The Experts below are selected from a list of 38370 Experts worldwide ranked by ideXlab platform
Alison Morris - One of the best experts on this subject based on the ideXlab platform.
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Lower Respiratory Tract myeloid cells harbor sars cov 2 and display an inflammatory phenotype
Chest, 2021Co-Authors: William Bain, Hernan F Penaloza, Mark S Ladinsky, Rick Van Der Geest, Mara Sullivan, Mark A Ross, Georgios D Kitsios, Barbara Methe, Bryan J Mcverry, Alison MorrisAbstract:SARS-CoV-2 pneumonia may induce an aberrant immune response with brisk recruitment of myeloid cells into the Lower Respiratory Tract, which may contribute to morbidity and mortality. We describe endotracheal aspirate samples from seven patients with SARS-CoV-2 pneumonia requiring mechanical ventilation. We note SARS-CoV-2 virions within Lower Respiratory Tract myeloid cells shown by electron tomography, immunofluorescence confocal imaging, and immuno-electron microscopy. Endotracheal aspirates are primarily composed of mononuclear and polymorphonuclear leukocytes. These myeloid cells that harbor virus are frequently positive for CD14 and/or CD16 and most display an inflammatory phenotype marked by expression of IL-6 and tissue factor mRNA transcript and protein expression.
Sachiko Seo - One of the best experts on this subject based on the ideXlab platform.
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human herpesvirus 6b and Lower Respiratory Tract disease after hematopoietic cell transplantation
Journal of Clinical Oncology, 2019Co-Authors: Sachiko Seo, Hu Xie, Joshua A Hill, Lisa Vande K Vusse, Lisa E Chung, Cecilia C S Yeung, Terry StevensayersAbstract:PURPOSEHuman herpesvirus 6B (HHV-6B) DNA is frequently detected in bronchoalveolar lavage fluid (BALF) from immunocompromised subjects with Lower Respiratory Tract disease (LRTD). Whether HHV-6B is...
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human rhinovirus detection in the Lower Respiratory Tract of hematopoietic cell transplant recipients association with mortality
Haematologica, 2017Co-Authors: Sachiko Seo, Alpana Waghmare, Hu Xie, Sumi Choi, Wendy M Leisenring, Angela P. Campbell, Robert C Hackman, Jane Kuypers, Emily Scott, Keith R. JeromeAbstract:Human rhinoviruses are the most common Respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe Lower Respiratory Tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the Lower Respiratory Tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in Respiratory samples. As comparative cohorts, 273 recipients with Lower Respiratory Tract infection caused by Respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed. Factors associated with mortality were analyzed using Cox proportional hazard models. Among 569 subjects with rhinovirus upper Respiratory Tract infection and 128 subjects with rhinovirus Lower Respiratory Tract infection, probabilities of overall mortality at 90 days were 6% and 41%, respectively (P<0.001). The survival rate after Lower Respiratory Tract infection was not affected by the presence of co-pathogens (55% in patients with co-pathogens, 64% in patients without, P=0.34). Low monocyte count (P=0.027), oxygen use (P=0.015), and steroid dose greater than 1 mg/kg/day (P=0.003) before diagnosis were significantly associated with mortality among patients with Lower Respiratory Tract infection in multivariable analysis. Mortality after rhinovirus Lower Respiratory Tract infection was similar to that after Lower Respiratory Tract infection by Respiratory syncytial virus, parainfluenza virus or influenza in an adjusted model. In summary, transplant recipients with rhinovirus detection in the Lower Respiratory Tract had high mortality rates comparable to viral pneumonia associated with other well-established Respiratory viruses. Our data suggest rhinovirus can contribute to severe pulmonary disease in immunocompromised hosts.
