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Tatiana Sevostyanova - One of the best experts on this subject based on the ideXlab platform.

  • comparative sensitivity of the Test with tuberculosis recombinant allergen containing esat6 cfp10 protein and Mantoux Test with 2 tu ppd l in newly diagnosed tuberculosis children and adolescents in moscow
    PLOS ONE, 2018
    Co-Authors: Liudmila Slogotskaya, Elena Bogorodskaya, D Ivanova, Tatiana Sevostyanova
    Abstract:

    Background A group of Russian scientists has developed DiaskinTest, which comprises Mycobacterium tuberculosis-specific recombinant proteins CFP10-ESAT6, for skin Testing (0.2 μg/0.1 ml). Study purpose To evaluate the comparative sensitivity of TST with 2 TU PPD-L and a skin Test with tuberculous recombinant allergen (DiaskinTest) containing the ESAT6-CFP10 protein in children and adolescents with newly diagnosed active tuberculosis during mass screening in the primary medical service in Moscow. Materials and methods The trial was a comprehensive retrospective group study of children and adolescents diagnosed in Moscow with active tuberculosis in 2013–2016, aged 0 to 17 years inclusive. Results From 441 patients selected for analysis 408 patients had both Tests (TST with 2 TU PPD-L and DiaskinTest) performed, in 193 patients both Tests were given simultaneously, of them 162 patients were BCG-vaccinated. Comparative results of both Tests in 408 patients with tuberculosis: at cut-off ≥ 5 mm, both Tests has similar sensitivity: DiaskinTest 98.3% (95% CI 97.0–99.6%), TST 98.0% (95% CI 96.7–99.4%), at cut-off ≥10 mm, the sensitivity decreases for both Tests: DiaskinTest 90.0% (95% CI 87.0–93.0%), TST 88.7% (95% CI 85.6–91.9%), but at cut-off ≥ 15 mm, the decrease in sensitivity is statistically significant: for DiaskinTest 61.5% (95% CI 56.7–66.3%), and for TST 46.3% (95% CI 41.4–51.3%), p <0.0001. The results of simultaneous setting of Tests on different hands in 193 people (including 162 BCG-vaccinated), do not differ from the results for 408 people. The correlation between the results of DiaskinTest and TST was significant in all groups. Conclusion In children and adolescents with active tuberculosis, DiaskinTest of 0.2 μg/ml and the Mantoux Test with 2 TU PPD-L have high sensitivity (98%) at a cut-off of 5 mm; however, at cut-off ≥ 15 mm sensitivity is significantly reduced, and the decrease is more pronounced in the Mantoux Test. The advantage of DiaskinTest is that, unlike the Mantoux Test, it has high specificity under the conditions of mass BCG vaccination. The Test is simple to carry out, and can be used in mass screening.

  • comparative sensitivity of the Test with tuberculosis recombinant allergen containing esat6 cfp10 protein and Mantoux Test with 2 tu ppd l in newly diagnosed tuberculosis children and adolescents in moscow
    bioRxiv, 2018
    Co-Authors: Liudmila Slogotskaya, Elena Bogorodskaya, D Ivanova, Tatiana Sevostyanova
    Abstract:

    Background. A group of Russian scientists has developed DiaskinTest, which comprises Mycobacterium tuberculosis - specific recombinant proteins CFP10 - ESAT6, for skin Testing (0.2 mg/0.1 ml). Study purpose: to evaluate the comparative sensitivity of TST with 2 TU PPD - L and a skin Test with tuberculous recombinant allergen (DiaskinTest) containing the ESAT6 - CFP10 protein in children and adolescents with newly diagnosed respiratory tuberculosis during mass screening in the primary medical service in Moscow, 2013 - 2016. Materials and methods. The trial was a comprehensive retrospective group study of children and adolescents diagnosed in Moscow with respiratory tuberculosis in 2013 - 2016, aged 0 to 17 years inclusive. From 441 patients selected for analysis 408 patients had both Tests (TST with 2 TU PPD-L and DiaskinTest) performed, in 193 patients both Tests were given simultaneously, of them 162 patients were BCG-vaccinated. Results. Comparative results of both Tests in 408 patients with tuberculosis: at cut-off >= 5 mm, both Tests has similar sensitivity: DiaskinTest 98.3 % (95 % CI 97.0 - 99.6 %), TST 98.0 % (95 % CI 96.7 - 99.4 %), at cut-off >=10 mm, the sensitivity decreases for both Tests: DiaskinTest 90.0 % (95 % CI 87.0 - 93.0 %), TST 88.7 % (95 % CI 85.6 - 91.9 %), but at cut-off >= 15 mm, the decrease in sensitivity is statistically significant: for DiaskinTest 61.5 % (95 % CI 56.7 - 66.3 %), and for TST 46.3 % (95 % CI 41.4 - 51.3 %), p =15 mm sensitivity is significantly reduced, and the decrease is more pronounced in the Mantoux Test. The advantage of DiaskinTest is that, unlike the Mantoux Test, it has high specificity under the conditions of mass BCG vaccination. The Test is cost-effective, simple to carry out, and can be used in mass screening.

