Lymphatic Disease

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 19305 Experts worldwide ranked by ideXlab platform

Dinnen P. - One of the best experts on this subject based on the ideXlab platform.

Caroline Cheng - One of the best experts on this subject based on the ideXlab platform.

  • Lymphatic vascular regeneration the next step in tissue engineering
    Tissue Engineering Part B-reviews, 2015
    Co-Authors: Eline Huethorst, Merle M Krebber, Joost O Fledderus, Hendrik Gremmels, Jiayi Pei, Marianne C Verhaar, Caroline Cheng
    Abstract:

    The Lymphatic system plays a crucial role in interstitial fluid drainage, lipid absorption, and immunological defense. Lymphatic dysfunction results in lymphedema, fluid accumulation, and swelling of soft tissues, as well as a potentially impaired immune response. Lymphedema significantly reduces quality of life of patients on a physical, mental, social, and economic basis. Current therapeutic approaches in treatment of Lymphatic Disease are limited. Over the last decades, great progress has been made in the development of therapeutic strategies to enhance vascular regeneration. These solutions to treat vascular Disease may also be applicable in the treatment of Lymphatic Diseases. Comparison of the organogenic process and biological organization of the vascular and Lymphatic systems and studies in the regulatory mechanisms involved in lymphangiogenesis and angiogenesis show many common features. In this study, we address the similarities between both transport systems, and focus in depth on the biology of Lymphatic development. Based on the current advances in vascular regeneration, we propose different strategies for Lymphatic tissue engineering that may be used for treatment of primary and secondary lymphedema.

Stanley G Rockson - One of the best experts on this subject based on the ideXlab platform.

  • establishing standards for centers of excellence for the diagnosis and treatment of Lymphatic Disease
    Lymphatic Research and Biology, 2021
    Co-Authors: David W Chang, Stanley G Rockson, Joseph Dayan, Phyllis Fried, Ketan M Patel, William Repicci, Dhruv Singhal, Melissa B Aldrich
    Abstract:

    Background: Lymphatic Disease patients make up a significant proportion of the US and world populations. Due to inadequate medical school training and underestimation of the impact of Lymphatic circulation, Lymphatic Disease patients often have difficulty finding competent diagnosis and care. Methods and Results: The Lymphatic Education & Research Network has initiated a Centers of Excellence program to designate institutions that provide services for Lymphatic Disease patients. Committees of experts drafted standards for five types of Centers of Excellence. Conclusions: The Centers of Excellence program is now launched, and the description of the formation process herein could provide other organizations guidance for similar ventures.

  • comorbidity and Lymphatic Disease the Lymphatic continuum re examined
    Lymphatic Research and Biology, 2021
    Co-Authors: Stanley G Rockson
    Abstract:

    It has now been ∼20 years since the original Lymphatic Continuum conference was convened, and this continuum has transitioned from a compelling concept to a reality. The explosive growth in our com...

  • new developments in clinical aspects of Lymphatic Disease
    Journal of Clinical Investigation, 2014
    Co-Authors: P S Mortimer, Stanley G Rockson
    Abstract:

    The Lymphatic system is fundamentally important to cardiovascular Disease, infection and immunity, cancer, and probably obesity--the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of Lymphatic genes and molecular mechanisms has demonstrated that Lymphatic dysfunction should no longer be considered a passive bystander in Disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the Lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn's Disease, obesity, cancer, and cancer-related lymphedema are highlighted.

  • causes and consequences of Lymphatic Disease
    Annals of the New York Academy of Sciences, 2010
    Co-Authors: Stanley G Rockson
    Abstract:

    The visceral manifestations of Lymphatic disorders (lymphangiomatosis and lymphangiectasia) are particularly severe. Any pathology of the Lymphatic vasculature, whether superficial or internal, regional, or systemic, is predominated by the appearance of lymphedema, the characteristic form of tissue edema that occurs when Lymphatic dysfunction supervenes. Disease manifestations may include dysregulation of body fluid homeostasis, immune traffic impairment, and disturbances of lipid and protein reabsorption from the gut lumen. The appearance of Lymphatic edema invokes complex biological alterations. Many of these changes seem to relate uniquely to chronic Lymphatic edema, including a profound stimulus to collagen and adipose deposition. Despite the recent advances in our understanding of these disorders, substantial knowledge gaps remain; these gaps inhibit our ability to accurately identify, categorize, treat, and prevent these Diseases. Future diagnostic, therapeutic, and reproductive decisions for affected individuals require an accurate knowledge of the clinical and laboratory presentation, mode of inheritance, treatment response, outcomes, and prognosis.

  • the clinical spectrum of Lymphatic Disease
    Annals of the New York Academy of Sciences, 2008
    Co-Authors: Kavita Radhakrishnan, Stanley G Rockson
    Abstract:

    Lymphatic Disease is quite prevalent, and often not well clinically characterized. Beyond lymphedema, there is a broad array of human Disease that directly or indirectly alters Lymphatic structure and function. The symptomatic and objective presentation of these patients can be quite diverse. In this review, we have attempted to provide a systematic overview of the subjective and objective spectrum of Lymphatic Disease, with consideration of all of the categories of Disease that primarily or secondarily impair the functional integrity of the Lymphatic system. Lymphedema is discussed, along with chromosomal disorders, lymphangioma, infectious Diseases, lymphangioleiomyomatosis, lipedema, heritable genetic disorders, complex vascular malformations, protein-losing enteropathy, and intestinal lymphangiectasia.

Kevin L Winthrop - One of the best experts on this subject based on the ideXlab platform.

  • the clinical management and outcome of nail salon acquired mycobacterium fortuitum skin infection
    Clinical Infectious Diseases, 2004
    Co-Authors: Kevin L Winthrop, Kim Albridge, David South, Peggy Albrecht, Marcy Abrams, Michael C Samuel, Wendy Leonard, Joanna Wagner, Duc J Vugia
    Abstract:

    Nontuberculous mycobacterial infections are becoming more common. Recently, Mycobacterium fortuitum and other rapidly growing mycobacteria have been found to cause severe skin and soft-tissue infections in association with nail salon whirlpool footbaths. We recently investigated a large outbreak of M. fortuitum furunculosis among women who received pedicures at a single nail salon. To better define the clinical course of such infections, we collected clinical details from physicians who were treating outbreak patients. We constructed multivariable linear models to evaluate the effect of antibiotic treatment on Disease duration. Sixty-one patients were included in the investigation. The mean Disease duration was 170 days (range, 41-336 days). Forty-eight persons received antibiotic therapy for a median period of 4 months (range, 1-6 months), and 13 persons were untreated. Isolates were most susceptible to ciprofloxacin and minocycline. Early administration of therapy was associated with shorter duration of Disease only in persons with multiple boils (P<.01). One untreated, healthy patient had Lymphatic Disease dissemination.

Parsi K. - One of the best experts on this subject based on the ideXlab platform.