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Gustavo F Gonzales - One of the best experts on this subject based on the ideXlab platform.

  • Synergistic effect of the hydroalcoholic extract from Lepidium meyenii (Brassicaceae) and Fagara tessmannii (Rutaceae) on male sexual organs and hormone level in rats.
    Pharmacognosy Research, 2020
    Co-Authors: Dieudonné Massoma Lembè, Manuel Gasco, Gustavo F Gonzales
    Abstract:

    Background: Lepidium meyenii is a plant, which has been used in folk medicine to treat infertility and to increase sexual desire. However, few reports have investigated the administration of this plant with other plants having the same properties. Objective: The present investigation was designed to evaluate whether the combination of Lepidium meyenii and Fagara tessmannii can improve spermatogenesis and testosterone level in rats. Materials and Method: Twenty male rats were treated daily for 2 weeks with the hydroalcoholic extract of Fagara tessmannii and Lepidium meyenii (Fag + MN) as follow: (vehicle), (0.01 g + 0.5 mg), (0.1 g + 5 mg) and (1 g+ 50 mg)/kg BW. Results: At doses Fag 0.01 g/MN 0.5 mg and Fag 0.1 g/MN 5 mg, the weight of seminal vesicle, prostate, and testis significantly decreased ( P P P P P P P P P P Conclusion: The results indicated that the combination of Lepidium meyenii (Black Maca) with Fagara tessmannii can improve male reproductive organs activities.

  • maca Lepidium meyenii walp a review of its biological properties
    Revista Peruana de Medicina Experimental y Salud Pública, 2014
    Co-Authors: Gustavo F Gonzales, Manuel Gasco, Julio Rubio, Leonidas Villaorduna, Carla Gonzales
    Abstract:

    La maca (Lepidium meyenii) es una planta que crece sobre los 4000 metros de altitud en los Andes Centrales del Peru, presenta diferentes variedades de acuerdo al color de su hipocotilo. La presente revision resume los resultados de estudios sobre los efectos de la maca en la funcion sexual, la espermatogenesis, la funcion reproductiva femenina, la memoria, la depresion y la ansiedad, como energizante y contra la hiperplasia benigna de prostata, osteoporosis y sindrome metabolico. Se discute tambien su efecto antienvejecimiento y la seguridad en su consumo. Se han demostrado diferencias en el efecto de las variedades negra, amarilla y roja de maca. La maca negra es la que mejores resultados presenta sobre la espermatogenesis, la memoria y contra la fatiga, mientras que la maca roja es la variedad que mejor revierte la hiperplasia benigna de prostata y la osteoporosis inducida experimentalmente. Ademas, la maca reduce los niveles de glucosa, y su consumo se relaciona con la reduccion de la presion arterial y un mejor puntaje de salud. Estudios experimentales han demostrado que el consumo a corto como a largo plazo no muestra toxicidad tanto in vivo como in vitro. A pesar que los estudios experimentales han demostrado que la maca presenta diversos efectos beneficos, son necesarios mas estudios clinicos para confirmar estos resultados

  • Lepidium meyenii (maca) consumption prevent benign prostatic hyperplasia
    The FASEB Journal, 2013
    Co-Authors: Giuliana Noratto, Luis Condezo-hoyos, Manuel Gasco, Gustavo F Gonzales
    Abstract:

    Lepidium meyenii (maca) is a Peruvian Andean with effects against benign prostatic hyperplasia (BPH); a disease associated with male sexual dysfunction. BPH was induced in mice with two doses of te...

