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Weinan Yu - One of the best experts on this subject based on the ideXlab platform.
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Ischemia-Modified Albumin in type 2 diabetic patients with and without peripheral arterial disease
Clinics, 2020Co-Authors: Shao-gang Ma, Bing Hong, Weinan YuAbstract:OBJECTIVE: To determine whether there is an association between serum Ischemia-Modified Albumin and the risk factor profile in type 2 diabetic patients with peripheral arterial disease and to identify the risk markers for peripheral arterial disease. METHODS: Participants included 290 patients (35.2% women) with type 2 diabetes. The ankle-brachial pressure index was measured using a standard protocol, and peripheral arterial disease was defined as an ankle-brachial index 1.3. The basal Ischemia-Modified Albumin levels and clinical parameters were measured and analyzed. The risk factors for peripheral arterial disease were examined by multiple logistic analyses. RESULTS: Age, systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, urine Albumin, homocysteine, and Ischemia-Modified Albumin were significantly higher in patients with peripheral arterial disease than in disease-free patients (p
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Evaluation of serum Ischemia-Modified Albumin levels in pregnant women with and without gestational diabetes mellitus
Gynecological Endocrinology, 2012Co-Authors: Shao-gang Ma, Bing Hong, Weinan Yu, Wen HuAbstract:Objective. To investigate serum Ischemia-Modified Albumin (IMA) levels in gestational diabetes mellitus and the effect of treatment with continuous subcutaneous insulin infusion on the biomarker. Methods. The gestational diabetes mellitus women in the second trimester were evaluated before and after the two kinds of treatments with continuous subcutaneous insulin infusion and medical nutrition therapy for 6 weeks. Maternal serum Ischemia-Modified Albumin and metabolic parameters were measured at baseline and at the 6th week. Results.Serum Ischemia-Modified Albumin levels and metabolic parameters were higher in patients with gestational diabetes mellitus at baseline than in controls. Ischemia-Modified Albumin levels were correlated with plasma glucose (p < 0.05). Variables of glycemic control and Ischemia-Modified Albumin levels were significantly reduced at the 6th week. The effect of insulin treatment was generally better than diet therapy. Linear regression analysis showed that fasting plasma glucose wa...
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evaluation of Ischemia Modified Albumin and c reactive protein in type 2 diabetics with and without ketosis
Biomarker Insights, 2012Co-Authors: Wen Hu, Wen Xu, Weinan YuAbstract:Overview: To investigate whether serum Ischemia-Modified Albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis. Approach: One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum Ischemia-Modified Albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis. Results: Compared to the controls, the Ischemia-Modified Albumin and C-reactive protein levels were higher in patients with diabetic ketosis and type 2 diabetes at the baseline. The levels of Ischemia-Modified Albumin were higher in patients with type 2 diabetes than in the controls. C-reactive protein and Ischemia-Modified Albumin levels were reduced after insulin treatment. The level of Ischemia-Modified Albumin was an independent risk marker for diabetic ketosis (OR = 1.085, P = 0.008, 95% CI: 1.022–1.152). Receiver operating characteristic curves revealed that the areas under the curve were 0.917 for the Modified Albumin and 0.357 for C-reactive protein. Conclusion: This study indicates that Ischemia-Modified Albumin was significantly associated with diabetic ketosis and was more sensitive than C-reactive protein in reflecting diabetic ketosis.
