The Experts below are selected from a list of 27717 Experts worldwide ranked by ideXlab platform

Christophe Pagnoulle - One of the best experts on this subject based on the ideXlab platform.

  • RESEARCH ARTICLE RGD Surface Functionalization of the Hydrophilic Acrylic Intraocular Lens Material to Control Posterior Capsular
    2016
    Co-Authors: Yi-shiang Huang, Dimitriya Bozukova, Christophe Pagnoulle, Edwin De Pauw, Virginie Bertr, Marie-claire De Pauw-gillet, Marie-christine Durrieu
    Abstract:

    Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient’s age or disease, surgical technique, and IOL design and Material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic Materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL Material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation i

  • , and Marie-Christine
    2016
    Co-Authors: Dimitriya Bozukova, Christophe Pagnoulle, Christine Labrugere, Edwin De Pauw
    Abstract:

    Full title: RGD surface functionalization of the hydrophilic acrylic intraocular Lens Material to control posterior capsular opacification Authors

  • rgd surface functionalization of the hydrophilic acrylic intraocular Lens Material to control posterior capsular opacification
    PLOS ONE, 2014
    Co-Authors: Yi-shiang Huang, Virginie Bertrand, Dimitriya Bozukova, Christophe Pagnoulle, Edwin De Pauw, Christine Labrugere, Marieclaire De Pauwgillet, Marie-christine Durrieu
    Abstract:

    Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient's age or disease, surgical technique, and IOL design and Material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic Materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL Material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative bioMaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting Material. In addition, compared to the hydrophobic IOL Material, our bioactive bioMaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this bioMaterial has the potential to reduce the risk factor of PCO development.

  • assessment of new generation glistening free hydrophobic acrylic intraocular Lens Material
    Journal of Cataract and Refractive Surgery, 2012
    Co-Authors: Christophe Pagnoulle, Virginie Bertrand, Dimitriya Bozukova, Laure Gobin, Marieclaire Gilletde Pauw
    Abstract:

    PURPOSE:Todeterminethehydrophobic,antiglistening,andbioadhesivenesspropertiesofanewpolymer,GFrawMaterial,andtodeterminethesuitabilityofthisMaterialforuseinintraocularLenses(IOLs). SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: Intraocular Lenses made of the new hydrophobic acrylic Material were tested and compared with reference acrylic Materials. The stability of their polymer matrix was estimated by testing forglistenings.Therelative surface hydrophobicitywasquantifiedvia contact-angle measurements. The degrees of bioadhesiveness of the reference and test Materials were assessed by in vitro porcine Lens epithelial cell (LEC) culture. RESULTS: The glistening test showed that the new Material had greater stability under worst-case conditions than previous-generation hydrophobic acrylic Materials. The new polymer had the same hydrophobic properties as the hydrophobic Acrysof IQ SN60WF Material; both Materials were less hydrophobic than the hydrophobic Sensar AR40e Material and more hydrophobic than the hydrophilic Ioflex IOL Material. The in vitro bioadhesiveness tests showed that porcine LEC adhesion levels of the new Material were intermediate with respect to those of the 2 reference hydrophobic Materials. CONCLUSIONS: When equilibrated in aqueous medium, the new-generation hydrophobic acrylic Material reached a low water content at equilibrium, making it glistening free. The hydrophobicity and bioadhesiveness of the new raw Material were comparable to those of state-of-the-art reference Materials; these properties may resist the formation of posterior capsule opacification. Financial Disclosure: Dr. Pagnoulle has a proprietary interest in the GF Material. Drs. Pagnoulle, Gobin, and Bozukova are employees of Physiol S.A. Mme. V. Bertrand and Dr. Gillet-De Pauw have no financial or proprietary interest in any Material or method mentioned.

Dimitriya Bozukova - One of the best experts on this subject based on the ideXlab platform.

