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Pratibha Singh - One of the best experts on this subject based on the ideXlab platform.
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Sertoli–Leydig Cell Tumour with Heterologous Element with Rare Mitotic Figure Associated with Multinodular Goitre: A Rare Case of Sex Cord Stromal Tumour of Ovary with Rare Association
Indian Journal of Gynecologic Oncology, 2017Co-Authors: Meenakshi Gothwal, Hemanta Kumar Pradhan, Garima Yadav, Pratibha SinghAbstract:Sertoli–Leydig Cell Tumours are uncommon sex cord stromal Tumours of the ovary that often present diagnostic confusion due to the various morphological and histopathological patterns that may be assumed by the Tumour. A 28-year-old female presented with abnormal uterine bleeding and thyromegaly is found to have right adnexal mass with elevated serum testosterone. The mass was diagnosed as a Sertoli–Leydig Cell Tumour, intermediate differentiation with heterologous elements and focal anaplasia. She was treated with surgical resection followed by adjuvant chemotherapy. Definitive diagnosis is made by histopathological study with immunohistochemistry. Prognosis is related to the degree of Cellular differentiation and to the presence of heterologous elements with stage of disease at the time of diagnosis.
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Sertoli–Leydig Cell Tumour with Heterologous Element with Rare Mitotic Figure Associated with Multinodular Goitre: A Rare Case of Sex Cord Stromal Tumour of Ovary with Rare Association
Indian Journal of Gynecologic Oncology, 2017Co-Authors: Meenakshi Gothwal, Hemanta Kumar Pradhan, Garima Yadav, Pratibha SinghAbstract:Background Sertoli–Leydig Cell Tumours are uncommon sex cord stromal Tumours of the ovary that often present diagnostic confusion due to the various morphological and histopathological patterns that may be assumed by the Tumour. Case A 28-year-old female presented with abnormal uterine bleeding and thyromegaly is found to have right adnexal mass with elevated serum testosterone. The mass was diagnosed as a Sertoli–Leydig Cell Tumour, intermediate differentiation with heterologous elements and focal anaplasia. She was treated with surgical resection followed by adjuvant chemotherapy. Conclusion Definitive diagnosis is made by histopathological study with immunohistochemistry. Prognosis is related to the degree of Cellular differentiation and to the presence of heterologous elements with stage of disease at the time of diagnosis.
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sertoli Leydig Cell Tumour with heterologous element with rare mitotic figure associated with multinodular goitre a rare case of sex cord stromal Tumour of ovary with rare association
Indian Journal of Gynecologic Oncology, 2017Co-Authors: Meenakshi Gothwal, Hemanta Kumar Pradhan, Garima Yadav, Pratibha SinghAbstract:Sertoli–Leydig Cell Tumours are uncommon sex cord stromal Tumours of the ovary that often present diagnostic confusion due to the various morphological and histopathological patterns that may be assumed by the Tumour. A 28-year-old female presented with abnormal uterine bleeding and thyromegaly is found to have right adnexal mass with elevated serum testosterone. The mass was diagnosed as a Sertoli–Leydig Cell Tumour, intermediate differentiation with heterologous elements and focal anaplasia. She was treated with surgical resection followed by adjuvant chemotherapy. Definitive diagnosis is made by histopathological study with immunohistochemistry. Prognosis is related to the degree of Cellular differentiation and to the presence of heterologous elements with stage of disease at the time of diagnosis.
Per-anders Jansson - One of the best experts on this subject based on the ideXlab platform.
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Sertoli-Leydig Cell Tumour in a postmenopausal woman showing all facets of the insulin resistance syndrome (IRS).
