The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Scott E Lukas - One of the best experts on this subject based on the ideXlab platform.
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A single dose of Kudzu extract reduces alcohol consumption in a binge drinking paradigm.
Drug and alcohol dependence, 2015Co-Authors: David M Penetar, Lindsay H. Toto, David Y.w. Lee, Scott E LukasAbstract:Overconsumption of alcohol has significant negative effects on an individual's health and contributes to an enormous economic impact on society as a whole. Pharmacotherapies to curb excessive drinking are important for treating alcohol use disorders. Twenty (20) men participated in a placebo-controlled, double-blind, between subjects design experiment (n=10/group) that tested the effects of Kudzu extract (Alkontrol-Herbal™) for its ability to alter alcohol consumption in a natural settings laboratory. A single dose of Kudzu extract (2g total with an active isoflavone content of 520mg) or placebo was administered 2.5h before the onset of a 90min afternoon drinking session during which participants had the opportunity to drink up to 6 beers ad libitum; water and juice were always available as alternative beverages. During the baseline session, the placebo-randomized group consumed 2.7±0.78 beers before treatment and increased consumption to 3.4±1.1 beers after treatment. The Kudzu group significantly reduced consumption from 3.0±1.7 at baseline to 1.9±1.3 beers after treatment. The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the Kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment. Additionally, Kudzu-treated participants drank slower. This is the first demonstration that a single dose of Kudzu extract quickly reduces alcohol consumption in a binge drinking paradigm. These data add to the mounting clinical evidence that Kudzu extract may be a safe and effective adjunctive pharmacotherapy for alcohol abuse and dependence. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
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A standardized Kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers
Psychopharmacology, 2012Co-Authors: Scott E Lukas, David M Penetar, Christopher M Palmer, Thomas Geaghan, Melissa A. Maywalt, Michael Tracy, John Rodolico, David Y.w. LeeAbstract:Objective We previously demonstrated that short-term treatment with a standardized Kudzu extract (NPI-031) reduced alcohol drinking by men and women in a natural setting. The present study was conducted in nontreatment-seeking heavy drinkers to assess the safety and efficacy of 4 weeks of Kudzu extract in an outpatient setting.
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Kudzu root extract does not perturb the sleep wake cycle of moderate drinkers
Journal of Alternative and Complementary Medicine, 2011Co-Authors: Bethany K Bracken, David M Penetar, Ross R Maclean, Scott E LukasAbstract:Abstract Objectives: According to ancient Chinese medicine, Kudzu root has been used as an ingredient to treat alcohol intoxication for centuries. Kudzu root extract is effective at reducing alcohol intake in animals and in humans, both in a natural-settings laboratory environment and on an outpatient basis. In dependent populations, withdrawal from alcohol is associated with disturbed sleep. These disturbances to the quantity and quality of sleep likely impact relapse to drinking. Many medications used to treat alcohol dependence also affect sleep. Therefore, as a possible treatment for alcohol dependence, the impact of Kudzu root extract on the sleep/wake cycle is an important aspect of its effectiveness. Design: This double-blind, placebo-controlled, crossover trial tested the effects of Kudzu root extract on the sleep/wake cycles of moderate drinkers. Results: Kudzu extract had no effect on any of the sleep parameters measured, including sleep efficiency, sleep latency, total time asleep per night, nu...
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Kudzu extract treatment does not increase the intoxicating effects of acute alcohol in human volunteers.
