The Experts below are selected from a list of 264 Experts worldwide ranked by ideXlab platform
Lance L. Munn - One of the best experts on this subject based on the ideXlab platform.
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the Lymphatic System in disease processes and cancer progression
Annual Review of Biomedical Engineering, 2016Co-Authors: Timothy P. Padera, Eelco F J Meijer, Lance L. MunnAbstract:Advances in our understanding of the structure and function of the Lymphatic System have made it possible to identify its role in a variety of disease processes. Because it is involved not only in fluid homeostasis but also in immune cell trafficking, the Lymphatic System can mediate and ultimately alter immune responses. Our rapidly increasing knowledge of the molecular control of the Lymphatic System will inevitably lead to new and effective therapies for patients with Lymphatic dysfunction. In this review, we discuss the molecular and physiological control of Lymphatic vessel function and explore how the Lymphatic System contributes to many disease processes, including cancer and lymphedema.
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Imaging the Lymphatic System
Microvascular research, 2014Co-Authors: Lance L. Munn, Timothy P. PaderaAbstract:Visualization of the Lymphatic System is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating Lymphatic structures so they can be spared during surgical procedures. Imaging Lymphatic anatomy and function also plays an important role in experimental studies of Lymphatic development and function, where spatial resolution and accessibility are better. Here, we review technologies for visualizing and imaging the Lymphatic System for clinical applications. We then describe the use of Lymphatic imaging in experimental Systems as well as some of the emerging technologies for improving these methodologies.
Timothy P. Padera - One of the best experts on this subject based on the ideXlab platform.
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the Lymphatic System in disease processes and cancer progression
Annual Review of Biomedical Engineering, 2016Co-Authors: Timothy P. Padera, Eelco F J Meijer, Lance L. MunnAbstract:Advances in our understanding of the structure and function of the Lymphatic System have made it possible to identify its role in a variety of disease processes. Because it is involved not only in fluid homeostasis but also in immune cell trafficking, the Lymphatic System can mediate and ultimately alter immune responses. Our rapidly increasing knowledge of the molecular control of the Lymphatic System will inevitably lead to new and effective therapies for patients with Lymphatic dysfunction. In this review, we discuss the molecular and physiological control of Lymphatic vessel function and explore how the Lymphatic System contributes to many disease processes, including cancer and lymphedema.
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Imaging the Lymphatic System
Microvascular research, 2014Co-Authors: Lance L. Munn, Timothy P. PaderaAbstract:Visualization of the Lymphatic System is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating Lymphatic structures so they can be spared during surgical procedures. Imaging Lymphatic anatomy and function also plays an important role in experimental studies of Lymphatic development and function, where spatial resolution and accessibility are better. Here, we review technologies for visualizing and imaging the Lymphatic System for clinical applications. We then describe the use of Lymphatic imaging in experimental Systems as well as some of the emerging technologies for improving these methodologies.
Hiroo Suami - One of the best experts on this subject based on the ideXlab platform.
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Anatomy of the Lymphatic System and Its Structural Disorders in Lymphoedema
Lymphedema, 2017Co-Authors: Hiroo Suami, Seiji KatoAbstract:The anatomy of the Lymphatic System is the least studied field in gross anatomical research. Our current knowledge about the normal anatomy of the Lymphatic System still largely depends on dissection studies performed using the mercury injection technique in cadavers over 100 years ago. In addition, there has been insufficient investigation from the anatomical perspective of the pathophysiology of lymphoedema that develops congenitally or after cancer treatment. The recent development of a new cadaver dissection technique by the authors and use of indocyanine green fluorescence lymphography in the clinical setting have enabled us to visualise the anatomical structure of the Lymphatic System and provide further understanding about normal Lymphatic anatomy and the structural alterations that occur in lymphoedema.
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Lymphosome concept: Anatomical study of the Lymphatic System
Journal of surgical oncology, 2016Co-Authors: Hiroo SuamiAbstract:The gross anatomical study of the Lymphatic System in humans and animals has been suspended for almost 100 years. This article introduces the author's technique for investigating the Lymphatic System using the concept of the lymphosome. In revisiting the anatomical study of the Lymphatic System, our updated knowledge can potentially be utilized either to reassure surgeons about their current procedures in the surgical management of cancers and lymphedema or assist them to refine them. J. Surg. Oncol. 2017;115:13-17. © 2016 Wiley Periodicals, Inc.
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Demonstrating the Lymphatic System in rats with microinjection.
