelial (ICE) Syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The purpose of this study was to define the histological appearances typical of this disease and in particular the ultrastructural morphology of the ICE cell. Thirty-five corneas, 11 trabeculectomy specimens, and 3 failed corneal grafts taken from patients with the ICE Syndrome were examined by transmission and scanning electron microscopy. Comparison was made with seven normal corneas. Ten corneas and two trabeculectomy specimens demonstrated a population of well-differentiated cells with epithelial features such as desmosomes, tonofilaments, and microvilli. Other cell types identified were cells that resembled those of normal corneal endothelium, inflammatory cells, and cells with a fibroblast-like morphology. It seems likely that the epithelial cells of our specimens are the histological equivalent of the ICE cell seen by specular photomicroscopy. The other cell types may be either residual normal Endothelial cells or else arise from secondary phenomena of various kinds.
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pathology of the Iridocorneal Endothelial Syndrome the ice cell
Investigative Ophthalmology & Visual Science, 1995Co-Authors: S G Levy, A C E Mccartney, M H Baghai, M C Barrett, J MossAbstract:Purpose. The Iridocorneal-Endothelial (ICE) Syndrome is characterized by glaucoma, corneal failure, and iris destruction. Specular photomicroscopy of the corneal endothelium in this disease shows a population of abnormal cells named ICE-cells. Comparison between ultrastructural examination and specular photomicroscopy demonstrates that the histologic equivalent of ICE-cells are cells with an epithelial phenotype. The authors have studied the differentiation markers expressed by ICE-cells using an ultrastructural immunocytochemical technique. Methods. Seven keratoplasty specimens from patients with the ICE Syndrome were examined by scanning and transmission electron microscopy and light and electron microscopic immunocytochemistry. Comparison was made with three normal corneas. Immunocytochemical studies were performed with monoclonal antibodies to broad-spectrum cytokeratins, cytokeratins 3, 5/8, 8/18 and 19, vimentin, and epithelial membrane antigen. Results. ICE-cells were morphologically similar to epithelial cells and expressed the same profile of differentiation markers as did normal limbal epithelial cells. Conclusions. ICE-cells may arise from an embryologic ectopia of ocular surface epithelium. Alternatively, these findings are consistent with a metaplastic stimulus resulting in a profound change in the phenotype of normal corneal Endothelial cells.
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descemet s membrane in the Iridocorneal Endothelial Syndrome morphology and composition
Experimental Eye Research, 1995Co-Authors: S G Levy, A C E Mccartney, Hajime Sawada, Patricia J C Doppinghepenstal, R A Alexander, J MossAbstract:The Iridocorneal-Endothelial Syndrome is a disease of the ocular anterior segment characterized by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies suggest the disorder is caused by a population of abnormal corneal Endothelial cells. In other corneal endotheliopathies Descemet's membrane, the basement membrane underlying the Endothelial cells, is disfigured by the presence of an abnormal region of extracellular matrix termed a posterior collagenous layer, which is laid down by the diseased Endothelial cells. In this study we sought to establish the typical morphology and composition of Descemet's membrane in the Iridocorneal-Endothelial Syndrome. Ultrastructural examination of Descemet's membrane in 27 keratoplasty specimens identified three morphologic patterns. In the majority there was a posterior collagenous layer which in all cases consisted of an anterior layer of wide-spaced collagen and a posterior layer of microfibrils embedded in an amorphous matrix. In four specimens which did not possess a posterior collagenous layer the anterior banded zone of Descemet's membrane was absent. In five corneas Descemet's membrane was normal. The composition of the posterior collagenous layer was examined by immunoelectron microscopy (five corneas) and histochemistry (six corneas). Collagen Types I, III, V, VI and VIII, fibronectin, tenascin and oxytalan were microfibrillar components, collagen Type VIII formed wide-spaced collagen whilst laminin was present in the amorphous matrix. The stereotyped derangements of structure and composition identified in the Endothelial basement membrane may significantly influence the pathobiology of this disorder.
