The Experts below are selected from a list of 10842 Experts worldwide ranked by ideXlab platform
Shih-ming Huang - One of the best experts on this subject based on the ideXlab platform.
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effectiveness and mechanism of preoperative Lugol solution for reducing thyroid blood flow in patients with euthyroid graves disease
World Journal of Surgery, 2016Co-Authors: Shih-ming HuangAbstract:Background To reduce intraoperative and postoperative complications, using Lugol solution to preoperatively prepare patients with Graves’ disease has (1) rapidly reduced the severity of thyrotoxicosis and (2) reduced the vascularity of the thyroid gland. The vascularity reduction normally accompanies reducing the severity of thyrotoxicosis. However, the effects and mechanism of Lugol solution for reducing blood flow have not been well investigated in the patients with euthyroid (normally functioning thyroid) Graves’ disease.
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Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves’ Disease
World Journal of Surgery, 2016Co-Authors: Shih-ming Huang, Wei-ting Liao, Chiou-feng Lin, H. Sunny Sun, Nan-haw ChowAbstract:Background To reduce intraoperative and postoperative complications, using Lugol solution to preoperatively prepare patients with Graves’ disease has (1) rapidly reduced the severity of thyrotoxicosis and (2) reduced the vascularity of the thyroid gland. The vascularity reduction normally accompanies reducing the severity of thyrotoxicosis. However, the effects and mechanism of Lugol solution for reducing blood flow have not been well investigated in the patients with euthyroid (normally functioning thyroid) Graves’ disease. Methods Twenty-five patients with euthyroid Graves’ disease being preoperatively treated with Lugol solution for 10 days were measured, at baseline and on the operative day, for (1) superior thyroid artery blood flow; (2) systemic angiogenic factor (VEGF); and (3) systemic inflammatory factor [interleukin (IL)-16]. Results All three parameters were significantly ( p
Kazuaki Chayama - One of the best experts on this subject based on the ideXlab platform.
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characteristics of esophageal squamous cell carcinomas and Lugol voiding lesions in patients with head and neck squamous cell carcinoma
Journal of Clinical Gastroenterology, 2010Co-Authors: Tatsuma Fukuhara, Toru Hiyama, Shinji Tanaka, Shiro Oka, Masaharu Yoshihara, Koji Arihiro, Kazuaki ChayamaAbstract:BackgroundThe relationship between esophageal squamous cell carcinoma (ESCC) and Lugol-voiding lesions (LVLs) in patients with head and neck squamous cell carcinoma (HNSCC) is unclear.AimTo investigate the characteristics of ESCC and the relationship between ESCC and LVLs in patients with HNSCC.Meth
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natural course of Lugol voiding lesions in patients with superficial esophageal squamous cell carcinoma
Digestion, 2010Co-Authors: Tatsuma Fukuhara, Toru Hiyama, Shinji Tanaka, Shiro Oka, Masaharu Yoshihara, Koji Arihiro, Kazuaki ChayamaAbstract:Background: The presence of multiple Lugol-voiding lesions (LVLs) in the esophageal mucosa can indicate a high risk of esophageal squamous cell carcinoma (ESCC) as well as a diagnosis of ESCC and dysplasia. However, there have been no reports on the natural course of LVLs. Aim: This study aimed to clarify the characteristics and natural course of LVLs. Methods: Based on patients with ESCC who underwent endoscopic treatment, a retrospective study was conducted targeting 73 patients in whom the esophageal background mucosa was evaluated using Lugol staining and who were followed up for 12 months or more. LVLs were divided into groups A (none), B (several small), C (many small), and D (many irregular-shaped multiform). Results: The average follow-up period was 42.0 months. Groups A–D consisted of 13, 34, 21, and 5 patients, respectively. In group B, 3 of 34 (8.8%) patients advanced to group C. In group C, 2 of 21 (9.5%) patients advanced to group D. In total, 5 of all 73 (6.8%) patients advanced to a higher group. Conclusion: These data suggest that a risk of ESCC may obviously increase in only some of the patients by evaluation of LVLs.
