The Experts below are selected from a list of 78 Experts worldwide ranked by ideXlab platform
David J. Atherton - One of the best experts on this subject based on the ideXlab platform.
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Understanding Irritant napkin Dermatitis
International Journal of Dermatology, 2016Co-Authors: David J. AthertonAbstract:Irritant napkin Dermatitis (IND, often referred to as Irritant Diaper Dermatitis) is an exceedingly common problem in the first 2 years of life. It is now established that a number of factors are considered important in the etiology of IND. The principal Irritants are fecal enzymes, which damage infant skin and are further amplified by a number of factors, including skin maceration and friction, high pH, the presence of urine, and the duration of contact with feces. In recent years, the decreasing incidence and severity of IND reflects improvements in the design and performance of Diapers, Diaper skin care products, and overall awareness about maintaining infant skin health.
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a review of the pathophysiology prevention and treatment of Irritant Diaper Dermatitis
Current Medical Research and Opinion, 2004Co-Authors: David J. AthertonAbstract:SUMMARYIrritant Diaper Dermatitis (IDD) is a form of contact Dermatitis occurring in the Diaper area as a consequence of disruption of the barrier function of the skin through prolonged contact with faeces and urine. Despite advances in Diaper technology, it is a condition that still occurs regularly in young children. To combat this, barrier preparations can be used to protect the skin by coating the surface of the skin and/or by supplying lipids that can penetrate the intercellular spaces of the stratum corneum. In this review, the pathophysiology of IDD is outlined and its prevention and treatment are discussed, with particular reference to the role of emollients.
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The aetiology and management of Irritant Diaper Dermatitis
Journal of the European Academy of Dermatology and Venereology, 2001Co-Authors: David J. AthertonAbstract:Irritant Diaper Dermatitis (IDD) is a common condition caused by the combination of wearing Diapers, and incontinence of urine and faeces. The available evidence suggests that maceration of the stratum corneum by water increases susceptibility to frictional damage, and epidermal permeation of Irritants. The most important Irritants underlying IDD appear to be digestive enzymes persisting in faeces, particularly when these are activated by a high pH.
Fiona Macvane Phipps - One of the best experts on this subject based on the ideXlab platform.
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the basics baby skin integrity comparison survey study a prospective experimental study using maternal observations to report the effect of baby wipes on the incidence of Irritant Diaper Dermatitis in infants from birth to eight weeks of age
Pediatrics and Neonatology, 2021Co-Authors: Alan D Price, Jeanne Lythgoe, James Ackersjohnson, Penny A Cook, A M Clarkecornwell, Fiona Macvane PhippsAbstract:BACKGROUND Baby wipes have been shown to be safe and effective in maintaining skin integrity when compared to the use of water alone. However, no previous study has compared different formulations of wipe. The aim of the BaSICS study was to identify any differences in incidence of Irritant Diaper Dermatitis (IDD) in infants assigned to three different brands of wipe, all marketed as suitable for neonates, but which contained varying numbers of ingredients. METHODS Women were recruited during the prenatal period. Participants were randomly assigned to receive one of three brands of wipe for use during the first eight weeks following childbirth. All participants received the same nappies. Participants reported their infant's skin integrity on a scale of 1-5 daily using a bespoke smartphone application. Analysis of effect of brand on clinically significant IDD (score 3 or more) incidence was conducted using a negative binomial generalised linear model, controlling for possible confounders at baseline. Analysts were blind to brand of wipe. RESULTS Of 737 women enrolled, 15 were excluded (admitted to neonatal intensive care, premature or other infant health issues). Of the 722 eligible babies, 698 (97%) remained in the study for the full 8-week duration, 24.6% of whom had IDD at some point during the study. Mothers using the brand with the fewest ingredients reported fewer days of clinically significant nappy rash (score≥3) than participants using the two other brands (p = 0.002 and p < 0.001). Severe IDD (grades 4 and 5) was rare (2.4%). CONCLUSIONS Rarity of severe IDD suggested that sensitive formula baby wipes are safe when used in cleansing babies from birth to eight weeks during nappy changes. The brand with fewest ingredients had significantly fewer days of clinically significant IDD. Daily observations recorded on a smartphone application proved to be a highly acceptable method of obtaining real-time data on IDD. CLINICAL TRIAL REGISTRATION This study was not designed or registered as a clinical trial as no intervention in normal patterns of infant care took place. Mothers who had already decided to use disposable nappies and a baby wipe product agreed to observe and report on their infants' skin condition; in return they received a 9-week supply of free nappies and wipes.