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mortality rates of human metapneumovirus and Respiratory syncytial virus Lower Respiratory Tract infections in hematopoietic cell transplantation recipients
Biology of Blood and Marrow Transplantation, 2013Co-Authors: Sachiko Seo, Hu Xie, Jane Kuypers, Christian Renaud, Anne Cent, Lawrence Corey, Wendy M LeisenringAbstract:AbsTract Human metapneumovirus (HMPV), a common Respiratory virus, can cause severe disease in pre- and post-hematopoietic cell transplantation (HCT) recipients. We conducted a retrospective cohort analysis in HCT patients with HMPV (n = 23) or Respiratory syncytial virus (n = 23) detected in bronchoalveolar lavage samples by reverse transcription PCR between 2006 and 2011 to determine disease characteristics and factors associated with outcome. Mortality rates at 100 days were 43% for both HMPV and Respiratory syncytial virus Lower Respiratory Tract disease. Steroid therapy, oxygen requirement >2 L or mechanical ventilation, and bone marrow as cell source were significant risk factors for overall and virus-related mortality in multivariable models, whereas the virus type was not. The presence of centrilobular/nodular radiographic infiltrates was a possible protective factor for mechanical ventilation. Thus, HMPV Lower Respiratory Tract disease is associated with high mortality in HCT recipients. Earlier detection in combination with new antiviral therapy is needed to reduce mortality among HCT recipients.
Wendy M Leisenring - One of the best experts on this subject based on the ideXlab platform.
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human rhinovirus detection in the Lower Respiratory Tract of hematopoietic cell transplant recipients association with mortality
Haematologica, 2017Co-Authors: Sachiko Seo, Alpana Waghmare, Hu Xie, Sumi Choi, Wendy M Leisenring, Angela P. Campbell, Robert C Hackman, Jane Kuypers, Emily Scott, Keith R. JeromeAbstract:Human rhinoviruses are the most common Respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe Lower Respiratory Tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the Lower Respiratory Tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in Respiratory samples. As comparative cohorts, 273 recipients with Lower Respiratory Tract infection caused by Respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed. Factors associated with mortality were analyzed using Cox proportional hazard models. Among 569 subjects with rhinovirus upper Respiratory Tract infection and 128 subjects with rhinovirus Lower Respiratory Tract infection, probabilities of overall mortality at 90 days were 6% and 41%, respectively (P<0.001). The survival rate after Lower Respiratory Tract infection was not affected by the presence of co-pathogens (55% in patients with co-pathogens, 64% in patients without, P=0.34). Low monocyte count (P=0.027), oxygen use (P=0.015), and steroid dose greater than 1 mg/kg/day (P=0.003) before diagnosis were significantly associated with mortality among patients with Lower Respiratory Tract infection in multivariable analysis. Mortality after rhinovirus Lower Respiratory Tract infection was similar to that after Lower Respiratory Tract infection by Respiratory syncytial virus, parainfluenza virus or influenza in an adjusted model. In summary, transplant recipients with rhinovirus detection in the Lower Respiratory Tract had high mortality rates comparable to viral pneumonia associated with other well-established Respiratory viruses. Our data suggest rhinovirus can contribute to severe pulmonary disease in immunocompromised hosts.
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mortality rates of human metapneumovirus and Respiratory syncytial virus Lower Respiratory Tract infections in hematopoietic cell transplantation recipients
Biology of Blood and Marrow Transplantation, 2013Co-Authors: Sachiko Seo, Hu Xie, Jane Kuypers, Christian Renaud, Anne Cent, Lawrence Corey, Wendy M LeisenringAbstract:AbsTract Human metapneumovirus (HMPV), a common Respiratory virus, can cause severe disease in pre- and post-hematopoietic cell transplantation (HCT) recipients. We conducted a retrospective cohort analysis in HCT patients with HMPV (n = 23) or Respiratory syncytial virus (n = 23) detected in bronchoalveolar lavage samples by reverse transcription PCR between 2006 and 2011 to determine disease characteristics and factors associated with outcome. Mortality rates at 100 days were 43% for both HMPV and Respiratory syncytial virus Lower Respiratory Tract disease. Steroid therapy, oxygen requirement >2 L or mechanical ventilation, and bone marrow as cell source were significant risk factors for overall and virus-related mortality in multivariable models, whereas the virus type was not. The presence of centrilobular/nodular radiographic infiltrates was a possible protective factor for mechanical ventilation. Thus, HMPV Lower Respiratory Tract disease is associated with high mortality in HCT recipients. Earlier detection in combination with new antiviral therapy is needed to reduce mortality among HCT recipients.
Jane Kuypers - One of the best experts on this subject based on the ideXlab platform.
