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Katsutoshi Terasawa - One of the best experts on this subject based on the ideXlab platform.
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principal component vector rotation of the tongue color spectrum to predict mibyou disease oriented state
Computer Assisted Radiology and Surgery, 2011Co-Authors: Satoshi Yamamoto, Takao Namiki, Norimichi Tsumura, Toshiya Nakaguchi, Yuji Kasahara, Keiko Ogawaochiai, Katsutoshi Terasawa, Yoichi MiyakeAbstract:Purpose Kampo medicine (Japanese traditional herbal medicine) contains concepts useful for preventive medicine. For example, “Mibyou” (disease-oriented state) aims to prevent illness by early recognition. Kampo diagnosis is based on subjective examinations, such as tongue inspection, by trained specialist physicians. An objective metric of the tongue color spectrum was developed as a surrogate for subjective visual inspection.
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incidence and clinical features of liver injury related to Kampo japanese herbal medicine in 2 496 cases between 1979 and 1999 problems of the lymphocyte transformation test as a diagnostic method
Phytomedicine, 2002Co-Authors: Naoki Mantani, Toshiaki Kita, Naotoshi Shibahara, Yutaka Shimada, Toshiaki Kogure, S Sakai, Hirozo Goto, Katsutoshi TerasawaAbstract:We retrospectively examined the summaries of all admission records of patients from 1979 to 1999 in our department, and selected for further study all liver injuries suspected of being related to Kampo medicines. Among 2,496 summaries, 30 summaries described liver disorders suspected of being related to Kampo medicines. Whether there was a causal relationship between the use of Kampo medication and the occurrence of liver injury was assessed according to the criteria described by Haller and Benowitz (2000), independently of the results of the lymphocyte transformation test (LTT). Among 30 events, we concluded that 9 were definitely unrelated, and 6 were probably unrelated to the use of Kampo medicines. Nine events (0.36% of 2,496 patient admissions and 0.06% of 14,616 outpatients) were considered possibly related, and only 6 events (0.24% of 2,496 patient admissions and 0.04% of 14,616 outpatients) were judged to be definitely or probably related to Kampo medicines. Low-grade eosinophilia was observed in a few patients of these "related" groups, and no fever or rash was observed in these "related" groups. Other clinical features, including type of liver injury, duration of Kampo medicine-use, recovery period and laboratory data, were not different from liver injuries associated with western drugs. Most patients in the definitely "unrelated" group were positive in the LTT for the suspect Kampo medicine, suggesting that the LTT may be unreliable for the diagnosis of Kampo-medicine-induced liver injury. From 1979 to 1999, our use of Kampo medicines to treat patients resulted in a low rate of liver injury and no fatalities.
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Herbal Medicine and False-Positive Results on Lymphocyte Transformation Test ―Regular Articles―
2001Co-Authors: Naoki Mantani, Yutaka Shimada, Shinya A Sakai, Toshiaki A Kogure, Katsutoshi TerasawaAbstract:In vitro mitogenic activity of 16 herbs and 3 Kampo (herbal medicine) formulae have been reported in experimental studies. It is not known how many herbs and Kampo formulae in total have mitogenic activity. Lymphocyte transformation test (LTT) is generally utilized to diagnose drug-induced liver injury. In LTT, mitogenic activity is assessed by measuring 3 H�thymidine incorporation. The objective of the present study was to determine which herbs and which Kampo formulae caused false-positivity on LTT. We examined 2496 summaries of all admission records from 1979 to 1999 in our department. We selected patients in whom liver injuries were diagnosed as deˆnitely unrelated to Kampo medication. In these patients, LTT was performed for some herbs contained in the suspect Kampo medicines, resultin
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successful Kampo treatment for three patients with hypogeusia
Kampo Medicine, 1999Co-Authors: Takashi Itoh, Nobuhiko Satoh, Toshiaki Kita, Naotoshi Shibahara, Yutaka Shimada, Katsutoshi TerasawaAbstract:味覚異常の治療として亜鉛製剤が使用される場合が多いが, 反応しない症例や高齢者においては難治となる例も少なくない。筆者らは漢方治療が奏功した味覚低下の三症例を経験した。第1例49歳女。口腔疾患の後遺症で味覚と知覚の低下があり, 黄連解毒湯が奏功した。第2例43歳男, 精神分裂病合併例と, 第3例76歳女, 特発性味覚低下症には, ともに柴胡加竜骨牡蛎湯が奏功した。漢方薬による味覚異常改善の機序として, 味蕾で亜鉛の関与する種々の情報伝達系に好影響を及ぼしている可能性が推測されているが, 今回の症例においてはさらに黄連解毒湯の口腔粘膜修復作用, あるいは柴胡加竜骨牡蛎湯の向精神作用が症状改善に貢献したものと考えられた。高齢者の味覚異常が近年増加しているが, その原因として加齢に伴う抑鬱状態が潜んでいるとの指摘があり, 気鬱を改善する柴胡加竜骨牡蛎湯をはじめとする漢方方剤によるアプローチは本症の治療にとって有用性が増すものと考えられる。
Yutaka Shimada - One of the best experts on this subject based on the ideXlab platform.
