The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform
Jörg Neumann - One of the best experts on this subject based on the ideXlab platform.
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Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography--electrospray ionization mass spectrometry.
Journal of analytical toxicology, 2001Co-Authors: Miriam Rittner, Fritz Pragst, Wolf-rainer Bork, Jörg NeumannAbstract:A screening method for 70 psychoactive drugs or drug metabolites in human serum by solid-phase extraction with subsequent high-performance liquid chromatography and electrospray ionization mass spectrometry was developed. Enhanced selectivity of detection was obtained by collision-induced dissociation using two different skimmer voltages for the individual scan. The mass spectra and the retention times of the compounds were incorporated into a self-generated spectra library for identification in screening experiments. The detection limits were found to be between 0.1 and 5 ng/mL serum for the majority of the compounds when measured in the selected ion mode. Because of the very small serum concentrations and the rather low extraction yield, Lysergide could not be detected in this way. It was demonstrated with 140 serum samples from alcohol-related traffic cases that this method is suitable for a routine screening in a forensic laboratory.
Hans H. Maurer - One of the best experts on this subject based on the ideXlab platform.
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Absorption, distribution, metabolism and excretion pharmacogenomics of drugs of abuse
Pharmacogenomics, 2011Co-Authors: Markus R. Meyer, Hans H. MaurerAbstract:Pharmacologic and toxic effects of xenobiotics, such as drugs of abuse, depend on the genotype and phenotype of an individual, and conversely on the isoenzymes involved in their metabolism and transport. The current knowledge of such isoenzymes of frequently abused therapeutics such as opioids (oxycodone, hydrocodone, methadone, fentanyl, buprenorphine, tramadol, heroin, morphine and codeine), anesthetics (γ-hydroxybutyric acid, propofol, ketamine and phencyclidine) and cognitive enhancers (methylphenidate and modafinil), and some important plant-derived hallucinogens (Lysergide, salvinorin A, psilocybin and psilocin), as well as of nicotine in humans are summarized in this article. The isoenzymes (e.g., cytochrome P450, glucuronyltransferases, esterases and reductases) involved in the metabolism of drugs and some pharmacokinetic data are discussed. The relevance of such data is discussed for predicting possible interactions with other xenobiotics, understanding pharmacokinetic behavior and pharmacogenomi...
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Liquid chromatography-mass spectrometry in forensic and clinical toxicology.
Journal of chromatography. B Biomedical sciences and applications, 1998Co-Authors: Hans H. MaurerAbstract:This paper reviews liquid chromatographic-mass spectrometric (LC-MS) procedures for the identification and/or quantification of drugs of abuse, therapeutic drugs, poisons and/or their metabolites in biosamples (whole blood, plasma, serum, urine, cerebrospinal fluid, vitreous humor, liver or hair) of humans or animals (cattle, dog, horse, mouse, pig or rat). Papers published from 1995 to early 1997, which are relevant to clinical toxicology, forensic toxicology, doping control or drug metabolism and pharmacokinetics, were taken into consideration. They cover the following analytes: amphetamines, cocaine, Lysergide (LSD), opiates, anabolics, antihypertensives, benzodiazepines, cardiac glycosides, corticosteroids, immunosuppressants, neuroleptics, non-steroidal anti-inflammatory drugs (NSAID), opioids, quaternary amines, xanthins, biogenic poisons such as aconitines, aflatoxins, amanitins and nicotine, and pesticides. LC-MS interface types, mass spectral detection modes, sample preparation procedures and chromatographic systems applied in the reviewed papers are discussed. Basic information about the biosample assayed, work-up, LC column, mobile phase, interface type, mass spectral detection mode, and validation data of each procedure is summarized in tables. Examples of typical LC-MS applications are presented.
Miriam Rittner - One of the best experts on this subject based on the ideXlab platform.
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Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography--electrospray ionization mass spectrometry.