Alcoholism clinical and experimental research, 2011Co-Authors: David M Penetar, R. Ross Maclean, Jane F. Mcneil, Scott E LukasAbstract:Background—Isoflavone administration in the form of a purified extract from the herbal medication Kudzu root has been shown to reduce, but not eliminate, alcohol consumption in alcohol-abusing and alcohol-dependent men. The precise mechanism of this action is unknown, but one possible explanation for these results is that the isoflavones in Kudzu might actually increase the intensity or duration of alcohol’s effects and thus delay the desire for subsequent drinks. The present study was designed to test this hypothesis. Methods—Twelve (12) healthy adult men and women (27.5±1.89 yrs old) who consumed moderate amounts of alcohol (7.8±0.63 drinks/week) participated in a double-blind, placebocontrolled crossover study in which they were treated with either Kudzu extract (total isoflavone dose of 750 mg/day) or matched placebo for nine days. On days 8 and 9, participants received an acute challenge of ethyl alcohol (either 0.35 or 0.7 g/kg alcohol). During the challenges the following measures were collected: subjective effects, psychomotor (body sway), cognitive performance (vigilance/reaction time), physiological measures (heart rate and skin temperature), and plasma ethanol concentration. Results—Alcohol resulted in a dose-related alteration in subjective measures of intoxication, impairment of stance stability, and vigilance/reaction time. Kudzu extract did not alter participants’ subjective responses to the alcohol challenge or to alcohol’s effects on stance stability or vigilance/reaction time. However, individuals treated with Kudzu extract experienced a slightly more rapid rise in plasma ethanol levels, but only after the 0.7 g/kg dose. This transient effect during the first 30 minutes of the ascending plasma alcohol curve lasted only 10-15 minutes; there were no differences in peak plasma alcohol levels or alcohol elimination kinetics. Additionally, Kudzu pretreatment enhanced the effects of the 0.7 g/kg dose of alcohol on heart rate and skin temperature. Conclusions—These data suggest that individuals who drink alcohol while being treated with Kudzu extract experience no adverse consequences and further, the reported reductions in alcohol intake after Kudzu extract treatment are not related to an alteration in alcohol’s subjective or psychomotor effects.
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Kudzu Root Extract Does Not Perturb the Sleep/Wake Cycle of Moderate Drinkers
Journal of alternative and complementary medicine (New York N.Y.), 2011Co-Authors: Bethany K Bracken, David M Penetar, Ross R Maclean, Scott E LukasAbstract:According to ancient Chinese medicine, Kudzu root has been used as an ingredient to treat alcohol intoxication for centuries. Kudzu root extract is effective at reducing alcohol intake in animals and in humans, both in a natural-settings laboratory environment and on an outpatient basis. In dependent populations, withdrawal from alcohol is associated with disturbed sleep. These disturbances to the quantity and quality of sleep likely impact relapse to drinking. Many medications used to treat alcohol dependence also affect sleep. Therefore, as a possible treatment for alcohol dependence, the impact of Kudzu root extract on the sleep/wake cycle is an important aspect of its effectiveness. This double-blind, placebo-controlled, crossover trial tested the effects of Kudzu root extract on the sleep/wake cycles of moderate drinkers. Kudzu extract had no effect on any of the sleep parameters measured, including sleep efficiency, sleep latency, total time asleep per night, number of waking episodes, time awake per episode, number of moving minutes, number of sleep episodes, time asleep per episode, and number of immobile minutes. These data suggest that the administration of Kudzu root extract does not disturb sleep/wake cycles of moderate drinkers, and as such its utility as an adjunct treatment for alcohol dependence remains free of any potential side-effects on sleep.
S. Ohno - One of the best experts on this subject based on the ideXlab platform.
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Moisture Sorption Hysteresis in Kudzu Starch and Sweet Potato Starch
Journal of Food Science, 1991Co-Authors: Keito Boki, S. OhnoAbstract:Moisture sorption hysteresis loops of Kudzu starch and sweet potato starch were investigated to help understand the nature of the adsorption-desorption process. The second adsorption isotherms were above the first adsorption isotherms for Kudzu starch and sweet potato starch preheated to 110°C. This was explained as an increase in the number of hydrophilic sites due to rupturing of hydrogen bonds. The hysteresis loop for Kudzu starch was greater than that for sweet potato starch. This was interpreted as a difference in mesopore volume.
David M Penetar - One of the best experts on this subject based on the ideXlab platform.
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A single dose of Kudzu extract reduces alcohol consumption in a binge drinking paradigm.