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adverse events associated with ethical Kampo formulations analysis of the domestic adverse event data reports of the ministry of health labor and welfare in japan
Evidence-based Complementary and Alternative Medicine, 2019Co-Authors: Yutaka Shimada, Makoto Fujimoto, Tatsuya Nogami, Hidetoshi WatariAbstract:Objectives. Traditional Japanese Kampo medicines have been integrated into the Japanese national health-care system. In Japan, the Ministry of Health, Labor, and Welfare’s website discloses adverse drug-event data that have been obtained from medical personnel reports investigated by the Pharmaceutical and Medical Devices Agency. Using these data, we investigated adverse events associated with ethical Kampo formulations. Methods. Reports of adverse events associated with ethical Kampo formulations from the domestic adverse-event data were obtained from July 30, 2003, to March 31, 2018. Adverse events were then categorized, and the relationships between categories of adverse events and crude drugs were analyzed. Results. There were 4,232 reported adverse events associated with ethical Kampo formulations. The numbers of events by category were as follows: events related to liver injury, 1,193; lung injury, 1,177; pseudoaldosteronism, 889; mesenteric phlebosclerosis, 223; drug eruption, 185; and others, 565. Among events related to both liver injury and lung injury, approximately 70% were suspected to be induced by Kampo formulations containing Scutellariae Radix. The pseudoaldosteronism-related events, which are induced by Glycyrrhizae Radix, included several events related to muscle injury, heart failure, and arrhythmia. Events related to mesenteric phlebosclerosis, believed to be induced by long-term use of Kampo formulas containing Gardeniae Fructus, increased remarkably during the study period. Among the events related to drug eruption, approximately 35% were suspected to be induced by Kampo formulations containing Ephedrae Herba. Conclusion. Kampo medicines may cause various adverse events. The present results provide valuable information regarding adverse events associated with Kampo medicines from the viewpoint of patient safety.
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incidence and clinical features of liver injury related to Kampo japanese herbal medicine in 2 496 cases between 1979 and 1999 problems of the lymphocyte transformation test as a diagnostic method
Phytomedicine, 2002Co-Authors: Naoki Mantani, Toshiaki Kita, Naotoshi Shibahara, Yutaka Shimada, Toshiaki Kogure, S Sakai, Hirozo Goto, Katsutoshi TerasawaAbstract:We retrospectively examined the summaries of all admission records of patients from 1979 to 1999 in our department, and selected for further study all liver injuries suspected of being related to Kampo medicines. Among 2,496 summaries, 30 summaries described liver disorders suspected of being related to Kampo medicines. Whether there was a causal relationship between the use of Kampo medication and the occurrence of liver injury was assessed according to the criteria described by Haller and Benowitz (2000), independently of the results of the lymphocyte transformation test (LTT). Among 30 events, we concluded that 9 were definitely unrelated, and 6 were probably unrelated to the use of Kampo medicines. Nine events (0.36% of 2,496 patient admissions and 0.06% of 14,616 outpatients) were considered possibly related, and only 6 events (0.24% of 2,496 patient admissions and 0.04% of 14,616 outpatients) were judged to be definitely or probably related to Kampo medicines. Low-grade eosinophilia was observed in a few patients of these "related" groups, and no fever or rash was observed in these "related" groups. Other clinical features, including type of liver injury, duration of Kampo medicine-use, recovery period and laboratory data, were not different from liver injuries associated with western drugs. Most patients in the definitely "unrelated" group were positive in the LTT for the suspect Kampo medicine, suggesting that the LTT may be unreliable for the diagnosis of Kampo-medicine-induced liver injury. From 1979 to 1999, our use of Kampo medicines to treat patients resulted in a low rate of liver injury and no fatalities.
