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Celso Moura Rebello - One of the best experts on this subject based on the ideXlab platform.
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Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator’s Training
PLOS ONE, 2016Co-Authors: Cristiane Do Prado, Luciana Branco Haddad, Luciana Assis Pires Andrade Vale, Renata Suman Mascaretti, Ruth Guinsburg, Maria Fernanda Branco De Almeida, Celso Moura RebelloAbstract:Aim To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained Lung Inflation. Methods A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained Lung Inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants’ education and training. Results A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator’s ability to maintain the target pressure over the 10 seconds of sustained Lung Inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained Lung Inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. Conclusion The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator’s experience, and increased the ease of performing the sustained Lung Inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.
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manual ventilation and sustained Lung Inflation in an experimental model influence of equipment type and operator s training
PLOS ONE, 2016Co-Authors: Cristiane Do Prado, Luciana Branco Haddad, Renata Suman Mascaretti, Ruth Guinsburg, Maria Fernanda Branco De Almeida, Luciana Assis Vale, Celso Moura RebelloAbstract:Aim To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained Lung Inflation. Methods A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained Lung Inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants’ education and training. Results A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator’s ability to maintain the target pressure over the 10 seconds of sustained Lung Inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained Lung Inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. Conclusion The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator’s experience, and increased the ease of performing the sustained Lung Inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.
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Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator’s Training
PloS one, 2016Co-Authors: Cristiane Do Prado, Luciana Branco Haddad, Luciana Assis Pires Andrade Vale, Renata Suman Mascaretti, Ruth Guinsburg, Maria Fernanda Branco De Almeida, Celso Moura RebelloAbstract:To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained Lung Inflation. A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained Lung Inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants' education and training. A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator's ability to maintain the target pressure over the 10 seconds of sustained Lung Inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained Lung Inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator's experience, and increased the ease of performing the sustained Lung Inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.
Robert H. Brown - One of the best experts on this subject based on the ideXlab platform.
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effects of Lung Inflation on airway heterogeneity during histaminergic bronchoconstriction
Journal of Applied Physiology, 2013Co-Authors: David W Kaczka, Wayne Mitzner, Robert H. BrownAbstract:Lung Inflation has been shown to dilate airways by altering the mechanical equilibrium between opposing airway and parenchymal forces. However, it is not known how heterogeneously such dilation occ...
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Mechanisms of limited airway dimension with Lung Inflation.
Pulmonary pharmacology & therapeutics, 2006Co-Authors: Robert H. BrownAbstract:Airways distend with each inspiration, while a sigh or deep inspiration (DI) leads to a significant or a maximum distension of the airways. Distension of the airways is thought to play an important role in maintaining airway patency. Limited distension of the airways with Lung Inflation may be a major factor in certain Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). High resolution computed tomography (HRCT) has gained wide acceptance as a diagnostic and investigational radiological tool for the evaluation of airway function. HRCT has been used to measure dynamic changes in airway caliber in vivo that are not detectable by conventional global Lung measurements such as airway and Lung resistance. HRCT is uniquely capable of imaging and quantifying airway size at different Lung volumes. The current paper reviews the use of HRCT to examine the role of Lung Inflation on airway distension in animal models, and discusses potential mechanisms for limited distension of the airways with Lung Inflation in individuals with asthma and COPD.
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airways hyperresponsiveness and the effects of Lung Inflation
International Archives of Allergy and Immunology, 2001Co-Authors: Nicola Scichilone, Solbert Permutt, Robert H. Brown, George Pyrgos, Trigsevgeni Kapsali, Christina Anderlind, Alkis TogiasAbstract:Lung Inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial
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Airways Hyperresponsiveness and the Effects of Lung Inflation
International archives of allergy and immunology, 2001Co-Authors: Nicola Scichilone, Solbert Permutt, Robert H. Brown, George Pyrgos, Trigsevgeni Kapsali, Christina Anderlind, Alkis TogiasAbstract:Lung Inflation has a beneficial effect on the airways of healthy subjects. It acts as a bronchoprotector, that is to prevent bronchoconstriction, and as a bronchodilator, in that it reverses bronchial obstruction. The bronchoprotective effect of deep inspiration is more potent than the bronchodilatory one, and the two phenomena appear to advocate different mechanisms. Asthmatics and rhinitics with airways hyperresponsiveness show an impairment in bronchoprotection induced by deep breaths, whereas the bronchodilatory effect, although reduced, is still effective. The lack of the bronchoprotective effect of deep inspiration may contribute to the development of airways hyperresponsiveness. The mechanisms through which Lung Inflation exerts its beneficial role in healthy subjects, and the factors impairing such an effect in those with airways hyperresponsiveness, are currently under investigation.
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interaction between airway edema and Lung Inflation on responsiveness of individual airways in vivo
Journal of Applied Physiology, 1997Co-Authors: Robert H. Brown, Wayne Mitzner, Elizabeth M WagnerAbstract:Brown, Robert H., Wayne Mitzner, and Elizabeth M. Wagner.Interaction between airway edema and Lung Inflation on responsiveness of individual airways in vivo. J. Appl. Physiol. 83(2): 366–370, 1997....