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human rhinovirus detection in the Lower Respiratory Tract of hematopoietic cell transplant recipients association with mortality
Haematologica, 2017Co-Authors: Sachiko Seo, Alpana Waghmare, Hu Xie, Sumi Choi, Wendy M Leisenring, Angela P. Campbell, Robert C Hackman, Jane Kuypers, Emily Scott, Keith R. JeromeAbstract:Human rhinoviruses are the most common Respiratory viruses detected in patients after hematopoietic cell transplantation. Although rhinovirus appears to occasionally cause severe Lower Respiratory Tract infection in immunocompromised patients, the clinical significance of rhinovirus detection in the Lower Respiratory Tract remains unknown. We evaluated 697 recipients transplanted between 1993 and 2015 with rhinovirus in Respiratory samples. As comparative cohorts, 273 recipients with Lower Respiratory Tract infection caused by Respiratory syncytial virus (N=117), parainfluenza virus (N=120), or influenza (N=36) were analyzed. Factors associated with mortality were analyzed using Cox proportional hazard models. Among 569 subjects with rhinovirus upper Respiratory Tract infection and 128 subjects with rhinovirus Lower Respiratory Tract infection, probabilities of overall mortality at 90 days were 6% and 41%, respectively (P<0.001). The survival rate after Lower Respiratory Tract infection was not affected by the presence of co-pathogens (55% in patients with co-pathogens, 64% in patients without, P=0.34). Low monocyte count (P=0.027), oxygen use (P=0.015), and steroid dose greater than 1 mg/kg/day (P=0.003) before diagnosis were significantly associated with mortality among patients with Lower Respiratory Tract infection in multivariable analysis. Mortality after rhinovirus Lower Respiratory Tract infection was similar to that after Lower Respiratory Tract infection by Respiratory syncytial virus, parainfluenza virus or influenza in an adjusted model. In summary, transplant recipients with rhinovirus detection in the Lower Respiratory Tract had high mortality rates comparable to viral pneumonia associated with other well-established Respiratory viruses. Our data suggest rhinovirus can contribute to severe pulmonary disease in immunocompromised hosts.
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mortality rates of human metapneumovirus and Respiratory syncytial virus Lower Respiratory Tract infections in hematopoietic cell transplantation recipients
Biology of Blood and Marrow Transplantation, 2013Co-Authors: Sachiko Seo, Hu Xie, Jane Kuypers, Christian Renaud, Anne Cent, Lawrence Corey, Wendy M LeisenringAbstract:AbsTract Human metapneumovirus (HMPV), a common Respiratory virus, can cause severe disease in pre- and post-hematopoietic cell transplantation (HCT) recipients. We conducted a retrospective cohort analysis in HCT patients with HMPV (n = 23) or Respiratory syncytial virus (n = 23) detected in bronchoalveolar lavage samples by reverse transcription PCR between 2006 and 2011 to determine disease characteristics and factors associated with outcome. Mortality rates at 100 days were 43% for both HMPV and Respiratory syncytial virus Lower Respiratory Tract disease. Steroid therapy, oxygen requirement >2 L or mechanical ventilation, and bone marrow as cell source were significant risk factors for overall and virus-related mortality in multivariable models, whereas the virus type was not. The presence of centrilobular/nodular radiographic infiltrates was a possible protective factor for mechanical ventilation. Thus, HMPV Lower Respiratory Tract disease is associated with high mortality in HCT recipients. Earlier detection in combination with new antiviral therapy is needed to reduce mortality among HCT recipients.
William Bain - One of the best experts on this subject based on the ideXlab platform.
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Lower Respiratory Tract myeloid cells harbor sars cov 2 and display an inflammatory phenotype
Chest, 2021Co-Authors: William Bain, Hernan F Penaloza, Mark S Ladinsky, Rick Van Der Geest, Mara Sullivan, Mark A Ross, Georgios D Kitsios, Barbara Methe, Bryan J Mcverry, Alison MorrisAbstract:SARS-CoV-2 pneumonia may induce an aberrant immune response with brisk recruitment of myeloid cells into the Lower Respiratory Tract, which may contribute to morbidity and mortality. We describe endotracheal aspirate samples from seven patients with SARS-CoV-2 pneumonia requiring mechanical ventilation. We note SARS-CoV-2 virions within Lower Respiratory Tract myeloid cells shown by electron tomography, immunofluorescence confocal imaging, and immuno-electron microscopy. Endotracheal aspirates are primarily composed of mononuclear and polymorphonuclear leukocytes. These myeloid cells that harbor virus are frequently positive for CD14 and/or CD16 and most display an inflammatory phenotype marked by expression of IL-6 and tissue factor mRNA transcript and protein expression.