Upsala journal of medical sciences, 2005Co-Authors: Eva Dahlgren, Berit Gull, Roger Willén, Frank Sundler, Thord Rosen, Per-anders JanssonAbstract:Sertoli-Leydig Cell Tumours are rare sex stromal Tumours with an incidence of < 0.5% of all ovarian Tumours. Most frequently this Tumour occurs in young women with a history of amenorrhoea, hirsutism and lowered pitch. Here, we report on a woman with IRS, postmenopausal virilization and increased testosterone levels due to a Sertoli-Leydig Cell Tumour. This is the first case to suggest an association between IRS and Sertoli-Leydig Cell Tumours. Furthermore, we highlight the difficulties in detecting this ovarian Tumour with sonography.
Efthimios P Samoladas - One of the best experts on this subject based on the ideXlab platform.
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spinal cord compression by a solitary metastasis from a low grade Leydig Cell Tumour a case report and review of the literature
World Journal of Surgical Oncology, 2008Co-Authors: Efthimios P Samoladas, Ashraf S Anbar, J D Lucas, Hlias Fotiadis, Byron E ChalidisAbstract:Leydig Tumour is rare and there are only three cases with metastatic disease reported. A 52 year-old Caucasian male was admitted, on emergency basis to the Orthopaedic Department with six weeks history of increasing midthoracic back pain, change in gait, poor balance, subjective weakness and numbness of the lower trunk and legs. MRI scan showed change in the signal intensity of T4 and T5 vertebral body but their height were maintained. Urgent T4 and T5 corpectomies, decompression of the spinal cord and reconstruction of the vertebral bodies were performed followed by radiotherapy. Neurological status significantly improved with a mild residual numbness over the dorsum of the right foot. The histology of the excised Tumour was identical to the primary. At 2 years follow-up visit the patient is neurologically stable and disease free without other organs metastases. This is the first case in English literature, which shows that spinal metastases could occur even in the early stage of Leydig Cell Tumour, without other organs involvement. Aggressive surgical management of spinal metastases combined with post operative radiotherapy can give a better chance for long survivorship.
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World Journal of Surgical Oncology BioMed Central
2008Co-Authors: Efthimios P Samoladas, Ashraf S Anbar, Hlias Fotiadis, Jonathan D Lucas, Byron Chalidis Open E AccessAbstract:Spinal cord compression by a solitary metastasis from a low grade Leydig Cell Tumour: a case report and review of the literatur
James J. Vredenburgh - One of the best experts on this subject based on the ideXlab platform.
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a family with sertoli Leydig Cell Tumour multinodular goiter and dicer1 mutation
Current Oncology, 2019Co-Authors: M. G. Haley, Poorva Bindal, A. Mcauliffe, James J. VredenburghAbstract:Background DICER1 syndrome is an autosomal dominant Tumour predisposition syndrome associated with a wide variety of cancerous and noncancerous conditions, including ovarian sex cord–stromal Tumours and thyroid conditions, including multinodular goiter. The most common ovarian sex cord–stromal Tumour associated with DICER1 syndrome is Sertoli–Leydig Cell Tumour, with germline DICER1 mutations present in more than 50% of cases. We present a case in which a patient in her late 30s was diagnosed with a Sertoli–Leydig Cell Tumour in the background of a strong family history of multinodular goiter and Sertoli–Leydig Cell Tumour with a germline mutation in DICER1. Case Presentation A 38-year-old woman with history of multinodular goiter was found to have stage iiic ovarian Sertoli–Leydig Cell cancer after presenting with abdominal pain. She underwent multiple surgeries and chemotherapy. The patient developed rapid disease progression and died 7 months after diagnosis. Seven years earlier, a daughter had experienced the same disease and was found to have a germline DICER1 mutation. The mother had not undergone testing before her own diagnosis. Summary The co-occurrence of Sertoli–Leydig Cell Tumour and multinodular goiter is highly suggestive of DICER1 syndrome. The recognition of DICER1 syndrome within a family is essential for increased awareness and potential early recognition of complications. Most conditions associated with DICER1 syndrome occur in childhood, and most of the current screening recommendations are specific for childhood and young adulthood. Cancer risks and findings for the adult population are not as well defined. Clinicians who encounter DICER1 syndrome should review recommendations for genetic testing and surveillance and enrol patients in the DICER1 registry.
