The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Mohammad Javad Mehdipour Moghaddam - One of the best experts on this subject based on the ideXlab platform.
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skin wound healing acceleration by ag nanoparticles embedded in pva pvp pectin Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
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Skin wound healing acceleration by Ag nanoparticles embedded in PVA/PVP/Pectin/Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
Reza Alipour - One of the best experts on this subject based on the ideXlab platform.
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skin wound healing acceleration by ag nanoparticles embedded in pva pvp pectin Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
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Skin wound healing acceleration by Ag nanoparticles embedded in PVA/PVP/Pectin/Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
James H Holmes - One of the best experts on this subject based on the ideXlab platform.
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systemic absorption of amphotericin b with topical 5 Mafenide Acetate amphotericin b solution for grafted burn wounds is it clinically relevant
Burns, 2010Co-Authors: Rachel A Pendleton, James H HolmesAbstract:Abstract Objective To determine if patients receiving topical amphotericin B in combination with 5% Mafenide Acetate solution will acquire systemically detectable levels of amphotericin B. Methods A prospective, observational study of consecutive patients from May 2007 to March 2008 who received 5% Mafenide Acetate/amphotericin B (2 mcg/ml) solution topically every 4 h to their excised and grafted burn wounds for at least 5 days. Serum amphotericin B levels were measured every 5 days during treatment. In addition, the percentage of graft take, occurrence of infection, and potential adverse reactions or toxicities were monitored and recorded. Results A total of 27 patients were enrolled, accumulating 420 treatment days and 72 amphotericin B levels. Sixty-nine of the amphotericin B levels were undetectable, while 3 were detectable at non-therapeutic levels ( Conclusions We conclude that 5% Mafenide Acetate/amphotericin B (2 mcg/ml) solution, applied to excised and grafted burn wounds, does not produce clinically relevant serum levels of amphotericin B. Based on our observations, this topical regimen is safe.
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Systemic absorption of amphotericin B with topical 5% Mafenide Acetate/amphotericin B solution for grafted burn wounds: Is it clinically relevant?
Burns, 2009Co-Authors: Rachel A Pendleton, James H HolmesAbstract:Abstract Objective To determine if patients receiving topical amphotericin B in combination with 5% Mafenide Acetate solution will acquire systemically detectable levels of amphotericin B. Methods A prospective, observational study of consecutive patients from May 2007 to March 2008 who received 5% Mafenide Acetate/amphotericin B (2 mcg/ml) solution topically every 4 h to their excised and grafted burn wounds for at least 5 days. Serum amphotericin B levels were measured every 5 days during treatment. In addition, the percentage of graft take, occurrence of infection, and potential adverse reactions or toxicities were monitored and recorded. Results A total of 27 patients were enrolled, accumulating 420 treatment days and 72 amphotericin B levels. Sixty-nine of the amphotericin B levels were undetectable, while 3 were detectable at non-therapeutic levels ( Conclusions We conclude that 5% Mafenide Acetate/amphotericin B (2 mcg/ml) solution, applied to excised and grafted burn wounds, does not produce clinically relevant serum levels of amphotericin B. Based on our observations, this topical regimen is safe.
Alireza Khorshidi - One of the best experts on this subject based on the ideXlab platform.
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skin wound healing acceleration by ag nanoparticles embedded in pva pvp pectin Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
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Skin wound healing acceleration by Ag nanoparticles embedded in PVA/PVP/Pectin/Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
Abdollah Fallah Shojaei - One of the best experts on this subject based on the ideXlab platform.
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skin wound healing acceleration by ag nanoparticles embedded in pva pvp pectin Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
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Skin wound healing acceleration by Ag nanoparticles embedded in PVA/PVP/Pectin/Mafenide Acetate composite nanofibers
Polymer Testing, 2019Co-Authors: Reza Alipour, Alireza Khorshidi, Abdollah Fallah Shojaei, Farhad Mashayekhi, Mohammad Javad Mehdipour MoghaddamAbstract:Abstract Wound healing is an important issue in the modern world. In this research, wound healing properties of silver nanoparticles embedded in electrospun nanofibers containing polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), pectin (PEC) and Mafenide Acetate (MF) was studied. Reduction of Ag+ ions and stabilization of the Ag nanoparticles was achieved easily in PVA solution and the obtained colloid was then mixed with PVP, PEC and MF solutions to obtain the target electrospun nanofibers. Average diameter of the silver nanoparticles was estimated about 24 nm by using powder X-Ray diffraction (XRD) data. Antibacterial activity of the nanofibers against E. coli, P. aeroginosa and S. aureus was studied in vitro. The in vitro cytotoxicity test of the nanofibers was performed using MTT assay and showed that the nanofibers were nontoxic and biocompatible. Dermal regeneration studies of wound dressings were carried out in vivo on wound of animal models. It was found that incorporation of silver nanoparticles into PVA/PVP/PEC/MF matrix had a remarkable effect on wound healing in New Zealand white rabbits. The best result was obtained by AgNPs/PVA/PVP/PEC/MF composition of 0.7:91.8:2.5:2.5:2.5 wt%.