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Herbal Medicine and False-Positive Results on Lymphocyte Transformation Test ―Regular Articles―
2001Co-Authors: Naoki Mantani, Yutaka Shimada, Shinya A Sakai, Toshiaki A Kogure, Katsutoshi TerasawaAbstract:In vitro mitogenic activity of 16 herbs and 3 Kampo (herbal medicine) formulae have been reported in experimental studies. It is not known how many herbs and Kampo formulae in total have mitogenic activity. Lymphocyte transformation test (LTT) is generally utilized to diagnose drug-induced liver injury. In LTT, mitogenic activity is assessed by measuring 3 H�thymidine incorporation. The objective of the present study was to determine which herbs and which Kampo formulae caused false-positivity on LTT. We examined 2496 summaries of all admission records from 1979 to 1999 in our department. We selected patients in whom liver injuries were diagnosed as deˆnitely unrelated to Kampo medication. In these patients, LTT was performed for some herbs contained in the suspect Kampo medicines, resultin
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successful Kampo treatment for three patients with hypogeusia
Kampo Medicine, 1999Co-Authors: Takashi Itoh, Nobuhiko Satoh, Toshiaki Kita, Naotoshi Shibahara, Yutaka Shimada, Katsutoshi TerasawaAbstract:味覚異常の治療として亜鉛製剤が使用される場合が多いが, 反応しない症例や高齢者においては難治となる例も少なくない。筆者らは漢方治療が奏功した味覚低下の三症例を経験した。第1例49歳女。口腔疾患の後遺症で味覚と知覚の低下があり, 黄連解毒湯が奏功した。第2例43歳男, 精神分裂病合併例と, 第3例76歳女, 特発性味覚低下症には, ともに柴胡加竜骨牡蛎湯が奏功した。漢方薬による味覚異常改善の機序として, 味蕾で亜鉛の関与する種々の情報伝達系に好影響を及ぼしている可能性が推測されているが, 今回の症例においてはさらに黄連解毒湯の口腔粘膜修復作用, あるいは柴胡加竜骨牡蛎湯の向精神作用が症状改善に貢献したものと考えられた。高齢者の味覚異常が近年増加しているが, その原因として加齢に伴う抑鬱状態が潜んでいるとの指摘があり, 気鬱を改善する柴胡加竜骨牡蛎湯をはじめとする漢方方剤によるアプローチは本症の治療にとって有用性が増すものと考えられる。
Takao Namiki - One of the best experts on this subject based on the ideXlab platform.