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A family with Sertoli–Leydig Cell Tumour, multinodular goiter, and DICER1 mutation
Current oncology (Toronto Ont.), 2019Co-Authors: M. G. Haley, Poorva Bindal, A. Mcauliffe, James J. VredenburghAbstract:Background DICER1 syndrome is an autosomal dominant Tumour predisposition syndrome associated with a wide variety of cancerous and noncancerous conditions, including ovarian sex cord–stromal Tumours and thyroid conditions, including multinodular goiter. The most common ovarian sex cord–stromal Tumour associated with DICER1 syndrome is Sertoli–Leydig Cell Tumour, with germline DICER1 mutations present in more than 50% of cases. We present a case in which a patient in her late 30s was diagnosed with a Sertoli–Leydig Cell Tumour in the background of a strong family history of multinodular goiter and Sertoli–Leydig Cell Tumour with a germline mutation in DICER1. Case Presentation A 38-year-old woman with history of multinodular goiter was found to have stage iiic ovarian Sertoli–Leydig Cell cancer after presenting with abdominal pain. She underwent multiple surgeries and chemotherapy. The patient developed rapid disease progression and died 7 months after diagnosis. Seven years earlier, a daughter had experienced the same disease and was found to have a germline DICER1 mutation. The mother had not undergone testing before her own diagnosis. Summary The co-occurrence of Sertoli–Leydig Cell Tumour and multinodular goiter is highly suggestive of DICER1 syndrome. The recognition of DICER1 syndrome within a family is essential for increased awareness and potential early recognition of complications. Most conditions associated with DICER1 syndrome occur in childhood, and most of the current screening recommendations are specific for childhood and young adulthood. Cancer risks and findings for the adult population are not as well defined. Clinicians who encounter DICER1 syndrome should review recommendations for genetic testing and surveillance and enrol patients in the DICER1 registry.
John Andreou - One of the best experts on this subject based on the ideXlab platform.
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Leydig Cell Tumour of the ovary localised with positron emission tomography computed tomography
Gynecological Endocrinology, 2011Co-Authors: Vasileios Prassopoulos, Fotios Laspas, Fani Vlachou, Roxani Efthimiadou, Lida Gogou, John AndreouAbstract:Androgen-producing ovarian Tumours can lead to assessment difficulties because of their small size. We present a case of virilising steroid Cell ovarian Tumour in a 41-year-old woman localised with Fluorine-18-Deoxyglucose Positron Emission Tomography/Computed Tomography (18FDG-PET/CT). Although the biochemical evaluation pointed to an ovarian source of androgen, diagnostic attempts to localise the source of hyperandrogenism with transvaginal ultrasound (US), and magnetic resonance imaging (MRI) of pelvis failed. Additional evaluation with 18FDG-PET/CT showed an increased uptake in the right ovary. A laparoscopic right oophorectomy was performed and histopathology examination revealed a 1.2-cm Leydig Cell Tumour. The patient showed regression of clinical signs.
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Leydig Cell Tumour of the ovary localised with Positron Emission Tomography/Computed Tomography
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011Co-Authors: Vasileios Prassopoulos, Fotios Laspas, Fani Vlachou, Roxani Efthimiadou, Lida Gogou, John AndreouAbstract:Androgen-producing ovarian Tumours can lead to assessment difficulties because of their small size. We present a case of virilising steroid Cell ovarian Tumour in a 41-year-old woman localised with Fluorine-18-Deoxyglucose Positron Emission Tomography/Computed Tomography (18FDG-PET/CT). Although the biochemical evaluation pointed to an ovarian source of androgen, diagnostic attempts to localise the source of hyperandrogenism with transvaginal ultrasound (US), and magnetic resonance imaging (MRI) of pelvis failed. Additional evaluation with 18FDG-PET/CT showed an increased uptake in the right ovary. A laparoscopic right oophorectomy was performed and histopathology examination revealed a 1.2-cm Leydig Cell Tumour. The patient showed regression of clinical signs.