The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
G Calais - One of the best experts on this subject based on the ideXlab platform.
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long term results of a multicenter randomized phase iii trial of induction chemotherapy with cisplatin 5 fluorouracil docetaxel for Larynx preservation
Journal of the National Cancer Institute, 2016Co-Authors: G Janoray, Yoann Pointreau, P Garaud, S Chapet, M Alfonsi, C Sire, Eric Jadaud, G CalaisAbstract:BACKGROUND: The purpose of GORTEC 2000-01 was to compare the long-term efficacy and safety of induction chemotherapy with cisplatin (P) and 5-fluorouracil (F) with or without docetaxel (T) for Larynx preservation. METHODS: Operable patients with untreated stage III or IV Larynx or hypopharynx invasive squamous cell carcinoma who required total laryngectomy were randomly assigned to three cycles of induction chemotherapy with either TPF or PF, followed by radiation therapy for responders. The primary endpoint was three-year Larynx preservation rate. Secondary endpoints included Larynx dysfunction-free survival (LDFFS), overall survival (OS), disease-free survival (DFS), loco-regional control rate (LCR), cause of death, and later toxicity rates. Survival and other data were analyzed by Kaplan-Meier methods. All statistical tests were two-sided. RESULTS: Two hundred thirteen patients were treated with median follow-up of 105 months. The five- and 10-year Larynx preservation rates were 74.0% (95% CI = 0.64 to 0.82) vs 58.1% (95% CI = 0.47 to 0.68) and 70.3% (95% CI = 0.58 to 0.8) vs 46.5% (95% CI = 0.31 to 0.63, P = .01) in the TPF vs PF arm, respectively. The five- and 10-year LDFFS rates were 67.2% (95% CI = 0.57 to 0.76) vs 46.5% (95% CI = 0.36 to 0.57) and 63.7% (95% CI = 0.52 to 0.74) vs 37.2% (95% CI = 0.24 to 0.52, P = .001), respectively. OS, DFS, and LCR were not statistically improved in the TPF vs the PF arm. Statistically fewer grade 3-4 late toxicities of the Larynx occurred with the TPF regimen compared with the PF arm (9.3% vs 17.1%, G-test, P = .038). CONCLUSION: Long-term follow-up confirms that induction chemotherapy with TPF increased Larynx preservation and Larynx dysfunction-free survival. In this Larynx preservation approach using induction chemotherapy, TPF should be recommended, followed by radiation therapy.
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long term results of gortec 2000 01 a multicentric randomized phase iii trial of induction chemotherapy with cisplatin plus 5 fluorouracil with or without docetaxel for Larynx preservation
Journal of Clinical Oncology, 2015Co-Authors: G Janoray, Yoann Pointreau, P Garaud, S Chapet, M Alfonsi, C Sire, C Tuchais, G CalaisAbstract:6002 Background: To compare the long-term efficacy and safety of induction chemotherapy with cisplatin (P) and 5-fluorouracil (F) with or without docetaxel (T) for Larynx preservation. Methods: Operable patients with untreated stage-III or -IV Larynx or hypopharynx invasive squamous-cell carcinoma and who required a total laryngectomy were randomly assigned to receive three cycles of induction chemotherapy with either TPF or PF, followed by radiation therapy for responders. The primary endpoint was 3-year Larynx-preservation rate. Secondary endpoints included Larynx dysfunction-free survival (LDFFS), overall survival, disease-free survival, locoregional control rate, cause of death, and later toxicity rates. Results: Two hundred and thirteen patients were treated with a median follow-up for surviving patients of 105 months. The 5- and 10-year Larynx preservation rates were, 74.0% (95%CI, 0.64–0.82) vs. 58.1% (95%CI, 0.47–0.68) and 70.3% (95%CI, 0.58–0.8) vs. 46.5% (95%CI, 0.31–0.63, p = 0.01) in TPF versu...