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Prevention and Recovery of COVID-19 Patients With Kampo Medicine: Review of Case Reports and Ongoing Clinical Trials
'Frontiers Media SA', 2021Co-Authors: Shin Takayama, Takao Namiki, Ryutaro Arita, Hiroshi Odaguchi, Akito Hisanaga, Kazuo MitaniAbstract:Coronavirus disease 2019 (COVID-19) spread to Japan in 2020, where the number of infected patients exceeded 250,000 and COVID-related deaths exceeded 3,500 in one year. Basic guidelines for infection control were implemented in Japan, and research and development of effective drugs and vaccines were promoted. This included considering Kampo medicine, which has a long history of treating recurring emerging viral infections. Considering the characteristics of the disease (inflammation of the upper and lower respiratory tract as well as potential neural damage and vasculitis), Kampo medicine could be considered as a treatment strategy due to its antiviral and anti-inflammatory effects induced by multiple active substances that could aid in disease prevention and recovery. In this study, case reports on the management of COVID-19 with Kampo medicine, which were published until March 31, 2021, were reviewed. The search strategy involved the use of Medline and hand-searching. Twenty two patients were treated using Kampo medicines with or without Western medicine, based on individual conditions. On the other hand, the effects of Kampo medicines as a potential preventive treatment (pre-infection), active treatment (especially in the acute and subacute stage), or treatment of sequelae to aid recovery (after infection) in the different stages of COVID-19 are being studied as research projects in the Japan Society for Oriental Medicine (JSOM). JSOM has also organized a pioneering project of clinical trials for COVID-19, some of which are now in progress
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Abbreviation of Kampo formulations and basic terminology in Kampo medicine
Traditional & Kampo Medicine, 2017Co-Authors: Keisuke Hagihara, Shuji Yakubo, Takao NamikiAbstract:International standards regarding traditional medicine – particularly the International Organization for Standardization/Technical Committee (ISO/TC) 249 – are currently being debated. Kampo extract formulations of standardized quality are one area in which Japanese Kampo medicines have a global advantage. While there is increasing medical evidence regarding the efficacy of Kampo extract formulations such as daikenchuto and yokukansan, one issue in documenting this evidence is how to describe Kampo formulations using English notation. Researchers currently use abbreviations for Kampo formulations, which has led to some confusion. There is also a need for a system of English notation to facilitate searches on PubMed and other search engines by researchers in countries that do not use Chinese characters. We have therefore developed a system of abbreviated English notation for Kampo formulations in order to aid the global expansion of Kampo medicine. Our proposed system targets the 298 Kampo formulations, including over-the-counter Kampo extract formulations, which appear in the 2013 New Guidebook on Nonprescription Kampo Formulas. When developing the abbreviations, we investigated the notation used to express Kampo formulas in academic articles on Kampo identified using the PubMed search engine. Various notations were used in the literature for daikenchuto, which is a typical Kampo extract formulation, and the number of articles located differed according to the search term, thus demonstrating the need to create a system of abbreviations. We used the following four guidelines in creating the abbreviations: (i) abbreviations are generally selected by choosing three letters contained in the romanized name/notation of the Kampo formulation; (ii) when multiple Kampo formulations have the same abbreviation, priority is given to the formulation with the most search hits on PubMed; (iii) when multiple Kampo formulations have the same abbreviation, we select the one already in use; and (iv) for Kampo formulations containing herbal additives, the basic structure of the name is maintained and the name of the additive is abbreviated and added to the end. Based on these four guidelines, we submitted the proposed system of abbreviations for joint discussion by the Medical and Pharmaceutical Society for Wakan-Yaku and the Japan Society for Oriental Medicine (JSOM) in August 2014. We then sought public comment on the proposed system in October 2014 and, after receiving various suggestions for revision and corrections, the system of abbreviations for these 298 Kampo formulations was established. The Committee for Vocabulary in JSOM has been overseeing Japanese terminology in Kampo medicine since 1969. Approximately 300 basic terms were selected for English translation in 2014–2015. These terms are based on the terms in International Classification of Disease (ICD)-11. These terms have been translated into English and await future publication (planned for 2018).
