The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform
Ronald A Sherman - One of the best experts on this subject based on the ideXlab platform.
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Maggot Therapy for Wound Care in Austere Environments.
Journal of special operations medicine : a peer reviewed journal for SOF medical professionals, 2020Co-Authors: Ronald A Sherman, Michael R HetzlerAbstract:The past 25 years have seen an increase in use of Maggot Therapy for wound care. Maggot Therapy is very effective in wound debridement; it is simple to apply and requires very little in the way of resources, costs, or skilled personnel. These characteristics make it well suited for use in austere environments. The use of medical-grade Maggots makes Maggot Therapy nearly risk free, but medical grade Maggots may not always be available, especially in the wilderness or in resource-limited communities. By understanding myiasis and fly biology, it should be possible even for the nonentomologist to obtain Maggots from the wild and apply them therapeutically, with minimal risks.
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Medicinal Maggots: An Ancient Remedy for Some Contemporary Afflictions
Annual Review of Entomology, 2020Co-Authors: Ronald A Sherman, Martin J. R. Hall, S. ThomasAbstract:▪ Abstract Certain fly larvae can infest corpses or the wounds of live hosts. Those which are least invasive on live hosts have been used therapeutically, to remove dead tissue from wounds, and promote healing. This medicinal use of Maggots is increasing around the world, due to its efficacy, safety and simplicity. Given our low cultural esteem for Maggots, the increasing use and popularity of Maggot Therapy is evidence of its utility. Maggot Therapy has successfully treated many types of chronic wounds, but much clinical and basic research is needed still. In this review, the biology of myiasis and the history of Maggot Therapy are presented, the current status of our understanding and clinical use of medicinal Maggots is discussed, and opportunities for future research and applications are proposed.
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Survey of patients of the Tver region of Russia regarding Maggots and Maggot Therapy.
International Wound Journal, 2018Co-Authors: Artem M. Morozov, Ronald A ShermanAbstract:The 21st century is seeing a resurgence in the use of Maggot Therapy-using the physical and biochemical benefits of fly larvae to debride and heal chronic, problematic wounds. Maggots are repulsive to many people, and this could interfere with the acceptance of this modality. Before instituting a Maggot Therapy programme at our institution, we sought to better understand the psychological barriers that may exist among patients in the Tver region of Russia. Between 2014 and 2016, all patients with arterial insufficiency and trophic ulcers at City Clinical Hospital No. 7 in Tver were administered a survey consisting of six images. Subjects were asked to rank the images in the order of least to most repulsive or disgusting. A total of 576 subjects were recruited for this study: 414 (72%) women and 162 (28%) men. Nearly 60% of subjects considered the images of Maggots to be more repulsive than images of gangrenous wounds. This finding is significant because it indicates that much education and support will need to be conducted to address patient fears and anxiety if patients are to be comfortable with a Maggot Therapy programme.
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BioTherapy: Medicinal Maggots and Invertebrate Immunology from the Clinician’s Perspective
Advances in Comparative Immunology, 2018Co-Authors: Ronald A Sherman, Edwin L. CooperAbstract:BioTherapy is the practice of using live animals to treat or diagnose illness. Recent advances in technology have allowed us to better understand the mechanisms of action behind modalities such as Maggot Therapy, leech Therapy, and helminthic Therapy from a biochemical and immunological perspective. In turn, as our knowledge of vertebrate and invertebrate immunology has grown, we have applied this knowledge to advance human health through applications in pharmacoTherapy and nutrition.
