The Experts below are selected from a list of 177 Experts worldwide ranked by ideXlab platform
Patrick M Fuller - One of the best experts on this subject based on the ideXlab platform.
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a novel population of wake promoting gabaergic neurons in the ventral Lateral Hypothalamus
Current Biology, 2016Co-Authors: Anne Venner, Christelle Anaclet, Rebecca Y Broadhurst, Clifford B Saper, Patrick M FullerAbstract:The largest synaptic input to the sleep-promoting ventroLateral preoptic area (VLPO) [1] arises from the Lateral Hypothalamus [2], a brain area associated with arousal [3-5]. However, the neurochemical identity of the majority of these VLPO-projecting neurons within the Lateral Hypothalamus (LH), as well as their function in the arousal network, remains unknown. Herein we describe a population of VLPO-projecting neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neurons). In addition to the VLPO, these neurons also project to several other established sleep and arousal nodes, including the tuberomammillary nucleus, ventral periaqueductal gray, and locus coeruleus. Selective and acute chemogenetic activation of LH VGAT(+) neurons was profoundly wake promoting, whereas acute inhibition increased sleep. Because of its direct and massive inputs to the VLPO, this population may play a particularly important role in sleep-wake switching.
Dominique Fellmann - One of the best experts on this subject based on the ideXlab platform.
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Exploring the expression of the melanin-concentrating hormone messenger RNA in the rat Lateral Hypothalamus after goldthioglucose injection
Neuropeptides, 1997Co-Authors: S Grillon, Christine Hervé, Bernadette Griffond, Dominique FellmannAbstract:Melanin-concentrating hormone (MCH) is expressed in a large neuronal population of the rat Lateral Hypothalamus. This area is known to be implicated in the regulation of thirst and hunger and to contain glucose-sensitive cells. In the present study, we investigated the effects of goldthioglucose (GTG), a toxic form of glucose, on the expression of the MCH gene in the rat Lateral Hypothalamus by immunocytochemistry, in situ hybridization and competitive RT-PCR. We observed that the MCH immunoreactivity and the level of MCH mRNA were not changed after intraperitoneal GTG injection (0.35 mg/g body weight). These results together with previous data suggest that the glucose-sensitive cells of the Lateral Hypothalamus are different from the MCH neurons and remain to be identified.
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Alteration of dynorphin and secretogranin II in the prolactin immunoreactive neurons of the rat Lateral Hypothalamus upon osmotic stimulation
Neuroscience Letters, 1996Co-Authors: S Grillon, Bernadette Griffond, Dominique FellmannAbstract:The prolactin immunoreactive neurons of the rat Lateral Hypothalamus were previously reported to express the dynorphin and secretogranin II genes. In the present study, the response of these neurons to osmotic challenge was immunocytologically investigated by using prolactin, dynorphin, secretogranin II and c-Fos antisera. In addition, the mRNA levels for secretogranin II and dynorphin were compared by in situ hybridization in controls and salt-loaded rats. For this model of chronic hyperosmolality, the prolactin and c-Fos immunoreactivities were not stimulated by salt drinking, but dynorphin and secretogranin II immunoreactivities as well as mRNA levels for dynorphin and secretogranin II significantly increased in the Lateral Hypothalamus. We suggest that the prolactin-immunoreactive neurons may be involved in the regulation of water homeostasis.
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Occurrence of secretogranin II in the prolactin-immunoreactive neurons of the rat Lateral Hypothalamus: an in situ hybridization and immunocytochemical study
Journal of Chemical Neuroanatomy, 1995Co-Authors: Bernadette Griffond, S Grillon, J. Duval, C. Colard, Claude Jacquemard, A. Deray, Dominique FellmannAbstract:Abstract The occurrence of secretogranin II in a neuron population of the rat Lateral Hypothalamus specifically detected by an anti-serum to ovine prolactin was examined. As this population was previously reported to synthesize dynorphin, the distribution of neurons recognized by ovine prolactin-, dynorphin B- and secretogranin II anti-sera was investigated on adjacent sections of hypothalami. The prolactin immunoreactive neurons were the only cells in the Lateral Hypothalamus to be stained by secretogranin II anti-serum. Moreover, coupling immunocytochemical detection and in situ hybridization with an oligonucleotide probe complementary to secretogranin II mRNA showed that these neurons expressed the secretogranin II gene. These new findings should help to study the physiological role of the prolactin immunoreactive neurons of the Lateral Hypothalamus.
Qingchun Tong - One of the best experts on this subject based on the ideXlab platform.
