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Keertan Dheda - One of the best experts on this subject based on the ideXlab platform.
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hiv associated Lymphocytic Interstitial Pneumonia a clinical histological and radiographic study from an hiv endemic resource poor setting
BMC Pulmonary Medicine, 2015Co-Authors: Richard N Van Zylsmit, Jashira Naidoo, Helen Wainwright, Quanita Saidhartley, Malika Davids, Hillel Goodman, Sean Rogers, Keertan DhedaAbstract:There is a paucity of clinical and histopathological data about HIV-associated Lymphocytic Interstitial pneumonitis (LIP) in adults from HIV endemic settings. The role of Ebstein-Barr virus (EBV) in the pathogenesis remains unclear. We reviewed the clinical, radiographic and histopathological features of suspected adult LIP cases at the Groote Schuur Hospital, Cape Town South Africa, over a 6 year period. Archived tissue sections were stained for CD3, CD4, CD8, CD20 and LMP-1 antigen (an EBV marker). 42 cases of suspected LIP(100% HIV-infected) were identified. 75% of patients were empirically treated for TB prior to being referred to the chest service for further investigation. Tissue samples were obtained using trans-bronchial biopsy. 13/42 were classified as definite LIP (Lymphocytic infiltrate with no alternative diagnosis), 19/42 probable LIP (Lymphocytic infiltrate but evidence of anthracosis or fibrosis) and 10 as non-LIP (alternative histological diagnosis). Those with definite LIP were predominantly young females (85%) with a median CD4 count of 194 (IQR 119–359). Clinical or radiological features had poor predictive value for LIP. Histologically, the Lymphocytic infiltrate comprised mainly B cells and CD8 T cells. The frequency of positive EBV LMP-1 antigen staining was similar in definite and non- LIP patients [(2/13 (15%) vs. 3/10 (30%); p = 0.52]. In a HIV endemic setting adult HIV-associated LIP occurs predominantly in young women. The diagnosis can often be made on transbronchial biopsy and is characterized by a predominant CD8 T cell infiltrate. No association with EBV antigen was found.
Osamu Honda - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytic Interstitial Pneumonia follow up ct findings in 14 patients
Journal of Thoracic Imaging, 2000Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Masanori Akira, Osamu Honda, Noriyuki Tomiyama, Naoki Mihara, Seiki Hamada, T Kozuka, Mitsuhiro Koyama, Hironobu NakamuraAbstract:The aim of the present study was to assess the evolution of various computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia (LIP) with determination of potentially reversible or irreversible features. The study included 14 patients with biopsy-proved LIP who had serial thin-section CT examination 4 to 82 months (median 13 months) apart. Initial and follow-up CT scans were evaluated independently and then directly compared with each other by two observers. The main parenchymal abnormalities on the initial CT scan consisted of ground-glass attenuation (n = 14), thickening of interlobular septa (n = 13), centrilobular nodules (n = 12), cystic airspaces (n = 10), and airspace consolidation (n = 4). On follow-up CT, nine patients improved, one showed no change, and four showed increased extent of disease. With the exception of cysts, the parenchymal opacities were reversible. On follow-up CT, new cysts were seen in three patients; these developed mainly in areas with centrilobular nodules on initial CT. Honeycombing was seen on follow-up CT in four patients; in three patients it developed in areas of airspace consolidation and in one patient it developed in an area with ground-glass attenuation on initial CT. The majority of patients with LIP improved on follow-up. However, airspace consolidation may progress to honeycombing and centrilobular nodules may precede cystic formation.
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Lymphocytic Interstitial Pneumonia thin section ct findings in 22 patients
Radiology, 1999Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Heather A Pickford, Thomas E Hartman, Masanori Akira, Osamu Honda, Nestor L. Müller, Hironobu NakamuraAbstract:PURPOSE: To assess the thin-section computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia. MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24–83 years; mean age, 50 years) with biopsy-proved Lymphocytic Interstitial Pneumonia. The CT scans were obtained by using 1–3-mm collimation and reconstructed by using a high-spatial-frequency algorithm. RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening. CONCLUSION: Lymphocytic Interstitial Pneumonia is characterized by the...
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differential diagnosis of Lymphocytic Interstitial Pneumonia and malignant lymphoma on high resolution ct
American Journal of Roentgenology, 1999Co-Authors: Osamu Honda, Kazuya Ichikado, Takeshi Johkoh, Noriyuki Tomiyama, Munehiro Maeda, Naoki Mihara, Masahiro Higashi, Seiki Hamada, Hiroaki Naito, Shuji YamamotoAbstract:Lymphoproliferative disorders span a spectrum from inflammatory lesions to malignant neoplasms. The purpose of this study was to compare high-resolution CT findings of Lymphocytic Interstitial Pneumonia with those of malignant lymphoma of the chest.The study included 17 patients with Lymphocytic Interstitial Pneumonia and 44 patients with malignant lymphoma (35 with non-Hodgkin's lymphoma and nine with Hodgkin's disease). Without knowledge of the pathologic diagnosis, two chest radiologists evaluated the frequency and distribution of high-resolution CT findings in both groups of patients.Cysts were more common in patients with Lymphocytic Interstitial Pneumonia (14/17, 82%) than in patients with malignant lymphoma (1/44, 2%) (p < .0001). Air-space consolidation was more commonly seen in patients with malignant lymphoma (29/44, 66%) than in patients with Lymphocytic Interstitial Pneumonia (3/17, 18%) (p < .001). Large nodules (11-30 mm in diameter) were more common in patients with malignant lymphoma (41%)...