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On the pathology of the Iridocorneal-Endothelial Syndrome: The ultrastructural appearances of ‘subtotal-ICE’
Eye, 1995Co-Authors: S G Levy, J Moss, C M Kirkness, L Ficker, A C E MccartneyAbstract:The Iridocorneal-Endothelial Syndrome (ICE Syndrome) is characterised by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies of the corneal endothelium in this disease show a population of abnormal cells named ‘ICE-cells’. In many patients some areas of the endothelium are occupied by ICE-cells and others by normal cells, an appearance described as ‘subtotal-ICE’. Specular photomicroscopical observations suggest that. ICE-cells and normal Endothelial cells may actively interact at the boundary zone where they meet. The purpose of this study was to examine the ultrastructural appearances of the boundary zone to gain insight into the cellular pathology of this region. Thirty-five corneas taken from patients with the ICE Syndrome were examined by light, transmission and scanning electron microscopy. The subtotal-ICE appearance was demonstrated in four specimens. The morphology of ICE-cells at the boundary zone suggests that they are non-motile but also implies a general state of high metabolic activity. Many of the normal Endothelial cells in this region are damaged, an appearance which may result from a toxic effect from the nearby ICE-cells.
Robert Ritch - One of the best experts on this subject based on the ideXlab platform.
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the Iridocorneal Endothelial Syndrome
Survey of Ophthalmology, 2018Co-Authors: Luis Silva, Ahmad Najafi, Yanin Suwan, Chaiwat Teekhasaenee, Robert RitchAbstract:Abstract The Iridocorneal Endothelial Syndrome represents a unique group of ocular pathologies (Chandler Syndrome, progressive iris atrophy, and Cogan-Reese Syndrome) characterized by the proliferation of corneal Endothelial cells that migrate toward the Iridocorneal angle and iris surface causing, to a degree varying according to the subtype, corneal edema and decompensation and secondary glaucoma, whether by obstructing the angle or producing peripheral anterior synechiae by contraction of the basement membrane of the migrating cells over the surface of the iris. A triggering factor, possibly viral, induces the corneal Endothelial cells to proliferate and behave like epithelial cells. Diagnosis is made based on typical ocular findings on the cornea and iris. Iridocorneal Endothelial Syndrome is more frequent in young women, with unilateral involvement in most cases. In vivo confocal microscopy is an excellent diagnostic tool, especially in borderline presentations like early cases of Chandler Syndrome, which affects the cornea predominantly. Typical clinical management consists of treating the corneal edema and decompensation, where Endothelial keratoplasty techniques have replaced in many cases the need for a penetrating keratoplasty and treating the secondary glaucoma, which usually requires surgical intervention.
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Iridocorneal Endothelial Syndrome in a 16 year old
Journal of Glaucoma, 2011Co-Authors: Olusola Olawoye, Christopher C Teng, Jeffrey M Liebmann, Fred Wang, Robert RitchAbstract:: We report Iridocorneal Endothelial Syndrome in a male who presented at the age of 16 years with a 3-year history of complaints of blurred vision, altered pupillary shape, and monocular diplopia OD. The examination was notable for unilateral effacement of the iris architecture, stretch holes, corectopia, and localized ectropion uveae. Intraocular pressures were 41 mm Hg OD and 10 mm Hg OS. Gonioscopy revealed intermittent areas of broad synechiae anterior to Schwalbe's line alternating with a clinically normal appearance. The left eye and angle were unremarkable. Specular microscopy confirmed the presence of unilateral Endothelial pleomorphism and polymegathism. To our knowledge, this is the earliest reported case of Iridocorneal Endothelial Syndrome in a young man.
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Iridocorneal Endothelial Syndrome in thai patients clinical variations
Archives of Ophthalmology, 2000Co-Authors: Chaiwat Teekhasaenee, Robert RitchAbstract:Objective To evaluate the spectrum of Iridocorneal Endothelial Syndrome, to our knowledge, never studied previously in Orientals. Methods From 1986 to 1998, we examined 60 consecutive patients (20 men, 40 women) with characteristic signs of Iridocorneal Endothelial Syndrome and compared the clinical manifestations to those reported in white patients. Results Cogan-Reese Syndrome (CRS) was most common (38 patients), while 14 patients had Chandler Syndrome (CS), and 8 had progressive iris atrophy. Three patients initially classified as having CS and 1 as having progressive iris atrophy progressed to CRS. Glaucoma occurred in 46 patients (76.7%), most commonly in patients with progressive iris atrophy or CRS. Ten patients had slow progression of disease during the follow-up period of up to 12 years. Three patients (2 with CRS, 1 with CS) had asymptomatic localized islands of "hammered-silver" appearance and 11 (8 with CRS, 2 with CS, and 1 with progressive iris atrophy) had subclinical abnormal endothelium in the contralateral eyes. A translucent membrane was commonly seen on the brown iris surface. Total Endothelial involvement was present in 49 patients, while 6 (4 with CRS, 2 with CS) had focal Endothelial abnormalities with sharp demarcation from adjacent normal endothelium. Conclusions Iridocorneal Endothelial Syndrome occurs in Orientals. Cogan-Reese Syndrome is the most common form and is strongly associated with glaucoma. Although several clinical manifestations were similar between whites and Orientals (mean age of onset, sex predilection, iris changes, peripheral anterior synechiae formation, or corneal edema), CRS was most prevalent; a translucent membrane were more noticeable in Orientals.
