The Experts below are selected from a list of 303 Experts worldwide ranked by ideXlab platform
Timothy J Wilt - One of the best experts on this subject based on the ideXlab platform.
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systematic review effective management strategies for Lactose Intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Michael Levitt, Brent C Taylor, Roderick Macdonald, Tatyana Shamliyan, Robert L Kane, Timothy J WiltAbstract:Background: Lactose Intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of Lactose and interventions for reducing symptoms of Lactose Intolerance among persons with Lactose Intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with Lactose Intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or Lactose-hydrolyzed milk supplements, Lactose-reduced milk, or tolerable doses of Lactose; 7 on probiotics; 2 on incremental Lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of Lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that Lactose-reduced solution or milk with a Lactose content of 0 to 2 g, compared with greater than 12 g, is effective in reducing symptoms of Lactose Intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with Lactose malabsorption rather than Lactose Intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed Lactose Intolerance or malabsorption can tolerate 12 to 15 g of Lactose. Additional studies are needed to determine the effectiveness of Lactose Intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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Lactose Intolerance and health
Evidence Report Technology Assessment, 2010Co-Authors: Timothy J Wilt, Aasma Shaukat, Brent C Taylor, Roderick Macdonald, Tatyana Shamliyan, Robert L Kane, James Tacklind, Indulis Rutks, Sarah Jane Schwarzenberg, Michael LevittAbstract:OBJECTIVES We systematically reviewed evidence to determine Lactose Intolerance (LI) prevalence, bone health after dairy-exclusion diets, tolerable dose of Lactose in subjects with diagnosed LI, and management.
Riitta Korpela - One of the best experts on this subject based on the ideXlab platform.
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Symptoms of 'Lactose Intolerance'
Food & Nutrition Research, 2020Co-Authors: Riitta KorpelaAbstract:Factors affecting or confounding the symptoms of Lactose Intolerance were examined by us in randomised, placebo-controlled and double-blind studies on healthy adult subjects. Evaluation of the diagnostic methods of Lactose Intolerance showed that cut-off values, according to the blood glucose values, varied widely. This result was based on a postal questionnaire, sent to all Finnish health centres. Symptoms were seldom recorded for a sufficiently long period. In carefully diagnosed Lactose intolerant subjects, there was no difference in the severity of reported symptoms between ingestion of 0, 0.5, 1.5 and 7 g of Lactose. Lactose maldigesters reported more severe symptoms after ingestion of Lactose, but also sucrose, lactulose and fructo-oligosaccharides than controls. There was a strong relation among the reported symptoms in Lactose Intolerance, irritable bowel syndrome, the experience of abdominal pain in childhood, and female sex. Key words: Lactose Intolerance, Lactose maldigestion, symptoms
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role of irritable bowel syndrome in subjective Lactose Intolerance
The American Journal of Clinical Nutrition, 1998Co-Authors: T H Vesa, L M Seppo, P R Marteau, T Sahi, Riitta KorpelaAbstract:It has been suggested that the symptoms of irritable bowel syndrome (IBS) may be wrongly attributed to Lactose Intolerance. We examined the relations among IBS, demographic factors. living habits, and Lactose Intolerance. On the basis of a Lactose tolerance test with ethanol, 101 of the 427 healthy subjects studied were Lactose maldigesters and 326 were Lactose digesters. IBS was diagnosed by means of the Bowel Disease Questionnaire, according to the Rome criteria. The use of dairy products and symptoms experienced after their consumption were recorded. IBS was found in 15% of both the Lactose maldigesters and Lactose digesters. One-third of the subjects reported Intolerance to dairy products containing ≤20 g Lactose. About half of this third were Lactose maldigesters and about half were Lactose digesters. As explanations for this subjective Lactose Intolerance, the logistic regression model estimated Lactose maldigestion (odds ratio: 10.3: 95% Cl: 5.2. 20.4). IBS (4.6: 2., 10.1), experience of symptoms other than gastrointestinal ones 12.3; 1.2, 4.5). and female sex (2.1; 1.1. 4.0). Characteristics common to both subjective Lactose Intolerance and IBS were female sex and the experience of abdominal pain in childhood (P < 0.01). Age, regularity of meals, and the amount of physical activity were not associated with either subjective Lactose Intolerance or IBS. Of the subjects with IBS, the percentage of Lactose maldigesters was the same as in the whole study group (24%) but the number who reported Lactose Intolerance was higher (60% compared with 27%, P < 0.001). We showed a strong relation among subjective Lactose Intolerance, IBS, the experience of abdominal pain in childhood. and female sex.
