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Pierre Brousset - One of the best experts on this subject based on the ideXlab platform.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France.
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
Arun J Sanyal - One of the best experts on this subject based on the ideXlab platform.
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long term changes in Liver Histology following treatment of chronic hepatitis c virus
Annals of Hepatology, 2014Co-Authors: Mitchell L. Shiffman, Richard K Sterling, Velimir A. Luketic, Melissa J. Contos, Sarah Hubbard, April Long, Todd R Stravitz, Michael Fuchs, Arun J SanyalAbstract:Background and aims. The histologic hallmarks of chronic HCV include inflammation and fibrosis. The impact of interferon therapy on Liver Histology was evaluated. Material and methods. The study population consisted of 348 patients with chronic HCV who underwent a baseline Liver biopsy, received either no treatment or a single course of interferon based therapy, were followed for 5 years without any treatment or additional treatment and then underwent a repeat Liver biopsy. The patients were divided into 3 groups; deferred treatment (NoTx = 47), received interferon based therapy but failed to achieve SVR (NoSVR = 189) and achieved SVR (SVR = 112). Results. Patients with NoTx and NoSVR had significant increases in mean inflammation scores (from 4.3 to 6.3 and 5.4 to 6.7 respectively; p < 0.001 for both) and fibrosis scores (from 0.9 to 1.8 and 1.9 to 2.5; p < 0.001 for both). The amounts by which inflammation, fibrosis and rate of fibrosis progression increased were not significantly different between the two groups. Increases in total inflammation and the piecemeal necrosis sub-score over time were strongly associated with fibrosis progression. Patients with SVR had a significant decline in mean inflammation and fibrosis scores (from 6.7 to 2.2 and 3.3 to 1.8; p < 0.001 for both); 40% of patients resolved all fibrosis and 50% of patients resolved cirrhosis. Conclusion. Increases in inflammation are associated with fibrosis progression and in the absence of SVR interferon treatment does not appear to affect the long term natural history of this process. Patients with SVR have resolution of inflammation and fibrosis and many resolve cirrhosis.
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relationship between adipose tissue insulin resistance and Liver Histology in nonalcoholic steatohepatitis a pioglitazone versus vitamin e versus placebo for the treatment of nondiabetic patients with nonalcoholic steatohepatitis trial follow up stud
Hepatology, 2012Co-Authors: Lauren N. Bell, Arun J Sanyal, Jiangxia Wang, Sriya Muralidharan, Sadhana Chalasani, Allison M. Fullenkamp, Laura Wilson, Kris V. Kowdley, Brent A Neuschwandertetri, Elizabeth M BruntAbstract:The PIVENS (Pioglitazone versus Vitamin E versus Placebo for the Treatment of Nondiabetic Patients with Nonalcoholic Steatohepatitis [NASH]) trial demonstrated that pioglitazone and vitamin E improved Liver Histology to varying degrees, but the mechanisms are unknown. We conducted a study to examine the changes in adipose tissue insulin resistance (Adipo-IR) during the PIVENS trial and its relationship to histological endpoints. Adipo-IR (fasting nonesterified fatty acids [NEFAs] × fasting insulin) was calculated at baseline and after 16 and 96 weeks of therapy. Compared to placebo, the baseline Adipo-IR was not different in either the vitamin E group (P = 0.34) or the pioglitazone group (P = 0.29). Baseline Adipo-IR was significantly associated with fibrosis score (P = 0.02), but not with other histological features or nonalcoholic fatty Liver disease (NAFLD) activity score (NAS). After 16 weeks, compared to placebo, the pioglitazone group had a significant reduction in Adipo-IR (−15.7 versus −1.91; P = 0.02), but this effect did not persist at 96 weeks (−3.25 versus −4.28; P = 0.31). Compared to placebo, Adipo-IR in the vitamin E group did not change significantly either after 16 weeks (P = 0.70) or after 96 weeks (P = 0.85). Change in Adipo-IR at week 16 was not associated with changes in any histological parameters at week 96, but improvement in Adipo-IR at week 96 was significantly associated with improvement in ballooning (P = 0.03), fibrosis (P = 0.004), and NAS (P = 0.01). Conclusion: Vitamin E improved Liver Histology independent of changes in Adipo-IR, and pioglitazone treatment acutely improved Adipo-IR, but this was not sustained. Changes in Adipo-IR were associated with changes in Liver Histology, including fibrosis. (HEPATOLOGY 2012)
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Relationship between Adipose Tissue Insulin Resistance and Liver Histology in NASH: A PIVENS Follow-Up Study