  • Fertility and estrogenic activity of Turraeanthus africanus in combination with Lepidium meyenii (Black maca) in female mice
    European Journal of Integrative Medicine, 2012
    Co-Authors: Dieudonné Massoma Lembè, Manuel Gasco, Gustavo F Gonzales
    Abstract:

    Abstract Aim of the study The effect of Black maca ( Lepidium meyenii) and Turraeanthus africanus on fertility and estrogenic activity in female mice was investigated. Materials and methods Thirty female mice were treated daily with extracts of Black maca plus T. africanus (BM+TA), T. africanus alone (TA) or vehicle (control) at dose 1 g/kg BW for 30 days. Results The length of the estrous cycle inside the group of (BM+TA)-treated mice significantly ( p p p p The number of fetuses in the uterus after (BM+TA) treatment (14.66 ± 0.25) was significantly higher ( p No significant difference between groups ( p  > 0.05) was observed for the two treatments concerning the Fertility index. Conclusions TA can affect the number of embryo implantation and the uterine weight. This effect increased in association with BM. BM could regulate estrous cycle.

  • ethnobiology and ethnopharmacology of Lepidium meyenii maca a plant from the peruvian highlands
    Evidence-based Complementary and Alternative Medicine, 2012
    Co-Authors: Gustavo F Gonzales
    Abstract:

    Lepidium meyenii (maca) is a Peruvian plant of the Brassicaceae family cultivated for more than 2000 years, which grows exclusively in the central Andes between 4000 and 4500 m altitude. Maca is used as a food supplement and also for its medicinal properties described traditionally. Since the 90s of the XX century, an increasing interest in products from maca has been observed in many parts of the world. In the last decade, exportation of maca from Peru has increased from 1,415,000 USD in 2001 to USD 6,170,000 USD in 2010. Experimental scientific evidence showed that maca has nutritional, energizer, and fertility-enhancer properties, and it acts on sexual dysfunctions, osteoporosis, benign prostatic hyperplasia, memory and learning, and protects skin against ultraviolet radiation. Clinical trials showed efficacy of maca on sexual dysfunctions as well as increasing sperm count and motility. Maca is a plant with great potential as an adaptogen and appears to be promising as a nutraceutical in the prevention of several diseases.

Jitka Ulrichová - One of the best experts on this subject based on the ideXlab platform.

  • The in vitro biological activity of Lepidium meyenii extracts
    Cell Biology and Toxicology, 2006
    Co-Authors: Katerina Valentová, Jitka Ulrichová, D. Buckiová, J. Pěknicová, V. Šimánek
    Abstract:

    The biological activity of methanolic and aqueous extracts from dehydrated hypocotyls of Lepidium meyenii (Brassicaceae, vernacular name “maca”), was studied on rat hepatocytes and human breast cancer MCF-7 cells. The extracts did not exhibit cytotoxicity in hepatocyte primary cultures up to 10 mg/ml as measured by the MTT viability test, and lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) leakage. Moreover, after 72 h, extracts inhibited LDH and AST leakage from the hepatocytes. When hepatocytes were intoxicated by t -butyl hydroperoxide, neither extract prevented oxidative damage. Both extracts showed weak antioxidant activity in the DPPH radical scavenging test with IC_50 values of 3.46 ± 0.16 and 0.71 ± 0.10 mg/ml, for aqueous and methanolic extracts, respectively. Thus, the observed effect on spontaneous enzyme leakage is probably mediated through mechanisms other than antioxidant activity. Both methanolic and aqueous extracts have shown estrogenic activity comparable with that of silymarin in MCF-7 cell line. Maca estrogenicity was exhibited in the range from 100 to 200 μg of extract per ml. The findings in the present study show that maca does not display in vitro hepatotoxicity. In contrast, a slight cytoprotective effect, probably not mediated by antioxidant capacity, was noted. Maca extracts exhibited estrogenic activity comparably to the effect of silymarin in MCF-7 cells.