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Ischemia Modified Albumin in type 2 diabetic patients with and without peripheral arterial disease
Clinics, 2011Co-Authors: Bing Hong, Weinan YuAbstract:OBJECTIVE: To determine whether there is an association between serum Ischemia-Modified Albumin and the risk factor profile in type 2 diabetic patients with peripheral arterial disease and to identify the risk markers for peripheral arterial disease. METHODS: Participants included 290 patients (35.2% women) with type 2 diabetes. The ankle-brachial pressure index was measured using a standard protocol, and peripheral arterial disease was defined as an ankle-brachial index 1.3. The basal Ischemia-Modified Albumin levels and clinical parameters were measured and analyzed. The risk factors for peripheral arterial disease were examined by multiple logistic analyses. RESULTS: Age, systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, urine Albumin, homocysteine, and Ischemia-Modified Albumin were significantly higher in patients with peripheral arterial disease than in disease-free patients (p<0.05), while ankle-brachial index was lower in the former group (p<0.05). Ischemia-Modified Albumin was positively associated with HbA1c and homocysteine levels (r = 0.220, p = 0.030; r = 0.446, p = 0.044, respectively), while no correlation was found with ankle-brachial index. Multiple logistic analyses indicated that HbA1c, systolic blood pressure, homocysteine and Ischemia-Modified Albumin were independent risk factors for peripheral arterial disease in the diabetic subjects. CONCLUSION: The baseline Ischemia-Modified Albumin levels were significantly higher and positively associated with HbA1c and homocysteine levels in type 2 diabetic patients with peripheral arterial disease. Ischemia-Modified Albumin was a risk marker for peripheral arterial disease. Taken together, these results might be helpful for monitoring diabetic peripheral arterial disease.
Suleyman Caner Karahan - One of the best experts on this subject based on the ideXlab platform.
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investigation of the possibility of using Ischemia Modified Albumin in testicular torsion an experimental study
Fertility and Sterility, 2011Co-Authors: Omer Kutlu, Suleyman Turedi, Abdulkadir Gunduz, Ahmet Mentese, Esin Yulug, Suha Turkmen, Ahmet Alver, Suleyman Caner KarahanAbstract:Objective To investigate the serum Ischemia-Modified Albumin levels with use of an experimental testicular torsion (TT) model. Design Randomized, controlled experimental study. Setting University hospital. Animal(s) Thirty mature male Wistar rats. Intervention(s) Rats were divided into five groups: a sham operation group, 2- and 4-hour control (groups I and III, respectively), and 2- and 4-hour torsion groups (groups II and IV, respectively). Ischemia-Modified Albumin, tissue and blood malondialdehyde (MDA), tissue and blood myeloperoxidase (MPO) activity levels, and histopathologic damage scores then were compared. Main Outcome Measure(s) Ischemia-Modified Albumin, tissue and blood MDA, tissue and blood MPO activity levels, and histopathologic damage scores. Result(s) There was a significantly higher level of histopathologic damage in the 4-hour torsion group, and the serum Ischemia-Modified Albumin levels in this group were significantly higher than those of the other groups. There was no difference between the groups in terms of blood and tissue MDA and MPO levels. There was no significant correlation between Ischemia-Modified Albumin levels and blood and tissue MDA and MPO levels. The only significant correlation between histopathologic score and biochemical markers was that with blood and tissue MPO. Conclusion(s) The results from this pioneering study determined a high level of Ischemia-Modified Albumin in TT, indicating a potential value for TT diagnosis. The value of Ischemia-Modified Albumin levels in TT should be investigated also with respect to prognosis.
