The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Henri A. Bergoënd - One of the best experts on this subject based on the ideXlab platform.
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Tiopronin-induced Lichenoid Eruption
Journal of the American Academy of Dermatology, 1994Co-Authors: Eric Piérard, Emmanuel Delaporte, René-marc Flipo, Valérie Duneton-bitbol, Yves Dejobert, Frédéric Piette, Henri A. BergoëndAbstract:Sulfhydryl drugs such as D-penicillamine or captopril have many side effects, notably cutaneous Eruptions. 1-3Tiopronin (Thiola.Acadione) is a sulfhydryl drug that is prescribed primarily for the treatment of cystinuria. It was recently proposed for the treatment of rheumatoid arthritis. Its efficacy is comparable to D-penicillamine. Among the side effects of tiopronin, cutaneous reactions are the most common and occur in 10% to 32% of patients." These reactions include pruritus, stomatitis," pemphigus6 maculopapular exanthems, erythemamultiforme, andeczematous Eruptions.3 Lichenoid Eruptions caused by tiopronin appear to be rare. In Japan, where this drug has been prescribed for more than 15 years, eight cases have been reported.' To our knowledge this is the first documented French case.
Lúcia Arruda - One of the best experts on this subject based on the ideXlab platform.
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Erupção liquenóide: secundária ao uso de adalimumabe? Lichenoid Eruption: secondary to adalimumab?
Sociedade Brasileira de Reumatologia, 2008Co-Authors: Maria Cristina Bezzan Goldschmidt, Mariana Colombini Zaniboni, José Roberto Provenza, Lúcia ArrudaAbstract:O adalimumabe é um anticorpo recombinante monoclonal IgG1, completamente humano, que se liga especificamente ao fator de necrose tumoral alfa (TNF-a) e neutraliza sua atividade. Relatamos aqui um caso de erupção liquenóide secundária ao uso de adalimuma-be em uma paciente com artrite reumatóide. O quadro melhorou após a suspensão do adalimumabe, com recidiva à reintrodução do medicamento e nova melhora após a suspensão definitiva deste. Embora a paciente estivesse recebendo, concomitantemente ao adalimumabe, metotrexate, corticosteróides e outras drogas, não houve suspensão ou modificação das medicações, exceto o adalimumabe durante todo o período. A ocorrência de erupção liquenóide com o uso do adalimumabe é um evento não esperado, uma vez que, na imunopatologia do líquen plano, o papel do TNF-a parece ser o de propagador da doença. Desse modo, esperaria-se que drogas anti-TNF-a pudessem ser usadas no tratamento do líquen plano e não que atuassem como indutoras desta condição.Adalimumab is a recombinant, fully human IgG1 monoclonal antibody that binds specifically to human TNF-a and neutralizes the activity of this cytokine. We report herein the case of a Lichenoid Eruption with the use of adalimumab in a patient with rheumatoid arthritis. The Eruption improved after interruption of adalimumab, with recurrence at the reintroduction and improvement again with definitive suspension. Although this patient was receiving concomitant adalimumab with methotrexate, corticosteroids and other drugs, these medications except the adalimumab were not discontinued or modified at any moment during the period. The occurrence of Lichenoid Eruption with adalimumab is a not expected event since the function of the TNF-a in the immunopathology of lichen planus seems to be as a propagator of disease. This way, we would expect that drugs with anti-TNF-a effect would not act as inductors of lichen planus but could be used in its treatment
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Erupção liquenóide: secundária ao uso de adalimumabe?
Revista Brasileira de Reumatologia, 2008Co-Authors: Maria Cristina Bezzan Goldschmidt, Mariana Colombini Zaniboni, José Roberto Provenza, Lúcia ArrudaAbstract:Adalimumab is a recombinant, fully human IgG1 monoclonal antibody that binds specifically to human TNF-a and neutralizes the activity of this cytokine. We report herein the case of a Lichenoid Eruption with the use of adalimumab in a patient with rheumatoid arthritis. The Eruption improved after interruption of adalimumab, with recurrence at the reintroduction and improvement again with definitive suspension. Although this patient was receiving concomitant adalimumab with methotrexate, corticosteroids and other drugs, these medications except the adalimumab were not discontinued or modified at any moment during the period. The occurrence of Lichenoid Eruption with adalimumab is a not expected event since the function of the TNF-a in the immunopathology of lichen planus seems to be as a propagator of disease. This way, we would expect that drugs with anti-TNF-a effect would not act as inductors of lichen planus but could be used in its treatment.
Steven Kossard - One of the best experts on this subject based on the ideXlab platform.
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Lichenoid graft-versus-host disease occurring in Blaschko's lines
European Journal of Dermatology, 1996Co-Authors: K Atkinson, Steven KossardAbstract:We describe a case of Lichenoid graft-versus-host disease (GVHD) occurring along the distribution of Blaschko's lines, 8 months after bone marrow transplantation. Although the exact mechanism for this unusual distribution of GVHD is unknown, it is believed to be a result of cellular mosaicism. We review the literature on this unusual linear Lichenoid Eruption.
Eric Piérard - One of the best experts on this subject based on the ideXlab platform.