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Maggot Therapy for wound care in iran a case series of the first 28 patients
Journal of Wound Care, 2017Co-Authors: A Mirabzadeh, M J Ladani, B Imani, S A B Rosen, Ronald A ShermanAbstract:Objective: The need for improved wound care is receiving considerable attention in the Islamic Republic of Iran. Beginning in 2003, Maggot Therapy (MT) became part of Iran's effort to advance its wound care technology. The first cohort of patients treated with MT was analysed to evaluate the use of this treatment. Method: Patients treated with MT at three hospitals in Tehran were analysed retrospectively. Primary outcomes were time to wound debridement and time to wound healing. Factors potentially influencing primary outcomes were also recorded, including demographic factors (such as age, race, gender), wound characteristics, underlying medical illnesses, and treatment attitudes. Results: We analysed 28 patients with 29 wounds. Most (55%) of the wounds were ischaemic, neuropathic or mixed-pathology foot ulcers in patients with diabetes. Half were considered unsalvageable. All were completely debrided and subsequently healed with MT, without amputation, grafts, or advanced interventions. Osteomyelitis was...
Yamni Nigam - One of the best experts on this subject based on the ideXlab platform.
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does Maggot Therapy promote wound healing the clinical and cellular evidence
Journal of The European Academy of Dermatology and Venereology, 2016Co-Authors: Yamni Nigam, Claire MorganAbstract:The larvae of Lucillia sericata, or Maggots of the green-bottle fly, are used worldwide to help debride chronic, necrotic and infected wounds. Whilst there is abundant clinical and scientific evidence to support the role of Maggots for debriding and disinfecting wounds, not so much emphasis has been placed on their role in stimulating wound healing. However, there is accumulating evidence to suggest that Maggots and their externalized secretions may also promote wound healing in stubborn, recalcitrant chronic ulcers. There are a growing number of clinical reports which support the observation that wounds which have been exposed to a course of Maggot debridement Therapy also show earlier healing and closure end-points. In addition, recent pre-clinical laboratory studies also indicate that Maggot secretions can promote important cellular processes which explain this increased healing activity. Such processes include activation of fibroblast migration, angiogenesis (the formation of new blood vessels from pre-existing vessels) within the wound bed, and an enhanced production of growth factors within the wound environment. Thus, in this review, we summarize the clinical evidence which links Maggots and improved wound healing, and we precis recent scientific studies which examine and identify the role of Maggots, particularly individual components of Maggot secretions, on specific cellular aspects of wound healing.
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amino acid derivatives from lucilia sericata excretions secretions may contribute to the beneficial effects of Maggot Therapy via increased angiogenesis
British Journal of Dermatology, 2010Co-Authors: Alyson Bexfield, Norman A Ratcliffe, A E Bond, Claire Morgan, J Wagstaff, Russell P Newton, Edward G Dudley, Yamni NigamAbstract:Summary Background Maggot Therapy, utilizing the larvae of Lucilia sericata, has been reported to reduce the bacterial load within wounds and also to enhance wound healing. Maggot excretions/secretions (ES) have been shown to have a role in the success of Maggot Therapy. While the protein content of ES has been investigated, to date little research has focused on the small metabolites present in ES and their potential contribution to the Therapy. Study of the molecular composition of the secretions and the potential bioactivities present will allow for a more detailed evaluation of the efficacy of Maggot Therapy. Objectives We studied the amino acid-like compounds present in ES of L. sericata larvae in order to determine the compounds present and their potential role in the wound healing process. Methods These included thin-layer chromatography/mass spectrometric analysis of ES to identify amino acid-like components, a turbidometric assay to investigate their potential antibacterial activity and cell proliferation studies to investigate their potential mitogenic ability. Results Three prominent compounds were detected and identified as histidine, valinol and 3-guanidinopropionic acid. While these amino acids were not shown to exhibit antibacterial activity, a proliferative effect on the growth of human endothelial cells, but not fibroblasts, was noted. Conclusions The demonstrated proliferative effect, selectively on endothelial cells, suggests that the amino acid-like compounds present in Maggot ES may have a role in wound healing, by stimulating angiogenesis.
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Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of Maggot Therapy via increased angiogenesis.