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antibodies to epstein barr virus in Iridocorneal Endothelial Syndrome
Archives of Ophthalmology, 1990Co-Authors: Clark S Tsai, Robert Ritch, Stephen E Straus, Henry D Perry, F Y HsiehAbstract:• Antibody titers to Epstein-Barr virus were determined in 13 patients with Iridocorneal Endothelial Syndrome and in 13 healthy race-, age-, and sex-matched controls. Both the geometric mean titer of IgG antibodies to the Epstein-Barr virus capsid antigen and the proportion with high titers of IgG antibodies to the Epstein-Barr virus capsid antigen (≥1:640) were significantly higher in 12 seropositive patients with Iridocorneal Endothelial Syndrome than in 12 seropositive controls (1/761:1/202, P =.001; 83.3%:8.3%, P P P >.1). Antibody levels to cytomegalovirus or measles virus were not different between patients with Iridocorneal Endothelial Syndrome and controls. Additional studies showed no evidence of humoral immune disorder or collagen vascular disease in the patients with Iridocorneal Endothelial Syndrome. The serologic profiles suggest that the patients with Iridocorneal Endothelial Syndrome examined had a cellular immune abnormality sufficient to permit reactivation of latent Epstein-Barr virus infection and imply, but do not establish, a role for Epstein-Barr virus infection in the pathogenesis of some cases of the Iridocorneal Endothelial Syndrome.
S G Levy - One of the best experts on this subject based on the ideXlab platform.
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The composition of wide-spaced collagen in normal and diseased Descemet's membrane
Current Eye Research, 2009Co-Authors: S G Levy, Hajime Sawada, Jilly Moss, Patricia J.c. Dopping-hepenstal, A C E MccartneyAbstract:Descemet's membrane, the specialised basement membrane of the corneal endothelium, contains a form of extracellular matrix described as wide-spaced collagen. In healthy human Descemet's membrane, wide-spaced collagen forms a highly ordered array in a region called the anterior banded zone. However, in corneal endotheliopathies such as Fuchs' Endothelial dystrophy and the Iridocorneal-Endothelial Syndrome large amounts of wide-spaced collagen are deposited posterior to Descemet's membrane in a grotesque parody of the anterior banded zone termed a posterior collagenous layer. The purpose of this study was to identify the composition of the wide-spaced collagen found in the Descemet's membrane of normal and diseased human corneas.Tissue from three normal human corneas, three from patients with Fuchs' Endothelial dystrophy and five from patients with the Iridocorneal-Endothelial Syndrome was prepared for immunoelectron microscopy by freezing or embedding in Lowicryl K4M resin. Immunocytochemistry on ultrathin...
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the histopathology of the Iridocorneal Endothelial Syndrome
Cornea, 1996Co-Authors: S G Levy, Colin M. Kirkness, J Moss, Linda A Ficker, A C E MccartneyAbstract:: The Iridocorneal-Endothelial (ICE) Syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The purpose of this study was to define the histological appearances typical of this disease and in particular the ultrastructural morphology of the ICE cell. Thirty-five corneas, 11 trabeculectomy specimens, and 3 failed corneal grafts taken from patients with the ICE Syndrome were examined by transmission and scanning electron microscopy. Comparison was made with seven normal corneas. Ten corneas and two trabeculectomy specimens demonstrated a population of well-differentiated cells with epithelial features such as desmosomes, tonofilaments, and microvilli. Other cell types identified were cells that resembled those of normal corneal endothelium, inflammatory cells, and cells with a fibroblast-like morphology. It seems likely that the epithelial cells of our specimens are the histological equivalent of the ICE cell seen by specular photomicroscopy. The other cell types may be either residual normal Endothelial cells or else arise from secondary phenomena of various kinds.
