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Ane Fisker - One of the best experts on this subject based on the ideXlab platform.
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Is early Measles Vaccination associated with stronger survival benefits than later Measles Vaccination
BMC public health, 2018Co-Authors: Jesper Sloth Hansen, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Ane FiskerAbstract:Measles vaccine (MV) may protect against non-Measles mortality. We tested whether survival depended on age of Measles Vaccination. Bandim Health Project follows children under 5 years of age through a Health and Demographic Surveillance System in rural Guinea-Bissau. Children aged 6–36 months with a Vaccination card inspected were followed to the next visit or for a maximum of 6 months. In Cox proportional-hazards models adjusted for age and village cluster, we compared the survival of children vaccinated with MV early ( 12+ months) with the survival of Measles-unvaccinated children. Among Measles-vaccinated children, we modelled the effect of age at Measles Vaccination linearly to assess mortality changes per month increase in Vaccination age. From 1999 to 2006, 14,813 children (31,725 observations) were included. Children vaccinated with MV had a Hazard Ratio (HR) of 0.76 (95% CI: 0.63–0.91) compared with Measles-unvaccinated children; censoring Measles deaths did not change the results (HR = 0.79 (0.65–0.95)). For early MV the HR was 0.68 (0.53–0.87), for MV as recommended the HR was 0.77 (0.62–0.96) and for late MV the HR was 0.86 (0.67–1.11). Limiting the analysis to Measles-vaccinated children, age at Measles Vaccination was associated with a 2.6% (0.4–5.1%) increase in mortality per month increase in Vaccination age. Early MV was associated with a large survival advantage. The current policy to increase Vaccination age, when Measles control improves, may not optimize the impact of MV on child survival.
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Additional file 1: of Is early Measles Vaccination associated with stronger survival benefits than later Measles Vaccination?
2018Co-Authors: Jesper Hansen, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Ane FiskerAbstract:Supplementary Results. Table S1. List of Vaccination campaigns in Guinea-Bissau 1999â2006. Table S2. Mortality of children with and without Measles vaccine with information on potential confounders. Stratified by age of Vaccination. Table S3. Characteristics at the beginning of an observation period for children by age at entry into the analyses. Table S4. Mortality of children with and without Measles vaccine with deaths due to Measles censored. Stratified by age of Vaccination and by sex. Table S5. Mortality before meningitis and Measles Vaccinations campaigns. Stratified by age at Measles Vaccination and by sex. Table S6. Mortality of Measles-vaccinated children with MV as most recent vaccine, and Measles-unvaccinated children with DTP as most recent vaccine. Stratified by age at Measles Vaccination and by sex. Table S7. Mortality of children with and without Measles vaccine. Children with no vaccines at all are excluded. Stratified by age at Measles Vaccination and by sex. (DOCX 45 kb
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A general Measles Vaccination campaign in urban Guinea-Bissau: Comparing child mortality among participants and non-participants
Vaccine, 2016Co-Authors: Stine Byberg, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Peter Aaby, Christine Stabell Benn, Claudina Cabral, M. Careme, Ane FiskerAbstract:Abstract Background Measles Vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of Measles vaccine. We compared mortality one year after the December 2012 Measles Vaccination campaign in Bissau city for children who received campaign Measles vaccine with children who did not receive campaign Measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project’s study area who received Measles Vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign Measles Vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing Measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine Measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving Measles vaccine during the 2012 campaign, especially for girls and children with previous routine Measles Vaccination. Measles Vaccination campaigns may be an effective way of improving child survival.
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Household experience and costs of seeking Measles Vaccination in rural Guinea-Bissau.
Tropical medicine & international health : TM & IH, 2016Co-Authors: Stine Byberg, Amabelia Rodrigues, Ane Fisker, Ibriama Balde, Ulrika Enemark, Peter Aaby, Christine Stabell Benn, Ulla K. GriffithsAbstract:: Children younger than 12 months of age are eligible for childhood vaccines through the public health system in Guinea-Bissau. To limit open vial wastage, a restrictive vial opening policy has been implemented; 10-dose Measles vaccine vials are only opened if six or more children aged 9-11 months are present at the Vaccination post. Consequently, mothers who bring their child for Measles Vaccination can be told to return another day. We aimed to describe the household experience and estimate household costs of seeking Measles Vaccination in rural Guinea-Bissau. : Within a national sample of village clusters under demographic surveillance, we interviewed mothers of children aged 9-21 months about their experience with seeking Measles Vaccination. From information about time and money spent, we calculated household costs of seeking Measles Vaccination. : We interviewed mothers of 1308 children of whom 1043 (80%) had sought Measles Vaccination at least once. Measles Vaccination coverage was 70% (910/1308). Coverage decreased with increasing distance to the health centre. On average, mothers who had taken their child for Vaccination took their child 1.4 times. Mean costs of achieving 70% coverage were 2.04 USD (SD 3.86) per child taken for Vaccination. Half of the mothers spent more than 2 h seeking Vaccination and 11% spent money on transportation. : We found several indications of missed opportunities for Measles Vaccination resulting in suboptimal coverage. The household costs comprised 3.3% of the average monthly income and should be taken into account when assessing the costs of delivering Vaccinations.
Cesario Martins - One of the best experts on this subject based on the ideXlab platform.