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gabaergic projections from Lateral Hypothalamus to paraventricular hypothalamic nucleus promote feeding
The Journal of Neuroscience, 2015Co-Authors: Zhaofei Wu, Yong Xu, Leandra R Mangieri, De Pei Li, Benjamin R Arenkiel, Qingchun TongAbstract:Lesions of the Lateral Hypothalamus (LH) cause hypophagia. However, activation of glutamatergic neurons in LH inhibits feeding. These results suggest a potential importance for other LH neurons in stimulating feeding. Our current study in mice showed that disruption of GABA release from adult LH GABAergic neurons reduced feeding. LH GABAergic neurons project extensively to the paraventricular hypothalamic nucleus (PVH), and optogenetic stimulation of GABAergic LH → PVH fibers induced monosynaptic IPSCs in PVH neurons, and potently increased feeding, which depended on GABA release. In addition, disruption of GABA-A receptors in the PVH reduced feeding. Thus, we have identified a new feeding pathway in which GABAergic projections from the LH to the PVH promote feeding.
Anne Venner - One of the best experts on this subject based on the ideXlab platform.
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a novel population of wake promoting gabaergic neurons in the ventral Lateral Hypothalamus
Current Biology, 2016Co-Authors: Anne Venner, Christelle Anaclet, Rebecca Y Broadhurst, Clifford B Saper, Patrick M FullerAbstract:The largest synaptic input to the sleep-promoting ventroLateral preoptic area (VLPO) [1] arises from the Lateral Hypothalamus [2], a brain area associated with arousal [3-5]. However, the neurochemical identity of the majority of these VLPO-projecting neurons within the Lateral Hypothalamus (LH), as well as their function in the arousal network, remains unknown. Herein we describe a population of VLPO-projecting neurons in the LH that express the vesicular GABA transporter (VGAT; a marker for GABA-releasing neurons). In addition to the VLPO, these neurons also project to several other established sleep and arousal nodes, including the tuberomammillary nucleus, ventral periaqueductal gray, and locus coeruleus. Selective and acute chemogenetic activation of LH VGAT(+) neurons was profoundly wake promoting, whereas acute inhibition increased sleep. Because of its direct and massive inputs to the VLPO, this population may play a particularly important role in sleep-wake switching.
Christian Luscher - One of the best experts on this subject based on the ideXlab platform.
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accumbal d1r neurons projecting to Lateral Hypothalamus authorize feeding
Neuron, 2015Co-Authors: Eoin C Oconnor, Yves Kremer, Sandrine Lefort, Masaya Harada, Vincent Pascoli, Clement Rohner, Christian LuscherAbstract:Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or predator threat. Nucleus accumbens shell (NAcSh) projections to the Lateral Hypothalamus (LH) are implicated in mediating such feeding control, but the neurons involved and their mechanism of action remain elusive. We show that dopamine D1R-expressing NAcSh neurons (D1R-MSNs) provide the dominant source of accumbal inhibition to LH and provide rapid control over feeding via LH GABA neurons. In freely feeding mice, D1R-MSN activity reduced during consumption, while their optogenetic inhibition prolonged feeding, even in the face of distracting stimuli. Conversely, activation of D1R-MSN terminals in LH was sufficient to abruptly stop ongoing consumption, even during hunger. Direct inhibition of LH GABA neurons, which received input from D1R-MSNs, fully recapitulated these findings. Together, our study resolves a feeding circuit that overrides immediate metabolic need to allow rapid consumption control in response to changing external stimuli. VIDEO ABSTRACT.
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accumbal d1r neurons projecting to Lateral Hypothalamus authorize feeding
Neuron, 2015Co-Authors: Eoin C Oconnor, Yves Kremer, Sandrine Lefort, Masaya Harada, Vincent Pascoli, Clement Rohner, Christian LuscherAbstract:Summary Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or predator threat. Nucleus accumbens shell (NAcSh) projections to the Lateral Hypothalamus (LH) are implicated in mediating such feeding control, but the neurons involved and their mechanism of action remain elusive. We show that dopamine D1R-expressing NAcSh neurons (D1R-MSNs) provide the dominant source of accumbal inhibition to LH and provide rapid control over feeding via LH GABA neurons. In freely feeding mice, D1R-MSN activity reduced during consumption, while their optogenetic inhibition prolonged feeding, even in the face of distracting stimuli. Conversely, activation of D1R-MSN terminals in LH was sufficient to abruptly stop ongoing consumption, even during hunger. Direct inhibition of LH GABA neurons, which received input from D1R-MSNs, fully recapitulated these findings. Together, our study resolves a feeding circuit that overrides immediate metabolic need to allow rapid consumption control in response to changing external stimuli. Video Abstract
