The Experts below are selected from a list of 1506 Experts worldwide ranked by ideXlab platform
Alexandra Geusau - One of the best experts on this subject based on the ideXlab platform.
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neuroSyphilis is unlikely in patients with late Latent Syphilis and a negative blood vdrl test
Acta Dermato-venereologica, 2006Co-Authors: Stefan Wohrl, Alexandra GeusauAbstract:Patients with Latent Syphilis or Syphilis of unknown duration should be evaluated for tertiary disease and neuroSyphilis. The aim of this retrospective study was to determine relevant serological parameters for the identi fication of those individuals with Syphilis who are most likely to have neuroSyphilis and who therefore require lumbar puncture. After excluding repeated estimates and patients whose blood Syphilis serology had either been negative or not been determined within 3 months of lumbar puncture, 265 out of 710 cerebrospinal fluids from 1988 to 2004 were analysed. In each of those pa tients the earliest available pairs of serum and cerebro spinal fluid samples were evaluated. The diagnosis of neuroSyphilis was based on criteria according to esta blished guidelines. Fortythree of 265 patients (16.2%; 5 women, 38 men; mean age 47±16 years) had neuro Syphilis. Seven of 72 (9.7%) of those testing HIVpositive, fulfilled the criteria of neuroSyphilis. Not a single patient with neuroSyphilis tested Venereal Disease Research Laboratory test (VDRL)negative in peripheral blood, an effect which was highly significant ( p<0.01, χ 2 test). The median blood-VDRL titre was significantly higher in patients with neuroSyphilis than in those without (1:32 vs. 1:0; p<0.01, ttest, twosided). Hence, neuroSyphilis is very unlikely in patients with a negative bloodVDRL.
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neuroSyphilis is unlikely in patients with late Latent Syphilis and a negative blood vdrl test
Acta Dermato-venereologica, 2006Co-Authors: Stefan Wohrl, Alexandra GeusauAbstract:Patients with Latent Syphilis or Syphilis of unknown duration should be evaluated for tertiary disease and neuroSyphilis. The aim of this retrospective study was to determine relevant serological parameters for the identification of those individuals with Syphilis who are most likely to have neuroSyphilis and who therefore require lumbar puncture. After excluding repeated estimates and patients whose blood Syphilis serology had either been negative or not been determined within 3 months of lumbar puncture, 265 out of 710 cerebrospinal fluids from 1988 to 2004 were analysed. In each of those patients the earliest available pairs of serum and cerebrospinal fluid samples were evaluated. The diagnosis of neuroSyphilis was based on criteria according to established guidelines. Forty-three of 265 patients (16.2%; 5 women, 38 men; mean age 47+/-16 years) had neuroSyphilis. Seven of 72 (9.7%) of those testing HIV-positive, fulfilled the criteria of neuroSyphilis. Not a single patient with neuroSyphilis tested Venereal Disease Research Laboratory test (VDRL)-negative in peripheral blood, an effect which was highly significant (p < 0.01, chi2-test). The median blood-VDRL titre was significantly higher in patients with neuroSyphilis than in those without (1:32 vs. 1:0; p < 0.01, t-test, two-sided). Hence, neuroSyphilis is very unlikely in patients with a negative blood-VDRL. Therefore, lumbar puncture is not recommended in these patients.
Stefan Wohrl - One of the best experts on this subject based on the ideXlab platform.
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neuroSyphilis is unlikely in patients with late Latent Syphilis and a negative blood vdrl test
Acta Dermato-venereologica, 2006Co-Authors: Stefan Wohrl, Alexandra GeusauAbstract:Patients with Latent Syphilis or Syphilis of unknown duration should be evaluated for tertiary disease and neuroSyphilis. The aim of this retrospective study was to determine relevant serological parameters for the identi fication of those individuals with Syphilis who are most likely to have neuroSyphilis and who therefore require lumbar puncture. After excluding repeated estimates and patients whose blood Syphilis serology had either been negative or not been determined within 3 months of lumbar puncture, 265 out of 710 cerebrospinal fluids from 1988 to 2004 were analysed. In each of those pa tients the earliest available pairs of serum and cerebro spinal fluid samples were evaluated. The diagnosis of neuroSyphilis was based on criteria according to esta blished guidelines. Fortythree of 265 patients (16.2%; 5 women, 38 men; mean age 47±16 years) had neuro Syphilis. Seven of 72 (9.7%) of those testing HIVpositive, fulfilled the criteria of neuroSyphilis. Not a single patient with neuroSyphilis tested Venereal Disease Research Laboratory test (VDRL)negative in peripheral blood, an effect which was highly significant ( p<0.01, χ 2 test). The median blood-VDRL titre was significantly higher in patients with neuroSyphilis than in those without (1:32 vs. 1:0; p<0.01, ttest, twosided). Hence, neuroSyphilis is very unlikely in patients with a negative bloodVDRL.
