The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Trevor C. Lindley - One of the best experts on this subject based on the ideXlab platform.
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Electron backscattering diffraction study of acicular ferrite, bainite, and martensite steel microstructures
Materials Science and Technology, 2004Co-Authors: H. M. Flower, Trevor C. LindleyAbstract:This study deals with acicular ferrite, bainite, and martensite microstructures observed in three low alloy steels. Electron backscattering diffraction (EBSD) was used to assess crystallographic features of these microstructures. In each area studied by EBSD mapping, crystallographic packets defined as clusters of points sharing the same crystallographic orientation were compared with morphological packets observed in the corresponding light micrograph. Microtexture studies suggested that acicular ferrite and upper bainite grow with Nishiyama Wassermann relationships with the parent austenite phase, whereas lower bainite and martensite consist of highly intricate packets having KurdjumovSachs relationships with the parent phase. In all cases three highly misoriented texture components were found within each former austenite grain. Electron backscattering diffraction also gave information about the cleavage and intergranular reverse temper embrittlement fracture mechanisms of these steels. In conclusion, it is shown that EBSD is a powerful tool for studying phase transformation and fracture mechanisms in steels on a microscopic scale.
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Electron backscattering diffraction study of acicular ferrite, bainite, and martensite steel microstructures
Materials Science and Technology, 2000Co-Authors: H. M. Flower, Trevor C. LindleyAbstract:AbstractThis study deals with acicular ferrite, bainite, and martensite microstructures observed in three low alloy steels. Electron backscattering diffraction (EBSD) was used to assess crystallographic features of these microstructures. In each area studied by EBSD mapping, ‘crystallographic packets’ defined as clusters of points sharing the same crystallographic orientation were compared with ‘morphological packets’ observed in the corresponding light micrograph. Microtexture studies suggested that acicular ferrite and upper bainite grow with Nishiyama– Wassermann relationships with the parent austenite phase, whereas lower bainite and martensite consist of highly intricate packets having Kurdjumov–Sachs relationships with the parent phase. In all cases three highly misoriented texture components were found within each former austenite grain. Electron backscattering diffraction also gave information about the cleavage and intergranular reverse temper embrittlement fracture mechanisms of these steels. In...
Yoland Smith - One of the best experts on this subject based on the ideXlab platform.
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Subcellular and Subsynaptic Localization of Presynaptic and Postsynaptic Kainate Receptor Subunits in the Monkey Striatum
J. Neurosci., 2001Co-Authors: Jeremy Z. Kieval, George W. Hubert, Jean-francois Pare, Yoland SmithAbstract:The localization and functions of kainate receptors (KARs) in the CNS are still poorly known. In the striatum, GluR6/7 and KA2 immunoreactivity is expressed presynaptically in a subpopulation of glutamatergic terminals and postsynaptically in dendrites and spines. The goal of this study was to further characterize the subcellular and subsynaptic localization of kainate receptor subunits in the monkey striatum. Immunoperoxidase data reveal that the relative abundance of GluR6/7- and KA2-immunoreactive terminals is homogeneous throughout the striatum irrespective of the differential degree of striatal degeneration in Huntington's disease. Pre-embedding and post-embedding immunogold data indicate that >70% of the presynaptic or postsynaptic GluR6/7 and KA2 labeling is expressed intracellularly. In material stained with the post-embedding immunogold method, approximately one-third of plasma membrane-bound gold particles labeling in axon terminals and spines is associated with asymmetric synapses, thereby representing synaptic kainate receptor subunits. On the other hand, >60% of the plasma-membrane bound labeling is extrasynaptic. Both GluR6/7 and KA2 labeling in glutamatergic terminals often occurs in clusters of gold particles along the membrane of large vesicular organelles located at various distances from the presynaptic grid. Anterograde labeling from the primary motor cortex or the centromedian thalamic nucleus indicate that both corticostriatal and thalamostriatal terminals express presynaptic GluR6/7 and KA2 immunoreactivity in the postcommissural putamen. In conclusion, these data demonstrate that kainate receptors in the striatum display a pattern of subcellular distribution different from other ionotropic glutamate receptor subtypes, but consistent with their metabotropic-like functions recently shown in the hippocampus.\n
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presynaptic kainate receptors in the monkey striatum
Neuroscience, 1999Co-Authors: E. Blankstein, Yoland SmithAbstract:Abstract Although kainate has long been known as a powerful axon-sparing neurotoxin, the localization and functions of kainate receptors in the CNS are largely unknown. In the present study we examined the distribution of kainate receptor subunits in the monkey striatum using kainate receptor subunits GluR6/7 and kainate receptor subunit KA2 subunit antibodies at the electron microscope level. We found that kainate receptor subunits GluR6/7 immunoreactivity is expressed not only in neuronal perikarya and dendritic processes, but also in a large population of terminals which form axospinous and axodendritic asymmetric synapses. The ultrastructural features of these terminals resembled those of glutamatergic corticostriatal boutons. In contrast, very few kainate receptor subunit KA2-containing terminals were encountered. Although the functions of these presynaptic kainate receptors remain to be established, the present data suggest the possibility that they are located to modulate the release of glutamate from cortical afferents in the monkey striatum, and that an abnormal regulation of these presynaptic receptors might be involved in the death of striatal neurons in Huntington's disease. Accordingly, recent findings demonstrated that the variance in the age of onset of Huntington's disease could be attributed to the genotype variation of kainate receptor subunit GluR6 in humans. 24