Drug and alcohol dependence, 2015Co-Authors: David M Penetar, Lindsay H. Toto, David Y.w. Lee, Scott E LukasAbstract:Overconsumption of alcohol has significant negative effects on an individual's health and contributes to an enormous economic impact on society as a whole. Pharmacotherapies to curb excessive drinking are important for treating alcohol use disorders. Twenty (20) men participated in a placebo-controlled, double-blind, between subjects design experiment (n=10/group) that tested the effects of Kudzu extract (Alkontrol-Herbal™) for its ability to alter alcohol consumption in a natural settings laboratory. A single dose of Kudzu extract (2g total with an active isoflavone content of 520mg) or placebo was administered 2.5h before the onset of a 90min afternoon drinking session during which participants had the opportunity to drink up to 6 beers ad libitum; water and juice were always available as alternative beverages. During the baseline session, the placebo-randomized group consumed 2.7±0.78 beers before treatment and increased consumption to 3.4±1.1 beers after treatment. The Kudzu group significantly reduced consumption from 3.0±1.7 at baseline to 1.9±1.3 beers after treatment. The placebo-treated group opened 33 beers during baseline conditions and 38 following treatment whereas the Kudzu-treated group opened 32 beers during baseline conditions and only 21 following treatment. Additionally, Kudzu-treated participants drank slower. This is the first demonstration that a single dose of Kudzu extract quickly reduces alcohol consumption in a binge drinking paradigm. These data add to the mounting clinical evidence that Kudzu extract may be a safe and effective adjunctive pharmacotherapy for alcohol abuse and dependence. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
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A standardized Kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers
Psychopharmacology, 2012Co-Authors: Scott E Lukas, David M Penetar, Christopher M Palmer, Thomas Geaghan, Melissa A. Maywalt, Michael Tracy, John Rodolico, David Y.w. LeeAbstract:Objective We previously demonstrated that short-term treatment with a standardized Kudzu extract (NPI-031) reduced alcohol drinking by men and women in a natural setting. The present study was conducted in nontreatment-seeking heavy drinkers to assess the safety and efficacy of 4 weeks of Kudzu extract in an outpatient setting.
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Kudzu root extract does not perturb the sleep wake cycle of moderate drinkers
Journal of Alternative and Complementary Medicine, 2011Co-Authors: Bethany K Bracken, David M Penetar, Ross R Maclean, Scott E LukasAbstract:Abstract Objectives: According to ancient Chinese medicine, Kudzu root has been used as an ingredient to treat alcohol intoxication for centuries. Kudzu root extract is effective at reducing alcohol intake in animals and in humans, both in a natural-settings laboratory environment and on an outpatient basis. In dependent populations, withdrawal from alcohol is associated with disturbed sleep. These disturbances to the quantity and quality of sleep likely impact relapse to drinking. Many medications used to treat alcohol dependence also affect sleep. Therefore, as a possible treatment for alcohol dependence, the impact of Kudzu root extract on the sleep/wake cycle is an important aspect of its effectiveness. Design: This double-blind, placebo-controlled, crossover trial tested the effects of Kudzu root extract on the sleep/wake cycles of moderate drinkers. Results: Kudzu extract had no effect on any of the sleep parameters measured, including sleep efficiency, sleep latency, total time asleep per night, nu...
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Kudzu extract treatment does not increase the intoxicating effects of acute alcohol in human volunteers.