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Milk fat does not affect the symptoms of Lactose Intolerance
European Journal of Clinical Nutrition, 1997Co-Authors: T H Vesa, M Lember, Riitta KorpelaAbstract:Objective: This study investigated the role of the fat content of milk on symptoms of Lactose Intolerance. Design: Subjects recorded Intolerance symptoms using a visual analogue scale (VAS) following ingestion of three test milks of varying fat content for a two-day period. Subjects/Setting: The subjects were thirty adult volunteers, patients of two Estonian out-patient clinics with diagnosed Lactose Intolerance. The study milks were drunk at home or at work. All thirty subjects completed the study protocol. Intervention: Each subject drank, in random order, fat-free milk (4.9% Lactose), high-fat milk (8% fat, 4.9% Lactose), and a Lactose-free and fat-free control milk. They drank 200 ml of the milk twice a day for two days, one milk type per session, with five days between sessions. The subjects noted their gastrointestinal symptoms during the test periods and during a 5 d milk-free period at the beginning of the study. The occurrence and severity of symptoms were compared. A global measure of the severity of symptoms was defined by computing the sum of the symptom scores. Results: The sum of symptoms was higher during all milk periods than during the milk-free period (P< 0.01). There were no statistically significant differences in the occurrence or severity of symptoms during the fat-free milk period compared with the high-fat milk period. Conclusions: Even a marked difference in the fat content of milk did not affect the symptoms of Lactose Intolerance. Consequently, there seems to be no case for recommending full-fat milk products in the treatment of Lactose Intolerance. Sponsorship: The study was supported by the Foundation of the Finnish Association of Agronomists: Valio Ltd, Finland, provided the test milks. Descriptors: Lactose Intolerance; milk fat; Lactose-free milk; gastrointestinal symptoms
Jeremy D Sanderson - One of the best experts on this subject based on the ideXlab platform.
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review article Lactose Intolerance in clinical practice myths and realities
Alimentary Pharmacology & Therapeutics, 2007Co-Authors: Miranda Lomer, Gareth Parkes, Jeremy D SandersonAbstract:Summary Background Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity. However, not everyone has Lactose Intolerance, as several nutritional and genetic factors influence tolerance. Aims To review current clinical practice and identify published literature on the management of Lactose Intolerance. Methods PubMed was searched using the terms Lactose, lactase and diet to find original research and reviews. Relevant articles and clinical experience provided the basis for this review. Results Lactose is found only in mammalian milk and is hydrolysed by lactase in the small intestine. The lactase gene has recently been identified. ‘Wild-type’ is characterized by lactase nonpersistence, often leading to Lactose Intolerance. Two genetic polymorphisms responsible for persistence have been identified, with their distribution concentrated in north Europeans. Symptoms of Lactose Intolerance include abdominal pain, bloating, flatulence and diarrhoea. Diagnosis is most commonly by the Lactose hydrogen breath test. However, most people with hypolactasia, if given appropriate advice, can tolerate some Lactose-containing foods without symptoms. Conclusion In clinical practice, some people with Lactose Intolerance can consume milk and dairy foods without developing symptoms, whereas others will need Lactose restriction.
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Review article: Lactose Intolerance in clinical practice – myths and realities
Alimentary Pharmacology & Therapeutics, 2007Co-Authors: Miranda Lomer, Gareth Parkes, Jeremy D SandersonAbstract:Summary Background Approximately 70% of the world population has hypolactasia, which often remains undiagnosed and has the potential to cause some morbidity. However, not everyone has Lactose Intolerance, as several nutritional and genetic factors influence tolerance. Aims To review current clinical practice and identify published literature on the management of Lactose Intolerance. Methods PubMed was searched using the terms Lactose, lactase and diet to find original research and reviews. Relevant articles and clinical experience provided the basis for this review. Results Lactose is found only in mammalian milk and is hydrolysed by lactase in the small intestine. The lactase gene has recently been identified. ‘Wild-type’ is characterized by lactase nonpersistence, often leading to Lactose Intolerance. Two genetic polymorphisms responsible for persistence have been identified, with their distribution concentrated in north Europeans. Symptoms of Lactose Intolerance include abdominal pain, bloating, flatulence and diarrhoea. Diagnosis is most commonly by the Lactose hydrogen breath test. However, most people with hypolactasia, if given appropriate advice, can tolerate some Lactose-containing foods without symptoms. Conclusion In clinical practice, some people with Lactose Intolerance can consume milk and dairy foods without developing symptoms, whereas others will need Lactose restriction.