H. M. Flower - One of the best experts on this subject based on the ideXlab platform.
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Electron backscattering diffraction study of acicular ferrite, bainite, and martensite steel microstructures
Materials Science and Technology, 2004Co-Authors: H. M. Flower, Trevor C. LindleyAbstract:This study deals with acicular ferrite, bainite, and martensite microstructures observed in three low alloy steels. Electron backscattering diffraction (EBSD) was used to assess crystallographic features of these microstructures. In each area studied by EBSD mapping, crystallographic packets defined as clusters of points sharing the same crystallographic orientation were compared with morphological packets observed in the corresponding light micrograph. Microtexture studies suggested that acicular ferrite and upper bainite grow with Nishiyama Wassermann relationships with the parent austenite phase, whereas lower bainite and martensite consist of highly intricate packets having KurdjumovSachs relationships with the parent phase. In all cases three highly misoriented texture components were found within each former austenite grain. Electron backscattering diffraction also gave information about the cleavage and intergranular reverse temper embrittlement fracture mechanisms of these steels. In conclusion, it is shown that EBSD is a powerful tool for studying phase transformation and fracture mechanisms in steels on a microscopic scale.
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Electron backscattering diffraction study of acicular ferrite, bainite, and martensite steel microstructures
Materials Science and Technology, 2000Co-Authors: H. M. Flower, Trevor C. LindleyAbstract:AbstractThis study deals with acicular ferrite, bainite, and martensite microstructures observed in three low alloy steels. Electron backscattering diffraction (EBSD) was used to assess crystallographic features of these microstructures. In each area studied by EBSD mapping, ‘crystallographic packets’ defined as clusters of points sharing the same crystallographic orientation were compared with ‘morphological packets’ observed in the corresponding light micrograph. Microtexture studies suggested that acicular ferrite and upper bainite grow with Nishiyama– Wassermann relationships with the parent austenite phase, whereas lower bainite and martensite consist of highly intricate packets having Kurdjumov–Sachs relationships with the parent phase. In all cases three highly misoriented texture components were found within each former austenite grain. Electron backscattering diffraction also gave information about the cleavage and intergranular reverse temper embrittlement fracture mechanisms of these steels. In...
R D K Misra - One of the best experts on this subject based on the ideXlab platform.
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Significance of Finish Cooling Temperature to Microstructure and Property Relationship of Low-Carbon V-N-Cr Microalloyed High-Strength Steel
Journal of Materials Engineering and Performance, 2019Co-Authors: Yue Liu, Lin-xiu Du, Hong-yan Wu, Bin Zhang, R D K MisraAbstract:Herein, three final cooling temperatures were employed to achieve high strength and toughness communication in the V-N-Cr microalloyed steels. This study shows that V-N-Cr microalloyed steel primarily consisted of ferrite, granular bainite, acicular ferrite, and a small quantity of M/A phase at the final cooling temperature of 600 °C, while the polygonal ferrite, lamellar bainite, granular bainite, and a small fraction of acicular ferrite were obtained at 450 °C. The width of lamellar bainite was ~ 200-400 nm, and acicular ferrite was composed of fine non-parallel ferrite platelet structures with high dislocations densities. As the final cooling temperature decreased further, the microstructure included granular bainite and lath bainite at 350 °C. The nanoscale precipitates of V-N-Cr microalloyed steel were divided into two types, large-scale precipitates near the grain boundary that precipitated at high temperatures and small precipitates of diameter 5-10 nm at low temperatures, which significantly contributed toward strength. The hot rolled low-carbon V-N-Cr microalloy steel exhibited optimal mechanical properties at the final rolling temperature of 830 °C, as well the final cooling temperature was 450 °C. The highest yield strength and tensile strength of V-N-Cr microalloyed steel were 835 MPa and 989 MPa, respectively. The outstanding impact toughness of 161 J tested at − 60 °C was received. The transformation strengthening and precipitation hardening played a crucial role in affecting the thermo-mechanical properties.
Jeremy M Henley - One of the best experts on this subject based on the ideXlab platform.
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Kainate receptors: Subunits, synaptic localization and function
Trends in Pharmacological Sciences, 1999Co-Authors: Ramesh Chittajallu, Steven P. Braithwaite, Vernon R.j. Clarke, Jeremy M HenleyAbstract:Although it is well established that kainate receptors constitute an entirely separate group of proteins from AMPA receptors, their physiological functions remain unclear. The molecular cloning of subunits that form kainate receptors and the ability to study recombinant receptors is leading to an increased understanding of their functional properties. Furthermore, the development of kainate receptor-selective agonists and antagonists over the past few years is now allowing the physiological roles of these receptors and, in some cases, specific subunits to be investigated. As a consequence, the synaptic activation of postsynaptic kainate receptors and the presence of presynaptic kainate receptors that serve to regulate excitatory and inhibitory synaptic transmission have been described.