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pathology of the Iridocorneal Endothelial Syndrome the ice cell
Investigative Ophthalmology & Visual Science, 1995Co-Authors: S G Levy, A C E Mccartney, M H Baghai, M C Barrett, J MossAbstract:Purpose. The Iridocorneal-Endothelial (ICE) Syndrome is characterized by glaucoma, corneal failure, and iris destruction. Specular photomicroscopy of the corneal endothelium in this disease shows a population of abnormal cells named ICE-cells. Comparison between ultrastructural examination and specular photomicroscopy demonstrates that the histologic equivalent of ICE-cells are cells with an epithelial phenotype. The authors have studied the differentiation markers expressed by ICE-cells using an ultrastructural immunocytochemical technique. Methods. Seven keratoplasty specimens from patients with the ICE Syndrome were examined by scanning and transmission electron microscopy and light and electron microscopic immunocytochemistry. Comparison was made with three normal corneas. Immunocytochemical studies were performed with monoclonal antibodies to broad-spectrum cytokeratins, cytokeratins 3, 5/8, 8/18 and 19, vimentin, and epithelial membrane antigen. Results. ICE-cells were morphologically similar to epithelial cells and expressed the same profile of differentiation markers as did normal limbal epithelial cells. Conclusions. ICE-cells may arise from an embryologic ectopia of ocular surface epithelium. Alternatively, these findings are consistent with a metaplastic stimulus resulting in a profound change in the phenotype of normal corneal Endothelial cells.
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descemet s membrane in the Iridocorneal Endothelial Syndrome morphology and composition
Experimental Eye Research, 1995Co-Authors: S G Levy, A C E Mccartney, Hajime Sawada, Patricia J C Doppinghepenstal, R A Alexander, J MossAbstract:The Iridocorneal-Endothelial Syndrome is a disease of the ocular anterior segment characterized by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies suggest the disorder is caused by a population of abnormal corneal Endothelial cells. In other corneal endotheliopathies Descemet's membrane, the basement membrane underlying the Endothelial cells, is disfigured by the presence of an abnormal region of extracellular matrix termed a posterior collagenous layer, which is laid down by the diseased Endothelial cells. In this study we sought to establish the typical morphology and composition of Descemet's membrane in the Iridocorneal-Endothelial Syndrome. Ultrastructural examination of Descemet's membrane in 27 keratoplasty specimens identified three morphologic patterns. In the majority there was a posterior collagenous layer which in all cases consisted of an anterior layer of wide-spaced collagen and a posterior layer of microfibrils embedded in an amorphous matrix. In four specimens which did not possess a posterior collagenous layer the anterior banded zone of Descemet's membrane was absent. In five corneas Descemet's membrane was normal. The composition of the posterior collagenous layer was examined by immunoelectron microscopy (five corneas) and histochemistry (six corneas). Collagen Types I, III, V, VI and VIII, fibronectin, tenascin and oxytalan were microfibrillar components, collagen Type VIII formed wide-spaced collagen whilst laminin was present in the amorphous matrix. The stereotyped derangements of structure and composition identified in the Endothelial basement membrane may significantly influence the pathobiology of this disorder.
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On the pathology of the Iridocorneal-Endothelial Syndrome: The ultrastructural appearances of ‘subtotal-ICE’
Eye, 1995Co-Authors: S G Levy, J Moss, C M Kirkness, L Ficker, A C E MccartneyAbstract:The Iridocorneal-Endothelial Syndrome (ICE Syndrome) is characterised by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies of the corneal endothelium in this disease show a population of abnormal cells named ‘ICE-cells’. In many patients some areas of the endothelium are occupied by ICE-cells and others by normal cells, an appearance described as ‘subtotal-ICE’. Specular photomicroscopical observations suggest that. ICE-cells and normal Endothelial cells may actively interact at the boundary zone where they meet. The purpose of this study was to examine the ultrastructural appearances of the boundary zone to gain insight into the cellular pathology of this region. Thirty-five corneas taken from patients with the ICE Syndrome were examined by light, transmission and scanning electron microscopy. The subtotal-ICE appearance was demonstrated in four specimens. The morphology of ICE-cells at the boundary zone suggests that they are non-motile but also implies a general state of high metabolic activity. Many of the normal Endothelial cells in this region are damaged, an appearance which may result from a toxic effect from the nearby ICE-cells.
