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Taisen Iguchi - One of the best experts on this subject based on the ideXlab platform.
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Morphometric analysis of the pelvis in mice treated neonatally with tamoxifen.
The Anatomical record, 1993Co-Authors: Yasuo Uesugi, Tomomi Sato, Taisen IguchiAbstract:The pelves of male and female C57BL/Tw mice given five daily injection of 100 micrograms tamoxifen, 50 micrograms dihydrotestosterone (DHT), or 2 micrograms diethylstilbestrol (DES) from the day of birth were examined morphometrically and histomorphometrically. Total areas of the pelvis, ilium, Ischium, and pubis were significantly smaller in neonatally tamoxifen-treated mice than in the controls. There was no significant difference in length of the Ischium between tamoxifen-treated and control mice of both sexes. However, lengths of ilium and pubis, and widths of ilium, pubis, and Ischium in tamoxifen-treated male and female mice were significantly smaller than in the respective controls. In contrast, neonatal treatment with DHT or DES did not affect the shape of the pelvis of either sex. In the neonatally tamoxifen-treated females, the number of osteoblasts and osteoclasts per 200 microns trabecular surface length and per 10,000 microns2 subperiosteal area of pubic bone section was smaller than in the controls. Inhibition of ossification persisted in the junction of the pubis and Ischium of pelves treated with tamoxifen in vitro. These results suggest that neonatally administered tamoxifen mainly retards the growth of the ilium and pubis in mice by changing the activities of osteoclasts and osteoblasts, and that tamoxifen acts directly on the neonatal mouse pubis to inhibit its ossification.
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Effects of sex steroids on the development of sexual dimorphism in mouse innominate bone.
The Anatomical record, 1992Co-Authors: Yasuo Uesugi, Osamu Taguchi, Tetsuo Noumura, Taisen IguchiAbstract:The sexual dimorphism of the innominate bone was examined in 14 strains of mice. In female mice of all strains, the pubis was significantly longer and thinner than that in the strain-matched males. In 13 of 14 strains, the Ischium in the male was longer and thicker than in the female. In the testicular-feminized male (Tfm) mouse, the Ischium was longer and thinner than that in the wild-type male, resembling that of the wild-type female. The pubis of the Tfm mouse was longer than in the wild-type males. The pubis width in the Tfm mouse was between those of the wild-type male and female. Gonadectomy at ages of 5, 10, 20, 30, and 60 days in both sexes showed that the Ischium develops as the female type when sex hormones are absent. In contrast, postnatal testicular androgen induces the male-type Ischium. Gonadectomy at 60 days had a slight effect on the pubis, indicating that sexual dimorphism of the pubis was determined before 60 days of age. Estrogen receptors (ER) were immunohistochemically demonstrated in bone cells of 0- to 60-day-old mice. ER was found exclusively in the periosteum of the pubis at the day of birth; however, it appeared in bone cells of all parts of pelvis at 10–60 days. These results indicate that sexual dimorphism of the pubis is consistent for the 14 mouse strains examined, and that the shape of the pubis is determined by sex steroids before 60 days of age. Since ER exist in the bone cells, morphogenesis of the pelvis may be regulated by these sex steroids.© Willey-Liss, Inc.
Yasuo Uesugi - One of the best experts on this subject based on the ideXlab platform.
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Morphometric analysis of the pelvis in mice treated neonatally with tamoxifen.
The Anatomical record, 1993Co-Authors: Yasuo Uesugi, Tomomi Sato, Taisen IguchiAbstract:The pelves of male and female C57BL/Tw mice given five daily injection of 100 micrograms tamoxifen, 50 micrograms dihydrotestosterone (DHT), or 2 micrograms diethylstilbestrol (DES) from the day of birth were examined morphometrically and histomorphometrically. Total areas of the pelvis, ilium, Ischium, and pubis were significantly smaller in neonatally tamoxifen-treated mice than in the controls. There was no significant difference in length of the Ischium between tamoxifen-treated and control mice of both sexes. However, lengths of ilium and pubis, and widths of ilium, pubis, and Ischium in tamoxifen-treated male and female mice were significantly smaller than in the respective controls. In contrast, neonatal treatment with DHT or DES did not affect the shape of the pelvis of either sex. In the neonatally tamoxifen-treated females, the number of osteoblasts and osteoclasts per 200 microns trabecular surface length and per 10,000 microns2 subperiosteal area of pubic bone section was smaller than in the controls. Inhibition of ossification persisted in the junction of the pubis and Ischium of pelves treated with tamoxifen in vitro. These results suggest that neonatally administered tamoxifen mainly retards the growth of the ilium and pubis in mice by changing the activities of osteoclasts and osteoblasts, and that tamoxifen acts directly on the neonatal mouse pubis to inhibit its ossification.
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Effects of sex steroids on the development of sexual dimorphism in mouse innominate bone.
