The Experts below are selected from a list of 46878 Experts worldwide ranked by ideXlab platform
Ramin Pourghorban - One of the best experts on this subject based on the ideXlab platform.
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association between pulmonary arterial obstruction index and right Lateral ventricular Wall thickness with in hospital mortality in patients with acute pulmonary embolism
Emergency Radiology, 2021Co-Authors: Taraneh Faghihi Langroudi, Abbas Arjmand Shabestari, Shahrzad Hekmati, Ramin PourghorbanAbstract:PURPOSE To retrospectively assess the correlation between pulmonary arterial obstruction index (PAOI) and right Lateral ventricular Wall thickness with in-hospital mortality in patients with acute pulmonary embolism. METHODS CT angiography (CTA) of 55 consecutive patients (30 males; 25 females; mean age ± SD, 59 ± 11 years) with proven acute pulmonary embolism was investigated. PAOI was determined according to the Qanadli score on CTA. Right ventricular Lateral Wall thickness was also measured, and patients' in-hospital mortality was recorded. The correlation between PAOI and mortality, right ventricular Lateral Wall thickness and mortality, and PAOI and right ventricular Lateral Wall thickness was evaluated. RESULTS PAOI was 23.6 and 10.4 in patients with and without in-hospital mortality, respectively (P < 0.001). Right ventricular Lateral Wall thickness was 8.7 mm and 7.5 mm in patients with and without in-hospital mortality, respectively (P < 0.001). PAOI more than 21.5 and right ventricular Lateral Wall thickness more than 8.75 were predictive of in-hospital mortality with a high accuracy. Also, PAOI and right ventricular Lateral Wall thickness had a significant correlation with each other (P < 0.001; r = 0.695). CONCLUSION PAOI and right ventricular Lateral Wall thickness on CTA were highly predictive of in-hospital mortality in patients with pulmonary embolism. Right ventricular Lateral Wall thickness and PAOI had a significant correlation with each other as well.
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association between pulmonary arterial obstruction index and right Lateral ventricular Wall thickness with in hospital mortality in patients with acute pulmonary embolism
Emergency Radiology, 2021Co-Authors: Taraneh Faghihi Langroudi, Abbas Arjmand Shabestari, Shahrzad Hekmati, Ramin PourghorbanAbstract:To retrospectively assess the correlation between pulmonary arterial obstruction index (PAOI) and right Lateral ventricular Wall thickness with in-hospital mortality in patients with acute pulmonary embolism. CT angiography (CTA) of 55 consecutive patients (30 males; 25 females; mean age ± SD, 59 ± 11 years) with proven acute pulmonary embolism was investigated. PAOI was determined according to the Qanadli score on CTA. Right ventricular Lateral Wall thickness was also measured, and patients’ in-hospital mortality was recorded. The correlation between PAOI and mortality, right ventricular Lateral Wall thickness and mortality, and PAOI and right ventricular Lateral Wall thickness was evaluated. PAOI was 23.6 and 10.4 in patients with and without in-hospital mortality, respectively (P < 0.001). Right ventricular Lateral Wall thickness was 8.7 mm and 7.5 mm in patients with and without in-hospital mortality, respectively (P < 0.001). PAOI more than 21.5 and right ventricular Lateral Wall thickness more than 8.75 were predictive of in-hospital mortality with a high accuracy. Also, PAOI and right ventricular Lateral Wall thickness had a significant correlation with each other (P < 0.001; r = 0.695). PAOI and right ventricular Lateral Wall thickness on CTA were highly predictive of in-hospital mortality in patients with pulmonary embolism. Right ventricular Lateral Wall thickness and PAOI had a significant correlation with each other as well.
Wei Liu - One of the best experts on this subject based on the ideXlab platform.
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the human cochlear battery claudin 11 barrier and ion transport proteins in the Lateral Wall of the cochlea
Frontiers in Molecular Neuroscience, 2017Co-Authors: Wei Liu, Rudolf Glueckert, Heval Benav, Annelies Schrottfischer, Helge RaskandersenAbstract:Background: The cochlea produces an electric field potential essential for hair cell transduction and hearing. This biological "battery" is situated in the Lateral Wall of the cochlea and contains ...