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metachronous multiple esophageal squamous cell carcinomas and Lugol voiding lesions after endoscopic mucosal resection
Endoscopy, 2009Co-Authors: Yuji Urabe, Shinji Tanaka, Shiro Oka, Masaharu Yoshihara, Koji Arihiro, Tooru Hiyama, Kazuaki ChayamaAbstract:Background and study aims Endoscopic mucosal resection (EMR) has been applied to the treatment of superficial esophageal squamous cell carcinoma (SCC). The incidence and characteristics of metachronous multiple esophageal SCCs and Lugol-voiding lesions (LVLs) were investigated in a retrospective study in patients who had undergone EMR for superficial esophageal SCC. Patients and methods 96 patients with esophageal SCC who had been treated by EMR were followed up by endoscopy for 12 months or longer. Clinicopathologic parameters such as tumor size and location and presence of LVLs were examined. Results 10 patients (10 %) had synchronous multiple SCCs, and 12 (13 %) developed metachronous multiple SCCs. The mean annual incidence of newly diagnosed tumor was 4.4 %. The incidence of a speckled pattern of LVLs was 20/74 (27 %) in patients with solitary SCC, 5/10 (50 %) in synchronous multiple SCC, and 10/12 (83 %) in metachronous multiple SCC. The incidence of the presence of speckled pattern of LVLs was significantly higher in patients with multiple SCCs than in those with solitary SCC (68 % vs. 27 %, P = 0.0004). Conclusions Patients who have undergone EMR for esophageal SCC, especially those with metachronous multiple LVLs in the background mucosa, should undergo follow-up with close endoscopic observation using Lugol staining.
Stéphane Lecleire - One of the best experts on this subject based on the ideXlab platform.
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Narrow-band imaging versus Lugol chromoendoscopy for esophageal squamous cell cancer screening in normal endoscopic practice: randomized controlled trial.
Endoscopy, 2020Co-Authors: Melissa Gruner, Angélique Denis, Claude Masliah, Morgane Amil, Metivier-cesbron E, Dominique Luet, Medhi Kaasis, Emmanuel Coron, Marc Le Rhun, Stéphane LecleireAbstract:Background Narrow-band imaging (NBI) is as sensitive as Lugol chromoendoscopy to detect esophageal squamous cell carcinoma (SCC) but its specificity, which appears higher than that of Lugol chromoendoscopy in expert centers, remains to be established in general practice. This study aimed to prove the superiority of NBI specificity over Lugol chromoendoscopy in the detection of esophageal SCC and high grade dysplasia (HGD) in current general practice (including tertiary care centers, local hospitals, and private clinics). Methods This prospective randomized multicenter trial included consecutive patients with previous or current SCC of the upper aerodigestive tract who were scheduled for gastroscopy. Patients were randomly allocated to either the Lugol or NBI group. In the Lugol group, examination with white light and Lugol chromoendoscopy were successively performed. In the NBI group, NBI examination was performed after white-light endoscopy. We compared the diagnostic characteristics of NBI and Lugol chromoendoscopy in a per-patient analysis. Results 334 patients with history of SCC were included and analyzed (intention-to-treat) from 15 French institutions between March 2011 and December 2015. In per-patient analysis, sensitivity, specificity, positive and negative likelihood values were 100 %, 66.0 %, 21.2 %, and 100 %, respectively, for Lugol chromoendoscopy vs. 100 %, 79.9 %, 37.5 %, and 100 %, respectively, for NBI. Specificity was greater with NBI than with Lugol (P = 0.002). Conclusions As previously demonstrated in expert centers, NBI was more specific than Lugol in current gastroenterology practice for the detection of early SCC, but combined approaches with both NBI and Lugol could improve the detection of squamous neoplasia.