Michael Levitt - One of the best experts on this subject based on the ideXlab platform.
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systematic review effective management strategies for Lactose Intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Michael Levitt, Brent C Taylor, Roderick Macdonald, Tatyana Shamliyan, Robert L Kane, Timothy J WiltAbstract:Background: Lactose Intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of Lactose and interventions for reducing symptoms of Lactose Intolerance among persons with Lactose Intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with Lactose Intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or Lactose-hydrolyzed milk supplements, Lactose-reduced milk, or tolerable doses of Lactose; 7 on probiotics; 2 on incremental Lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of Lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that Lactose-reduced solution or milk with a Lactose content of 0 to 2 g, compared with greater than 12 g, is effective in reducing symptoms of Lactose Intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with Lactose malabsorption rather than Lactose Intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed Lactose Intolerance or malabsorption can tolerate 12 to 15 g of Lactose. Additional studies are needed to determine the effectiveness of Lactose Intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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Lactose Intolerance and health
Evidence Report Technology Assessment, 2010Co-Authors: Timothy J Wilt, Aasma Shaukat, Brent C Taylor, Roderick Macdonald, Tatyana Shamliyan, Robert L Kane, James Tacklind, Indulis Rutks, Sarah Jane Schwarzenberg, Michael LevittAbstract:OBJECTIVES We systematically reviewed evidence to determine Lactose Intolerance (LI) prevalence, bone health after dairy-exclusion diets, tolerable dose of Lactose in subjects with diagnosed LI, and management.
Aasma Shaukat - One of the best experts on this subject based on the ideXlab platform.
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systematic review effective management strategies for Lactose Intolerance
Annals of Internal Medicine, 2010Co-Authors: Aasma Shaukat, Michael Levitt, Brent C Taylor, Roderick Macdonald, Tatyana Shamliyan, Robert L Kane, Timothy J WiltAbstract:Background: Lactose Intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear. Purpose: To assess the maximum tolerable dose of Lactose and interventions for reducing symptoms of Lactose Intolerance among persons with Lactose Intolerance and malabsorption. Data Sources: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. Study Selection: Randomized, controlled trials of individuals with Lactose Intolerance or malabsorption. Data Extraction: Three investigators independently reviewed articles, extracted data, and assessed study quality. Data Synthesis: 36 unique randomized studies (26 on lactase- or Lactose-hydrolyzed milk supplements, Lactose-reduced milk, or tolerable doses of Lactose; 7 on probiotics; 2 on incremental Lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of Lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that Lactose-reduced solution or milk with a Lactose content of 0 to 2 g, compared with greater than 12 g, is effective in reducing symptoms of Lactose Intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. Limitations: Most studies evaluated persons with Lactose malabsorption rather than Lactose Intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. Conclusion: Most individuals with presumed Lactose Intolerance or malabsorption can tolerate 12 to 15 g of Lactose. Additional studies are needed to determine the effectiveness of Lactose Intolerance treatment. Primary Funding Source: Agency for Healthcare Research and Quality.
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Lactose Intolerance and health
Evidence Report Technology Assessment, 2010Co-Authors: Timothy J Wilt, Aasma Shaukat, Brent C Taylor, Roderick Macdonald, Tatyana Shamliyan, Robert L Kane, James Tacklind, Indulis Rutks, Sarah Jane Schwarzenberg, Michael LevittAbstract:OBJECTIVES We systematically reviewed evidence to determine Lactose Intolerance (LI) prevalence, bone health after dairy-exclusion diets, tolerable dose of Lactose in subjects with diagnosed LI, and management.