Cristiane Do Prado - One of the best experts on this subject based on the ideXlab platform.
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Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator’s Training
PLOS ONE, 2016Co-Authors: Cristiane Do Prado, Luciana Branco Haddad, Luciana Assis Pires Andrade Vale, Renata Suman Mascaretti, Ruth Guinsburg, Maria Fernanda Branco De Almeida, Celso Moura RebelloAbstract:Aim To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained Lung Inflation. Methods A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained Lung Inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants’ education and training. Results A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator’s ability to maintain the target pressure over the 10 seconds of sustained Lung Inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained Lung Inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. Conclusion The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator’s experience, and increased the ease of performing the sustained Lung Inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.
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manual ventilation and sustained Lung Inflation in an experimental model influence of equipment type and operator s training
PLOS ONE, 2016Co-Authors: Cristiane Do Prado, Luciana Branco Haddad, Renata Suman Mascaretti, Ruth Guinsburg, Maria Fernanda Branco De Almeida, Luciana Assis Vale, Celso Moura RebelloAbstract:Aim To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained Lung Inflation. Methods A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained Lung Inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants’ education and training. Results A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator’s ability to maintain the target pressure over the 10 seconds of sustained Lung Inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained Lung Inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. Conclusion The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator’s experience, and increased the ease of performing the sustained Lung Inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.
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Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator’s Training
PloS one, 2016Co-Authors: Cristiane Do Prado, Luciana Branco Haddad, Luciana Assis Pires Andrade Vale, Renata Suman Mascaretti, Ruth Guinsburg, Maria Fernanda Branco De Almeida, Celso Moura RebelloAbstract:To compare the influence of devices for manual ventilation and individual experience on the applied respiratory mechanics and sustained Lung Inflation. A total of 114 instructors and non-instructors from the Neonatal Resuscitation Program of the Brazilian Society of Pediatrics participated in this study. Participants ventilated an intubated manikin. To evaluate respiratory mechanics and sustained Lung Inflation parameters, a direct comparison was made between the self-inflating bag and the T-shaped resuscitator (T-piece), followed by an analysis of the effectiveness of the equipment according to the participants' education and training. A difference between equipment types was observed for the tidal volume, with a median (interquartile range) of 28.5 mL (12.6) for the self-inflating bag and 20.1 mL (8.4) for the T-piece in the instructor group and 31.6 mL (14) for the self-inflating bag and 22.3 mL (8.8) for the T-piece in the non-instructor group. Higher inspiratory time values were observed with the T-piece in both groups of professionals, with no significant difference between them. The operator's ability to maintain the target pressure over the 10 seconds of sustained Lung Inflation was evaluated using the area under the pressure-time curve and was 1.7-fold higher with the use of the T-piece. Inspiratory pressure and mean airway pressure applied during sustained Lung Inflation were greater with the self-inflating bag, as evaluated between the beginning and the end of the procedure. The T-piece resulted in lower tidal volume and higher inspiratory time values, irrespective of the operator's experience, and increased the ease of performing the sustained Lung Inflation maneuver, as demonstrated by the maintenance of target pressure for the desired period and a higher mean airway pressure than that obtained using the self-inflating bag.
Phyllis M Gootman - One of the best experts on this subject based on the ideXlab platform.
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Emergence of Lung-Inflation-related sympathetic nerve activity in spinal cord transected neonatal swine.
Brain research, 1997Co-Authors: Anthony L. Sica, Bruce W. Hundley, David A. Ruggiero, Phyllis M GootmanAbstract:Sympathetic (SYMP) nerve activity in spinal intact neonatal swine is comprised of prominent bursts reflecting modulation by supraspinal structures involved in shaping central respiratory and baroreceptor activity. After spinal cord transection (SCT), we found no evidence of such modulation. SYMP activity was now related to the ventilatory cycle, exhibiting bursts only during Lung Inflation. Such activity suggests the emergence of latent spinal circuits which may have the capacity to regulate cardiovascular activity.
Jack L. Feldman - One of the best experts on this subject based on the ideXlab platform.
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Phasic Lung Inflation Shortens Inspiration and Respiratory Period in the Lung-Attached Neonate Rat Brain Stem Spinal Cord
Journal of neurophysiology, 2000Co-Authors: Nicholas M. Mellen, Jack L. FeldmanAbstract:In intact mammals, Lung Inflation during inspiration terminates inspiration (Breuer-Hering inspiratory reflex, BHI) and the presence of Lung afferents increases respiratory frequency. To test whether these responses could be obtained in vitro, a neonate rat brain stem/spinal cord preparation retaining the Lungs and their vagal innervation was used. It was found that 1) the BHI could be replicated in vitro, 2) phasic Lung Inflation during inspiration caused increased respiratory frequency with declining efficacy as Inflation delay increased, and 3) increased respiratory frequency did not require inspiratory shortening.