British Journal of Dermatology, 2009Co-Authors: Alyson Bexfield, Norman A Ratcliffe, A E Bond, Claire Morgan, J Wagstaff, Russell P Newton, Edward G Dudley, Yamni NigamAbstract:Summary Background Maggot Therapy, utilizing the larvae of Lucilia sericata, has been reported to reduce the bacterial load within wounds and also to enhance wound healing. Maggot excretions/secretions (ES) have been shown to have a role in the success of Maggot Therapy. While the protein content of ES has been investigated, to date little research has focused on the small metabolites present in ES and their potential contribution to the Therapy. Study of the molecular composition of the secretions and the potential bioactivities present will allow for a more detailed evaluation of the efficacy of Maggot Therapy. Objectives We studied the amino acid-like compounds present in ES of L. sericata larvae in order to determine the compounds present and their potential role in the wound healing process. Methods These included thin-layer chromatography/mass spectrometric analysis of ES to identify amino acid-like components, a turbidometric assay to investigate their potential antibacterial activity and cell proliferation studies to investigate their potential mitogenic ability. Results Three prominent compounds were detected and identified as histidine, valinol and 3-guanidinopropionic acid. While these amino acids were not shown to exhibit antibacterial activity, a proliferative effect on the growth of human endothelial cells, but not fibroblasts, was noted. Conclusions The demonstrated proliferative effect, selectively on endothelial cells, suggests that the amino acid-like compounds present in Maggot ES may have a role in wound healing, by stimulating angiogenesis.
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Maggot Therapy the science and implication for cam part i history and bacterial resistance
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen Thomas, Norman A RatcliffeAbstract:It is now a universally acknowledged fact that Maggot Therapy can be used successfully to treat chronic, long-standing, infected wounds, which have previously failed to respond to conventional treatment. Such wounds are typically characterized by the presence of necrotic tissue, underlying infection and poor healing. Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. In this review article, we will discuss the role of Maggots and their preparation for clinical use. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part I we explore our current understanding of the mechanisms underlying these effects.
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Maggot Therapy the science and implication for cam part ii Maggots combat infection
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen M Thomas, Norman A RatcliffeAbstract:Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part II of this review article, we discuss clinical infections and the evidence supporting the potent antibacterial action of Maggot secretions. Enhancement of wound healing by Maggots is discussed along with the future of this highly successful, often controversial, alternative treatment.
Norman A Ratcliffe - One of the best experts on this subject based on the ideXlab platform.
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amino acid derivatives from lucilia sericata excretions secretions may contribute to the beneficial effects of Maggot Therapy via increased angiogenesis
British Journal of Dermatology, 2010Co-Authors: Alyson Bexfield, Norman A Ratcliffe, A E Bond, Claire Morgan, J Wagstaff, Russell P Newton, Edward G Dudley, Yamni NigamAbstract:Summary Background Maggot Therapy, utilizing the larvae of Lucilia sericata, has been reported to reduce the bacterial load within wounds and also to enhance wound healing. Maggot excretions/secretions (ES) have been shown to have a role in the success of Maggot Therapy. While the protein content of ES has been investigated, to date little research has focused on the small metabolites present in ES and their potential contribution to the Therapy. Study of the molecular composition of the secretions and the potential bioactivities present will allow for a more detailed evaluation of the efficacy of Maggot Therapy. Objectives We studied the amino acid-like compounds present in ES of L. sericata larvae in order to determine the compounds present and their potential role in the wound healing process. Methods These included thin-layer chromatography/mass spectrometric analysis of ES to identify amino acid-like components, a turbidometric assay to investigate their potential antibacterial activity and cell proliferation studies to investigate their potential mitogenic ability. Results Three prominent compounds were detected and identified as histidine, valinol and 3-guanidinopropionic acid. While these amino acids were not shown to exhibit antibacterial activity, a proliferative effect on the growth of human endothelial cells, but not fibroblasts, was noted. Conclusions The demonstrated proliferative effect, selectively on endothelial cells, suggests that the amino acid-like compounds present in Maggot ES may have a role in wound healing, by stimulating angiogenesis.
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Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of Maggot Therapy via increased angiogenesis.