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Research Article A Valid Approach in Refractory Glossodynia: A Single-Institution 5-Year Experience Treating with Japanese Traditional Herbal (Kampo) Medicine
2016Co-Authors: Masaki Raimura, Takao NamikiAbstract:Copyright © 2013 Hideki Okamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Glossodynia is often refractory to conventional medicine, and there is only limited evidence to guide clinicians in its management. Patients with refractory glossodynia are often introduced to Japanese traditional herbal (Kampo) medicine experts under such circumstances becauseKampomedicine has becomeknown in Japan to be effective in treating awide variety of symptoms refractory to conventional medicine. Herein, we report our single-institution 5-year experience treating patients with Kampo medicine for primary glossodynia that was refractory to conventional medicine. We found that 69.2 % of patients reported a beneficial effect of Kampomedicine on glossodynia, and the average onset of improvement was 8.0 ± 7.7 weeks after starting Kampo treatment.The top two frequently used Kampomedicines for glossodynia were seinetsuhokito andmibakuekkito among high responders who showed a decrease of severity by 50 % or more.The top four most overlapped herbs among effective Kampomedicines for glossodynia were Glycyrrhiza Root, Ginseng Root, Hoelen, and Atractylodes (lancea) Rhizome, which compose an essential Kampo prescription called shikunshito. Although more research is required to further clarify the effectiveness of Kampo medicine, it has valid efficacy even in cases of glossodynia that remain incurable by conventional treatments. 1
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a valid approach in refractory glossodynia a single institution 5 year experience treating with japanese traditional herbal Kampo medicine
Evidence-based Complementary and Alternative Medicine, 2013Co-Authors: Hideki Okamoto, Atsushi Chino, Yoshiro Hirasaki, Keigo Ueda, Masaki Raimura, Takao NamikiAbstract:Glossodynia is often refractory to conventional medicine, and there is only limited evidence to guide clinicians in its management. Patients with refractory glossodynia are often introduced to Japanese traditional herbal (Kampo) medicine experts under such circumstances because Kampo medicine has become known in Japan to be effective in treating a wide variety of symptoms refractory to conventional medicine. Herein, we report our single-institution 5-year experience treating patients with Kampo medicine for primary glossodynia that was refractory to conventional medicine. We found that 69.2% of patients reported a beneficial effect of Kampo medicine on glossodynia, and the average onset of improvement was 8.0 ± 7.7 weeks after starting Kampo treatment. The top two frequently used Kampo medicines for glossodynia were seinetsuhokito and mibakuekkito among high responders who showed a decrease of severity by 50% or more. The top four most overlapped herbs among effective Kampo medicines for glossodynia were Glycyrrhiza Root, Ginseng Root, Hoelen, and Atractylodes (lancea) Rhizome, which compose an essential Kampo prescription called shikunshito. Although more research is required to further clarify the effectiveness of Kampo medicine, it has valid efficacy even in cases of glossodynia that remain incurable by conventional treatments.
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principal component vector rotation of the tongue color spectrum to predict mibyou disease oriented state
Computer Assisted Radiology and Surgery, 2011Co-Authors: Satoshi Yamamoto, Takao Namiki, Norimichi Tsumura, Toshiya Nakaguchi, Yuji Kasahara, Keiko Ogawaochiai, Katsutoshi Terasawa, Yoichi MiyakeAbstract:Purpose Kampo medicine (Japanese traditional herbal medicine) contains concepts useful for preventive medicine. For example, “Mibyou” (disease-oriented state) aims to prevent illness by early recognition. Kampo diagnosis is based on subjective examinations, such as tongue inspection, by trained specialist physicians. An objective metric of the tongue color spectrum was developed as a surrogate for subjective visual inspection.
Naoki Mantani - One of the best experts on this subject based on the ideXlab platform.
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incidence and clinical features of liver injury related to Kampo japanese herbal medicine in 2 496 cases between 1979 and 1999 problems of the lymphocyte transformation test as a diagnostic method
Phytomedicine, 2002Co-Authors: Naoki Mantani, Toshiaki Kita, Naotoshi Shibahara, Yutaka Shimada, Toshiaki Kogure, S Sakai, Hirozo Goto, Katsutoshi TerasawaAbstract:We retrospectively examined the summaries of all admission records of patients from 1979 to 1999 in our department, and selected for further study all liver injuries suspected of being related to Kampo medicines. Among 2,496 summaries, 30 summaries described liver disorders suspected of being related to Kampo medicines. Whether there was a causal relationship between the use of Kampo medication and the occurrence of liver injury was assessed according to the criteria described by Haller and Benowitz (2000), independently of the results of the lymphocyte transformation test (LTT). Among 30 events, we concluded that 9 were definitely unrelated, and 6 were probably unrelated to the use of Kampo medicines. Nine events (0.36% of 2,496 patient admissions and 0.06% of 14,616 outpatients) were considered possibly related, and only 6 events (0.24% of 2,496 patient admissions and 0.04% of 14,616 outpatients) were judged to be definitely or probably related to Kampo medicines. Low-grade eosinophilia was observed in a few patients of these "related" groups, and no fever or rash was observed in these "related" groups. Other clinical features, including type of liver injury, duration of Kampo medicine-use, recovery period and laboratory data, were not different from liver injuries associated with western drugs. Most patients in the definitely "unrelated" group were positive in the LTT for the suspect Kampo medicine, suggesting that the LTT may be unreliable for the diagnosis of Kampo-medicine-induced liver injury. From 1979 to 1999, our use of Kampo medicines to treat patients resulted in a low rate of liver injury and no fatalities.
