The Experts below are selected from a list of 519 Experts worldwide ranked by ideXlab platform

David Crews - One of the best experts on this subject based on the ideXlab platform.

  • Environmental Endocrine Disruptors and Male Reproductive Toxicology
    Comprehensive Toxicology, 2010
    Co-Authors: Paul S. Cooke, Liz Simon, M.a. Cimafranca, Andrea C. Gore, David Crews
    Abstract:

    Many natural and synthetic chemicals can alter endocrine signaling by mimicking or inhibiting the actions of endogenous hormones. These chemicals, now commonly referred to as endocrine disruptors or endocrine disrupting chemicals (EDCs), can alter Male Reproductive tract development and function by effects on the estrogen, androgen, thyroid hormone, and other endocrine signaling systems. This chapter reviews the historical development of work on endocrine disruption, and describes our present knowledge related to the types of chemicals that can function as EDCs in the Male tract and the effects these chemicals can produce.

John H. Richburg - One of the best experts on this subject based on the ideXlab platform.

  • Male Reproductive Toxicology
    Comprehensive Toxicology, 2018
    Co-Authors: John H. Richburg
    Abstract:

    Since publication of the first edition of the “Reproductive and Endocrine” volume of Comprehensive Toxicology in 1997, many exciting advances have been made in understanding the mechanisms that regulate the Male Reproductive system. These new developments have often been fostered by innovations in the fields of molecular and cellular biology and the development of sophisticated genomic and proteomic approaches as well as the generation of transgenic animal models. The contributions of toxicological approaches over the last decade have not only been important for understanding the mechanistic basis for Male Reproductive pathogenesis, but have also significantly contributed to the understanding of Male Reproductive tissue development and the physiological regulation of reproduction. The credo of Toxicology is that “the dose makes the poison.” In addition, Reproductive toxicologist (s) further appreciate the caveat to this credo that the “timing makes the poison,” referring to the fact that certain toxicants will only manifest a negative effect on reproduction if the exposure occurs during a sensitive period of development or distinct phase of the cyclic process of spermatogenesis.

Robert E. Chapin - One of the best experts on this subject based on the ideXlab platform.

  • Male Reproductive Toxicology
    Current protocols in immunology, 2004
    Co-Authors: Kim Boekelheide, Robert E. Chapin
    Abstract:

    R.E. Chapin and J.J. Heindel, Introduction. C. Chubb, Male Mouse Sexual Behaviour Test. M.D. Culler, In Vitro Techniques for Assessing Pituitary Secretory Function. R.A. Hess and B.J Moore, Histological Methods for Evaluation of the Testis. W.F. Blazak, KA. Treinen, and P.E. Juniewicz, The Application of Testicular Spermatid Head Counts in the Assessment of Male Reproductive Toxicity. C.C. Linder and M.D. Griswold, Stage Synchronization in Rat Seminiferous Tubules Using Vitamin A Depletion and Repletion. M.L. Meistrich and Maria E.A.B. van Beek, Spermatogonial Stem Cells: Assessing Their Survival and Ability to Produce Differentiated Cells. W.M. Generoso and W. W. Piegorsch, Dominant Lethal Tests in Male and FeMale Mice. M. Parvinen, J. Toppari, and J. Laehdetie, Transillumination-Phase Contrast Microscopic Techniques for Evaluation of Male Germ Cell Toxicity and Matagenicity. G.R. Klinefelter, W.R. Kelce, and M.P. Hardy, The Isolation and Culture of Leydig Cells from Adult Rats. L.B. Biegel J.C. Cook, and M.E. Hurtt, Isolation and Primary Culture of Leydig Cells. A.H. Payne and L. Sha, Purification and Primary Culture of Leydig Cells. W.W. Ku and R.E. Chapin, The Preparation and Use of Sertoli Cell-Enriched Cultures from 18-Day-Old Rats. A. Steinberger and J-P. Clinton, Two-Compartment Cultures of Sertoli Cells: Applications in Testicular Toxicology. D.A. O'Brien, Isolation, Separation, and Short-Term Culture of Spermatogenic Cells. G.L. Rehnberg, The Collection of Interstitial Fluid and Seminiferous Tubule Fluid from the Rat Testis. G.R. Klinefelter, The Isolation and Culture of Epididymal Epithelial Cells from Adult Rats. B.J Danzo, Evaluation of Protein Synthesis by the Epididymis. G.P. Toth, E.J. Read, and M.K. Smith, Utilizing Cryo Resources CellSoft Computer-Assisted Sperm Analysis System for Rat Sperm Motility Studies. V.L. Slott and S. D, Perreault, Computer-Assisted Sperm Analysis of Rodent Epididymal Sperm Motility Using the Hamilton-Thorn Motility Analyzer. R. Filler, Evaluation of Rat Epididymal Sperm Morphology. J. Williams, Semen Analysis and Fertility Assessment in the Rabbit. S.M. Schrader, General Techniques for Assessing Male Reproductive Potential in Human Field Studies.

Yinusa Raji - One of the best experts on this subject based on the ideXlab platform.

  • cytotoxicity and acute oral toxicity study on quassin and fractions of quassia amara extract
    International Journal of Sciences: Basic and Applied Research, 2014
    Co-Authors: Olawale O Obembe, Ganiyat K. Oloyede, Yinusa Raji
    Abstract:

    Different fractions of Quassia amara and its bioactive compound quassin have been implicated in Male Reproductive Toxicology. Toxicity results obtained from brine shrimp lethality test on chloroform, methanol and hexane fractions of Quassia amara gave LC50 value of 93.4569μg/ml, 172.0463μg/ml, and 46.1941μg/ml respectively. LC50 of quassin was 0.0000μg/ml. Acute oral toxicity was by OECD limit test procedure and methanol extract of Quassia amara showed no lethality up to 5000mg/kg. Quassia amara and quassin therefore has toxicity activity. Methanol fraction is comparatively least toxic to brine shrimp and also well tolerated by the systemic organs of experimental rats.

Raji Yinusa - One of the best experts on this subject based on the ideXlab platform.