S I Azam - One of the best experts on this subject based on the ideXlab platform.

  • is there a value of Mantoux Test and erythrocyte sedimentation rate in pre employment screening of health care workers for tuberculosis in a high prevalence country
    International Journal of Tuberculosis and Lung Disease, 2002
    Co-Authors: N S Ali, S F Hussain, S I Azam
    Abstract:

    SETTING Pre-employment screening of health care workers (HCWs) is practiced widely. Research needs to be carried out to evaluate the screening procedure in developing countries. OBJECTIVE To evaluate the efficacy of Mantoux Test and erythrocyte sedimentation rate (ESR) for the diagnosis of active tuberculosis (TB), in pre-employment screening of HCWs, in a high prevalence country. DESIGN Pre-employment screening of all new employees was reviewed from June to September 2000. The screening consisted of history, physical examination, blood and urine Tests, Mantoux Test and a chest radiograph. Patients with clinical, laboratory or radiological features suggestive of active TB were referred to a specialist. RESULTS Out of 207 employees, a Mantoux reaction of > or = 10 mm and ESR of > or = 25 mm/first hour was noted in 90 (43.5%) and 21 (10.1%), respectively. One person had symptoms suggestive of TB and was already on anti-tuberculosis therapy at the time of screening. All other employees were asymptomatic. Based on radiographic findings, four (2%) cases were referred and one was given anti-tuberculosis therapy. An additional 48 (23.1%) employees were referred on the basis of positive Mantoux or elevated ESR; none were found to have active TB. CONCLUSION In high prevalence countries use of Mantoux Test and ESR in pre-employment screening of HCWs is not recommended for detection of active TB.

Liudmila Slogotskaya - One of the best experts on this subject based on the ideXlab platform.

  • comparative sensitivity of the Test with tuberculosis recombinant allergen containing esat6 cfp10 protein and Mantoux Test with 2 tu ppd l in newly diagnosed tuberculosis children and adolescents in moscow
    PLOS ONE, 2018
    Co-Authors: Liudmila Slogotskaya, Elena Bogorodskaya, D Ivanova, Tatiana Sevostyanova
    Abstract:

    Background A group of Russian scientists has developed DiaskinTest, which comprises Mycobacterium tuberculosis-specific recombinant proteins CFP10-ESAT6, for skin Testing (0.2 μg/0.1 ml). Study purpose To evaluate the comparative sensitivity of TST with 2 TU PPD-L and a skin Test with tuberculous recombinant allergen (DiaskinTest) containing the ESAT6-CFP10 protein in children and adolescents with newly diagnosed active tuberculosis during mass screening in the primary medical service in Moscow. Materials and methods The trial was a comprehensive retrospective group study of children and adolescents diagnosed in Moscow with active tuberculosis in 2013–2016, aged 0 to 17 years inclusive. Results From 441 patients selected for analysis 408 patients had both Tests (TST with 2 TU PPD-L and DiaskinTest) performed, in 193 patients both Tests were given simultaneously, of them 162 patients were BCG-vaccinated. Comparative results of both Tests in 408 patients with tuberculosis: at cut-off ≥ 5 mm, both Tests has similar sensitivity: DiaskinTest 98.3% (95% CI 97.0–99.6%), TST 98.0% (95% CI 96.7–99.4%), at cut-off ≥10 mm, the sensitivity decreases for both Tests: DiaskinTest 90.0% (95% CI 87.0–93.0%), TST 88.7% (95% CI 85.6–91.9%), but at cut-off ≥ 15 mm, the decrease in sensitivity is statistically significant: for DiaskinTest 61.5% (95% CI 56.7–66.3%), and for TST 46.3% (95% CI 41.4–51.3%), p <0.0001. The results of simultaneous setting of Tests on different hands in 193 people (including 162 BCG-vaccinated), do not differ from the results for 408 people. The correlation between the results of DiaskinTest and TST was significant in all groups. Conclusion In children and adolescents with active tuberculosis, DiaskinTest of 0.2 μg/ml and the Mantoux Test with 2 TU PPD-L have high sensitivity (98%) at a cut-off of 5 mm; however, at cut-off ≥ 15 mm sensitivity is significantly reduced, and the decrease is more pronounced in the Mantoux Test. The advantage of DiaskinTest is that, unlike the Mantoux Test, it has high specificity under the conditions of mass BCG vaccination. The Test is simple to carry out, and can be used in mass screening.