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the relationship between diabetic retinopathy and serum levels of Ischemia Modified Albumin and malondialdehyde
Retina-the Journal of Retinal and Vitreous Diseases, 2011Co-Authors: Adem Turk, Ahmet Mentese, Suleyman Caner Karahan, Irfan Nuhoglu, Hidayet Erdol, Cihangir EremAbstract:PURPOSE: To establish the correlation between Ischemia-Modified Albumin (IMA) and malondialdehyde (MDA) and the development of diabetic retinopathy (DRP) in patients with diabetes mellitus. METHODS: Seventy Type 2 diabetic patients, 35 with DRP, and 36 healthy controls were enrolled in this study. Serum IMA and MDA levels were compared statistically. Receiver operating characteristic curve analysis was also performed to calculate the value of IMA and MDA in distinguishing DRP. RESULTS: Mean serum IMA levels were 0.658 ± 0.128 absorbance units in the non-DRP group, compared with 0.767 ± 0.074 absorbance units in the DRP group and 0.619 ± 0.044 absorbance units in the control group. Mean serum MDA levels were 0.325 ± 0.172 nmol/mL, 0.244 ± 0.152 nmol/mL, and 0.178 ± 0.131 nmol/mL, respectively. The differences in IMA and MDA levels were statistically significant for all groups (P < 0.05 for all). The areas under the receiver operating characteristic curves for the determination of DRP in diabetic patients were 0.789 (95% confidence interval, 0.682-0.896) for IMA and 0.3 (95% confidence interval, 0.175-0.426) for MDA. CONCLUSION: Both serum IMA and serum MDA levels were higher in the diabetic patients compared with the control group. In particular, the high sensitivity of IMA toward DRP showed that it reflected retinal vascular complication better than MDA. Ischemia-Modified Albumin may be a useful marker in monitoring the risk of DRP development.
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Ischemia Modified Albumin in the diagnosis of pulmonary embolism an experimental study
American Journal of Emergency Medicine, 2009Co-Authors: Suleyman Turedi, Tevfik Patan, Abdulkadir Gunduz, Ahmet Mentese, Celal Tekinbas, Murat Topbas, Suleyman Caner Karahan, Esin Yulug, Suha Turkmen, Utku UcarAbstract:STUDY OBJECTIVE: We designed this experimental study to determine the value of Ischemia-Modified Albumin in the diagnosis of pulmonary embolism. METHODS: Twenty-four mature female New Zealand rabbits were divided into 4 groups, each consisting of 6 animals. These were classified into group 1 ,the control group; group 2, the deep venous thrombosis group; group 3, the deep venous thrombosis with pulmonary embolism group; and group 4, the pulmonary embolism-alone group. Deep venous thrombosis was produced by ligation of the iliac vein. To establish pulmonary embolism, 2 clots were administered from the iliac vein. Blood samples were taken from all the groups at hours 0, 1, 3, and 6 for Ischemia-Modified Albumin measurement. RESULTS: Pulmonary embolism was established in all the rabbits in groups 3 and 4, and this was confirmed by tomographic and histologic findings. Measurement of mean Ischemia-Modified Albumin levels for all rabbits at hours 0, 1, 3, and 6 revealed that mean Ischemia-Modified Albumin levels in groups 3 and 4 were statistically significantly higher than those in groups 1 and 2. There was no difference between the mean Ischemia-Modified Albumin levels in groups 1 and 2 nor between groups 3 and 4. The alteration in Ischemia-Modified Albumin levels over time was statistically significant. CONCLUSIONS: The results of our experimental study demonstrate that Ischemia-Modified Albumin levels may be useful in the diagnosis of pulmonary embolism.
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Ischemia Modified Albumin levels in cerebrovascular accidents
American Journal of Emergency Medicine, 2008Co-Authors: Abdulkadir Gunduz, Suleyman Turedi, Ahmet Mentese, Murat Topbas, Suleyman Caner Karahan, Vildan Altunayoglu, Ibrahim Turan, Murat Aydin, Ismet Eraydin, Buket AkcanAbstract:Background: Previous studies have demonstrated that Ischemia-Modified Albumin (IMA) is a useful marker for the diagnosis of ischemic events. It was also recently demonstrated that IMA levels increase in the acute phase of cerebrovascular diseases. Yet the data regarding IMA levels in various types of cerebrovascular events are insufficient. The aim of this study was to evaluate IMA levels in various types of cerebrovascular events such as ischemic stroke, subarachnoid hemorrhage (SAH), and intracranial hemorrhage. Methods: This case-controlled study consisted of 106 consecutive patients, 43 with brain infarction (BI), 11 with brain hemorrhage (ICH), 52 with SAH, and a 43-member control group. We investigated whether there was a statistical correlation between these 3 groups and the control group. The relations among the 3 groups were also examined. Comparisons among groups were done with analysis of variance. Results: Mean serum IMA levels were 0.280 ± 0.045 absorbance units (ABSU) for BI patients, 0.259 ± 0.053 ABSU for ICH patients, 0.243 ± 0.061 ABSU for SAH patients, and 0.172 ± 0.045 ABSU for the control group.There was a statistically significant difference between the mean IMA levels of BI, ICH, and SAH patients and the mean control patient IMA levels (P b .0001). Conclusions: Ischemia-Modified Albumin levels are high in cerebrovascular diseases. IschemiaModified Albumin measurement can also be used to distinguish SAH from BI during the acute phase of cerebrovascular event in the emergency department.
