The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Murat Kartal - One of the best experts on this subject based on the ideXlab platform.
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intellectual property protection in the natural product drug discovery Traditional Herbal Medicine and Herbal medicinal products
Phytotherapy Research, 2007Co-Authors: Murat KartalAbstract:Traditional Medicine is an important part of human health care in many developing countries and also in developed countries, increasing their commercial value. Although the use of medicinal plants in therapy has been known for centuries in all parts of the world, the demand for Herbal Medicines has grown dramatically in recent years. The world market for such Medicines has reached US $ 60 billion, with annual growth rates of between 5% and 15%. Researchers or companies may also claim intellectual property rights over biological resources and/or Traditional knowledge, after slightly modifying them. The fast growth of patent applications related to Herbal Medicine shows this trend clearly. This review presents the patent applications in the field of natural products, Traditional Herbal Medicine and Herbal medicinal products. Medicinal plants and related plant products are important targets of patent claims since they have become of great interest to the international drug and cosmetic industry. Copyright © 2006 John Wiley & Sons, Ltd.
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intellectual property protection in the natural product drug discovery Traditional Herbal Medicine and Herbal medicinal products
Phytotherapy Research, 2007Co-Authors: Murat KartalAbstract:Traditional Medicine is an important part of human health care in many developing countries and also in developed countries, increasing their commercial value. Although the use of medicinal plants in therapy has been known for centuries in all parts of the world, the demand for Herbal Medicines has grown dramatically in recent years. The world market for such Medicines has reached US $ 60 billion, with annual growth rates of between 5% and 15%. Researchers or companies may also claim intellectual property rights over biological resources and/or Traditional knowledge, after slightly modifying them. The fast growth of patent applications related to Herbal Medicine shows this trend clearly. This review presents the patent applications in the field of natural products, Traditional Herbal Medicine and Herbal medicinal products. Medicinal plants and related plant products are important targets of patent claims since they have become of great interest to the international drug and cosmetic industry.
Changquan Ling - One of the best experts on this subject based on the ideXlab platform.
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Traditional Herbal Medicine prevents postoperative recurrence of small hepatocellular carcinoma a randomized controlled study
Cancer, 2018Co-Authors: Xiaofeng Zhai, Xiaolin Liu, Feng Shen, Jia Fan, Changquan LingAbstract:Background To explore the clinical efficacy of Traditional Herbal Medicine (THM) in the prevention of disease recurrence of small hepatocellular carcinoma after surgery, a prospective randomized controlled study was conducted between October 2006 and May 2010. The results indicated that THM prevented the recurrence of SHCC with an efficacy that was superior to that of transarterial chemoembolization (TACE) during a median follow-up of 26.61 months. Methods The patients were followed up every 6 months, and the clinical data before October 20, 2015 were analyzed. The primary outcome measure was recurrence-free survival (RFS), and the secondary outcome measure was overall survival (OS). Results The 364 patients included 180 in the THM group and 184 in the TACE group. At the time of the data cutoff of October 20, 2015, a total of 205 patients demonstrated disease recurrence, including 85 patients in the THM group and 120 patients in the TACE group. The median RFS of the THM and TACE groups demonstrated a statistically significant difference (P Conclusions The efficacy of THM was found to be superior to that of TACE in preventing disease recurrence in patients with small hepatocellular carcinoma and prolonging OS. Cancer 2018;124:2161-8. © 2018 American Cancer Society.
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Traditional Herbal Medicine in preventing recurrence after resection of small hepatocellular carcinoma a multicenter randomized controlled trial
Journal of Integrative Medicine, 2013Co-Authors: Xiaofeng Zhai, Feng Shen, Jia Fan, Zhe Chen, Weiping Zhou, Yunke Yang, Xiao Qin, Changquan LingAbstract:Background Disease recurrence is a main challenge in treatment of hepatocellular carcinoma (HCC). There is no generally accepted method for preventing recurrence of HCC after resection.
Sumio Watanabe - One of the best experts on this subject based on the ideXlab platform.
