The Experts below are selected from a list of 62754 Experts worldwide ranked by ideXlab platform
Jon Dobson - One of the best experts on this subject based on the ideXlab platform.
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Magnetic Nanoparticles for gene and drug delivery
International Journal of Nanomedicine, 2008Co-Authors: Stuart C. Mcbain, Humprey H.p. Yiu, Jon DobsonAbstract:Investigations of Magnetic micro-and Nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in Magnetic Nanoparticle design, in vitro and animal experiments with Magnetic Nanoparticle-based drug and gene delivery, and clinical trials of drug targeting.
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Gene therapy progress and prospects: Magnetic Nanoparticle-based gene delivery
Gene Therapy, 2006Co-Authors: Jon DobsonAbstract:The recent emphasis on the development of non-viral transfection agents for gene delivery has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. One of these techniques which shows much promise for both in vitro and in vivo transfection involves the use of biocompatible Magnetic Nanoparticles for gene delivery. In these systems, therapeutic or reporter genes are attached to Magnetic Nanoparticles, which are then focused to the target site/cells via high-field/high-gradient magnets. The technique promotes rapid transfection and, as more recent work indicates, excellent overall transfection levels as well. The advantages and difficulties associated with Magnetic Nanoparticle-based transfection will be discussed as will the underlying physical principles, recent studies and potential future applications.
Kai Chen - One of the best experts on this subject based on the ideXlab platform.
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removal of cadmium and lead ions from water by sulfonated Magnetic Nanoparticle adsorbents
Journal of Colloid and Interface Science, 2017Co-Authors: Kai Chen, Junyong He, Yulian Li, Kaisheng Zhang, Yi Hu, Lingtao KongAbstract:Abstract A new adsorbent, Fe3O4 sulfonated Magnetic Nanoparticle (Fe3O4-SO3H MNP), was developed for heavy metal ions removal from water, which could be effectively separated from the solution owing to the superparaMagnetic property. The Nanoparticles can be used to remove heavy metal ions due to the additional active site, “sulfo-group”, introduced by the AMPS branches grafted onto the iron oxide. The as-synthesized materials were characterized by SEM, TEM, FT-IR and BET. The FTIR, XPS and Zeta potential were used to describe the adsorption mechanism. The Fe3O4-SO3H MNPs showed rapid removal for Pb2+ and Cd2+ with maximum of adsorption capacity of 108. 93 and 80.9 mg/g at 25 °C, respectively. The adsorption isotherms for Pb2+ and Cd2+ fitted better with Langmuir than Freundlich models, indicated that the processes of the removal of Pb2+ and Cd2+ could follow a kind of similar adsorption manner. The adsorption kinetic was consistent with pseudo-second-order model. Furthermore, the reuse experiments results showed the adsorbent might have potential in treating heavy metal ions pollution in water.
Maria Valletregi - One of the best experts on this subject based on the ideXlab platform.
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smart drug delivery through dna Magnetic Nanoparticle gates
ACS Nano, 2011Co-Authors: Eduardo Ruizhernandez, Alejandro Baeza, Maria ValletregiAbstract:Mesoporous silica Nanoparticles can be modified to perform on-demand stimuli-responsive dosing of therapeutic molecules. The silica network was loaded with iron oxide superparaMagnetic nanocrystals, providing the potential to perform targeting and Magnetic resonance imaging. Single-stranded DNA was immobilized onto the material surface. The complementary DNA sequence was then attached to Magnetic Nanoparticles. The present work demonstrates that DNA/Magnetic Nanoparticle conjugates are able to cap the pores of the Magnetic silica particles upon hybridization of both DNA strands. Progressive double-stranded DNA melting as a result of temperature increase gave rise to uncapping and the subsequent release of a mesopore-filled model drug, fluorescein. The reversibility of DNA linkage results in an “on−off” release mechanism. Moreover, the Magnetic component of the whole system allows reaching hyperthermic temperatures (42−47 °C) under an alternating Magnetic field. This feature leaves open the possibility of ...
Ramani Kandasamy - One of the best experts on this subject based on the ideXlab platform.
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a novel single step synthesis and surface functionalization of iron oxide Magnetic Nanoparticles and thereof for the copper removal from pigment industry effluent
Separation and Purification Technology, 2017Co-Authors: Hepziba S Suganthi, Ramani KandasamyAbstract:Abstract In the present investigation, it is attempted to carry out the synthesis and surface modification of iron oxide Magnetic Nanoparticle in a single step using the iron precursors and biomolecules present in culture supernatant produced by S.thermolineatus utilizing the fish processing waste as a substrate. The biomolecules in the culture supernatant acts as the stabilizing and capping agent so that the desired functionality is achieved on the iron oxide Magnetic Nanoparticle surface. The synthesized iron oxide Magnetic Nanoparticles were characterised by UV–Visible spectroscopy, Fourier Transform-Infrared spectroscopy, Scanning electron microscopy, Transmission electron microscopy, X-ray diffraction analysis, Thermogravimetric analysis, Vibrating sample magnetometer and dynamic light scattering. The synthesized iron oxide Magnetic Nanoparticle was employed for the removal of copper from pigment industry effluent. Response surface methodology was used to optimize the conditions for the maximum removal of copper ions. The synthesised iron oxide Magnetic Nanoparticle with surface modification was found to be efficient in removing the copper by 85% from the pigment industry effluent. Desorption studies revealed that the iron oxide Magnetic Nanoparticle can be reused for four cycles.
Dino Di Carlo - One of the best experts on this subject based on the ideXlab platform.
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Magnetic Nanoparticle mediated massively parallel mechanical modulation of single cell behavior
Nature Methods, 2012Co-Authors: Peter Tseng, Jack W Judy, Dino Di CarloAbstract:Cells are dosed with Magnetic Nanoparticles and patterned onto microMagnetic substrates, enabling the application of controlled and variable mechanical force to tens of thousands of cells. We report a technique for generating controllable, time-varying and localizable forces on arrays of cells in a massively parallel fashion. To achieve this, we grow Magnetic Nanoparticle–dosed cells in defined patterns on microMagnetic substrates. By manipulating and coalescing Nanoparticles within cells, we apply localized Nanoparticle-mediated forces approaching cellular yield tensions on the cortex of HeLa cells. We observed highly coordinated responses in cellular behavior, including the p21-activated kinase–dependent generation of active, leading edge–type filopodia and biasing of the metaphase plate during mitosis. The large sample size and rapid sample generation inherent to this approach allow the analysis of cells at an unprecedented rate: in a single experiment, potentially tens of thousands of cells can be stimulated for high statistical accuracy in measurements. This technique shows promise as a tool for both cell analysis and control.