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the basics baby skin integrity comparison survey study a prospective experimental study using maternal observations to report the effect of baby wipes on the incidence of Irritant Diaper Dermatitis in infants from birth to eight weeks of age
Pediatrics and Neonatology, 2021Co-Authors: Alan D Price, Jeanne Lythgoe, James Ackersjohnson, Penny A Cook, A M Clarkecornwell, Fiona Macvane PhippsAbstract:Background Baby wipes have been shown to be safe and effective in maintaining skin integrity when compared to the use of water alone. However, no previous study has compared different formulations of wipe. The aim of the BaSICS study was to identify any differences in incidence of Irritant Diaper Dermatitis (IDD) in infants assigned to three different brands of wipe, all marketed as suitable for neonates, but which contained varying numbers of ingredients. Methods Women were recruited during the prenatal period. Participants were randomly assigned to receive one of three brands of wipe for use during the first eight weeks following childbirth. All participants received the same nappies. Participants reported their infant’s skin integrity on a scale of 1 to 5 daily using a bespoke smartphone application. Analysis of effect of brand on clinically significant IDD (score 3 or more) incidence was conducted using a negative binomial generalised linear model, controlling for possible confounders at baseline. Analysts were blind to brand of wipe. Results Of 737 women enrolled, 15 were excluded (admitted to neonatal intensive care, premature or other infant health issues). Of the 722 eligible babies, 698 (97%) remained in the study for the full 8-week duration, 24.6% of whom had IDD at some point during the study. Mothers using the brand with the fewest ingredients reported fewer days of clinically significant nappy rash (score≥3) than participants using the two other brands (p=0.002 and p<0.001). Severe IDD (grades 4 and 5) was rare (2.4%). Conclusions Rarity of severe IDD suggested that sensitive formula baby wipes are safe when used in cleansing babies from birth to eight weeks during nappy changes. The brand with fewest ingredients had significantly fewer days of clinically significant IDD. Daily observations recorded on a smartphone application proved to be a highly acceptable method of obtaining real-time data on IDD.
Wanee Wisuthsarewong - One of the best experts on this subject based on the ideXlab platform.
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Comparison of Dexpanthenol and Zinc Oxide Ointment with Ointment Base in the Treatment of Irritant Diaper Dermatitis from Diarrhea: A Multicenter Study
2015Co-Authors: Siriwan Wananukul, Wanida Limpongsanuruk, Srisupalak Singalavanija, Wanee WisuthsarewongAbstract:Background: Severity of Irritant Diaper Dermatitis (IDD) from diarrhea varies from patient to patient depend-ing on the nature of feces and the number of bowel movements. The purpose of the present study was to compare the effectiveness of dexpanthenol and zinc oxide ointment with ointment base in the treatment of Irritant Diaper Dermatitis from acute diarrhea in children by measuring transepidermal water loss (TEWL). Material and Method: Forty-six children with diarrhea were prospectively, block randomized, investigator-blinded to receive dexpanthenol and zinc oxide ointment on one side and ointment base on the other side. TEWL was measured before and on days 1, 3, and 7 of treatment together with the assessment of severity score. The efficacy of treatment was defined by complete clearance of the lesion. Results: TEWL in the treated and control side was not different before the application of the topical medica-tion. In the present study, the efficacy of 5 % dexpanthenol and zinc oxide ointment on D3 was 39 % (18 from 46 patients) compared to 32 % in the ointment base side. On D7, the efficacy of the treated side was 58.7 % and the ointment base side was 56%. The patients who still had skin lesions were those who had prolonged diarrhea. On the treated side, the mean of TEWL was lower than the control side on D1 (p = 0.18) and had significant improvement on D3 (p = 0.002). At the end of the present study, TEWL on the treated side was less than TEWL of the control side but it did not have statistical significance (p = 0.07). There was no rash or sign o
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comparison of dexpanthenol and zinc oxide ointment with ointment base in the treatment of Irritant Diaper Dermatitis from diarrhea a multicenter study