Hepatology, 2012Co-Authors: Lauren N. Bell, Arun J Sanyal, Jiangxia Wang, Sriya Muralidharan, Sadhana Chalasani, Allison M. Fullenkamp, Laura Wilson, Kris V. Kowdley, Brent A. Neuschwander-tetri, Arthur J. McculloughAbstract:The PIVENS [Pioglitazone versus Vitamin E versus Placebo for the Treatment of Non-diabetic Patients with Nonalcoholic Steatohepatitis (NASH)] trial demonstrated that pioglitazone and vitamin E improved Liver Histology to varying degrees but mechanisms are unknown. We conducted a study to examine the changes in adipose tissue insulin resistance (Adipo-IR) during the PIVENS trial and its relationship to histological end points. Adipo-IR [fasting non-esterified fatty acids (NEFA) × fasting insulin] was calculated at baseline and after 16 and 96 weeks of therapy. Compared to placebo, the baseline Adipo-IR was not different in either vitamin E group (p=0.34) or pioglitazone group (p=0.29).). Baseline Adipo-IR was significantly associated with fibrosis score (p=0.017) but not with other histological features or NAFLD activity score (NAS). After 16 weeks, compared to placebo, the pioglitazone group had significant reduction in Adipo-IR (−15.7 vs. −1.91, p=0.02) but this effect did not persist at 96 weeks (−3.25 vs. −4.28, p=0.31). Compared to placebo, Adipo-IR in the vitamin E group did not change significantly either after 16 weeks (p=0.70) or after 96 weeks (p=0.85). Change in Adipo-IR at week 16 was not associated with changes in any histological parameters at week 96, but improvement in Adipo-IR at week 96 was significantly associated with improvement in ballooning (p=0.02), fibrosis (p=0.004), and NAFLD activity score (p=0.01). Conclusion Vitamin E improved Liver Histology independent of changes in Adipo-IR, and pioglitazone treatment acutely improved Adipo-IR but this was not sustained. Changes in Adipo-IR were associated with changes in Liver Histology, including fibrosis.
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association between metabolic syndrome and Liver Histology among children with nonalcoholic fatty Liver disease
The American Journal of Gastroenterology, 2010Co-Authors: Heather Patton, Katherine Yates, Aynur Unalparida, Cynthia Behling, Terry T K Huang, Philip J Rosenthal, Arun J Sanyal, Jeffrey B Schwimmer, Joel E LavineAbstract:Association Between Metabolic Syndrome and Liver Histology Among Children With Nonalcoholic Fatty Liver Disease
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Chronic hepatitis C infection in patients with end stage renal disease: characterization of Liver Histology and viral load in patients awaiting renal transplantation
American Journal of Gastroenterology, 1999Co-Authors: Richard K Sterling, Arun J Sanyal, Velimir A. Luketic, R. Todd Stravitz, Anne L. King, Anthony B. Post, A. Scott Mills, Melissa J. Contos, Mitchell L. ShiffmanAbstract:Chronic hepatitis C infection in patients with end stage renal disease: characterization of Liver Histology and viral load in patients awaiting renal transplantation
Jean-marie Peron - One of the best experts on this subject based on the ideXlab platform.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France.
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
Jean-pierre Vinel - One of the best experts on this subject based on the ideXlab platform.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France.
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
Nassim Kamar - One of the best experts on this subject based on the ideXlab platform.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.
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Liver Histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France.
Virchows Archiv, 2007Co-Authors: Jean-marie Peron, Marie Danjoux, Nassim Kamar, Réda Missoury, Hélène Poirson, Jean-pierre Vinel, Jean-michel Mansuy, Christophe Bureau, Jacques Izopet, Pierre BroussetAbstract:Hepatitis E virus is a ribonucleic acid (RNA) enterically transmitted virus that causes both epidemics and sporadic cases of acute hepatitis E in many countries of Asia and Africa. Domestically acquired (non-travel-associated) hepatitis E has been reported recently in many industrialized countries including the USA, Europe, and Japan. There is little information available on Liver Histology in these patients. We report a series of 11 patients with sporadic acute hepatitis E and needle Liver Histology in South-West France. Hepatitis E was diagnosed based on elevated transaminases (>10 upper limit normal) and the presence of specific serum antibodies (immunoglobulin-G class, present in all 11 patients) and/or viral RNA detection in serum and/or stools. Acute hepatitis lesions were observed in all cases with marked necro-inflammatory activity in nine patients. Confluent necrosis was present in five cases. Anisocaryosis and Kupffer’s cell aggregates with siderosis were observed in most of the 11 patients. Cholangitis was frequent (9/11 cases). Cholestasis was observed in eight cases. Pseudo-glandular pattern was present in only one case but without zonal repartition. Characteristic pathological signs of acute hepatitis E were severe intralobular necrosis, polymorph inflammation, and acute cholangitis with numerous neutrophils.