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The Human “Cochlear Battery” – Claudin-11 Barrier and Ion Transport Proteins in the Lateral Wall of the Cochlea
Frontiers Media S.A., 2017Co-Authors: Wei Liu, Annelies Schrott-fischer, Rudolf Glueckert, Heval Benav, Helge Rask-andersenAbstract:Background: The cochlea produces an electric field potential essential for hair cell transduction and hearing. This biological “battery” is situated in the Lateral Wall of the cochlea and contains molecular machinery that secretes and recycles K+ ions. Its functioning depends on junctional proteins that restrict the para-cellular escape of ions. The tight junction protein Claudin-11 has been found to be one of the major constituents of this barrier that maintains ion gradients (Gow et al., 2004; Kitajiri et al., 2004a). We are the first to elucidate the human Claudin-11 framework and the associated ion transport machinery using super-resolution fluorescence illumination microscopy (SR-SIM).Methods: Archival cochleae obtained during meningioma surgery were used for SR-SIM together with transmission electron microscopy after ethical consent.Results: Claudin-11-expressing cells formed parallel tight junction lamellae that insulated the epithelial syncytium of the stria vascularis and extended to the suprastrial region. Intercellular gap junctions were found between the barrier cells and fibrocytes.Conclusion: Transmission electron microscopy, confocal microscopy and SR-SIM revealed exclusive cell specialization in the various subdomains of the Lateral Wall of the human cochlea. The Claudin-11-expressing cells exhibited both conductor and isolator characteristics, and these micro-porous separators may selectively mediate the movement of charged units to the intrastrial space in a manner that is analogous to a conventional electrochemical “battery.” The function and relevance of this battery for the development of inner ear disease are discussed
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super resolution structured illumination fluorescence microscopy of the Lateral Wall of the cochlea the connexin26 30 proteins are separately expressed in man
Cell and Tissue Research, 2016Co-Authors: Wei Liu, Rudolf Glueckert, Annelies Schrottfischer, Fredrik Edin, Hans Blom, Peetra U Magnusson, Peter A Santi, Goran Laurell, Helge RaskandersenAbstract:Globally 360 million people have disabling hearing loss and, of these, 32 million are children. Human hearing relies on 15,000 hair cells that transduce mechanical vibrations to electrical signals in the auditory nerve. The process is powered by the endo-cochlear potential, which is produced by a vascularized epithelium that actively transports ions in conjunction with a gap junction (GJ) system. This "battery" is located "off-site" in the Lateral Wall of the cochlea. The GJ syncytium contains the GJ protein genes beta 2 (GJB2/connexin26 (Cx26)) and 6 (GJB6/connexin30 (Cx30)), which are commonly involved in hereditary deafness. Because the molecular arrangement of these proteins is obscure, we analyze GJ protein expression (Cx26/30) in human cochleae by using super-resolution structured illumination microscopy. At this resolution, the Cx26 and Cx30 proteins were visible as separate plaques, rather than being co-localized in heterotypic channels, as previously suggested. The Cx26 and Cx30 proteins thus seem not to be co-expressed but to form closely associated assemblies of GJ plaques. These results could assist in the development of strategies to treat genetic hearing loss in the future.
Helge Raskandersen - One of the best experts on this subject based on the ideXlab platform.
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the human cochlear battery claudin 11 barrier and ion transport proteins in the Lateral Wall of the cochlea
Frontiers in Molecular Neuroscience, 2017Co-Authors: Wei Liu, Rudolf Glueckert, Heval Benav, Annelies Schrottfischer, Helge RaskandersenAbstract:Background: The cochlea produces an electric field potential essential for hair cell transduction and hearing. This biological "battery" is situated in the Lateral Wall of the cochlea and contains ...