Ahmet Mentese - One of the best experts on this subject based on the ideXlab platform.
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is the measurement of serum Ischemia Modified Albumin the best test to diagnose ovarian torsion
Gynecologic and Obstetric Investigation, 2015Co-Authors: Suleyman Guven, Cavit Kart, Emine Seda Guvendag Guven, Esra Can Cetin, Ahmet MenteseAbstract:Aim: The aim of this study is to evaluate the diagnostic value of serum oxidative stress marker levels (Ischemia-Modified Albumin, IMA; malondialdehyde, MDA) and
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The predictive value of Ischemia-Modified Albumin in long-term results of Ischemia-reperfusion injury in an experimental testicular torsion model.
Urology, 2012Co-Authors: Ahmet Mentese, Esin Yulug, Suha Turkmen, Ersagun Karaguzel, Yunus Karaca, Ozgur Tatli, Aysegul Sumer, Suleyman TurediAbstract:Objective To establish the value of Ischemia-Modified Albumin levels in the determination of the long-term results of testicular torsion/detorsion–associated Ischemia-reperfusion injury. Methods Eighteen mature male Wistar rats were divided randomly into 3 groups (n = 6 for each group): control, acute torsion/detorsion (T/D) group, and long-term T/D. In the control group, scrotal incision only was performed; in the acute T/D group, after 4 hours of torsion, detorsion was performed and maintained for 2 hours. Blood samples and testicular tissue samples were taken after 2 hours of detorsion. The same T/D procedures were performed in the long-term T/D group. The long-term T/D groups were kept alive for 2 months, and samples were taken at 2 months post procedure. Serum Ischemia-Modified Albumin, serum and tissue malondialdehyde levels, and histopathological damage scores were measured. Results Serum Ischemia-Modified Albumin levels were significantly higher compared with the control group, in the acute-term T/D ( P = .004). This elevation remained pronounced in the long term compared with the control group and acute period ( P = .008 and P = .017, respectively). There was a significant negative correlation between serum Ischemia-Modified Albumin levels and histopathological injury score in both the torsioned and contralateral testes ( r = −.929, P r = −.560, P = .02, respectively). Conclusion Ischemia-Modified Albumin is a valuable parameter in terms of reflecting testis injury in testicular torsion in both the acute period and the long term. It therefore has the potential to be used as data with predictive value regarding patients' fertility capacities.
