Macaca mulatta

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Katherine P Weld - One of the best experts on this subject based on the ideXlab platform.

Peter Nürnberg - One of the best experts on this subject based on the ideXlab platform.

Scott E. Hemby - One of the best experts on this subject based on the ideXlab platform.

  • De novo protein sequence analysis of Macaca mulatta
    BMC genomics, 2007
    Co-Authors: Nilesh S Tannu, Scott E. Hemby
    Abstract:

    Background Macaca mulatta is one of the most utilized non-human primate species in biomedical research offering unique behavioral, neuroanatomical, and neurobiochemcial similarities to humans. This makes it a unique organism to model various diseases such as psychiatric and neurodegenerative illnesses while also providing insight into the complexities of the primate brain. A major obstacle in utilizing rhesus monkey models for human disease is the paucity of protein annotations for this species (~42,000 protein annotations) compared to 330,210 protein annotations for humans. The lack of available information limits the use of rhesus monkey for proteomic scale studies which rely heavily on database searches for protein identification. While characterization of proteins of interest from Macaca mulatta using the standard database search engines (e.g., MASCOT) can be accomplished, searches must be performed using a 'broad species database' which does not provide optimal confidence in protein annotation. Therefore, it becomes necessary to determine partial or complete amino acid sequences using either manual or automated de novo peptide sequence analysis methods.

Dee J Higley - One of the best experts on this subject based on the ideXlab platform.

Stephen J Suomi - One of the best experts on this subject based on the ideXlab platform.

  • effect of tryptophan treatment on self biting and central nervous system serotonin metabolism in rhesus monkeys Macaca mulatta
    Neuropsychopharmacology, 1998
    Co-Authors: Katherine P Weld, Ruth A Woodward, Monica S Bolesta, Stephen J Suomi, Joy A Mench, Dee J Higley
    Abstract:

    Effect of Tryptophan Treatment on Self-Biting and Central Nervous System Serotonin Metabolism in Rhesus Monkeys ( Macaca mulatta )

  • Hand Preference in Infant Rhesus Macaques (Macaca mulatta)
    Child development, 1997
    Co-Authors: Gregory Charles Westergaard, Maribeth Champoux, Stephen J Suomi
    Abstract:

    In this research we examined hand preference in infant rhesus macaques (Macaca mulatta). The subjects were 20 Macaca mulatta, each aged between 4 and 11 months. We assessed hand preference using both a unimanual reaching task and a bimanual coordination task. In the unimanual reaching task, we presented subjects with raisins and noted which hand the animals used to retrieve the food. In the bimanual coordination task, we presented the same subjects with plastic tubes filled with raisin paste and noted which hand the animals used to hold the tubes and which hand the animals used to remove the food. We noted a population-level bias toward use of the left hand for both tasks. These results suggest early right hemisphere advantage for reaching and bimanual coordination in Macaca mulatta, although we acknowledge that this issue needs to be examined more directly through neuroimaging procedures such as Positron Emission Tomography (PET) or functional Magnetic Resonance Imaging (fMRI). We speculate that early right hemisphere advantage contributes to differential patterns of hand preference development for unimanual and bimanual action, and that the development of hand preference for bimanual coordination is related to the emergence of hemispheric specialization for processing species-specific vocalizations.