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neuroSyphilis is unlikely in patients with late Latent Syphilis and a negative blood vdrl test
Acta Dermato-venereologica, 2006Co-Authors: Stefan Wohrl, Alexandra GeusauAbstract:Patients with Latent Syphilis or Syphilis of unknown duration should be evaluated for tertiary disease and neuroSyphilis. The aim of this retrospective study was to determine relevant serological parameters for the identification of those individuals with Syphilis who are most likely to have neuroSyphilis and who therefore require lumbar puncture. After excluding repeated estimates and patients whose blood Syphilis serology had either been negative or not been determined within 3 months of lumbar puncture, 265 out of 710 cerebrospinal fluids from 1988 to 2004 were analysed. In each of those patients the earliest available pairs of serum and cerebrospinal fluid samples were evaluated. The diagnosis of neuroSyphilis was based on criteria according to established guidelines. Forty-three of 265 patients (16.2%; 5 women, 38 men; mean age 47+/-16 years) had neuroSyphilis. Seven of 72 (9.7%) of those testing HIV-positive, fulfilled the criteria of neuroSyphilis. Not a single patient with neuroSyphilis tested Venereal Disease Research Laboratory test (VDRL)-negative in peripheral blood, an effect which was highly significant (p < 0.01, chi2-test). The median blood-VDRL titre was significantly higher in patients with neuroSyphilis than in those without (1:32 vs. 1:0; p < 0.01, t-test, two-sided). Hence, neuroSyphilis is very unlikely in patients with a negative blood-VDRL. Therefore, lumbar puncture is not recommended in these patients.
Mei Shi - One of the best experts on this subject based on the ideXlab platform.
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Sensitive detection of Treponema pallidum DNA from the whole blood of patients with Syphilis by the nested PCR assay
2019Co-Authors: Cuini Wang, Yuanyua Cheng, Iao Liu, Yihong Qia, Zhifang Gua, Yuanyua Wang, Weiming Gong, Mei ShiAbstract:The aim of this work was to investigate the application of the nested PCR assay for the detection of Treponema pallidum (TP) DNA from the blood of patients with different stages of Syphilis. In this study, a nested PCR method targeting the Tpp47 and polA genes (Tpp47-Tp-PCR and polA-Tp-PCR) was developed to detect TP-DNA in whole blood samples collected from 262 patients with different stages of Syphilis (84 primary Syphilis, 97 secondary Syphilis, and 81 Latent Syphilis patients). The PCR assay detected T. pallidum DNA in 53.6% and 62.9% of the patients with primary and secondary Syphilis, respectively, which was much higher than the detection levels in patients with Latent Syphilis (7.4%) (both p
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risk profiles of neuroSyphilis in hiv negative patients with primary secondary and Latent Syphilis implications for clinical intervention
Journal of The European Academy of Dermatology and Venereology, 2016Co-Authors: Mei Shi, Ruirui Peng, Zixiao Gao, Sufang Zhang, Zhifang Guan, Ying Gao, C Wang, Pingyu ZhouAbstract:Background NeuroSyphilis is one of the most feared complications of Syphilis. The question of how to identify patients at higher risk in order for timely intervention whilst avoiding unnecessary lumbar puncture remains. Methods Between August 2009 and March 2013, a total of 834 HIV-negative patients with primary, secondary or Latent Syphilis were recruited. Venous blood and cerebrospinal fluid specimens were collected for diagnoses of Syphilis and/or neuroSyphilis and information of socio-demographic and behavioral characteristics was collected by interviewing with a questionnaire. Results The prevalence of neuroSyphilis differed among patients with primary (7.1%), secondary (23.8%) and Latent (26.6%) Syphilis. NeuroSyphilis was more likely in male patients (1.52-fold). Compared with patients aged <30 years, those aged 45–59 years and ≥60 years old had a 2.51-fold and 4.98-fold risk of neuroSyphilis respectively. Male gender and age ≥45 years were consistently associated with neuroSyphilis both in secondary and Latent stage. There was a 2.68-fold, 2.55-fold and 3.67-fold increased risk of neuroSyphilis when the serum RPR titer was 1:32, 1:64 and ≥1:128 compared to that of ≤1:16. ). Conclusions Male gender and age 45years are both correlated risk factors for neuroSyphilis in HIV-negative patients with primary, secondary and Latent Syphilis.