  • RESEARCH ARTICLE RGD Surface Functionalization of the Hydrophilic Acrylic Intraocular Lens Material to Control Posterior Capsular
    2016
    Co-Authors: Yi-shiang Huang, Dimitriya Bozukova, Christophe Pagnoulle, Edwin De Pauw, Virginie Bertr, Marie-claire De Pauw-gillet, Marie-christine Durrieu
    Abstract:

    Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient’s age or disease, surgical technique, and IOL design and Material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic Materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL Material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation i

  • , and Marie-Christine
    2016
    Co-Authors: Dimitriya Bozukova, Christophe Pagnoulle, Christine Labrugere, Edwin De Pauw
    Abstract:

    Full title: RGD surface functionalization of the hydrophilic acrylic intraocular Lens Material to control posterior capsular opacification Authors

  • rgd surface functionalization of the hydrophilic acrylic intraocular Lens Material to control posterior capsular opacification
    PLOS ONE, 2014
    Co-Authors: Yi-shiang Huang, Virginie Bertrand, Dimitriya Bozukova, Christophe Pagnoulle, Edwin De Pauw, Christine Labrugere, Marieclaire De Pauwgillet, Marie-christine Durrieu
    Abstract:

    Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient's age or disease, surgical technique, and IOL design and Material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic Materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL Material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative bioMaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting Material. In addition, compared to the hydrophobic IOL Material, our bioactive bioMaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this bioMaterial has the potential to reduce the risk factor of PCO development.

  • assessment of new generation glistening free hydrophobic acrylic intraocular Lens Material
    Journal of Cataract and Refractive Surgery, 2012
    Co-Authors: Christophe Pagnoulle, Virginie Bertrand, Dimitriya Bozukova, Laure Gobin, Marieclaire Gilletde Pauw
    Abstract:

    PURPOSE:Todeterminethehydrophobic,antiglistening,andbioadhesivenesspropertiesofanewpolymer,GFrawMaterial,andtodeterminethesuitabilityofthisMaterialforuseinintraocularLenses(IOLs). SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: Intraocular Lenses made of the new hydrophobic acrylic Material were tested and compared with reference acrylic Materials. The stability of their polymer matrix was estimated by testing forglistenings.Therelative surface hydrophobicitywasquantifiedvia contact-angle measurements. The degrees of bioadhesiveness of the reference and test Materials were assessed by in vitro porcine Lens epithelial cell (LEC) culture. RESULTS: The glistening test showed that the new Material had greater stability under worst-case conditions than previous-generation hydrophobic acrylic Materials. The new polymer had the same hydrophobic properties as the hydrophobic Acrysof IQ SN60WF Material; both Materials were less hydrophobic than the hydrophobic Sensar AR40e Material and more hydrophobic than the hydrophilic Ioflex IOL Material. The in vitro bioadhesiveness tests showed that porcine LEC adhesion levels of the new Material were intermediate with respect to those of the 2 reference hydrophobic Materials. CONCLUSIONS: When equilibrated in aqueous medium, the new-generation hydrophobic acrylic Material reached a low water content at equilibrium, making it glistening free. The hydrophobicity and bioadhesiveness of the new raw Material were comparable to those of state-of-the-art reference Materials; these properties may resist the formation of posterior capsule opacification. Financial Disclosure: Dr. Pagnoulle has a proprietary interest in the GF Material. Drs. Pagnoulle, Gobin, and Bozukova are employees of Physiol S.A. Mme. V. Bertrand and Dr. Gillet-De Pauw have no financial or proprietary interest in any Material or method mentioned.

Srirang Manohar - One of the best experts on this subject based on the ideXlab platform.