  • Smallanthus sonchifolius and Lepidium meyenii - prospective Andean crops for the prevention of chronic diseases.
    Biomedical papers of the Medical Faculty of the University Palacký Olomouc Czechoslovakia, 2003
    Co-Authors: Katerina Valentová, Jitka Ulrichová
    Abstract:

    Smallanthus sonchifolius (yacon) and Lepidium meyenii (maca) were the traditional crops of the original population of Peru where they are also still used in folk medicine. These plants are little known in Europe and Northern America although at least yacon can be cultivated in the climatic conditions of these regions. This article deals with the botany and the composition, the structure of main constituents, biological activity of these plants and the cultivation of yacon in the Czech Republic. The potential of yacon tubers to treat hyperglycemia, kidney problems and for skin rejuvenation and the antihyperglycemic and cytoprotective activity of its leaves seems to be related mostly to its oligofructan and phenolic content, respectively. Maca alkaloids, steroids, glucosinolates, isothicyanates and macamides are probably responsible for its aptitude to act as a fertility enhancer, aphrodisiac, adaptogen, immunostimulant, anabolic and to influence hormonal balance. Yacon and maca are already on the European market as prospective functional foods and dietary supplements, mainly for use in certain risk groups of the population, e.g. seniors, diabetics, postmenopausal women etc.

  • Yacon (Smallanthus sonchifolius) and Maca (Lepidium meyenii), Traditional Andean Crops as New Functional Foods on the European Market
    Chemicke Listy, 2001
    Co-Authors: Katerina Valentová, J. Frček, Jitka Ulrichová
    Abstract:

    Yacon (Smallanthus sonchifolius) and maca (Lepidium meyenii) are traditional crops of the original population of Peru, which are also used in traditional medicine. However, these plants are little known in Europe and Northern America, although they can be cultivated in the climatic conditions of these regions. This article is a review of their botanical aspects, their growing in the Czech Republic, composition and structure of main constituents, and biological activity. These plants are already on European market as prospective functional foods and nutraceuticals for use in certain risk groups of population.

Katerina Valentová - One of the best experts on this subject based on the ideXlab platform.

  • The in vitro biological activity of Lepidium meyenii extracts
    Cell Biology and Toxicology, 2006
    Co-Authors: Katerina Valentová, Jitka Ulrichová, D. Buckiová, J. Pěknicová, V. Šimánek
    Abstract:

    The biological activity of methanolic and aqueous extracts from dehydrated hypocotyls of Lepidium meyenii (Brassicaceae, vernacular name “maca”), was studied on rat hepatocytes and human breast cancer MCF-7 cells. The extracts did not exhibit cytotoxicity in hepatocyte primary cultures up to 10 mg/ml as measured by the MTT viability test, and lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) leakage. Moreover, after 72 h, extracts inhibited LDH and AST leakage from the hepatocytes. When hepatocytes were intoxicated by t -butyl hydroperoxide, neither extract prevented oxidative damage. Both extracts showed weak antioxidant activity in the DPPH radical scavenging test with IC_50 values of 3.46 ± 0.16 and 0.71 ± 0.10 mg/ml, for aqueous and methanolic extracts, respectively. Thus, the observed effect on spontaneous enzyme leakage is probably mediated through mechanisms other than antioxidant activity. Both methanolic and aqueous extracts have shown estrogenic activity comparable with that of silymarin in MCF-7 cell line. Maca estrogenicity was exhibited in the range from 100 to 200 μg of extract per ml. The findings in the present study show that maca does not display in vitro hepatotoxicity. In contrast, a slight cytoprotective effect, probably not mediated by antioxidant capacity, was noted. Maca extracts exhibited estrogenic activity comparably to the effect of silymarin in MCF-7 cells.