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investigation of the possibility of using Ischemia Modified Albumin in testicular torsion an experimental study
Fertility and Sterility, 2011Co-Authors: Omer Kutlu, Suleyman Turedi, Abdulkadir Gunduz, Ahmet Mentese, Esin Yulug, Suha Turkmen, Ahmet Alver, Suleyman Caner KarahanAbstract:Objective To investigate the serum Ischemia-Modified Albumin levels with use of an experimental testicular torsion (TT) model. Design Randomized, controlled experimental study. Setting University hospital. Animal(s) Thirty mature male Wistar rats. Intervention(s) Rats were divided into five groups: a sham operation group, 2- and 4-hour control (groups I and III, respectively), and 2- and 4-hour torsion groups (groups II and IV, respectively). Ischemia-Modified Albumin, tissue and blood malondialdehyde (MDA), tissue and blood myeloperoxidase (MPO) activity levels, and histopathologic damage scores then were compared. Main Outcome Measure(s) Ischemia-Modified Albumin, tissue and blood MDA, tissue and blood MPO activity levels, and histopathologic damage scores. Result(s) There was a significantly higher level of histopathologic damage in the 4-hour torsion group, and the serum Ischemia-Modified Albumin levels in this group were significantly higher than those of the other groups. There was no difference between the groups in terms of blood and tissue MDA and MPO levels. There was no significant correlation between Ischemia-Modified Albumin levels and blood and tissue MDA and MPO levels. The only significant correlation between histopathologic score and biochemical markers was that with blood and tissue MPO. Conclusion(s) The results from this pioneering study determined a high level of Ischemia-Modified Albumin in TT, indicating a potential value for TT diagnosis. The value of Ischemia-Modified Albumin levels in TT should be investigated also with respect to prognosis.
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the relationship between diabetic retinopathy and serum levels of Ischemia Modified Albumin and malondialdehyde
Retina-the Journal of Retinal and Vitreous Diseases, 2011Co-Authors: Adem Turk, Ahmet Mentese, Suleyman Caner Karahan, Irfan Nuhoglu, Hidayet Erdol, Cihangir EremAbstract:PURPOSE: To establish the correlation between Ischemia-Modified Albumin (IMA) and malondialdehyde (MDA) and the development of diabetic retinopathy (DRP) in patients with diabetes mellitus. METHODS: Seventy Type 2 diabetic patients, 35 with DRP, and 36 healthy controls were enrolled in this study. Serum IMA and MDA levels were compared statistically. Receiver operating characteristic curve analysis was also performed to calculate the value of IMA and MDA in distinguishing DRP. RESULTS: Mean serum IMA levels were 0.658 ± 0.128 absorbance units in the non-DRP group, compared with 0.767 ± 0.074 absorbance units in the DRP group and 0.619 ± 0.044 absorbance units in the control group. Mean serum MDA levels were 0.325 ± 0.172 nmol/mL, 0.244 ± 0.152 nmol/mL, and 0.178 ± 0.131 nmol/mL, respectively. The differences in IMA and MDA levels were statistically significant for all groups (P < 0.05 for all). The areas under the receiver operating characteristic curves for the determination of DRP in diabetic patients were 0.789 (95% confidence interval, 0.682-0.896) for IMA and 0.3 (95% confidence interval, 0.175-0.426) for MDA. CONCLUSION: Both serum IMA and serum MDA levels were higher in the diabetic patients compared with the control group. In particular, the high sensitivity of IMA toward DRP showed that it reflected retinal vascular complication better than MDA. Ischemia-Modified Albumin may be a useful marker in monitoring the risk of DRP development.
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Ischemia Modified Albumin in the diagnosis of pulmonary embolism an experimental study
American Journal of Emergency Medicine, 2009Co-Authors: Suleyman Turedi, Tevfik Patan, Abdulkadir Gunduz, Ahmet Mentese, Celal Tekinbas, Murat Topbas, Suleyman Caner Karahan, Esin Yulug, Suha Turkmen, Utku UcarAbstract:STUDY OBJECTIVE: We designed this experimental study to determine the value of Ischemia-Modified Albumin in the diagnosis of pulmonary embolism. METHODS: Twenty-four mature female New Zealand rabbits were divided into 4 groups, each consisting of 6 animals. These were classified into group 1 ,the control group; group 2, the deep venous thrombosis group; group 3, the deep venous thrombosis with pulmonary embolism group; and group 4, the pulmonary embolism-alone group. Deep venous thrombosis was produced by ligation of the iliac vein. To establish pulmonary embolism, 2 clots were administered from the iliac vein. Blood samples were taken from all the groups at hours 0, 1, 3, and 6 for Ischemia-Modified Albumin measurement. RESULTS: Pulmonary embolism was established in all the rabbits in groups 3 and 4, and this was confirmed by tomographic and histologic findings. Measurement of mean Ischemia-Modified Albumin levels for all rabbits at hours 0, 1, 3, and 6 revealed that mean Ischemia-Modified Albumin levels in groups 3 and 4 were statistically significantly higher than those in groups 1 and 2. There was no difference between the mean Ischemia-Modified Albumin levels in groups 1 and 2 nor between groups 3 and 4. The alteration in Ischemia-Modified Albumin levels over time was statistically significant. CONCLUSIONS: The results of our experimental study demonstrate that Ischemia-Modified Albumin levels may be useful in the diagnosis of pulmonary embolism.