J Moss - One of the best experts on this subject based on the ideXlab platform.
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the histopathology of the Iridocorneal Endothelial Syndrome
Cornea, 1996Co-Authors: S G Levy, Colin M. Kirkness, J Moss, Linda A Ficker, A C E MccartneyAbstract:: The Iridocorneal-Endothelial (ICE) Syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The purpose of this study was to define the histological appearances typical of this disease and in particular the ultrastructural morphology of the ICE cell. Thirty-five corneas, 11 trabeculectomy specimens, and 3 failed corneal grafts taken from patients with the ICE Syndrome were examined by transmission and scanning electron microscopy. Comparison was made with seven normal corneas. Ten corneas and two trabeculectomy specimens demonstrated a population of well-differentiated cells with epithelial features such as desmosomes, tonofilaments, and microvilli. Other cell types identified were cells that resembled those of normal corneal endothelium, inflammatory cells, and cells with a fibroblast-like morphology. It seems likely that the epithelial cells of our specimens are the histological equivalent of the ICE cell seen by specular photomicroscopy. The other cell types may be either residual normal Endothelial cells or else arise from secondary phenomena of various kinds.
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pathology of the Iridocorneal Endothelial Syndrome the ice cell
Investigative Ophthalmology & Visual Science, 1995Co-Authors: S G Levy, A C E Mccartney, M H Baghai, M C Barrett, J MossAbstract:Purpose. The Iridocorneal-Endothelial (ICE) Syndrome is characterized by glaucoma, corneal failure, and iris destruction. Specular photomicroscopy of the corneal endothelium in this disease shows a population of abnormal cells named ICE-cells. Comparison between ultrastructural examination and specular photomicroscopy demonstrates that the histologic equivalent of ICE-cells are cells with an epithelial phenotype. The authors have studied the differentiation markers expressed by ICE-cells using an ultrastructural immunocytochemical technique. Methods. Seven keratoplasty specimens from patients with the ICE Syndrome were examined by scanning and transmission electron microscopy and light and electron microscopic immunocytochemistry. Comparison was made with three normal corneas. Immunocytochemical studies were performed with monoclonal antibodies to broad-spectrum cytokeratins, cytokeratins 3, 5/8, 8/18 and 19, vimentin, and epithelial membrane antigen. Results. ICE-cells were morphologically similar to epithelial cells and expressed the same profile of differentiation markers as did normal limbal epithelial cells. Conclusions. ICE-cells may arise from an embryologic ectopia of ocular surface epithelium. Alternatively, these findings are consistent with a metaplastic stimulus resulting in a profound change in the phenotype of normal corneal Endothelial cells.
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descemet s membrane in the Iridocorneal Endothelial Syndrome morphology and composition
Experimental Eye Research, 1995Co-Authors: S G Levy, A C E Mccartney, Hajime Sawada, Patricia J C Doppinghepenstal, R A Alexander, J MossAbstract:The Iridocorneal-Endothelial Syndrome is a disease of the ocular anterior segment characterized by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies suggest the disorder is caused by a population of abnormal corneal Endothelial cells. In other corneal endotheliopathies Descemet's membrane, the basement membrane underlying the Endothelial cells, is disfigured by the presence of an abnormal region of extracellular matrix termed a posterior collagenous layer, which is laid down by the diseased Endothelial cells. In this study we sought to establish the typical morphology and composition of Descemet's membrane in the Iridocorneal-Endothelial Syndrome. Ultrastructural examination of Descemet's membrane in 27 keratoplasty specimens identified three morphologic patterns. In the majority there was a posterior collagenous layer which in all cases consisted of an anterior layer of wide-spaced collagen and a posterior layer of microfibrils embedded in an amorphous matrix. In four specimens which did not possess a posterior collagenous layer the anterior banded zone of Descemet's membrane was absent. In five corneas Descemet's membrane was normal. The composition of the posterior collagenous layer was examined by immunoelectron microscopy (five corneas) and histochemistry (six corneas). Collagen Types I, III, V, VI and VIII, fibronectin, tenascin and oxytalan were microfibrillar components, collagen Type VIII formed wide-spaced collagen whilst laminin was present in the amorphous matrix. The stereotyped derangements of structure and composition identified in the Endothelial basement membrane may significantly influence the pathobiology of this disorder.