Journal of the Medical Association of Thailand Chotmaihet thangphaet, 2006Co-Authors: Siriwan Wananukul, Wanida Limpongsanuruk, Srisupalak Singalavanija, Wanee WisuthsarewongAbstract:BACKGROUND: Severity of Irritant Diaper Dermatitis (IDD) from diarrhea varies from patient to patient depending on the nature of feces and the number of bowel movements. The purpose of the present study was to compare the effectiveness of dexpanthenol and zinc oxide ointment with ointment base in the treatment of Irritant Diaper Dermatitis from acute diarrhea in children by measuring transepidermal water loss (TEWL). MATERIAL AND METHOD: Forty-six children with diarrhea were prospectively, block randomized, investigator-blinded to receive dexpanthenol and zinc oxide ointment on one side and ointment base on the other side. TEWL was measured before and on days 1, 3, and 7 of treatment together with the assessment of severity score. The efficacy of treatment was defined by complete clearance of the lesion. RESULTS: TEWL in the treated and control side was not different before the application of the topical medication. In the present study, the efficacy of 5% dexpanthenol and zinc oxide ointment on D3 was 39% (18from 46 patients) compared to 32% in the ointment base side. On D7, the efficacy of the treated side was 58.7% and the ointment base side was 56%. The patients who still had skin lesions were those who had prolonged diarrhea. On the treated side, the mean of TEWL was lower than the control side on DI (p = 0.18) and had significant improvement on D3 (p = 0. 002). At the end of the present study, TEWL on the treated side was less than TEWL of the control side but it did not have statistical significance (p = 0.07). There was no rash or sign of abnormality on the treated side at the end of D7. CONCLUSION: In the treatment of lDD from acute diarrhea, 5% dexpanthenol and zinc oxide ointment significantly decreased TEWL in the treated side more than the ointment base on day 3 but the severity score was not significantly different on days 1, 3 and 7.
Lythgoe J - One of the best experts on this subject based on the ideXlab platform.
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698 mothers and babies, 38 390 nappy changes : what did we learn?
'Mark Allen Group', 2021Co-Authors: Macvane Phipps F, Ad Price, Ackers-johnson J, Pa Cook, Am Clarke-cornwell, Lythgoe JAbstract:Background Several industry funded studies between 2001–2018 have compared the use of a single brand of baby wipes to cleansing with water and either cloth or cotton wool during nappy changes. All of these studies found that wipes were safe and effective from birth. Recommendations from these studies have included the need for brand or formula comparison but to date, no previous study has done this. Aims The ‘Baby skin integrity comparison survey’ (BaSICS) study was designed to compare three brands of baby wipes to determine if there was any difference in the incidence of Irritant Diaper Dermatitis (IDD or nappy rash) during the first eight weeks of life. Methods Mothers who were allocated to a single brand of nappy but divided into three baby wipe allocation groups, collected and reported survey data on infant skin integrity during one nappy change daily with the use of a user-friendly smartphone application. Findings All brands of wipes were acceptable to mothers and safe and effective when cleaning during nappy changes. The brand containing the fewest ingredients showed a clinically significant advantage of fewer incidents of rash than the other two brands. Conclusion This study demonstrated that wipe formulation is a significant factor in prevention or reduction of IDD during the first eight weeks of life
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The BaSICS (Baby Skin Integrity Comparison Survey) study : a prospective experimental study using maternal observations to report the effect of baby wipes on the incidence of Irritant Diaper Dermatitis in infants, from birth to eight weeks of age
'Elsevier BV', 2020Co-Authors: Ad Price, Lythgoe J, Ackers-johnson J, Pa Cook, Am Clarke-cornwell, Fe ,macvane PhippsAbstract:Background Baby wipes have been shown to be safe and effective in maintaining skin integrity when compared to the use of water alone. However, no previous study has compared different formulations of wipe. The aim of the BaSICS study was to identify any differences in incidence of Irritant Diaper Dermatitis (IDD) in infants assigned to three different brands of wipe, all marketed as suitable for neonates, but which contained varying numbers of ingredients. Methods Women were recruited during the prenatal period. Participants were randomly assigned to receive one of three brands of wipe for use during the first eight weeks following childbirth. All participants received the same nappies. Participants reported their infant’s skin integrity on a scale of 1 to 5 daily using a bespoke smartphone application. Analysis of effect of brand on clinically significant IDD (score 3 or more) incidence was conducted using a negative binomial generalised linear model, controlling for possible confounders at baseline. Analysts were blind to brand of wipe. Results Of 737 women enrolled, 15 were excluded (admitted to neonatal intensive care, premature or other infant health issues). Of the 722 eligible babies, 698 (97%) remained in the study for the full 8-week duration, 24.6% of whom had IDD at some point during the study. Mothers using the brand with the fewest ingredients reported fewer days of clinically significant nappy rash (score≥3) than participants using the two other brands (p=0.002 and p
Alan D Price - One of the best experts on this subject based on the ideXlab platform.