Suleyman Turedi - One of the best experts on this subject based on the ideXlab platform.
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Role of Ischemia-Modified Albumin in clinical practice
Labmedicine, 2015Co-Authors: Ali Kemal Erenler, Turker Yardan, Celal Kati, Mehmet Altuntaş, Suleyman TurediAbstract:AbstractDifficulty in establishing a diagnosis of acute coronary syndrome (ACS) in the clinical setting has led researchers to investigate novel markers that show increased blood levels before the myocardial necrosis occurs. In ischemic conditions, some modifications occur in the amino acids located on the N-terminus of the human Albumin molecule. Ischemia-Modified Albumin (IMA) is a marker formed after damage in the N-terminal region of Albumin. The altered N-terminus can no longer bind transition metals, such as cobalt. The causes of the increases in IMA have been shown to be endothelial or extracellular hypoxia, acidosis, and free oxygen radicals. IMA, an early marker of ischemic disorders, is also a candidate marker for the detection of ACS. An assay measuring IMA might represent a promising marker for the identification of patients with myocardial Ischemia. The aim of this study was to evaluate the clinical utility of IMA in the assessment of ACS as well as other medical disorders in light of the recent literature.
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The predictive value of Ischemia-Modified Albumin in long-term results of Ischemia-reperfusion injury in an experimental testicular torsion model.
Urology, 2012Co-Authors: Ahmet Mentese, Esin Yulug, Suha Turkmen, Ersagun Karaguzel, Yunus Karaca, Ozgur Tatli, Aysegul Sumer, Suleyman TurediAbstract:Objective To establish the value of Ischemia-Modified Albumin levels in the determination of the long-term results of testicular torsion/detorsion–associated Ischemia-reperfusion injury. Methods Eighteen mature male Wistar rats were divided randomly into 3 groups (n = 6 for each group): control, acute torsion/detorsion (T/D) group, and long-term T/D. In the control group, scrotal incision only was performed; in the acute T/D group, after 4 hours of torsion, detorsion was performed and maintained for 2 hours. Blood samples and testicular tissue samples were taken after 2 hours of detorsion. The same T/D procedures were performed in the long-term T/D group. The long-term T/D groups were kept alive for 2 months, and samples were taken at 2 months post procedure. Serum Ischemia-Modified Albumin, serum and tissue malondialdehyde levels, and histopathological damage scores were measured. Results Serum Ischemia-Modified Albumin levels were significantly higher compared with the control group, in the acute-term T/D ( P = .004). This elevation remained pronounced in the long term compared with the control group and acute period ( P = .008 and P = .017, respectively). There was a significant negative correlation between serum Ischemia-Modified Albumin levels and histopathological injury score in both the torsioned and contralateral testes ( r = −.929, P r = −.560, P = .02, respectively). Conclusion Ischemia-Modified Albumin is a valuable parameter in terms of reflecting testis injury in testicular torsion in both the acute period and the long term. It therefore has the potential to be used as data with predictive value regarding patients' fertility capacities.