British Journal of Dermatology, 2009Co-Authors: Alyson Bexfield, Norman A Ratcliffe, A E Bond, Claire Morgan, J Wagstaff, Russell P Newton, Edward G Dudley, Yamni NigamAbstract:Summary Background Maggot Therapy, utilizing the larvae of Lucilia sericata, has been reported to reduce the bacterial load within wounds and also to enhance wound healing. Maggot excretions/secretions (ES) have been shown to have a role in the success of Maggot Therapy. While the protein content of ES has been investigated, to date little research has focused on the small metabolites present in ES and their potential contribution to the Therapy. Study of the molecular composition of the secretions and the potential bioactivities present will allow for a more detailed evaluation of the efficacy of Maggot Therapy. Objectives We studied the amino acid-like compounds present in ES of L. sericata larvae in order to determine the compounds present and their potential role in the wound healing process. Methods These included thin-layer chromatography/mass spectrometric analysis of ES to identify amino acid-like components, a turbidometric assay to investigate their potential antibacterial activity and cell proliferation studies to investigate their potential mitogenic ability. Results Three prominent compounds were detected and identified as histidine, valinol and 3-guanidinopropionic acid. While these amino acids were not shown to exhibit antibacterial activity, a proliferative effect on the growth of human endothelial cells, but not fibroblasts, was noted. Conclusions The demonstrated proliferative effect, selectively on endothelial cells, suggests that the amino acid-like compounds present in Maggot ES may have a role in wound healing, by stimulating angiogenesis.
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Maggot Therapy the science and implication for cam part i history and bacterial resistance
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen Thomas, Norman A RatcliffeAbstract:It is now a universally acknowledged fact that Maggot Therapy can be used successfully to treat chronic, long-standing, infected wounds, which have previously failed to respond to conventional treatment. Such wounds are typically characterized by the presence of necrotic tissue, underlying infection and poor healing. Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. In this review article, we will discuss the role of Maggots and their preparation for clinical use. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part I we explore our current understanding of the mechanisms underlying these effects.
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Maggot Therapy the science and implication for cam part ii Maggots combat infection
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen M Thomas, Norman A RatcliffeAbstract:Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part II of this review article, we discuss clinical infections and the evidence supporting the potent antibacterial action of Maggot secretions. Enhancement of wound healing by Maggots is discussed along with the future of this highly successful, often controversial, alternative treatment.
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Detection and partial characterisation of two antibacterial factors from the excretions/secretions of the medicinal Maggot Lucilia sericata and their activity against methicillin-resistant Staphylococcus aureus (MRSA).
Microbes and Infection, 2004Co-Authors: Alyson Bexfield, Yamni Nigam, Stephen Thomas, Norman A RatcliffeAbstract:Maggot Therapy is a simple and highly successful method for cleansing infected and necrotic wounds. The use of Maggots has become increasingly important in the treatment of non-healing wounds, particularly those infected with the multidrug-resistant pathogen, methicillin-resistant Staphylococcus aureus (MRSA). The increasing challenge concerning the treatment of MRSA infections and the recent finding of vancomycin-resistant strains of MRSA have elicited the search for novel antibacterial compounds and, in particular, investigations into the potent antibacterial mechanism(s) behind Maggot Therapy. In this study, we report that excretions/secretions (ES) from the blowfly, Lucilia sericata, exhibit potent, thermally stable, protease resistant antibacterial activity against MRSA in vitro. We describe the initial characterisation of two antibacterial factors from native ES of L. sericata. A small,
Alyson Bexfield - One of the best experts on this subject based on the ideXlab platform.