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randomized trial of induction chemotherapy with cisplatin and 5 fluorouracil with or without docetaxel for Larynx preservation
Journal of the National Cancer Institute, 2009Co-Authors: Yoann Pointreau, P Garaud, S Chapet, M Alfonsi, C Sire, C Tuchais, Jacques Tortochaux, Sandrine Faivre, Stephane Guerrif, G CalaisAbstract:BACKGROUND: Chemotherapy with cisplatin (P) and 5-fluorouracil (F) followed by radiotherapy in patients who respond to chemotherapy is an alternative to total laryngectomy for patients with locally advanced Larynx and hypopharynx cancer. Data suggest that docetaxel (T) may add to the efficacy of PF. The objective of this trial was to determine whether adding T to PF could increase the Larynx preservation rate. METHODS: Patients who had Larynx and hypopharynx cancer that required total laryngectomy were randomly assigned to receive three cycles of TPF or PF. Patients who responded to chemotherapy received radiotherapy with or without additional chemotherapy. Patients who did not respond to chemotherapy underwent total laryngectomy followed by radiotherapy with or without additional chemotherapy. The primary endpoint was 3-year Larynx preservation rate. Secondary endpoints included acute toxicities and overall response. All statistical tests were two-sided. RESULTS: Baseline patient and tumor characteristics were well balanced between the TPF (n = 110) and PF (n = 103) groups. With a median follow-up of 36 months, the 3-year actuarial Larynx preservation rate was 70.3% with TPF vs 57.5% with PF (difference = 12.8%; P = .03). Patients in the TPF group had more grade 2 alopecia, grade 4 neutropenia, and febrile neutropenia, whereas patients in the PF group had more grade 3 and 4 stomatitis, thrombocytopenia, and grade 4 creatinine elevation. The overall response was 80.0% in the TPF group vs 59.2% in the PF group (difference = 20.8%; P = .002). CONCLUSIONS: In patients with advanced Larynx and hypopharynx carcinomas, TPF induction chemotherapy was superior to the PF regimen in terms of overall response rate. These results suggest that Larynx preservation could be achieved for a higher proportion of patients.
F. Arai - One of the best experts on this subject based on the ideXlab platform.
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A new type of artificial Larynx using a PZT ceramics vibrator as a sound source
IEEE ASME Transactions on Mechatronics, 2000Co-Authors: T. Fukuda, F. AraiAbstract:Various speech production substitutes which aim to reconstruct speech functions have been developed and used practically, for vocalization-handicapped persons. However, current speech production substitutes have problems, and it is hoped that perfect speech production substitutes are developed. We pay attention to a PZT ceramics vibrator as a sound source of an artificial Larynx. We try to produce the artificial Larynx which uses a PZT ceramics vibrator, and we evaluate the performance. The power spectrum of the produced artificial Larynx user's voice is similar to that of a nonhandicapped person's voice. The vocalized sound of the produced artificial Larynx user shows good characteristics at formant frequency, which is important for vowel discrimination. Based on the result of listening estimation, this voice has good clarity. We hope that the proposed artificial Larynx will be widely used in the future.
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New type artificial Larynx using PZT ceramics vibrator as sound source
1999 IEEE ASME International Conference on Advanced Intelligent Mechatronics (Cat. No.99TH8399), 1999Co-Authors: T. Fukuda, F. AraiAbstract:Speech production substitutes used presently have problems, and perfect speech production substitutes are being developed. We paid attention to PZT ceramics vibrator as a sound source of an artificial Larynx. We tried to produce the artificial Larynx using a PZT ceramics vibrator, and evaluated its performance. The power spectrum of user's voice produced by the artificial Larynx is similar to that of nonhandicapped person's voice. The vocalized sound produced by artificial Larynx user shows good characteristics at formant frequency with the role which is important for the vowel discrimination. Based on the result of listening estimation, this voice has good clearness. We hope that the proposed artificial Larynx will be widely used in the future.
James O Cappellari - One of the best experts on this subject based on the ideXlab platform.
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distinguishing tumor recurrence from irradiation sequelae with positron emission tomography in patients treated for Larynx cancer
International Journal of Radiation Oncology Biology Physics, 1993Co-Authors: Kathryn M Greven, Daniel W Williams, John W Keyes, Fred W Mcguirt, Beth A Harkness, Nat E Watson, Milton Raben, Lisa C Frazier, Kim R Geisinger, James O CappellariAbstract:Abstract Purpose: Distinguishing persistent or recurrent tumor from postradiation edema, or soft tissue/cartilage necrosis in patients treated for carcinoma of the Larynx can be difficult. Because recurrent tumor is often submucosal, multiple deep biopsies may be necessary before a diagnosis can be established. Positron emission tomography with 18F-2fluoro-2deoxyglucose (FDG) was studied for its ability to aid in this problem. Methods and Materials: Positron emission tomography (18FDG) scans were performed on 11 patients who were suspected of having persistent or recurrent tumor after radiation treatment for carcinoma of the Larynx. Patients underwent thorough history and physical examinations, scans with computerized tomography, and pathologic evaluation when indicated. Standard uptake values were used to quantitate the FDG uptake in the Larynx. Results: The time between completion of radiation treatment and positron emission tomography examination ranged from 2 to 26 months with a median of 6 months. Ten patients underwent computed tomography (CT) of the Larynx, which revealed edema of the Larynx (six patients), glottic mass (four patients), and cervical nodes (one patient). Positron emission tomography scans revealed increased FDG uptake in the Larynx in five patients and laryngectomy confirmed the presence of carcinoma in these patients. Five patients had positron emission tomography results consistent with normal tissue changes in the Larynx, and one patient had increased FDG uptake in neck nodes. This patient underwent laryngectomy, and no cancer was found in the primary site, but nodes were pathologically positive. One patient had slightly elevated FDG uptake and negative biopsy results. The remaining patients have been followed for 11 to 14 months since their positron emission studies and their examinations have remained stable. In patients without tumor, average standard uptake values of the Larynx ranged from 2.4 to 4.7, and in patients with tumor, the range was 4.9 to 10.7. Conclusion: Positron emission tomography with labeled FDG appears to be useful in distinguishing benign from malignant changes in the Larynx after radiation treatment. This noninvasive technique may be preferable to biopsy, which could traumatize radiation-damaged tissues and precipitate necrosis.