Anatomical record (Hoboken N.J. : 2007), 2011Co-Authors: Hiroo Suami, David W. Chang, Kumiko Matsumoto, Yoshihiro KimataAbstract:The Lymphatic System plays an important role in human health and disease. In addition to a role in the immune response, the Lymphatics can serve as a pathway for cancer metastasis. Visualizing the Lymphatic System has been a difficult part of anatomic dissection studies. Anatomists have attempted to map the Lymphatic System using various methods and materials; vivisection of dogs, injection of mercury into the skin and Lymphatic vessel in cadavers, and injection of dye indirectly into the skin of dead and living specimens. In this study, we introduce a method of using a mixture of acrylic blue dye and hydrogen peroxide to visualize the Lymphatic System in rats. The Lymphatic vessels were cannulated with micropipettes, and radio-opaque orange lead oxide was selectively injected. The Lymphatic System became visible from the dorsal side of the hand and foot, and distal region of the tail to their termination at the left and right subclavicular veins via lymph nodes. Cisterna chyli in the abdominal cavity and thoracic duct ran along with the aorta. The advantage of this technique is that lymph nodes as well as Lymphatic channels could be recorded not only photographically but also radiographically. This microinjection technique is useful for demonstrating the Lymphatic System in rats and may provide further information that will help in cancer metastasis research.
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a new radiographic cadaver injection technique for investigating the Lymphatic System
Plastic and Reconstructive Surgery, 2005Co-Authors: Hiroo Suami, Wei-ren Pan, Ian G TaylorAbstract:Studies of the gross anatomy of the Lymphatic System are few and far between when compared with those of other vascular Systems. Our knowledge of the anatomy of the Lymphatic System is so limited that it seems vastly inadequate in explaining the clinical manifestations caused by its disorder. This study has developed an effective method to identify the Lymphatics using hydrogen peroxide, to demonstrate the Lymphatic vessels radiographically using a lead oxide suspension, and to dissect them out in adult human cadavers.
M A Swartz - One of the best experts on this subject based on the ideXlab platform.
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The physiology of the Lymphatic System.
Advanced drug delivery reviews, 2001Co-Authors: M A SwartzAbstract:This paper presents an overview of the anatomy, physiology, and biology of the Lymphatic System specifically relevant to Lymphatic drug delivery. We will briefly review the classic fluid and solute transport literature, and also examine the current research in Lymphatic endothelial cell biology and tumor metastasis in the Lymphatics because of the increasing potential for targeted delivery of immunomodulators, chemotherapeutics, and genetic material to specific lymph nodes (Refs. [1-7]).
Domenico Ribatti - One of the best experts on this subject based on the ideXlab platform.
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Scholars and scientists in the history of the Lymphatic System
Journal of anatomy, 2017Co-Authors: Gianfranco Natale, Guido Bocci, Domenico RibattiAbstract:The discovery of the Lymphatic System has a long and fascinating history. The interest in anatomy and physiology of this System paralleled that of the blood cardiocirculatory System and has been maybe obscured by the latter. Paradoxically, if the closed blood System appeared open in Galen's anatomy and physiology, and took a very long time to be correctly described in terms of pulmonary and general circulation by ibn Al-Nafis/Michael Servetus/Realdo Colombo and William Harvey, respectively, the open Lymphatic System was incorrectly described as a closed circuit connected with arteries and veins. In ancient times only macroscopic components of the Lymphatic System have been described, although misinterpreted, including lymph nodes and lacteals, the latter being easily identified because of their milk-like content. For about 15 centuries the dogmatic acceptance of Galen's notions did not allow a significant progress in medicine. After Vesalius' revolution in anatomical studies, new knowledge was accumulated, and the 17th century was the golden age for the investigation of the Lymphatic System with several discoveries: gut lacteals (Gaspare Aselli), cloacal bursa (Hieronimus Fabricius of Acquapendente), reservoir of the chyle (Jean Pecquet), extra-intestinal Lymphatic vessels (Thomas Bartholin and Olaus Rudbeck dispute), hepatic lymph circulation (Francis Glisson). In the Enlightenment century Frederik Ruysch described the function of Lymphatic valves, and Paolo Mascagni provided a magnificent iconography of the Lymphatic network in humans. In recent times, Leonetto Comparini realized three-dimensional reconstructions of the liver Lymphatic vessels, and Kari Alitalo discovered the Lymphatic growth factor/receptor System. Far from a complete understanding of its anatomy and function, the Lymphatic System still needs to be profoundly examined.