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Tiopronin-induced Lichenoid Eruption
Journal of the American Academy of Dermatology, 1994Co-Authors: Eric Piérard, Emmanuel Delaporte, René-marc Flipo, Valérie Duneton-bitbol, Yves Dejobert, Frédéric Piette, Henri A. BergoëndAbstract:Sulfhydryl drugs such as D-penicillamine or captopril have many side effects, notably cutaneous Eruptions. 1-3Tiopronin (Thiola.Acadione) is a sulfhydryl drug that is prescribed primarily for the treatment of cystinuria. It was recently proposed for the treatment of rheumatoid arthritis. Its efficacy is comparable to D-penicillamine. Among the side effects of tiopronin, cutaneous reactions are the most common and occur in 10% to 32% of patients." These reactions include pruritus, stomatitis," pemphigus6 maculopapular exanthems, erythemamultiforme, andeczematous Eruptions.3 Lichenoid Eruptions caused by tiopronin appear to be rare. In Japan, where this drug has been prescribed for more than 15 years, eight cases have been reported.' To our knowledge this is the first documented French case.
Vinod K Sharma - One of the best experts on this subject based on the ideXlab platform.
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photosensitive spongiotic Lichenoid Eruption of micropapules and plaques a morphologically distinct entity
Indian Journal of Dermatology Venereology and Leprology, 2013Co-Authors: Nidhi Shah, M. Ramam, Vinod K Sharma, Binod K. Khaitan, Manoj K. SinghAbstract:Background: A distinct morphological pattern of photodermatosis has been observed with shiny skin colored to hypopigmented tiny papules, discrete or coalescing to form plaques. Aims: To study the clinico-pathological features of patients presenting with these lesions. Methods: A total of 72 patients were recruited. Clinical examination and skin biopsy was carried out to evaluate the morphological patterns and the histopathological features. Results: In all patients, tiny discrete to coalescent papules were observed on sun-exposed sites but usually sparing the face. The condition occurred more commonly in women. Three specific histopathological patterns were observed : 0 spongiotic (43.7%), Lichenoid (22.5%), psoriasiform (18.7%) and also perivascular pattern in 5%. Conclusion: Photosensitive Lichenoid Eruption is a morphologically distinct photodermatoses that is commonly seen in Indian patients with pathological features showing mostly spongiotic changes and in some cases Lichenoid changes.
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Photosensitive spongiotic/Lichenoid Eruption of micropapules and plaques: A morphologically distinct entity
Indian journal of dermatology venereology and leprology, 2013Co-Authors: Nidhi Shah, M. Ramam, Vinod K Sharma, Binod K. Khaitan, Manoj K. SinghAbstract:Background: A distinct morphological pattern of photodermatosis has been observed with shiny skin colored to hypopigmented tiny papules, discrete or coalescing to form plaques. Aims: To study the clinico-pathological features of patients presenting with these lesions. Methods: A total of 72 patients were recruited. Clinical examination and skin biopsy was carried out to evaluate the morphological patterns and the histopathological features. Results: In all patients, tiny discrete to coalescent papules were observed on sun-exposed sites but usually sparing the face. The condition occurred more commonly in women. Three specific histopathological patterns were observed : 0 spongiotic (43.7%), Lichenoid (22.5%), psoriasiform (18.7%) and also perivascular pattern in 5%. Conclusion: Photosensitive Lichenoid Eruption is a morphologically distinct photodermatoses that is commonly seen in Indian patients with pathological features showing mostly spongiotic changes and in some cases Lichenoid changes.
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Parthenium dermatitis presenting as photosensitive Lichenoid Eruption. A new clinical variant.
Contact dermatitis, 2002Co-Authors: Kaushal K. Verma, Chandra Sekhar Sirka, M. Ramam, Vinod K SharmaAbstract:Parthenium hysterophorus is the commonest cause of airborne contact dermatitis (ABCD) in India. The disease usually manifests as itchy erythematous, papular, papulovesicular and plaque lesions on exposed areas of the body. Rarely, however, the disease may present as actinic reticuloid or photocontact dermatitis. We have observed a different clinical variant of this disease where certain patients with Parthenium dermatitis have presented with discrete, flat, violaceous papules and plaques on exposed areas of the body closely simulating photosensitive Lichenoid Eruption. We had 8 patients, 6 males and 2 females between 30 and 62 years of age, with itchy, violaceous, papules and plaques on the face, neck, ears, upper chest and dorsa of the hands for 6 months to 6.5 years. Four of these patients had a history of improvement of the lesions up to 30% in winter and aggravation of lesions on exposure to sunlight. There was no personal or family history of atopy. Cutaneous examination in all patients revealed multiple flat, violaceous, mildly erythematous papules and plaques on the forehead, sides and nape of neck, ears, 'V' area of the chest, and extensor aspects of the forearms and hands. Skin biopsies from these lesions showed features of chronic non-specific dermatitis. Patch testing with standardized plant antigens showed a positive patch test reaction to Parthenium hysterophorus in all patients, with a titre of contact hypersensitivity (TCH) varying from undiluted to 1 : 100. We conclude that Parthenium dermatitis may occasionally present with lesions very similar to the lesions of photosensitive Lichenoid Eruption in morphology and distribution. This clinical presentation of Parthenium dermatitis needs to be recognized to avoid misdiagnosis.