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super resolution structured illumination fluorescence microscopy of the Lateral Wall of the cochlea the connexin26 30 proteins are separately expressed in man
Cell and Tissue Research, 2016Co-Authors: Wei Liu, Rudolf Glueckert, Annelies Schrottfischer, Fredrik Edin, Hans Blom, Peetra U Magnusson, Peter A Santi, Goran Laurell, Helge RaskandersenAbstract:Globally 360 million people have disabling hearing loss and, of these, 32 million are children. Human hearing relies on 15,000 hair cells that transduce mechanical vibrations to electrical signals in the auditory nerve. The process is powered by the endo-cochlear potential, which is produced by a vascularized epithelium that actively transports ions in conjunction with a gap junction (GJ) system. This "battery" is located "off-site" in the Lateral Wall of the cochlea. The GJ syncytium contains the GJ protein genes beta 2 (GJB2/connexin26 (Cx26)) and 6 (GJB6/connexin30 (Cx30)), which are commonly involved in hereditary deafness. Because the molecular arrangement of these proteins is obscure, we analyze GJ protein expression (Cx26/30) in human cochleae by using super-resolution structured illumination microscopy. At this resolution, the Cx26 and Cx30 proteins were visible as separate plaques, rather than being co-localized in heterotypic channels, as previously suggested. The Cx26 and Cx30 proteins thus seem not to be co-expressed but to form closely associated assemblies of GJ plaques. These results could assist in the development of strategies to treat genetic hearing loss in the future.
Shin Aizawa - One of the best experts on this subject based on the ideXlab platform.
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the correlation of femoral tunnel length with the height and area of the Lateral Wall of the femoral intercondylar notch in anatomical single bundle acl reconstruction
Knee Surgery Sports Traumatology Arthroscopy, 2017Co-Authors: Takanori Iriuchishima, Keinosuke Ryu, Makoto Suruga, Shin AizawaAbstract:Purpose The purpose of this study was to reveal the correlation between femoral tunnel length and the height and area of the Lateral Wall of the femoral intercondylar notch in anatomical single-bundle anterior cruciate ligament (ACL) reconstruction .
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blumensaat s line is not always straight morphological variations of the Lateral Wall of the femoral intercondylar notch
Knee Surgery Sports Traumatology Arthroscopy, 2016Co-Authors: Takanori Iriuchishima, Keinosuke Ryu, Shin AizawaAbstract:The purpose of this study was to evaluate the morphological variations of the Lateral Wall of the femoral intercondylar notch. Fifty-two non-paired human cadaver knees were used. All soft tissues around the knee were resected except the ACL. The ACL was cut in the middle, and the femoral bone was cut at the most proximal point of the femoral notch parallel to the plane of the femoral bone shaft. The ACL was carefully dissected, and the periphery of the ACL insertion site was outlined on the femoral side. An accurate Lateral view of the femoral condyle was photographed with a digital camera, and the images were downloaded to a personal computer. The morphological variations of Blumensaat’s line, the height and area of the Lateral Wall of the femoral intercondylar notch and the size of the femoral ACL footprints were measured with Image J software. Blumensaat’s line exhibited three types of morphological variations. A straight line was observed in 19 knees (37 %) (straight type). A protrusion spanning less than half of the line was observed at the proximal part of Blumensaat’s line in 10 knees (19 %) (small hill type). A protrusion spanning more than half of the line was observed at the proximal part of the line in 23 knees (44 %) (large hill type). In some knees with this large hill type variation, the appearance was similar to that of anterior spur. No significant differences between these three types were observed in either the height and area of the Lateral Wall of the femoral intercondylar notch or the area of the femoral ACL footprint. In conclusion, Blumensaat’s line has three types of morphological variations (straight, small hill and large hill types). For the clinical relevance, when ACL surgery is performed in knees with small or large hill type variations, surgeons should pay close attention to femoral tunnel evaluation and placement, especially for the use of Quadrant method. The grid placement of Quadrant method would be changed in the knees of these type variations.
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acl footprint size is correlated with the height and area of the Lateral Wall of femoral intercondylar notch
Knee Surgery Sports Traumatology Arthroscopy, 2013Co-Authors: Takanori Iriuchishima, Kenji Shirakura, Hiroshi Yorifuji, Shin Aizawa, Tohru MurakamiAbstract:The purpose of this study was to reveal the correlation between the size of the native anterior cruciate ligament (ACL) footprint and the size of the Lateral Wall of femoral intercondylar notch. Eighteen non-paired human cadaver knees were used. All soft tissues around the knee were resected except the ACL. The ACL was cut in the middle, and the femoral bone was cut at the most proximal point of the femoral notch. The ACL was carefully dissected, and the periphery of the ACL insertion site was outlined on both the femoral and tibial sides. An accurate Lateral view of the femoral condyle and the tibial plateau was photographed with a digital camera, and the images were downloaded to a personal computer. The size of the femoral and tibial ACL footprints, length of Blumensaat’s line, and the height and area of the Lateral Wall of femoral intercondylar notch were measured with Image J software (National Institution of Health). The sizes of the native femoral and tibial ACL footprints were 84 ± 25.3 and 144.7 ± 35.9 mm2, respectively. The length of Blumensaat’s line and the height and area of the Lateral Wall of femoral intercondylar notch were 29.4 ± 2.8 mm, 17.1 ± 2.7 mm, and 392.4 ± 86 mm2, respectively. Both the height and the area of the Lateral Wall of femoral intercondylar notch were significantly correlated with the size of the ACL footprint on both the femoral and tibial sides. For clinical relevance, the height and area of the Lateral Wall of femoral intercondylar notch can be a predictor of native ACL size prior to surgery. However, the length of Blumensaat’s line showed no significant correlation with native ACL size.