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investigation of the possibility of using Ischemia Modified Albumin in testicular torsion an experimental study
Fertility and Sterility, 2011Co-Authors: Omer Kutlu, Suleyman Turedi, Abdulkadir Gunduz, Ahmet Mentese, Esin Yulug, Suha Turkmen, Ahmet Alver, Suleyman Caner KarahanAbstract:Objective To investigate the serum Ischemia-Modified Albumin levels with use of an experimental testicular torsion (TT) model. Design Randomized, controlled experimental study. Setting University hospital. Animal(s) Thirty mature male Wistar rats. Intervention(s) Rats were divided into five groups: a sham operation group, 2- and 4-hour control (groups I and III, respectively), and 2- and 4-hour torsion groups (groups II and IV, respectively). Ischemia-Modified Albumin, tissue and blood malondialdehyde (MDA), tissue and blood myeloperoxidase (MPO) activity levels, and histopathologic damage scores then were compared. Main Outcome Measure(s) Ischemia-Modified Albumin, tissue and blood MDA, tissue and blood MPO activity levels, and histopathologic damage scores. Result(s) There was a significantly higher level of histopathologic damage in the 4-hour torsion group, and the serum Ischemia-Modified Albumin levels in this group were significantly higher than those of the other groups. There was no difference between the groups in terms of blood and tissue MDA and MPO levels. There was no significant correlation between Ischemia-Modified Albumin levels and blood and tissue MDA and MPO levels. The only significant correlation between histopathologic score and biochemical markers was that with blood and tissue MPO. Conclusion(s) The results from this pioneering study determined a high level of Ischemia-Modified Albumin in TT, indicating a potential value for TT diagnosis. The value of Ischemia-Modified Albumin levels in TT should be investigated also with respect to prognosis.
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Ischemia Modified Albumin in the diagnosis of pulmonary embolism an experimental study
American Journal of Emergency Medicine, 2009Co-Authors: Suleyman Turedi, Tevfik Patan, Abdulkadir Gunduz, Ahmet Mentese, Celal Tekinbas, Murat Topbas, Suleyman Caner Karahan, Esin Yulug, Suha Turkmen, Utku UcarAbstract:STUDY OBJECTIVE: We designed this experimental study to determine the value of Ischemia-Modified Albumin in the diagnosis of pulmonary embolism. METHODS: Twenty-four mature female New Zealand rabbits were divided into 4 groups, each consisting of 6 animals. These were classified into group 1 ,the control group; group 2, the deep venous thrombosis group; group 3, the deep venous thrombosis with pulmonary embolism group; and group 4, the pulmonary embolism-alone group. Deep venous thrombosis was produced by ligation of the iliac vein. To establish pulmonary embolism, 2 clots were administered from the iliac vein. Blood samples were taken from all the groups at hours 0, 1, 3, and 6 for Ischemia-Modified Albumin measurement. RESULTS: Pulmonary embolism was established in all the rabbits in groups 3 and 4, and this was confirmed by tomographic and histologic findings. Measurement of mean Ischemia-Modified Albumin levels for all rabbits at hours 0, 1, 3, and 6 revealed that mean Ischemia-Modified Albumin levels in groups 3 and 4 were statistically significantly higher than those in groups 1 and 2. There was no difference between the mean Ischemia-Modified Albumin levels in groups 1 and 2 nor between groups 3 and 4. The alteration in Ischemia-Modified Albumin levels over time was statistically significant. CONCLUSIONS: The results of our experimental study demonstrate that Ischemia-Modified Albumin levels may be useful in the diagnosis of pulmonary embolism.