Journal of analytical toxicology, 2001Co-Authors: Miriam Rittner, Fritz Pragst, Wolf-rainer Bork, Jörg NeumannAbstract:A screening method for 70 psychoactive drugs or drug metabolites in human serum by solid-phase extraction with subsequent high-performance liquid chromatography and electrospray ionization mass spectrometry was developed. Enhanced selectivity of detection was obtained by collision-induced dissociation using two different skimmer voltages for the individual scan. The mass spectra and the retention times of the compounds were incorporated into a self-generated spectra library for identification in screening experiments. The detection limits were found to be between 0.1 and 5 ng/mL serum for the majority of the compounds when measured in the selected ion mode. Because of the very small serum concentrations and the rather low extraction yield, Lysergide could not be detected in this way. It was demonstrated with 140 serum samples from alcohol-related traffic cases that this method is suitable for a routine screening in a forensic laboratory.
Ricardo Gobato - One of the best experts on this subject based on the ideXlab platform.
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ANovel Approach to Reduce Toxicities and to Improve Bioavailabilities of DNA/RNAof Human Cancer Cells–Containing Cocaine (Coke), Lysergide (Lysergic AcidDiethyl Amide or LSD), Δ9–Tetrahydrocannabinol (THC) [(–)–trans–Δ⁹–Tetrahydrocannabinol],Theobrom
viXra, 2018Co-Authors: Alireza Heidari, Ricardo GobatoAbstract:The aim of the present study was to reduce toxicities and to improve bioavailabilities of DNA/RNA of human cancer cells–containing Cocaine (Coke), Lysergide (Lysergic Acid Diethyl Amide or LSD), Δ9–Tetrahydrocannabinol (THC) [(–)–trans–Δ⁹–Tetrahydrocannabinol], Theobromine (Xantheose), Caffeine, Aspartame (APM) (NutraSweet) and Zidovudine (ZDV) [Azidothymidine (AZT)] as anti–cancer Nano drugs by coassembly of dual anti–cancer Nano drugs to inhibit DNA/RNA of human cancer cells drug resistance.
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anovel approach to reduce toxicities and to improve bioavailabilities of dna rnaof human cancer cells containing cocaine coke Lysergide lysergic aciddiethyl amide or lsd δ9 tetrahydrocannabinol thc trans δ tetrahydrocannabinol theobromine
viXra, 2018Co-Authors: Alireza Heidari, Ricardo GobatoAbstract:The aim of the present study was to reduce toxicities and to improve bioavailabilities of DNA/RNA of human cancer cells–containing Cocaine (Coke), Lysergide (Lysergic Acid Diethyl Amide or LSD), Δ9–Tetrahydrocannabinol (THC) [(–)–trans–Δ⁹–Tetrahydrocannabinol], Theobromine (Xantheose), Caffeine, Aspartame (APM) (NutraSweet) and Zidovudine (ZDV) [Azidothymidine (AZT)] as anti–cancer Nano drugs by coassembly of dual anti–cancer Nano drugs to inhibit DNA/RNA of human cancer cells drug resistance.
Wolf-rainer Bork - One of the best experts on this subject based on the ideXlab platform.
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Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography--electrospray ionization mass spectrometry.
Journal of analytical toxicology, 2001Co-Authors: Miriam Rittner, Fritz Pragst, Wolf-rainer Bork, Jörg NeumannAbstract:A screening method for 70 psychoactive drugs or drug metabolites in human serum by solid-phase extraction with subsequent high-performance liquid chromatography and electrospray ionization mass spectrometry was developed. Enhanced selectivity of detection was obtained by collision-induced dissociation using two different skimmer voltages for the individual scan. The mass spectra and the retention times of the compounds were incorporated into a self-generated spectra library for identification in screening experiments. The detection limits were found to be between 0.1 and 5 ng/mL serum for the majority of the compounds when measured in the selected ion mode. Because of the very small serum concentrations and the rather low extraction yield, Lysergide could not be detected in this way. It was demonstrated with 140 serum samples from alcohol-related traffic cases that this method is suitable for a routine screening in a forensic laboratory.