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amino acid derivatives from lucilia sericata excretions secretions may contribute to the beneficial effects of Maggot Therapy via increased angiogenesis
British Journal of Dermatology, 2010Co-Authors: Alyson Bexfield, Norman A Ratcliffe, A E Bond, Claire Morgan, J Wagstaff, Russell P Newton, Edward G Dudley, Yamni NigamAbstract:Summary Background Maggot Therapy, utilizing the larvae of Lucilia sericata, has been reported to reduce the bacterial load within wounds and also to enhance wound healing. Maggot excretions/secretions (ES) have been shown to have a role in the success of Maggot Therapy. While the protein content of ES has been investigated, to date little research has focused on the small metabolites present in ES and their potential contribution to the Therapy. Study of the molecular composition of the secretions and the potential bioactivities present will allow for a more detailed evaluation of the efficacy of Maggot Therapy. Objectives We studied the amino acid-like compounds present in ES of L. sericata larvae in order to determine the compounds present and their potential role in the wound healing process. Methods These included thin-layer chromatography/mass spectrometric analysis of ES to identify amino acid-like components, a turbidometric assay to investigate their potential antibacterial activity and cell proliferation studies to investigate their potential mitogenic ability. Results Three prominent compounds were detected and identified as histidine, valinol and 3-guanidinopropionic acid. While these amino acids were not shown to exhibit antibacterial activity, a proliferative effect on the growth of human endothelial cells, but not fibroblasts, was noted. Conclusions The demonstrated proliferative effect, selectively on endothelial cells, suggests that the amino acid-like compounds present in Maggot ES may have a role in wound healing, by stimulating angiogenesis.
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Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of Maggot Therapy via increased angiogenesis.
British Journal of Dermatology, 2009Co-Authors: Alyson Bexfield, Norman A Ratcliffe, A E Bond, Claire Morgan, J Wagstaff, Russell P Newton, Edward G Dudley, Yamni NigamAbstract:Summary Background Maggot Therapy, utilizing the larvae of Lucilia sericata, has been reported to reduce the bacterial load within wounds and also to enhance wound healing. Maggot excretions/secretions (ES) have been shown to have a role in the success of Maggot Therapy. While the protein content of ES has been investigated, to date little research has focused on the small metabolites present in ES and their potential contribution to the Therapy. Study of the molecular composition of the secretions and the potential bioactivities present will allow for a more detailed evaluation of the efficacy of Maggot Therapy. Objectives We studied the amino acid-like compounds present in ES of L. sericata larvae in order to determine the compounds present and their potential role in the wound healing process. Methods These included thin-layer chromatography/mass spectrometric analysis of ES to identify amino acid-like components, a turbidometric assay to investigate their potential antibacterial activity and cell proliferation studies to investigate their potential mitogenic ability. Results Three prominent compounds were detected and identified as histidine, valinol and 3-guanidinopropionic acid. While these amino acids were not shown to exhibit antibacterial activity, a proliferative effect on the growth of human endothelial cells, but not fibroblasts, was noted. Conclusions The demonstrated proliferative effect, selectively on endothelial cells, suggests that the amino acid-like compounds present in Maggot ES may have a role in wound healing, by stimulating angiogenesis.
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Maggot Therapy the science and implication for cam part i history and bacterial resistance
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen Thomas, Norman A RatcliffeAbstract:It is now a universally acknowledged fact that Maggot Therapy can be used successfully to treat chronic, long-standing, infected wounds, which have previously failed to respond to conventional treatment. Such wounds are typically characterized by the presence of necrotic tissue, underlying infection and poor healing. Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. In this review article, we will discuss the role of Maggots and their preparation for clinical use. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part I we explore our current understanding of the mechanisms underlying these effects.
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Maggot Therapy the science and implication for cam part ii Maggots combat infection
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen M Thomas, Norman A RatcliffeAbstract:Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part II of this review article, we discuss clinical infections and the evidence supporting the potent antibacterial action of Maggot secretions. Enhancement of wound healing by Maggots is discussed along with the future of this highly successful, often controversial, alternative treatment.
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Detection and partial characterisation of two antibacterial factors from the excretions/secretions of the medicinal Maggot Lucilia sericata and their activity against methicillin-resistant Staphylococcus aureus (MRSA).