  • Smallanthus sonchifolius and Lepidium meyenii - prospective Andean crops for the prevention of chronic diseases.
    Biomedical papers of the Medical Faculty of the University Palacký Olomouc Czechoslovakia, 2003
    Co-Authors: Katerina Valentová, Jitka Ulrichová
    Abstract:

    Smallanthus sonchifolius (yacon) and Lepidium meyenii (maca) were the traditional crops of the original population of Peru where they are also still used in folk medicine. These plants are little known in Europe and Northern America although at least yacon can be cultivated in the climatic conditions of these regions. This article deals with the botany and the composition, the structure of main constituents, biological activity of these plants and the cultivation of yacon in the Czech Republic. The potential of yacon tubers to treat hyperglycemia, kidney problems and for skin rejuvenation and the antihyperglycemic and cytoprotective activity of its leaves seems to be related mostly to its oligofructan and phenolic content, respectively. Maca alkaloids, steroids, glucosinolates, isothicyanates and macamides are probably responsible for its aptitude to act as a fertility enhancer, aphrodisiac, adaptogen, immunostimulant, anabolic and to influence hormonal balance. Yacon and maca are already on the European market as prospective functional foods and dietary supplements, mainly for use in certain risk groups of the population, e.g. seniors, diabetics, postmenopausal women etc.

  • Yacon (Smallanthus sonchifolius) and Maca (Lepidium meyenii), Traditional Andean Crops as New Functional Foods on the European Market
    Chemicke Listy, 2001
    Co-Authors: Katerina Valentová, J. Frček, Jitka Ulrichová
    Abstract:

    Yacon (Smallanthus sonchifolius) and maca (Lepidium meyenii) are traditional crops of the original population of Peru, which are also used in traditional medicine. However, these plants are little known in Europe and Northern America, although they can be cultivated in the climatic conditions of these regions. This article is a review of their botanical aspects, their growing in the Czech Republic, composition and structure of main constituents, and biological activity. These plants are already on European market as prospective functional foods and nutraceuticals for use in certain risk groups of population.

Lily Stojanovska - One of the best experts on this subject based on the ideXlab platform.

  • beneficial effects of Lepidium meyenii maca on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content
    Menopause, 2008
    Co-Authors: Nicole Brooks, Gisela Wilcox, Karen Z. Walker, John Ashton, Lily Stojanovska
    Abstract:

    AbstractObjective:To examine the estrogenic and androgenic activity of Lepidium meyenii (Maca) and its effect on the hormonal profile and symptoms in postmenopausal women.Design:Fourteen postmenopausal women completed a randomized, double-blind, placebo-controlled, crossover trial. They received 3.5

  • Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content
    Menopause, 2008
    Co-Authors: Nicole A. Brooks, John F. Ashton, Marc B. Cox, Gisela Wilcox, Karen Z. Walker, Lily Stojanovska
    Abstract:

    OBJECTIVE: To examine the estrogenic and androgenic activity of Lepidium meyenii (Maca) and its effect on the hormonal profile and symptoms in postmenopausal women. DESIGN: Fourteen postmenopausal women completed a randomized, double-blind, placebo-controlled, crossover trial. They received 3.5 g/day of powered Maca for 6 weeks and matching placebo for 6 weeks, in either order, over a total of 12 weeks. At baseline and weeks 6 and 12 blood samples were collected for the measurement of estradiol, follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin, and the women completed the Greene Climacteric Scale to assess the severity of menopausal symptoms. In addition, aqueous and methanolic Maca extracts were tested for androgenic and estrogenic activity using a yeast-based hormone-dependent reporter assay. RESULTS: No differences were seen in serum concentrations of estradiol, follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin between baseline, Maca treatment, and placebo (P > 0.05). The Greene Climacteric Scale revealed a significant reduction in scores in the areas of psychological symptoms, including the subscales for anxiety and depression and sexual dysfunction after Maca consumption compared with both baseline and placebo (P < 0.05). These findings did not correlate with androgenic or alpha-estrogenic activity present in the Maca as no physiologically significant activity was observed in yeast-based assays employing up to 4 mg/mL Maca extract (equivalent to 200 mg/mL Maca). CONCLUSIONS: Preliminary findings show that Lepidium meyenii (Maca) (3.5 g/d) reduces psychological symptoms, including anxiety and depression, and lowers measures of sexual dysfunction in postmenopausal women independent of estrogenic and androgenic activity.