Ameeta E Singh - One of the best experts on this subject based on the ideXlab platform.
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impact of reverse sequence Syphilis screening on new diagnoses of late Latent Syphilis in edmonton canada
Sexually Transmitted Diseases, 2012Co-Authors: Jennifer Gratrix, Sabrina Plitt, Bonita E Lee, Leslie Ferron, Barbara Anderson, Bob Verity, Errol Prasad, Roxanne Bunyan, George Zahariadis, Ameeta E SinghAbstract:After the introduction of reverse sequence Syphilis screening in Alberta, Canada, there was an increase in the diagnosis of late Latent Syphilis in individuals screening positive with the treponemal test; these cases required additional public health follow-up.
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characteristics of primary and late Latent Syphilis cases which were initially non reactive with the rapid plasma reagin as the screening test
International Journal of Std & Aids, 2008Co-Authors: Ameeta E Singh, Tom WongAbstract:SummaryThe aim of the study was to determine the characteristics of primary and late Latent Syphilis cases that were non-reactive on initial screening by rapid plasma reagin (RPR) but reactive by treponemal tests. RPR test results of all primary and late Latent Syphilis cases in the province of Alberta, Canada during 1980–2001 were compiled. The proportion of Syphilis cases that were non-reactive by RPR testing was compared with reactive cases. Multiple logistic regression was used to identify factors associated with non-reactive RPR results. Among primary Syphilis cases, 224 (26%) were non-reactive on initial RPR and were compared with 639 reactive primary cases. Independent factors associated with a non-reactive result were male gender (odds ratio, [OR] = 1.99 [1.22–3.26]), Caucasian ethnicity (OR = 1.77 [1.20–2.61]) and diagnosis during the 1980–1986 Syphilis outbreak period in Alberta (OR = 3.13 [1.45–6.74]). Of the late Latent cases, 512 (39%) were non-reactive by RPR and 791 were reactive. A non-rea...
Pingyu Zhou - One of the best experts on this subject based on the ideXlab platform.
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risk profiles of neuroSyphilis in hiv negative patients with primary secondary and Latent Syphilis implications for clinical intervention
Journal of The European Academy of Dermatology and Venereology, 2016Co-Authors: Mei Shi, Ruirui Peng, Zixiao Gao, Sufang Zhang, Zhifang Guan, Ying Gao, C Wang, Pingyu ZhouAbstract:Background NeuroSyphilis is one of the most feared complications of Syphilis. The question of how to identify patients at higher risk in order for timely intervention whilst avoiding unnecessary lumbar puncture remains. Methods Between August 2009 and March 2013, a total of 834 HIV-negative patients with primary, secondary or Latent Syphilis were recruited. Venous blood and cerebrospinal fluid specimens were collected for diagnoses of Syphilis and/or neuroSyphilis and information of socio-demographic and behavioral characteristics was collected by interviewing with a questionnaire. Results The prevalence of neuroSyphilis differed among patients with primary (7.1%), secondary (23.8%) and Latent (26.6%) Syphilis. NeuroSyphilis was more likely in male patients (1.52-fold). Compared with patients aged <30 years, those aged 45–59 years and ≥60 years old had a 2.51-fold and 4.98-fold risk of neuroSyphilis respectively. Male gender and age ≥45 years were consistently associated with neuroSyphilis both in secondary and Latent stage. There was a 2.68-fold, 2.55-fold and 3.67-fold increased risk of neuroSyphilis when the serum RPR titer was 1:32, 1:64 and ≥1:128 compared to that of ≤1:16. ). Conclusions Male gender and age 45years are both correlated risk factors for neuroSyphilis in HIV-negative patients with primary, secondary and Latent Syphilis.