  • a new acoustic Lens Material for large area detectors in photoacoustic breast tomography
    arXiv: Medical Physics, 2013
    Co-Authors: Wenfeng Xia, Daniele Piras, Johan C G Van Hespen, Wiendelt Steenbergen, Srirang Manohar
    Abstract:

    Acoustic Lenses made of acrylic plastic (PMMA) have been used to enlarge the acceptance angle of sensitive large surface area detectors and improve lateral resolution. However, PMMA Lenses introduce image artifacts due to ultrasound internal reflections within the Lenses. In this work we investigated this issue proposing a new Lens Material Stycast 1090SI. We characterized the acoustic properties of the proposed Material in comparison with PMMA. Detector performance using negative Lenses with the two Materials, was tested using finite element simulation and experiment. Further the image quality of a photoacoustic tomography system was studied using k-Wave simulation and experiment. Our acoustic characterization showed that Stycast 1090SI has tissue-like acoustic impedance, high speed of sound and low acoustic attenuation. Both acoustic Lenses show significant enlargement of detector acceptance angle and lateral resolution improvement. However, image artifacts induced by acoustic Lenses are reduced using the proposed Lens compared to PMMA Lens.

  • a new acoustic Lens Material for large area detectors in photoacoustic breast tomography
    Photoacoustics, 2013
    Co-Authors: Wenfeng Xia, Daniele Piras, Johan C G Van Hespen, Wiendelt Steenbergen, Srirang Manohar
    Abstract:

    Objectives We introduce a new acoustic Lens Material for photoacoustic tomography (PAT) to improve lateral resolution while possessing excellent acoustic acoustic impedance matching with tissue to minimize Lens induced image artifacts. Background A large surface area detector due to its high sensitivity is preferable to detect weak signals in photoacoustic mammography. The lateral resolution is then limited by the narrow acceptance angle of such detectors. Acoustic Lenses made of acrylic plastic (PMMA) have been used to enlarge the acceptance angle of such detectors and improve lateral resolution. However, such PMMA Lenses introduce image artifacts due to internal reflections of ultrasound within the Lenses, the result of acoustic impedance mismatch with the coupling medium or tissue. Methods A new Lens is proposed based on the 2-component resin Stycast 1090SI. We characterized the acoustic properties of the proposed Lens Material in comparison with commonly used PMMA, inspecting the speed of sound, acoustic attenuation and density. We fabricated acoustic Lenses based on the new Material and PMMA, and studied the effect of the acoustic Lenses on detector performance comparing finite element (FEM) simulations and measurements of directional sensitivity, pulse-echo response and frequency response. We further investigated the effect of using the acoustic Lenses on the image quality of a photoacoustic breast tomography system using k-Wave simulations and experiments. Results Our acoustic characterization shows that Stycast 1090SI has tissue-like acoustic impedance, high speed of sound and low acoustic attenuation. These acoustic properties ensure an excellent acoustic Lens Material to minimize the acoustic insertion loss. Both acoustic Lenses show significant enlargement of detector acceptance angle and lateral resolution improvement from modeling and experiments. However, the image artifacts induced by the presence of an acoustic Lens are reduced using the proposed Lens compared to PMMA Lens, due to the minimization of internal reflections. Conclusions The proposed Stycast 1090SI acoustic Lens improves the lateral resolution of photoacoustic tomography systems while not suffering from internal reflection-induced image artifacts compared a Lens made of PMMA.

Marieclaire Gilletde Pauw - One of the best experts on this subject based on the ideXlab platform.

  • assessment of new generation glistening free hydrophobic acrylic intraocular Lens Material
    Journal of Cataract and Refractive Surgery, 2012
    Co-Authors: Christophe Pagnoulle, Virginie Bertrand, Dimitriya Bozukova, Laure Gobin, Marieclaire Gilletde Pauw
    Abstract:

    PURPOSE:Todeterminethehydrophobic,antiglistening,andbioadhesivenesspropertiesofanewpolymer,GFrawMaterial,andtodeterminethesuitabilityofthisMaterialforuseinintraocularLenses(IOLs). SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: Intraocular Lenses made of the new hydrophobic acrylic Material were tested and compared with reference acrylic Materials. The stability of their polymer matrix was estimated by testing forglistenings.Therelative surface hydrophobicitywasquantifiedvia contact-angle measurements. The degrees of bioadhesiveness of the reference and test Materials were assessed by in vitro porcine Lens epithelial cell (LEC) culture. RESULTS: The glistening test showed that the new Material had greater stability under worst-case conditions than previous-generation hydrophobic acrylic Materials. The new polymer had the same hydrophobic properties as the hydrophobic Acrysof IQ SN60WF Material; both Materials were less hydrophobic than the hydrophobic Sensar AR40e Material and more hydrophobic than the hydrophilic Ioflex IOL Material. The in vitro bioadhesiveness tests showed that porcine LEC adhesion levels of the new Material were intermediate with respect to those of the 2 reference hydrophobic Materials. CONCLUSIONS: When equilibrated in aqueous medium, the new-generation hydrophobic acrylic Material reached a low water content at equilibrium, making it glistening free. The hydrophobicity and bioadhesiveness of the new raw Material were comparable to those of state-of-the-art reference Materials; these properties may resist the formation of posterior capsule opacification. Financial Disclosure: Dr. Pagnoulle has a proprietary interest in the GF Material. Drs. Pagnoulle, Gobin, and Bozukova are employees of Physiol S.A. Mme. V. Bertrand and Dr. Gillet-De Pauw have no financial or proprietary interest in any Material or method mentioned.

Virginie Bertrand - One of the best experts on this subject based on the ideXlab platform.

  • rgd surface functionalization of the hydrophilic acrylic intraocular Lens Material to control posterior capsular opacification
    PLOS ONE, 2014
    Co-Authors: Yi-shiang Huang, Virginie Bertrand, Dimitriya Bozukova, Christophe Pagnoulle, Edwin De Pauw, Christine Labrugere, Marieclaire De Pauwgillet, Marie-christine Durrieu
    Abstract:

    Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient's age or disease, surgical technique, and IOL design and Material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic Materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL Material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative bioMaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting Material. In addition, compared to the hydrophobic IOL Material, our bioactive bioMaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this bioMaterial has the potential to reduce the risk factor of PCO development.

  • assessment of new generation glistening free hydrophobic acrylic intraocular Lens Material
    Journal of Cataract and Refractive Surgery, 2012
    Co-Authors: Christophe Pagnoulle, Virginie Bertrand, Dimitriya Bozukova, Laure Gobin, Marieclaire Gilletde Pauw
    Abstract:

    PURPOSE:Todeterminethehydrophobic,antiglistening,andbioadhesivenesspropertiesofanewpolymer,GFrawMaterial,andtodeterminethesuitabilityofthisMaterialforuseinintraocularLenses(IOLs). SETTING: University of Liege, Liege, Belgium. DESIGN: Experimental study. METHODS: Intraocular Lenses made of the new hydrophobic acrylic Material were tested and compared with reference acrylic Materials. The stability of their polymer matrix was estimated by testing forglistenings.Therelative surface hydrophobicitywasquantifiedvia contact-angle measurements. The degrees of bioadhesiveness of the reference and test Materials were assessed by in vitro porcine Lens epithelial cell (LEC) culture. RESULTS: The glistening test showed that the new Material had greater stability under worst-case conditions than previous-generation hydrophobic acrylic Materials. The new polymer had the same hydrophobic properties as the hydrophobic Acrysof IQ SN60WF Material; both Materials were less hydrophobic than the hydrophobic Sensar AR40e Material and more hydrophobic than the hydrophilic Ioflex IOL Material. The in vitro bioadhesiveness tests showed that porcine LEC adhesion levels of the new Material were intermediate with respect to those of the 2 reference hydrophobic Materials. CONCLUSIONS: When equilibrated in aqueous medium, the new-generation hydrophobic acrylic Material reached a low water content at equilibrium, making it glistening free. The hydrophobicity and bioadhesiveness of the new raw Material were comparable to those of state-of-the-art reference Materials; these properties may resist the formation of posterior capsule opacification. Financial Disclosure: Dr. Pagnoulle has a proprietary interest in the GF Material. Drs. Pagnoulle, Gobin, and Bozukova are employees of Physiol S.A. Mme. V. Bertrand and Dr. Gillet-De Pauw have no financial or proprietary interest in any Material or method mentioned.