Takeshi Johkoh - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytic Interstitial Pneumonia follow up ct findings in 14 patients
Journal of Thoracic Imaging, 2000Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Masanori Akira, Osamu Honda, Noriyuki Tomiyama, Naoki Mihara, Seiki Hamada, T Kozuka, Mitsuhiro Koyama, Hironobu NakamuraAbstract:The aim of the present study was to assess the evolution of various computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia (LIP) with determination of potentially reversible or irreversible features. The study included 14 patients with biopsy-proved LIP who had serial thin-section CT examination 4 to 82 months (median 13 months) apart. Initial and follow-up CT scans were evaluated independently and then directly compared with each other by two observers. The main parenchymal abnormalities on the initial CT scan consisted of ground-glass attenuation (n = 14), thickening of interlobular septa (n = 13), centrilobular nodules (n = 12), cystic airspaces (n = 10), and airspace consolidation (n = 4). On follow-up CT, nine patients improved, one showed no change, and four showed increased extent of disease. With the exception of cysts, the parenchymal opacities were reversible. On follow-up CT, new cysts were seen in three patients; these developed mainly in areas with centrilobular nodules on initial CT. Honeycombing was seen on follow-up CT in four patients; in three patients it developed in areas of airspace consolidation and in one patient it developed in an area with ground-glass attenuation on initial CT. The majority of patients with LIP improved on follow-up. However, airspace consolidation may progress to honeycombing and centrilobular nodules may precede cystic formation.
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Lymphocytic Interstitial Pneumonia thin section ct findings in 22 patients
Radiology, 1999Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Heather A Pickford, Thomas E Hartman, Masanori Akira, Osamu Honda, Nestor L. Müller, Hironobu NakamuraAbstract:PURPOSE: To assess the thin-section computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia. MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24–83 years; mean age, 50 years) with biopsy-proved Lymphocytic Interstitial Pneumonia. The CT scans were obtained by using 1–3-mm collimation and reconstructed by using a high-spatial-frequency algorithm. RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening. CONCLUSION: Lymphocytic Interstitial Pneumonia is characterized by the...
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differential diagnosis of Lymphocytic Interstitial Pneumonia and malignant lymphoma on high resolution ct
American Journal of Roentgenology, 1999Co-Authors: Osamu Honda, Kazuya Ichikado, Takeshi Johkoh, Noriyuki Tomiyama, Munehiro Maeda, Naoki Mihara, Masahiro Higashi, Seiki Hamada, Hiroaki Naito, Shuji YamamotoAbstract:Lymphoproliferative disorders span a spectrum from inflammatory lesions to malignant neoplasms. The purpose of this study was to compare high-resolution CT findings of Lymphocytic Interstitial Pneumonia with those of malignant lymphoma of the chest.The study included 17 patients with Lymphocytic Interstitial Pneumonia and 44 patients with malignant lymphoma (35 with non-Hodgkin's lymphoma and nine with Hodgkin's disease). Without knowledge of the pathologic diagnosis, two chest radiologists evaluated the frequency and distribution of high-resolution CT findings in both groups of patients.Cysts were more common in patients with Lymphocytic Interstitial Pneumonia (14/17, 82%) than in patients with malignant lymphoma (1/44, 2%) (p < .0001). Air-space consolidation was more commonly seen in patients with malignant lymphoma (29/44, 66%) than in patients with Lymphocytic Interstitial Pneumonia (3/17, 18%) (p < .001). Large nodules (11-30 mm in diameter) were more common in patients with malignant lymphoma (41%)...
Kazuya Ichikado - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytic Interstitial Pneumonia follow up ct findings in 14 patients
Journal of Thoracic Imaging, 2000Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Masanori Akira, Osamu Honda, Noriyuki Tomiyama, Naoki Mihara, Seiki Hamada, T Kozuka, Mitsuhiro Koyama, Hironobu NakamuraAbstract:The aim of the present study was to assess the evolution of various computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia (LIP) with determination of potentially reversible or irreversible features. The study included 14 patients with biopsy-proved LIP who had serial thin-section CT examination 4 to 82 months (median 13 months) apart. Initial and follow-up CT scans were evaluated independently and then directly compared with each other by two observers. The main parenchymal abnormalities on the initial CT scan consisted of ground-glass attenuation (n = 14), thickening of interlobular septa (n = 13), centrilobular nodules (n = 12), cystic airspaces (n = 10), and airspace consolidation (n = 4). On follow-up CT, nine patients improved, one showed no change, and four showed increased extent of disease. With the exception of cysts, the parenchymal opacities were reversible. On follow-up CT, new cysts were seen in three patients; these developed mainly in areas with centrilobular nodules on initial CT. Honeycombing was seen on follow-up CT in four patients; in three patients it developed in areas of airspace consolidation and in one patient it developed in an area with ground-glass attenuation on initial CT. The majority of patients with LIP improved on follow-up. However, airspace consolidation may progress to honeycombing and centrilobular nodules may precede cystic formation.