  • comparative sensitivity of the Test with tuberculosis recombinant allergen containing esat6 cfp10 protein and Mantoux Test with 2 tu ppd l in newly diagnosed tuberculosis children and adolescents in moscow
    bioRxiv, 2018
    Co-Authors: Liudmila Slogotskaya, Elena Bogorodskaya, D Ivanova, Tatiana Sevostyanova
    Abstract:

    Background. A group of Russian scientists has developed DiaskinTest, which comprises Mycobacterium tuberculosis - specific recombinant proteins CFP10 - ESAT6, for skin Testing (0.2 mg/0.1 ml). Study purpose: to evaluate the comparative sensitivity of TST with 2 TU PPD - L and a skin Test with tuberculous recombinant allergen (DiaskinTest) containing the ESAT6 - CFP10 protein in children and adolescents with newly diagnosed respiratory tuberculosis during mass screening in the primary medical service in Moscow, 2013 - 2016. Materials and methods. The trial was a comprehensive retrospective group study of children and adolescents diagnosed in Moscow with respiratory tuberculosis in 2013 - 2016, aged 0 to 17 years inclusive. From 441 patients selected for analysis 408 patients had both Tests (TST with 2 TU PPD-L and DiaskinTest) performed, in 193 patients both Tests were given simultaneously, of them 162 patients were BCG-vaccinated. Results. Comparative results of both Tests in 408 patients with tuberculosis: at cut-off >= 5 mm, both Tests has similar sensitivity: DiaskinTest 98.3 % (95 % CI 97.0 - 99.6 %), TST 98.0 % (95 % CI 96.7 - 99.4 %), at cut-off >=10 mm, the sensitivity decreases for both Tests: DiaskinTest 90.0 % (95 % CI 87.0 - 93.0 %), TST 88.7 % (95 % CI 85.6 - 91.9 %), but at cut-off >= 15 mm, the decrease in sensitivity is statistically significant: for DiaskinTest 61.5 % (95 % CI 56.7 - 66.3 %), and for TST 46.3 % (95 % CI 41.4 - 51.3 %), p =15 mm sensitivity is significantly reduced, and the decrease is more pronounced in the Mantoux Test. The advantage of DiaskinTest is that, unlike the Mantoux Test, it has high specificity under the conditions of mass BCG vaccination. The Test is cost-effective, simple to carry out, and can be used in mass screening.

R. Vaccaro - One of the best experts on this subject based on the ideXlab platform.

  • Mantoux Test in Kawasaki disease.
    Pediatrics, 1996
    Co-Authors: Alberto Bertotto, Fabrizio Spinozzi, Maurizio Radicioni, R. Vaccaro
    Abstract:

    Localized erythema at the site of a previous bacillus Calmette-Guerin (BCG) inoculation is a relatively specific and early manifestation of Kawasaki disease (KD),1 and redness and crusting are characteristic features at the site of BCG immunization during the acute phase of the illness.2 With these findings in mind, we evaluated the tuberculin skin Test reactivity of children with KD, as determined by a commercially available (Sclavo, Siena, Italy) and intradermally injected (5 TU) purified protein derivative (PPD).

N S Ali - One of the best experts on this subject based on the ideXlab platform.

  • is there a value of Mantoux Test and erythrocyte sedimentation rate in pre employment screening of health care workers for tuberculosis in a high prevalence country
    International Journal of Tuberculosis and Lung Disease, 2002
    Co-Authors: N S Ali, S F Hussain, S I Azam
    Abstract:

    SETTING Pre-employment screening of health care workers (HCWs) is practiced widely. Research needs to be carried out to evaluate the screening procedure in developing countries. OBJECTIVE To evaluate the efficacy of Mantoux Test and erythrocyte sedimentation rate (ESR) for the diagnosis of active tuberculosis (TB), in pre-employment screening of HCWs, in a high prevalence country. DESIGN Pre-employment screening of all new employees was reviewed from June to September 2000. The screening consisted of history, physical examination, blood and urine Tests, Mantoux Test and a chest radiograph. Patients with clinical, laboratory or radiological features suggestive of active TB were referred to a specialist. RESULTS Out of 207 employees, a Mantoux reaction of > or = 10 mm and ESR of > or = 25 mm/first hour was noted in 90 (43.5%) and 21 (10.1%), respectively. One person had symptoms suggestive of TB and was already on anti-tuberculosis therapy at the time of screening. All other employees were asymptomatic. Based on radiographic findings, four (2%) cases were referred and one was given anti-tuberculosis therapy. An additional 48 (23.1%) employees were referred on the basis of positive Mantoux or elevated ESR; none were found to have active TB. CONCLUSION In high prevalence countries use of Mantoux Test and ESR in pre-employment screening of HCWs is not recommended for detection of active TB.