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Research Article Traditional Herbal Medicine, Rikkunshito, Induces HSP60 and Enhances Cytoprotection of Small Intestinal Mucosal Cells as a Nontoxic Chaperone Inducer
2013Co-Authors: Kumiko Tamaki, Michiro Otaka, Tomoyoshi Shibuya, Naoto Sakamoto, Soh Yamamoto, Masaru Odashima, Hideaki Itoh, Sumio WatanabeAbstract:Copyright © 2012 Kumiko Tamaki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Increasing incidence of small intestinal ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs) has become a topic with recent advances of endoscopic technology. However, the pathogenesis and therapy are not fully understood. The aim of this study is to examine the effect of Rikkunshito (TJ-43), a Traditional Herbal Medicine, on expression of HSP60 and cytoprotective ability in small intestinal cell line (IEC-6). Effect of TJ-43 on HSP60 expression in IEC-6 cells was evaluated by immunoblot analysis. The effect of TJ-43 on cytoprotective abilities of IEC-6 cells against hydrogen peroxide or indomethacin was studied by MTT assay, LDH-release assay, caspase-8 activity, and TUNEL. HSP60 was significantly induced by TJ-43. Cell necrosis and apoptosis were significantly suppressed in IEC-6 cells pretreated by TJ-43 with overexpression of HSP60. Our results suggested that HSP60 induced by TJ-43 might play an important role in protecting small intestinal epithelial cells from apoptosis and necrosis in vitro. 1
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Traditional Herbal Medicine rikkunshito induces hsp60 and enhances cytoprotection of small intestinal mucosal cells as a nontoxic chaperone inducer
Evidence-based Complementary and Alternative Medicine, 2012Co-Authors: Kumiko Tamaki, Michiro Otaka, Tomoyoshi Shibuya, Naoto Sakamoto, Soh Yamamoto, Masaru Odashima, Hideaki Itoh, Sumio WatanabeAbstract:Increasing incidence of small intestinal ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs) has become a topic with recent advances of endoscopic technology. However, the pathogenesis and therapy are not fully understood. The aim of this study is to examine the effect of Rikkunshito (TJ-43), a Traditional Herbal Medicine, on expression of HSP60 and cytoprotective ability in small intestinal cell line (IEC-6). Effect of TJ-43 on HSP60 expression in IEC-6 cells was evaluated by immunoblot analysis. The effect of TJ-43 on cytoprotective abilities of IEC-6 cells against hydrogen peroxide or indomethacin was studied by MTT assay, LDH-release assay, caspase-8 activity, and TUNEL. HSP60 was significantly induced by TJ-43. Cell necrosis and apoptosis were significantly suppressed in IEC-6 cells pretreated by TJ-43 with overexpression of HSP60. Our results suggested that HSP60 induced by TJ-43 might play an important role in protecting small intestinal epithelial cells from apoptosis and necrosis in vitro.
Ted J Kaptchuk - One of the best experts on this subject based on the ideXlab platform.
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Herbal Medicine research and global health an ethical analysis
Bulletin of The World Health Organization, 2008Co-Authors: Jon C Tilburt, Ted J KaptchukAbstract:Governments, international agencies and corporations are increasingly investing in Traditional Herbal Medicine research. Yet little literature addresses ethical challenges in this research. In this paper, we apply concepts in a comprehensive ethical framework for clinical research to international Traditional Herbal Medicine research. We examine in detail three key, underappreciated dimensions of the ethical framework in which particularly difficult questions arise for international Herbal Medicine research: social value, scientific validity and favourable risk-benefit ratio. Significant challenges exist in determining shared concepts of social value, scientific validity and favourable risk-benefit ratio across international research collaborations. However, we argue that collaborative partnership, including democratic deliberation, offers the context and process by which many of the ethical challenges in international Herbal Medicine research can, and should be, resolved. By "cross-training" investigators, and investing in safety-monitoring infrastructure, the issues identified by this comprehensive framework can promote ethically sound international Herbal Medicine research that contributes to global health.
Xiaofeng Zhai - One of the best experts on this subject based on the ideXlab platform.
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Traditional Herbal Medicine prevents postoperative recurrence of small hepatocellular carcinoma a randomized controlled study
Cancer, 2018Co-Authors: Xiaofeng Zhai, Xiaolin Liu, Feng Shen, Jia Fan, Changquan LingAbstract:Background To explore the clinical efficacy of Traditional Herbal Medicine (THM) in the prevention of disease recurrence of small hepatocellular carcinoma after surgery, a prospective randomized controlled study was conducted between October 2006 and May 2010. The results indicated that THM prevented the recurrence of SHCC with an efficacy that was superior to that of transarterial chemoembolization (TACE) during a median follow-up of 26.61 months. Methods The patients were followed up every 6 months, and the clinical data before October 20, 2015 were analyzed. The primary outcome measure was recurrence-free survival (RFS), and the secondary outcome measure was overall survival (OS). Results The 364 patients included 180 in the THM group and 184 in the TACE group. At the time of the data cutoff of October 20, 2015, a total of 205 patients demonstrated disease recurrence, including 85 patients in the THM group and 120 patients in the TACE group. The median RFS of the THM and TACE groups demonstrated a statistically significant difference (P Conclusions The efficacy of THM was found to be superior to that of TACE in preventing disease recurrence in patients with small hepatocellular carcinoma and prolonging OS. Cancer 2018;124:2161-8. © 2018 American Cancer Society.
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Traditional Herbal Medicine in preventing recurrence after resection of small hepatocellular carcinoma a multicenter randomized controlled trial
Journal of Integrative Medicine, 2013Co-Authors: Xiaofeng Zhai, Feng Shen, Jia Fan, Zhe Chen, Weiping Zhou, Yunke Yang, Xiao Qin, Changquan LingAbstract:Background Disease recurrence is a main challenge in treatment of hepatocellular carcinoma (HCC). There is no generally accepted method for preventing recurrence of HCC after resection.