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Herbal Medicine and False-Positive Results on Lymphocyte Transformation Test ―Regular Articles―
2001Co-Authors: Naoki Mantani, Yutaka Shimada, Shinya A Sakai, Toshiaki A Kogure, Katsutoshi TerasawaAbstract:In vitro mitogenic activity of 16 herbs and 3 Kampo (herbal medicine) formulae have been reported in experimental studies. It is not known how many herbs and Kampo formulae in total have mitogenic activity. Lymphocyte transformation test (LTT) is generally utilized to diagnose drug-induced liver injury. In LTT, mitogenic activity is assessed by measuring 3 H�thymidine incorporation. The objective of the present study was to determine which herbs and which Kampo formulae caused false-positivity on LTT. We examined 2496 summaries of all admission records from 1979 to 1999 in our department. We selected patients in whom liver injuries were diagnosed as deˆnitely unrelated to Kampo medication. In these patients, LTT was performed for some herbs contained in the suspect Kampo medicines, resultin
Kenji S Suzuki - One of the best experts on this subject based on the ideXlab platform.
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japanese traditional herbal medicine reduces use of pregabalin and opioids for pain in patients with lumbar spinal canal stenosis a retrospective cohort study
JA Clinical Reports, 2017Co-Authors: Mitsuhiko Oohata, Yuko Aoki, Michiko Miyata, Hiroki Mizobe, Kenji S SuzukiAbstract:There has been an increase in the number of Japanese patients with lumbar spinal canal stenosis (LSCS) who complain of chronic pain or motor disturbance in the lower back or extremities. These patients are often treated with anti-convulsive drugs, opioids, antidepressants, acetaminophen, or nonsteroidal anti-inflammatory drugs, all of which can cause side effects. For this reason, Japanese traditional herbal medicine (Kampo) is of interest, because it produces fewer adverse reactions. The aim of this retrospective cohort study was to analyze the effects of Kampo in patients with LSCS. A total of 151 patients with LSCS were divided into two groups based on treatment with (n = 111, group K) and without (n = 40, group N) Kampo. Use of pregabalin and opioids decreased significantly in group K (p < 0.001). The hazard ratio for opioid discontinuation was 0.220 (p = 0.004) for group N vs. group K, while that for pregabalin and antidepressants discontinuation were 0.589 (p = 0.202) and 0.509 (p = 0.377), respectively. The mean duration of hospital visits and treatment did not differ between the groups, but the number of dropouts was significantly higher in group N (p < 0.0001). The hazard ratio for patient dropout was 4.118 (p = 0.001) for group N vs. group K. Kampo led to discontinuation of opioid use for pain in patients with LSCS, and patients who were treated with Kampo were more likely to continue treatment.
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Japanese traditional herbal medicine reduces use of pregabalin and opioids for pain in patients with lumbar spinal canal stenosis: a retrospective cohort study
'Springer Science and Business Media LLC', 2017Co-Authors: Mitsuhiko Oohata, Yuko Aoki, Michiko Miyata, Hiroki Mizobe, Kenji S SuzukiAbstract:Abstract Background There has been an increase in the number of Japanese patients with lumbar spinal canal stenosis (LSCS) who complain of chronic pain or motor disturbance in the lower back or extremities. These patients are often treated with anti-convulsive drugs, opioids, antidepressants, acetaminophen, or nonsteroidal anti-inflammatory drugs, all of which can cause side effects. For this reason, Japanese traditional herbal medicine (Kampo) is of interest, because it produces fewer adverse reactions. The aim of this retrospective cohort study was to analyze the effects of Kampo in patients with LSCS. Findings A total of 151 patients with LSCS were divided into two groups based on treatment with (n = 111, group K) and without (n = 40, group N) Kampo. Use of pregabalin and opioids decreased significantly in group K (p