Carla Gonzales - One of the best experts on this subject based on the ideXlab platform.

  • maca Lepidium meyenii walp a review of its biological properties
    Revista Peruana de Medicina Experimental y Salud Pública, 2014
    Co-Authors: Gustavo F Gonzales, Manuel Gasco, Julio Rubio, Leonidas Villaorduna, Carla Gonzales
    Abstract:

    La maca (Lepidium meyenii) es una planta que crece sobre los 4000 metros de altitud en los Andes Centrales del Peru, presenta diferentes variedades de acuerdo al color de su hipocotilo. La presente revision resume los resultados de estudios sobre los efectos de la maca en la funcion sexual, la espermatogenesis, la funcion reproductiva femenina, la memoria, la depresion y la ansiedad, como energizante y contra la hiperplasia benigna de prostata, osteoporosis y sindrome metabolico. Se discute tambien su efecto antienvejecimiento y la seguridad en su consumo. Se han demostrado diferencias en el efecto de las variedades negra, amarilla y roja de maca. La maca negra es la que mejores resultados presenta sobre la espermatogenesis, la memoria y contra la fatiga, mientras que la maca roja es la variedad que mejor revierte la hiperplasia benigna de prostata y la osteoporosis inducida experimentalmente. Ademas, la maca reduce los niveles de glucosa, y su consumo se relaciona con la reduccion de la presion arterial y un mejor puntaje de salud. Estudios experimentales han demostrado que el consumo a corto como a largo plazo no muestra toxicidad tanto in vivo como in vitro. A pesar que los estudios experimentales han demostrado que la maca presenta diversos efectos beneficos, son necesarios mas estudios clinicos para confirmar estos resultados

  • Effects of different varieties of Maca (Lepidium meyenii) on bone structure in ovariectomized rats.
    Forschende Komplementarmedizin, 2010
    Co-Authors: Carla Gonzales, Isaias Cárdenas-valencia, Johanna Leiva-revilla, Cecilia Anza-ramirez, Julio Rubio, Gustavo F Gonzales
    Abstract:

    Objective: This study was designed to determine the effect of different varieties of maca ( Lepidium meyenii ) on bone structure in ovariectomized (OVX) rats.

  • Lepidium meyenii maca a plant from the highlands of peru from tradition to science
    Forschende Komplementarmedizin, 2009
    Co-Authors: Gustavo F Gonzales, Carla Gonzales, Cynthia Gonzalescastaneda
    Abstract:

    This review summarizes the current state of knowledge on Lepidium meyenii (maca), a cruciferous plant (Brassicaceae family) which is cultivated exclusively at an altitude of 4,000–4

  • Lepidium meyenii (Maca): A Plant from the Highlands of Peru – from Tradition to Science
    Forschende Komplementarmedizin, 2009
    Co-Authors: Gustavo F Gonzales, Carla Gonzales, Cynthia Gonzales-castañeda
    Abstract:

    This review summarizes the current state of knowledge on Lepidium meyenii (maca), a cruciferous plant (Brassicaceae family) which is cultivated exclusively at an altitude of 4,000–4

  • effect of short term and long term treatments with three ecotypes of Lepidium meyenii maca on spermatogenesis in rats
    Journal of Ethnopharmacology, 2006
    Co-Authors: Carla Gonzales, Manuel Gasco, Julio Rubio, Jessica Nieto, Sandra Yucra, Gustavo F Gonzales
    Abstract:

    Abstract Lepidium meyenii (Brassicaceae), known as Maca, is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m above sea level in the central Andes. Maca is traditionally employed in the Andean region for its supposed fertility-enhancing properties. The study aimed to test the hypothesis that different ecotypes of Maca (Red, Yellow and Black) after short-term (7 days) and long-term (42 days) treatment affects differentially spermatogenesis adult rats. After 7 days of treatment with Yellow and Red Maca, the length of stage VIII was increased ( P P P P P P