Taraneh Faghihi Langroudi - One of the best experts on this subject based on the ideXlab platform.
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association between pulmonary arterial obstruction index and right Lateral ventricular Wall thickness with in hospital mortality in patients with acute pulmonary embolism
Emergency Radiology, 2021Co-Authors: Taraneh Faghihi Langroudi, Abbas Arjmand Shabestari, Shahrzad Hekmati, Ramin PourghorbanAbstract:PURPOSE To retrospectively assess the correlation between pulmonary arterial obstruction index (PAOI) and right Lateral ventricular Wall thickness with in-hospital mortality in patients with acute pulmonary embolism. METHODS CT angiography (CTA) of 55 consecutive patients (30 males; 25 females; mean age ± SD, 59 ± 11 years) with proven acute pulmonary embolism was investigated. PAOI was determined according to the Qanadli score on CTA. Right ventricular Lateral Wall thickness was also measured, and patients' in-hospital mortality was recorded. The correlation between PAOI and mortality, right ventricular Lateral Wall thickness and mortality, and PAOI and right ventricular Lateral Wall thickness was evaluated. RESULTS PAOI was 23.6 and 10.4 in patients with and without in-hospital mortality, respectively (P < 0.001). Right ventricular Lateral Wall thickness was 8.7 mm and 7.5 mm in patients with and without in-hospital mortality, respectively (P < 0.001). PAOI more than 21.5 and right ventricular Lateral Wall thickness more than 8.75 were predictive of in-hospital mortality with a high accuracy. Also, PAOI and right ventricular Lateral Wall thickness had a significant correlation with each other (P < 0.001; r = 0.695). CONCLUSION PAOI and right ventricular Lateral Wall thickness on CTA were highly predictive of in-hospital mortality in patients with pulmonary embolism. Right ventricular Lateral Wall thickness and PAOI had a significant correlation with each other as well.
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association between pulmonary arterial obstruction index and right Lateral ventricular Wall thickness with in hospital mortality in patients with acute pulmonary embolism
Emergency Radiology, 2021Co-Authors: Taraneh Faghihi Langroudi, Abbas Arjmand Shabestari, Shahrzad Hekmati, Ramin PourghorbanAbstract:To retrospectively assess the correlation between pulmonary arterial obstruction index (PAOI) and right Lateral ventricular Wall thickness with in-hospital mortality in patients with acute pulmonary embolism. CT angiography (CTA) of 55 consecutive patients (30 males; 25 females; mean age ± SD, 59 ± 11 years) with proven acute pulmonary embolism was investigated. PAOI was determined according to the Qanadli score on CTA. Right ventricular Lateral Wall thickness was also measured, and patients’ in-hospital mortality was recorded. The correlation between PAOI and mortality, right ventricular Lateral Wall thickness and mortality, and PAOI and right ventricular Lateral Wall thickness was evaluated. PAOI was 23.6 and 10.4 in patients with and without in-hospital mortality, respectively (P < 0.001). Right ventricular Lateral Wall thickness was 8.7 mm and 7.5 mm in patients with and without in-hospital mortality, respectively (P < 0.001). PAOI more than 21.5 and right ventricular Lateral Wall thickness more than 8.75 were predictive of in-hospital mortality with a high accuracy. Also, PAOI and right ventricular Lateral Wall thickness had a significant correlation with each other (P < 0.001; r = 0.695). PAOI and right ventricular Lateral Wall thickness on CTA were highly predictive of in-hospital mortality in patients with pulmonary embolism. Right ventricular Lateral Wall thickness and PAOI had a significant correlation with each other as well.