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On the pathology of the Iridocorneal-Endothelial Syndrome: The ultrastructural appearances of ‘subtotal-ICE’
Eye, 1995Co-Authors: S G Levy, J Moss, C M Kirkness, L Ficker, A C E MccartneyAbstract:The Iridocorneal-Endothelial Syndrome (ICE Syndrome) is characterised by corneal failure, glaucoma and iris destruction. Specular photomicroscopical and histological studies of the corneal endothelium in this disease show a population of abnormal cells named ‘ICE-cells’. In many patients some areas of the endothelium are occupied by ICE-cells and others by normal cells, an appearance described as ‘subtotal-ICE’. Specular photomicroscopical observations suggest that. ICE-cells and normal Endothelial cells may actively interact at the boundary zone where they meet. The purpose of this study was to examine the ultrastructural appearances of the boundary zone to gain insight into the cellular pathology of this region. Thirty-five corneas taken from patients with the ICE Syndrome were examined by light, transmission and scanning electron microscopy. The subtotal-ICE appearance was demonstrated in four specimens. The morphology of ICE-cells at the boundary zone suggests that they are non-motile but also implies a general state of high metabolic activity. Many of the normal Endothelial cells in this region are damaged, an appearance which may result from a toxic effect from the nearby ICE-cells.
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on the pathology of the Iridocorneal Endothelial Syndrome the ultrastructural appearances of subtotal ice
Eye, 1995Co-Authors: S G Levy, Colin M. Kirkness, J Moss, Linda A Ficker, A C E MccartneyAbstract:On the pathology of the Iridocorneal-Endothelial Syndrome: The ultrastructural appearances of ‘subtotal-ICE’
Suphi Acar - One of the best experts on this subject based on the ideXlab platform.
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Management of detached graft donor by SF_6 injection following Descemet stripping automated Endothelial keratoplasty of an eye with Iridocorneal Endothelial Syndrome and Ahmed glaucoma drainage tube
International Ophthalmology, 2012Co-Authors: Kansu Tahir Bozkurt, Banu Torun Acar, Suphi AcarAbstract:A 65-year-old woman with Iridocorneal Endothelial Syndrome and a history of Ahmed glaucoma drainage (AGD) tube implantation underwent Descemet stripping automated Endothelial keratoplasty (DSAEK) in her right eye. During the procedure, filling the anterior chamber with air was quite difficult due to escape of air via the AGD tube and a complete air fill of the anterior chamber could only be managed after multiple attempts. On operation night, there was no air left in the anterior chamber. On postoperative day 1, graft detachment was determined by slit-lamp biomicroscopy. For rebubbling, sulfur hexafluoride (SF_6) 20 % was injected into the anterior chamber. Two days later, there was still some SF_6 in the anterior chamber and the graft was completely attached. At postoperative week 2, visual acuity was 2/10. SF_6 use may be considered for DSAEK in cases of previous AGD tube implantation history due to its potential for longer duration in order to obtain a better tamponade with the bubble due to its expanding nature.
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management of detached graft donor by sf6 injection following descemet stripping automated Endothelial keratoplasty of an eye with Iridocorneal Endothelial Syndrome and ahmed glaucoma drainage tube
International Ophthalmology, 2012Co-Authors: Kansu Tahir Bozkurt, Banu Torun Acar, Suphi AcarAbstract:A 65-year-old woman with Iridocorneal Endothelial Syndrome and a history of Ahmed glaucoma drainage (AGD) tube implantation underwent Descemet stripping automated Endothelial keratoplasty (DSAEK) in her right eye. During the procedure, filling the anterior chamber with air was quite difficult due to escape of air via the AGD tube and a complete air fill of the anterior chamber could only be managed after multiple attempts. On operation night, there was no air left in the anterior chamber. On postoperative day 1, graft detachment was determined by slit-lamp biomicroscopy. For rebubbling, sulfur hexafluoride (SF6) 20 % was injected into the anterior chamber. Two days later, there was still some SF6 in the anterior chamber and the graft was completely attached. At postoperative week 2, visual acuity was 2/10. SF6 use may be considered for DSAEK in cases of previous AGD tube implantation history due to its potential for longer duration in order to obtain a better tamponade with the bubble due to its expanding nature.