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Ischemia Modified Albumin levels in cerebrovascular accidents
American Journal of Emergency Medicine, 2008Co-Authors: Abdulkadir Gunduz, Suleyman Turedi, Ahmet Mentese, Murat Topbas, Suleyman Caner Karahan, Vildan Altunayoglu, Ibrahim Turan, Murat Aydin, Ismet Eraydin, Buket AkcanAbstract:Background: Previous studies have demonstrated that Ischemia-Modified Albumin (IMA) is a useful marker for the diagnosis of ischemic events. It was also recently demonstrated that IMA levels increase in the acute phase of cerebrovascular diseases. Yet the data regarding IMA levels in various types of cerebrovascular events are insufficient. The aim of this study was to evaluate IMA levels in various types of cerebrovascular events such as ischemic stroke, subarachnoid hemorrhage (SAH), and intracranial hemorrhage. Methods: This case-controlled study consisted of 106 consecutive patients, 43 with brain infarction (BI), 11 with brain hemorrhage (ICH), 52 with SAH, and a 43-member control group. We investigated whether there was a statistical correlation between these 3 groups and the control group. The relations among the 3 groups were also examined. Comparisons among groups were done with analysis of variance. Results: Mean serum IMA levels were 0.280 ± 0.045 absorbance units (ABSU) for BI patients, 0.259 ± 0.053 ABSU for ICH patients, 0.243 ± 0.061 ABSU for SAH patients, and 0.172 ± 0.045 ABSU for the control group.There was a statistically significant difference between the mean IMA levels of BI, ICH, and SAH patients and the mean control patient IMA levels (P b .0001). Conclusions: Ischemia-Modified Albumin levels are high in cerebrovascular diseases. IschemiaModified Albumin measurement can also be used to distinguish SAH from BI during the acute phase of cerebrovascular event in the emergency department.
Juan Carlos Kaski - One of the best experts on this subject based on the ideXlab platform.
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Ischemia-Modified Albumin: the importance of oxidative stress.
Journal of the American College of Cardiology, 2007Co-Authors: Juan Carlos KaskiAbstract:We read with interest the recent study by Sbarouni et al. ([1][1]) which adds to the growing body of evidence regarding Ischemia-Modified Albumin (IMA). Interestingly, in their study, the IMA levels dropped significantly at peak exercise in both patients with positive and negative exercise stress-
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effect of radiofrequency catheter ablation on the biochemical marker Ischemia Modified Albumin
American Journal of Cardiology, 2004Co-Authors: Juan Quiles, David Gaze, Paul O Collinson, Manas Sinha, D Floros, Gary F Baxter, Juan Carlos KaskiAbstract:Ischemia-Modified Albumin (IMA) levels were measured after radiofrequency (RF) catheter ablation to evaluate the effect of direct myocardial necrosis on IMA formation. IMA levels have been shown to increase in patients after RF catheter ablation compared with those who undergo diagnostic electrophysiologic studies. The results of this study suggest that IMA may be a marker of myocardial injury.
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effect of direct current cardioversion on Ischemia Modified Albumin levels in patients with atrial fibrillation
American Journal of Cardiology, 2004Co-Authors: Juan Quiles, Guillermo Aldama, David Gaze, Manas Sinha, Juan Carlos KaskiAbstract:Ischemia-Modified Albumin (IMA), measured with the Albumin cobalt binding test, is a marker of myocardial Ischemia. We measured IMA concentrations after elective direct-current cardioversion for atrial fibrillation to determine whether transient myocardial Ischemia occurs. Patients with electrocardiographic changes after cardioversion (ST-depression and/or T-wave inversion) had significantly higher IMA levels than those without these changes. Thus, elevated levels of IMA after cardioversion may reflect transient myocardial Ischemia.
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comparison of Ischemia Modified Albumin levels in patients undergoing percutaneous coronary intervention for unstable angina pectoris with versus without coronary collaterals
American Journal of Cardiology, 2004Co-Authors: Iris P Garrido, Ramon Calvino, Jose M Vazquezrodriguez, Guillermo Aldama, Juan Cosinsales, Juan Quiles, David Gaze, Juan Carlos KaskiAbstract:This study compared Ischemia-Modified Albumin levels, a marker of Ischemia in patients undergoing percutaneous coronary intervention. Ischemia-Modified Albumin levels were significantly lower in patients with collateral circulation compared with those without collateral circulation.