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Lugol chromo endoscopy versus narrow band imaging for endoscopic screening of esophageal squamous cell carcinoma in patients with a history of cured esophageal cancer a feasibility study
Diseases of The Esophagus, 2011Co-Authors: Stéphane Lecleire, M Antonietti, I Iwanickicaron, A Duclos, F Lemoine, Florence Le Pessot, P Michel, Philippe Ducrotte, F Di FioreAbstract:SUMMARY To date, Lugol chromo-endoscopy is the reference technique to detect an esophageal neoplasia in patients with prior esophageal squamous-cell carcinoma (ESCC), but is not easy to perform without general anesthesia, which can limit its use in routine practice. The objective of this study were to compare the accuracy of white light, narrow band imaging (NBI), and Lugol to detect esophageal neoplasia in patients with a history of cured ESCC, in a prospective study. Thirty patients were prospectively included between June 2006 and June 2009. They all had a history of cured ESCC. Esophageal mucosa was examined first using white light, second NBI, and third after Lugol staining. Histology was obtained in all abnormalities detected by white light, NBI, and/or Lugol. Five neoplastic lesions in five different patients were identified at histology, four cancers, and one high-grade dysplasia. NBI and Lugol both detected all esophageal neoplastic lesions, whereas white light detected the four cancers but missed the high-grade dysplasia. In this feasibility study, NBI and Lugol both detected all identified esophageal neoplasia in very high-risk patients of ESCC. This result suggests that NBI could be used instead of Lugol to detect an esophageal neoplasia in patients with high risk of ESCC, but needs to be confirmed in a larger study.
Nan-haw Chow - One of the best experts on this subject based on the ideXlab platform.
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Effectiveness and Mechanism of Preoperative Lugol Solution for Reducing Thyroid Blood Flow in Patients with Euthyroid Graves’ Disease
World Journal of Surgery, 2016Co-Authors: Shih-ming Huang, Wei-ting Liao, Chiou-feng Lin, H. Sunny Sun, Nan-haw ChowAbstract:Background To reduce intraoperative and postoperative complications, using Lugol solution to preoperatively prepare patients with Graves’ disease has (1) rapidly reduced the severity of thyrotoxicosis and (2) reduced the vascularity of the thyroid gland. The vascularity reduction normally accompanies reducing the severity of thyrotoxicosis. However, the effects and mechanism of Lugol solution for reducing blood flow have not been well investigated in the patients with euthyroid (normally functioning thyroid) Graves’ disease. Methods Twenty-five patients with euthyroid Graves’ disease being preoperatively treated with Lugol solution for 10 days were measured, at baseline and on the operative day, for (1) superior thyroid artery blood flow; (2) systemic angiogenic factor (VEGF); and (3) systemic inflammatory factor [interleukin (IL)-16]. Results All three parameters were significantly ( p
Serdar Tezelman - One of the best experts on this subject based on the ideXlab platform.
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effect of Lugol solution on thyroid gland blood flow and microvessel density in the patients with graves disease
The Journal of Clinical Endocrinology and Metabolism, 2007Co-Authors: Yesim Erbil, Yasemin Ozluk, Murat Giris, Artur Salmaslioglu, Halim Issever, Umut Barbaros, Yersu Kapran, Selcuk Ozarmagan, Serdar TezelmanAbstract:Context: Although some endocrine surgeons administer Lugol solution to decrease thyroid gland vascularity, there is still not an agreement on its effectiveness. Objective: The aims of this clinical trial are to evaluate thyroid blood flow and microvessel density in patients with Graves’ disease who received Lugol solution treatment preoperatively. Design: This was a prospective clinical trial. Setting: This clinical trial took place at a tertiary referral center. Method: Thirty-six patients were randomly assigned to receive either preoperative treatment with Lugol solution (group 1, n = 17) or no preoperative treatment with Lugol solution (group 2, n = 19). Main Outcome Measures: Blood flow through the thyroid arteries of patients with Graves’ disease was measured by color flow Doppler ultrasonography. The microvessel density (MVD) was assessed by immunohistochemical and Western blot analysis of the level of expression of CD-34 in thyroid tissue. The weight and blood loss of the thyroid gland were measure...