Microbes and Infection, 2004Co-Authors: Alyson Bexfield, Yamni Nigam, Stephen Thomas, Norman A RatcliffeAbstract:Maggot Therapy is a simple and highly successful method for cleansing infected and necrotic wounds. The use of Maggots has become increasingly important in the treatment of non-healing wounds, particularly those infected with the multidrug-resistant pathogen, methicillin-resistant Staphylococcus aureus (MRSA). The increasing challenge concerning the treatment of MRSA infections and the recent finding of vancomycin-resistant strains of MRSA have elicited the search for novel antibacterial compounds and, in particular, investigations into the potent antibacterial mechanism(s) behind Maggot Therapy. In this study, we report that excretions/secretions (ES) from the blowfly, Lucilia sericata, exhibit potent, thermally stable, protease resistant antibacterial activity against MRSA in vitro. We describe the initial characterisation of two antibacterial factors from native ES of L. sericata. A small,
Stephen Thomas - One of the best experts on this subject based on the ideXlab platform.
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Maggot Therapy the science and implication for cam part i history and bacterial resistance
Evidence-based Complementary and Alternative Medicine, 2006Co-Authors: Yamni Nigam, Alyson Bexfield, Stephen Thomas, Norman A RatcliffeAbstract:It is now a universally acknowledged fact that Maggot Therapy can be used successfully to treat chronic, long-standing, infected wounds, which have previously failed to respond to conventional treatment. Such wounds are typically characterized by the presence of necrotic tissue, underlying infection and poor healing. Maggot Therapy employs the use of freshly emerged, sterile larvae of the common green-bottle fly, Phaenicia (Lucilia) sericata, and is a form of artificially induced myiasis in a controlled clinical situation. In this review article, we will discuss the role of Maggots and their preparation for clinical use. Maggot Therapy has the following three core beneficial effects on a wound: debridement, disinfection and enhanced healing. In part I we explore our current understanding of the mechanisms underlying these effects.
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Detection and partial characterisation of two antibacterial factors from the excretions/secretions of the medicinal Maggot Lucilia sericata and their activity against methicillin-resistant Staphylococcus aureus (MRSA).
Microbes and Infection, 2004Co-Authors: Alyson Bexfield, Yamni Nigam, Stephen Thomas, Norman A RatcliffeAbstract:Maggot Therapy is a simple and highly successful method for cleansing infected and necrotic wounds. The use of Maggots has become increasingly important in the treatment of non-healing wounds, particularly those infected with the multidrug-resistant pathogen, methicillin-resistant Staphylococcus aureus (MRSA). The increasing challenge concerning the treatment of MRSA infections and the recent finding of vancomycin-resistant strains of MRSA have elicited the search for novel antibacterial compounds and, in particular, investigations into the potent antibacterial mechanism(s) behind Maggot Therapy. In this study, we report that excretions/secretions (ES) from the blowfly, Lucilia sericata, exhibit potent, thermally stable, protease resistant antibacterial activity against MRSA in vitro. We describe the initial characterisation of two antibacterial factors from native ES of L. sericata. A small,
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the current status of Maggot Therapy in wound healing
British journal of nursing, 2001Co-Authors: Stephen Thomas, M Jones, Karen Wynn, Tony FowlerAbstract:The clinical use of sterile Maggots under the brand name LarveE has increased steadily in the UK since they were introduced in the UK in late 1995. Some 50 articles have been published in the last 4 years that describe the cost-effectiveness of Maggot Therapy in a variety of wound types including leg ulcers, pressure ulcers and diabetic ulcers. The ability of these creatures to combat wound infection has been well documented including those caused by antibiotic-resistant strains of bacteria such as methicillin-resistant Staphylococcus aureus. No significant risks or adverse events have been linked to the use of Maggots, although their presence may increase pain levels in leg ulcers associated with ischaemic disease.
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Using larvae in modern wound management
Journal of Wound Care, 1996Co-Authors: Stephen Thomas, M Jones, S. Shutler, Susan M. JonesAbstract:Initial clinical experience in the UK with Maggot Therapy for the treatment of necrotic or infected wounds has proved very encouraging. Sterile larvae have been reared in the Surgical Materials Testing Laboratory for this purpose. This paper reports the use of larvae in six patients and discusses some of the advantages and disadvantages of this form of Therapy.
