The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Yaling Liu - One of the best experts on this subject based on the ideXlab platform.
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Ultrastructural diversity of inclusions and aggregations in the Lumbar Spinal Cord of SOD1-G93A transgenic mice.
Brain research, 2010Co-Authors: Yansu Guo, Cheng Yang, Yaling LiuAbstract:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. We report the characteristics of ultrastructural pathological changes of inclusions and aggregations in the neuronal axons, glial cells and ventral roots of Lumbar Spinal Cord in SOD1-G93A transgenic mice using light and electron transmission microscope at different stages of disease. The most noteworthy is that mutant SOD1 accumulations in the cytoplasm of motor neurons precede the numerous inclusions. Inclusions manifested differently acCording to the specified locations. This study provided further information to the previous reports about pathological changes of ALS.
K. Gołembiowska - One of the best experts on this subject based on the ideXlab platform.
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The effect of p-chloroamphetamine and p-chlorophenylalanine on the level of thyrotropin-releasing hormone and its receptors in some brain structures and Lumbar Spinal Cord of the rat.
Neuropeptides, 1992Co-Authors: Edmund Przegaliński, L. Jaworska, K. GołembiowskaAbstract:Abstract The concentration of thyrotropin-releasing hormone (TRH) and the density and affinity of TRH receptors were examined in the ventral and dorsal Lumbar Spinal Cord, nucleus accumbens and striatum of rats with the 5-hydroxytryptamine (5-HT) nerve terminal destroyed with p-chloroamphetamine (PCA), or in animals treated with the inhibitor of 5-HT synthesis p-chlorophenylalanine (PCPA). PCA (2 × 10 mg/kg i.p., 9 and 8 d before killing) and PCPA (3 × 300 mg/kg i.p., 72, 48 and 24 h before killing)—either of them dramatically diminishing the 5-HT and 5-HIAA concentrations in all the examined structures—reduced the TRH level and increased the density of TRH receptors in the ventral Lumbar Spinal Cord. PCPA also reduced the TRH content in the nucleus accumbens. The PCA-induced reduction in the TRH level and increase in the density of TRH receptors in the ventral Lumbar Spinal Cord were significantly attenuated by citalopram (2 × 20 mg/kg i.p., 30 min before PCA), a selective inhibitor of 5-HT uptake. Our results constitute a further proof that coexistence of TRH and 5-HT takes place in the ventral Lumbar Spinal Cord and then indicate that other form(s) of relationship between 5-HT and TRH may exist in some parts of the central nervous system. They also suggest that an up-regulation of TRH receptors occurs in the Spinal Cord as a result of TRH depletion.
Yansu Guo - One of the best experts on this subject based on the ideXlab platform.
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Ultrastructural diversity of inclusions and aggregations in the Lumbar Spinal Cord of SOD1-G93A transgenic mice.
Brain research, 2010Co-Authors: Yansu Guo, Cheng Yang, Yaling LiuAbstract:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. We report the characteristics of ultrastructural pathological changes of inclusions and aggregations in the neuronal axons, glial cells and ventral roots of Lumbar Spinal Cord in SOD1-G93A transgenic mice using light and electron transmission microscope at different stages of disease. The most noteworthy is that mutant SOD1 accumulations in the cytoplasm of motor neurons precede the numerous inclusions. Inclusions manifested differently acCording to the specified locations. This study provided further information to the previous reports about pathological changes of ALS.
Ramsés Reina - One of the best experts on this subject based on the ideXlab platform.
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Detection of aluminum in Lumbar Spinal Cord of sheep subcutaneously inoculated with aluminum-hydroxide containing products.
Journal of inorganic biochemistry, 2019Co-Authors: Ricardo De Miguel, Javier Asín, Ana Rodríguez-largo, Jéssica Molín, Irache Echeverría, Damián De Andrés, Marta M. Pérez, Ignacio De Blas, Matthew Mold, Ramsés ReinaAbstract:Abstract The use of vaccines containing aluminum (Al) adjuvants is widespread in ovine production. Al adjuvants induce an effective immune-response but lead to the formation of post-vaccination granulomas from which Al can disseminate. This work aims to study the accumulation of Al in the central nervous system of sheep subcutaneously inoculated with Al-hydroxide containing products. Lumbar Spinal Cord and parietal lobe from 21 animals inoculated with 19 doses of Vaccine (n = 7), Adjuvant-only (n = 7) or phosphate-buffered saline as Control (n = 7) were analyzed with transversely heated graphite furnace atomic absorption spectroscopy and lumogallion staining for Al analytical measurements and Al tisular localization respectively. In the Lumbar Spinal Cord, Al median content was higher in both the Adjuvant-only and Vaccine group (p = .001) compared with the Control group. Animals of the Adjuvant-only group showed the higher individual measurements in the Lumbar Spinal Cord (14.36 μg/g and 7.83 μg/g). In the parietal lobe, Al median content tended to be higher in the Adjuvant-only group compared with Control group (p = .074). Except for three replicates of the Adjuvant-only group, Al content was always below 1 μg/g. In the Lumbar Spinal Cord, lumogallion-reactive Al deposits were more abundant in the gray matter than in the white matter in both Vaccine (p = .034) and Adjuvant-only groups (p = .017) and Al deposits were mostly associated with glial-like cells (p = .042). In the parietal lobe, few Al deposits, which were sometimes related to blood vessels, were found. In sheep, Al-hydroxide adjuvants inoculated in the subcutaneous tissue selectively accumulate in the Lumbar Spinal Cord.
Edmund Przegaliński - One of the best experts on this subject based on the ideXlab platform.
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The effect of p-chloroamphetamine and p-chlorophenylalanine on the level of thyrotropin-releasing hormone and its receptors in some brain structures and Lumbar Spinal Cord of the rat.
Neuropeptides, 1992Co-Authors: Edmund Przegaliński, L. Jaworska, K. GołembiowskaAbstract:Abstract The concentration of thyrotropin-releasing hormone (TRH) and the density and affinity of TRH receptors were examined in the ventral and dorsal Lumbar Spinal Cord, nucleus accumbens and striatum of rats with the 5-hydroxytryptamine (5-HT) nerve terminal destroyed with p-chloroamphetamine (PCA), or in animals treated with the inhibitor of 5-HT synthesis p-chlorophenylalanine (PCPA). PCA (2 × 10 mg/kg i.p., 9 and 8 d before killing) and PCPA (3 × 300 mg/kg i.p., 72, 48 and 24 h before killing)—either of them dramatically diminishing the 5-HT and 5-HIAA concentrations in all the examined structures—reduced the TRH level and increased the density of TRH receptors in the ventral Lumbar Spinal Cord. PCPA also reduced the TRH content in the nucleus accumbens. The PCA-induced reduction in the TRH level and increase in the density of TRH receptors in the ventral Lumbar Spinal Cord were significantly attenuated by citalopram (2 × 20 mg/kg i.p., 30 min before PCA), a selective inhibitor of 5-HT uptake. Our results constitute a further proof that coexistence of TRH and 5-HT takes place in the ventral Lumbar Spinal Cord and then indicate that other form(s) of relationship between 5-HT and TRH may exist in some parts of the central nervous system. They also suggest that an up-regulation of TRH receptors occurs in the Spinal Cord as a result of TRH depletion.