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Lymphocytic Interstitial Pneumonia thin section ct findings in 22 patients
Radiology, 1999Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Heather A Pickford, Thomas E Hartman, Masanori Akira, Osamu Honda, Nestor L. Müller, Hironobu NakamuraAbstract:PURPOSE: To assess the thin-section computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia. MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24–83 years; mean age, 50 years) with biopsy-proved Lymphocytic Interstitial Pneumonia. The CT scans were obtained by using 1–3-mm collimation and reconstructed by using a high-spatial-frequency algorithm. RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening. CONCLUSION: Lymphocytic Interstitial Pneumonia is characterized by the...
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differential diagnosis of Lymphocytic Interstitial Pneumonia and malignant lymphoma on high resolution ct
American Journal of Roentgenology, 1999Co-Authors: Osamu Honda, Kazuya Ichikado, Takeshi Johkoh, Noriyuki Tomiyama, Munehiro Maeda, Naoki Mihara, Masahiro Higashi, Seiki Hamada, Hiroaki Naito, Shuji YamamotoAbstract:Lymphoproliferative disorders span a spectrum from inflammatory lesions to malignant neoplasms. The purpose of this study was to compare high-resolution CT findings of Lymphocytic Interstitial Pneumonia with those of malignant lymphoma of the chest.The study included 17 patients with Lymphocytic Interstitial Pneumonia and 44 patients with malignant lymphoma (35 with non-Hodgkin's lymphoma and nine with Hodgkin's disease). Without knowledge of the pathologic diagnosis, two chest radiologists evaluated the frequency and distribution of high-resolution CT findings in both groups of patients.Cysts were more common in patients with Lymphocytic Interstitial Pneumonia (14/17, 82%) than in patients with malignant lymphoma (1/44, 2%) (p < .0001). Air-space consolidation was more commonly seen in patients with malignant lymphoma (29/44, 66%) than in patients with Lymphocytic Interstitial Pneumonia (3/17, 18%) (p < .001). Large nodules (11-30 mm in diameter) were more common in patients with malignant lymphoma (41%)...
Nestor L. Müller - One of the best experts on this subject based on the ideXlab platform.
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Lymphocytic Interstitial Pneumonia thin section ct findings in 22 patients
Radiology, 1999Co-Authors: Takeshi Johkoh, Kazuya Ichikado, Heather A Pickford, Thomas E Hartman, Masanori Akira, Osamu Honda, Nestor L. Müller, Hironobu NakamuraAbstract:PURPOSE: To assess the thin-section computed tomographic (CT) findings of Lymphocytic Interstitial Pneumonia. MATERIALS AND METHODS: The study included 22 patients (five men, 17 women; age range, 24–83 years; mean age, 50 years) with biopsy-proved Lymphocytic Interstitial Pneumonia. The CT scans were obtained by using 1–3-mm collimation and reconstructed by using a high-spatial-frequency algorithm. RESULTS: The predominant abnormalities consisted of areas of ground-glass attenuation and poorly defined centrilobular nodules present in all 22 patients and subpleural small nodules seen in 19 patients. Other common findings included thickening of bronchovascular bundles (n = 19), interlobular septal thickening (n = 18), cystic airspaces (n = 15), and lymph node enlargement (n = 15). Less common findings included large nodules, emphysema, airspace consolidation, bronchiectasis, architectural distortion, honeycombing, and pleural thickening. CONCLUSION: Lymphocytic Interstitial Pneumonia is characterized by the...
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intrathoracic lymphoproliferative disorders in the immunocompromised patient ct findings
Radiology, 1995Co-Authors: S Carignan, C A Staples, Nestor L. MüllerAbstract:PURPOSE: To assess the computed tomographic (CT) findings of intrathoracic lymphoproliferative disorders in the immunocompromised patient. MATERIALS AND METHODS: The authors retrospectively reviewed CT scans of the chest in 18 consecutive patients with pathologically proved intrathoracic lymphoproliferative disorders. Twelve patients had the acquired immunodeficiency syndrome (AIDS), and six were receiving immunosuppressive therapy. Final diagnosis included AIDS-related diffuse lymphoid hyperplasia (n = 1), Lymphocytic Interstitial Pneumonia (LIP) (n = 3), posttransplantation lymphoproliferative disorders (PTLDs) (n = 4), and lymphoma (n = 10). RESULTS: Diffuse areas of ground-glass attenuation were found in the patient with lymphoid hyperplasia and the three patients with LIP. The four patients with PTLDs had multiple, well-circumscribed pulmonary nodules, and nodules in three of the four patients had a halo of ground-glass attenuation. Nine of the 10 patients with lymphoma had well-circumscribed nodules...