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the basics baby skin integrity comparison survey study a prospective experimental study using maternal observations to report the effect of baby wipes on the incidence of Irritant Diaper Dermatitis in infants from birth to eight weeks of age
Pediatrics and Neonatology, 2021Co-Authors: Alan D Price, Jeanne Lythgoe, James Ackersjohnson, Penny A Cook, A M Clarkecornwell, Fiona Macvane PhippsAbstract:BACKGROUND Baby wipes have been shown to be safe and effective in maintaining skin integrity when compared to the use of water alone. However, no previous study has compared different formulations of wipe. The aim of the BaSICS study was to identify any differences in incidence of Irritant Diaper Dermatitis (IDD) in infants assigned to three different brands of wipe, all marketed as suitable for neonates, but which contained varying numbers of ingredients. METHODS Women were recruited during the prenatal period. Participants were randomly assigned to receive one of three brands of wipe for use during the first eight weeks following childbirth. All participants received the same nappies. Participants reported their infant's skin integrity on a scale of 1-5 daily using a bespoke smartphone application. Analysis of effect of brand on clinically significant IDD (score 3 or more) incidence was conducted using a negative binomial generalised linear model, controlling for possible confounders at baseline. Analysts were blind to brand of wipe. RESULTS Of 737 women enrolled, 15 were excluded (admitted to neonatal intensive care, premature or other infant health issues). Of the 722 eligible babies, 698 (97%) remained in the study for the full 8-week duration, 24.6% of whom had IDD at some point during the study. Mothers using the brand with the fewest ingredients reported fewer days of clinically significant nappy rash (score≥3) than participants using the two other brands (p = 0.002 and p < 0.001). Severe IDD (grades 4 and 5) was rare (2.4%). CONCLUSIONS Rarity of severe IDD suggested that sensitive formula baby wipes are safe when used in cleansing babies from birth to eight weeks during nappy changes. The brand with fewest ingredients had significantly fewer days of clinically significant IDD. Daily observations recorded on a smartphone application proved to be a highly acceptable method of obtaining real-time data on IDD. CLINICAL TRIAL REGISTRATION This study was not designed or registered as a clinical trial as no intervention in normal patterns of infant care took place. Mothers who had already decided to use disposable nappies and a baby wipe product agreed to observe and report on their infants' skin condition; in return they received a 9-week supply of free nappies and wipes.
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the basics baby skin integrity comparison survey study a prospective experimental study using maternal observations to report the effect of baby wipes on the incidence of Irritant Diaper Dermatitis in infants from birth to eight weeks of age
Pediatrics and Neonatology, 2021Co-Authors: Alan D Price, Jeanne Lythgoe, James Ackersjohnson, Penny A Cook, A M Clarkecornwell, Fiona Macvane PhippsAbstract:Background Baby wipes have been shown to be safe and effective in maintaining skin integrity when compared to the use of water alone. However, no previous study has compared different formulations of wipe. The aim of the BaSICS study was to identify any differences in incidence of Irritant Diaper Dermatitis (IDD) in infants assigned to three different brands of wipe, all marketed as suitable for neonates, but which contained varying numbers of ingredients. Methods Women were recruited during the prenatal period. Participants were randomly assigned to receive one of three brands of wipe for use during the first eight weeks following childbirth. All participants received the same nappies. Participants reported their infant’s skin integrity on a scale of 1 to 5 daily using a bespoke smartphone application. Analysis of effect of brand on clinically significant IDD (score 3 or more) incidence was conducted using a negative binomial generalised linear model, controlling for possible confounders at baseline. Analysts were blind to brand of wipe. Results Of 737 women enrolled, 15 were excluded (admitted to neonatal intensive care, premature or other infant health issues). Of the 722 eligible babies, 698 (97%) remained in the study for the full 8-week duration, 24.6% of whom had IDD at some point during the study. Mothers using the brand with the fewest ingredients reported fewer days of clinically significant nappy rash (score≥3) than participants using the two other brands (p=0.002 and p<0.001). Severe IDD (grades 4 and 5) was rare (2.4%). Conclusions Rarity of severe IDD suggested that sensitive formula baby wipes are safe when used in cleansing babies from birth to eight weeks during nappy changes. The brand with fewest ingredients had significantly fewer days of clinically significant IDD. Daily observations recorded on a smartphone application proved to be a highly acceptable method of obtaining real-time data on IDD.