Alcoholism clinical and experimental research, 2011Co-Authors: David M Penetar, R. Ross Maclean, Jane F. Mcneil, Scott E LukasAbstract:Background—Isoflavone administration in the form of a purified extract from the herbal medication Kudzu root has been shown to reduce, but not eliminate, alcohol consumption in alcohol-abusing and alcohol-dependent men. The precise mechanism of this action is unknown, but one possible explanation for these results is that the isoflavones in Kudzu might actually increase the intensity or duration of alcohol’s effects and thus delay the desire for subsequent drinks. The present study was designed to test this hypothesis. Methods—Twelve (12) healthy adult men and women (27.5±1.89 yrs old) who consumed moderate amounts of alcohol (7.8±0.63 drinks/week) participated in a double-blind, placebocontrolled crossover study in which they were treated with either Kudzu extract (total isoflavone dose of 750 mg/day) or matched placebo for nine days. On days 8 and 9, participants received an acute challenge of ethyl alcohol (either 0.35 or 0.7 g/kg alcohol). During the challenges the following measures were collected: subjective effects, psychomotor (body sway), cognitive performance (vigilance/reaction time), physiological measures (heart rate and skin temperature), and plasma ethanol concentration. Results—Alcohol resulted in a dose-related alteration in subjective measures of intoxication, impairment of stance stability, and vigilance/reaction time. Kudzu extract did not alter participants’ subjective responses to the alcohol challenge or to alcohol’s effects on stance stability or vigilance/reaction time. However, individuals treated with Kudzu extract experienced a slightly more rapid rise in plasma ethanol levels, but only after the 0.7 g/kg dose. This transient effect during the first 30 minutes of the ascending plasma alcohol curve lasted only 10-15 minutes; there were no differences in peak plasma alcohol levels or alcohol elimination kinetics. Additionally, Kudzu pretreatment enhanced the effects of the 0.7 g/kg dose of alcohol on heart rate and skin temperature. Conclusions—These data suggest that individuals who drink alcohol while being treated with Kudzu extract experience no adverse consequences and further, the reported reductions in alcohol intake after Kudzu extract treatment are not related to an alteration in alcohol’s subjective or psychomotor effects.
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Kudzu Root Extract Does Not Perturb the Sleep/Wake Cycle of Moderate Drinkers
Journal of alternative and complementary medicine (New York N.Y.), 2011Co-Authors: Bethany K Bracken, David M Penetar, Ross R Maclean, Scott E LukasAbstract:According to ancient Chinese medicine, Kudzu root has been used as an ingredient to treat alcohol intoxication for centuries. Kudzu root extract is effective at reducing alcohol intake in animals and in humans, both in a natural-settings laboratory environment and on an outpatient basis. In dependent populations, withdrawal from alcohol is associated with disturbed sleep. These disturbances to the quantity and quality of sleep likely impact relapse to drinking. Many medications used to treat alcohol dependence also affect sleep. Therefore, as a possible treatment for alcohol dependence, the impact of Kudzu root extract on the sleep/wake cycle is an important aspect of its effectiveness. This double-blind, placebo-controlled, crossover trial tested the effects of Kudzu root extract on the sleep/wake cycles of moderate drinkers. Kudzu extract had no effect on any of the sleep parameters measured, including sleep efficiency, sleep latency, total time asleep per night, number of waking episodes, time awake per episode, number of moving minutes, number of sleep episodes, time asleep per episode, and number of immobile minutes. These data suggest that the administration of Kudzu root extract does not disturb sleep/wake cycles of moderate drinkers, and as such its utility as an adjunct treatment for alcohol dependence remains free of any potential side-effects on sleep.
J. M. Rodríguez - One of the best experts on this subject based on the ideXlab platform.
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Thermal stability of Kudzu root (Pueraria Radix) isoflavones as additives to beef patties
Journal of Food Science and Technology-mysore, 2013Co-Authors: S. Kumari, Justin M. Raines, J M Martin, J. M. RodríguezAbstract:Kudzu root, Pueraria radix, extracts are a rich source of isoflavones. This study investigates the thermal stability of Pueraria radix extracts as a natural nutraceutical supplement in beef patties. The extract contained puerarin, diadzin, genistin, ononin, daidzein, glycitein, calycosin, genistein, formononetin and biochanin A; however, puerarin, daidzein and glycitein were the main components. The isoflavones concentrations in the spiked beef patties with Kudzu root extracts were unaffected by cooking.
Keito Boki - One of the best experts on this subject based on the ideXlab platform.
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Moisture Sorption Hysteresis in Kudzu Starch and Sweet Potato Starch
Journal of Food Science, 1991Co-Authors: Keito Boki, S. OhnoAbstract:Moisture sorption hysteresis loops of Kudzu starch and sweet potato starch were investigated to help understand the nature of the adsorption-desorption process. The second adsorption isotherms were above the first adsorption isotherms for Kudzu starch and sweet potato starch preheated to 110°C. This was explained as an increase in the number of hydrophilic sites due to rupturing of hydrogen bonds. The hysteresis loop for Kudzu starch was greater than that for sweet potato starch. This was interpreted as a difference in mesopore volume.