T. Fukuda - One of the best experts on this subject based on the ideXlab platform.
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A new type of artificial Larynx using a PZT ceramics vibrator as a sound source
IEEE ASME Transactions on Mechatronics, 2000Co-Authors: T. Fukuda, F. AraiAbstract:Various speech production substitutes which aim to reconstruct speech functions have been developed and used practically, for vocalization-handicapped persons. However, current speech production substitutes have problems, and it is hoped that perfect speech production substitutes are developed. We pay attention to a PZT ceramics vibrator as a sound source of an artificial Larynx. We try to produce the artificial Larynx which uses a PZT ceramics vibrator, and we evaluate the performance. The power spectrum of the produced artificial Larynx user's voice is similar to that of a nonhandicapped person's voice. The vocalized sound of the produced artificial Larynx user shows good characteristics at formant frequency, which is important for vowel discrimination. Based on the result of listening estimation, this voice has good clarity. We hope that the proposed artificial Larynx will be widely used in the future.
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New type artificial Larynx using PZT ceramics vibrator as sound source
1999 IEEE ASME International Conference on Advanced Intelligent Mechatronics (Cat. No.99TH8399), 1999Co-Authors: T. Fukuda, F. AraiAbstract:Speech production substitutes used presently have problems, and perfect speech production substitutes are being developed. We paid attention to PZT ceramics vibrator as a sound source of an artificial Larynx. We tried to produce the artificial Larynx using a PZT ceramics vibrator, and evaluated its performance. The power spectrum of user's voice produced by the artificial Larynx is similar to that of nonhandicapped person's voice. The vocalized sound produced by artificial Larynx user shows good characteristics at formant frequency with the role which is important for the vowel discrimination. Based on the result of listening estimation, this voice has good clearness. We hope that the proposed artificial Larynx will be widely used in the future.
Kathryn M Greven - One of the best experts on this subject based on the ideXlab platform.
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distinguishing tumor recurrence from irradiation sequelae with positron emission tomography in patients treated for Larynx cancer
International Journal of Radiation Oncology Biology Physics, 1993Co-Authors: Kathryn M Greven, Daniel W Williams, John W Keyes, Fred W Mcguirt, Beth A Harkness, Nat E Watson, Milton Raben, Lisa C Frazier, Kim R Geisinger, James O CappellariAbstract:Abstract Purpose: Distinguishing persistent or recurrent tumor from postradiation edema, or soft tissue/cartilage necrosis in patients treated for carcinoma of the Larynx can be difficult. Because recurrent tumor is often submucosal, multiple deep biopsies may be necessary before a diagnosis can be established. Positron emission tomography with 18F-2fluoro-2deoxyglucose (FDG) was studied for its ability to aid in this problem. Methods and Materials: Positron emission tomography (18FDG) scans were performed on 11 patients who were suspected of having persistent or recurrent tumor after radiation treatment for carcinoma of the Larynx. Patients underwent thorough history and physical examinations, scans with computerized tomography, and pathologic evaluation when indicated. Standard uptake values were used to quantitate the FDG uptake in the Larynx. Results: The time between completion of radiation treatment and positron emission tomography examination ranged from 2 to 26 months with a median of 6 months. Ten patients underwent computed tomography (CT) of the Larynx, which revealed edema of the Larynx (six patients), glottic mass (four patients), and cervical nodes (one patient). Positron emission tomography scans revealed increased FDG uptake in the Larynx in five patients and laryngectomy confirmed the presence of carcinoma in these patients. Five patients had positron emission tomography results consistent with normal tissue changes in the Larynx, and one patient had increased FDG uptake in neck nodes. This patient underwent laryngectomy, and no cancer was found in the primary site, but nodes were pathologically positive. One patient had slightly elevated FDG uptake and negative biopsy results. The remaining patients have been followed for 11 to 14 months since their positron emission studies and their examinations have remained stable. In patients without tumor, average standard uptake values of the Larynx ranged from 2.4 to 4.7, and in patients with tumor, the range was 4.9 to 10.7. Conclusion: Positron emission tomography with labeled FDG appears to be useful in distinguishing benign from malignant changes in the Larynx after radiation treatment. This noninvasive technique may be preferable to biopsy, which could traumatize radiation-damaged tissues and precipitate necrosis.