The Anatomical record, 1992Co-Authors: Yasuo Uesugi, Osamu Taguchi, Tetsuo Noumura, Taisen IguchiAbstract:The sexual dimorphism of the innominate bone was examined in 14 strains of mice. In female mice of all strains, the pubis was significantly longer and thinner than that in the strain-matched males. In 13 of 14 strains, the Ischium in the male was longer and thicker than in the female. In the testicular-feminized male (Tfm) mouse, the Ischium was longer and thinner than that in the wild-type male, resembling that of the wild-type female. The pubis of the Tfm mouse was longer than in the wild-type males. The pubis width in the Tfm mouse was between those of the wild-type male and female. Gonadectomy at ages of 5, 10, 20, 30, and 60 days in both sexes showed that the Ischium develops as the female type when sex hormones are absent. In contrast, postnatal testicular androgen induces the male-type Ischium. Gonadectomy at 60 days had a slight effect on the pubis, indicating that sexual dimorphism of the pubis was determined before 60 days of age. Estrogen receptors (ER) were immunohistochemically demonstrated in bone cells of 0- to 60-day-old mice. ER was found exclusively in the periosteum of the pubis at the day of birth; however, it appeared in bone cells of all parts of pelvis at 10–60 days. These results indicate that sexual dimorphism of the pubis is consistent for the 14 mouse strains examined, and that the shape of the pubis is determined by sex steroids before 60 days of age. Since ER exist in the bone cells, morphogenesis of the pelvis may be regulated by these sex steroids.© Willey-Liss, Inc.
Hal D. Martin - One of the best experts on this subject based on the ideXlab platform.
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Ischiofemoral impingement: defining the lesser trochanter–ischial space
Knee Surgery Sports Traumatology Arthroscopy, 2017Co-Authors: Benjamin R. Kivlan, Robroy L. Martin, Hal D. MartinAbstract:Purpose The purpose of this study was to define changes in the ischial–lesser trochanteric space associated with medial and lateral hip rotation in neutral and 10° of extension and adduction. Methods Twenty-five hip joints from 14 embalmed cadavers (7 males and 7 females) were used for this study. The pelvic region of each cadaver was skeletonized, and the hip capsule released distally. With the hip joint in 0° flexion–extension/abduction–adduction, the distance between the lesser trochanter and Ischium was measured in: neutral rotation, 40° medial rotation, and 60° lateral rotation. A one-way ANOVA with post hoc analysis determined the difference in the ischiofemoral space in these three positions. An additional position was then tested by laterally rotating the femur with the hip joint positioned in 10° extension and adduction. Results The average distance between the lesser trochanter and Ischium was different ( p
Dian Masyitha - One of the best experts on this subject based on the ideXlab platform.
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The Microscopic Structure Of Ischium Bones In Ovariectomized Rats with High Ratio Phosphate/Calcium Feeding
2003Co-Authors: Dian MasyithaAbstract:This experiment was conducted to study the microscopic structure of bones in ovariectomized rats with ratio phosphate/calcium feeding. Fifteen female Sprague Dawley rats 7 weeks old were randomly divided into 3 groups. The rats in the control group (non-ovariectimized). The rats in group II and III were ovariectomized. Phosphate/calcium diet were fed with ratio of 2 to 1 (K1, K2) and 6 to 1 (K3). After 12 weeks the rats were sacrificed. The Ischium bone were collected and processed for microscopic examination with trichrome staining. The results showed that structurally the osteoporosis occurred in Ischium bone of group K2 and K3. It could be concluded that estrogen deficiency condition (ovariectomy) and high ratio phosphate/calcium ration caused osteoporosis in Ischium bones.
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the microscopic structure of Ischium bones in ovariectomized rats with high ratio phosphate calcium feeding
Media Kedokteran Hewan, 2003Co-Authors: Dian MasyithaAbstract:This experiment was conducted to study the microscopic structure of bones in ovariectomized rats with ratio phosphate/calcium feeding. Fifteen female Sprague Dawley rats 7 weeks old were randomly divided into 3 groups. The rats in the control group (non-ovariectimized). The rats in group II and III were ovariectomized. Phosphate/calcium diet were fed with ratio of 2 to 1 (K1, K2) and 6 to 1 (K3). After 12 weeks the rats were sacrificed. The Ischium bone were collected and processed for microscopic examination with trichrome staining. The results showed that structurally the osteoporosis occurred in Ischium bone of group K2 and K3. It could be concluded that estrogen deficiency condition (ovariectomy) and high ratio phosphate/calcium ration caused osteoporosis in Ischium bones.
T.d. Bunker - One of the best experts on this subject based on the ideXlab platform.
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Stress fracture of os Ischium.
Injury, 1995Co-Authors: C. Smets, J. Roos, E. Vanlommel, T.d. BunkerAbstract:Figure 1. Radiograph showing that the fracture was in the non-weight-bearing portion and extended into the obturator fossa. reaching out and down to play a low ball he felt and heard a crack in his right hip and fell on to the floor. Initially he was thought to have a hamstring injury for which he was referred to the physiotherapist, who put him on crutches, not bearing weight. About I week later he was referred to the fracture clinic because of persisting hip pain. On clinical examination he had pain and spasm on hip flexion to 70". He had pain on rotation of the hip together with some limitation of its rotation. There was no gap palpable in the hamstrings. He was not able to bear weight on the right leg. He did not mention any leg or buttock pain in the preceding history. Radiographs taken at this stage revealed an isolated, undisplaced fracture of the right OS Ischium. The fracture was in the