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Is early Measles Vaccination associated with stronger survival benefits than later Measles Vaccination
BMC public health, 2018Co-Authors: Jesper Sloth Hansen, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Ane FiskerAbstract:Measles vaccine (MV) may protect against non-Measles mortality. We tested whether survival depended on age of Measles Vaccination. Bandim Health Project follows children under 5 years of age through a Health and Demographic Surveillance System in rural Guinea-Bissau. Children aged 6–36 months with a Vaccination card inspected were followed to the next visit or for a maximum of 6 months. In Cox proportional-hazards models adjusted for age and village cluster, we compared the survival of children vaccinated with MV early ( 12+ months) with the survival of Measles-unvaccinated children. Among Measles-vaccinated children, we modelled the effect of age at Measles Vaccination linearly to assess mortality changes per month increase in Vaccination age. From 1999 to 2006, 14,813 children (31,725 observations) were included. Children vaccinated with MV had a Hazard Ratio (HR) of 0.76 (95% CI: 0.63–0.91) compared with Measles-unvaccinated children; censoring Measles deaths did not change the results (HR = 0.79 (0.65–0.95)). For early MV the HR was 0.68 (0.53–0.87), for MV as recommended the HR was 0.77 (0.62–0.96) and for late MV the HR was 0.86 (0.67–1.11). Limiting the analysis to Measles-vaccinated children, age at Measles Vaccination was associated with a 2.6% (0.4–5.1%) increase in mortality per month increase in Vaccination age. Early MV was associated with a large survival advantage. The current policy to increase Vaccination age, when Measles control improves, may not optimize the impact of MV on child survival.
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Additional file 1: of Is early Measles Vaccination associated with stronger survival benefits than later Measles Vaccination?
2018Co-Authors: Jesper Hansen, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Ane FiskerAbstract:Supplementary Results. Table S1. List of Vaccination campaigns in Guinea-Bissau 1999â2006. Table S2. Mortality of children with and without Measles vaccine with information on potential confounders. Stratified by age of Vaccination. Table S3. Characteristics at the beginning of an observation period for children by age at entry into the analyses. Table S4. Mortality of children with and without Measles vaccine with deaths due to Measles censored. Stratified by age of Vaccination and by sex. Table S5. Mortality before meningitis and Measles Vaccinations campaigns. Stratified by age at Measles Vaccination and by sex. Table S6. Mortality of Measles-vaccinated children with MV as most recent vaccine, and Measles-unvaccinated children with DTP as most recent vaccine. Stratified by age at Measles Vaccination and by sex. Table S7. Mortality of children with and without Measles vaccine. Children with no vaccines at all are excluded. Stratified by age at Measles Vaccination and by sex. (DOCX 45 kb
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A general Measles Vaccination campaign in urban Guinea-Bissau: Comparing child mortality among participants and non-participants
Vaccine, 2016Co-Authors: Stine Byberg, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Peter Aaby, Christine Stabell Benn, Claudina Cabral, M. Careme, Ane FiskerAbstract:Abstract Background Measles Vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of Measles vaccine. We compared mortality one year after the December 2012 Measles Vaccination campaign in Bissau city for children who received campaign Measles vaccine with children who did not receive campaign Measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project’s study area who received Measles Vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign Measles Vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing Measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine Measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving Measles vaccine during the 2012 campaign, especially for girls and children with previous routine Measles Vaccination. Measles Vaccination campaigns may be an effective way of improving child survival.
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Risk factors for Measles in young infants in an urban African area with high Measles Vaccination coverage.
The Pediatric infectious disease journal, 2011Co-Authors: Carlito Balé, Cesario Martins, May-lill Garly, Jens Nielsen, Hilton Whittle, Peter AabyAbstract:BACKGROUND: We examined risk factors for Measles infection before Measles Vaccination at 9 months of age in Guinea-Bissau. METHODS: Among 1524 children enrolled in a trial of early Measles Vaccination at 4.5 months of age we assessed the relative risk (RR) of Measles before enrollment and the incidence rate ratio between 4.5 and 9 months of age for different groups. RESULTS: The incidence was high with 4% having Measles before 4.5 months and 10% having Measles between 4.5 and 9 months of age. The main risk factor was the age of the mother; children of young mothers (age 15-24 years) had lower antibody titers and higher risk of Measles than children of older mothers both before 4.5 months (RR = 1.74 [1.02-2.96]) and between 4.5 and 9 months of age (incidence rate ratio = 1.59 [1.05-2.41]). Having no Bacillus Calmette-Guerin scar was associated with a higher risk of Measles before 4.5 months of age (RR = 2.61 [1.54-4.45]). Children who were not breast-fed and had fever or respiratory infection at enrollment had a 2- to 4-fold higher risk of Measles between 4.5 and 9 months of age. INTERPRETATION: Young mothers transmit lower titers of antibodies to their children and an increasing proportion of infants become susceptible to Measles before the age of Measles Vaccination.
Amabelia Rodrigues - One of the best experts on this subject based on the ideXlab platform.
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Is early Measles Vaccination associated with stronger survival benefits than later Measles Vaccination
BMC public health, 2018Co-Authors: Jesper Sloth Hansen, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Ane FiskerAbstract:Measles vaccine (MV) may protect against non-Measles mortality. We tested whether survival depended on age of Measles Vaccination. Bandim Health Project follows children under 5 years of age through a Health and Demographic Surveillance System in rural Guinea-Bissau. Children aged 6–36 months with a Vaccination card inspected were followed to the next visit or for a maximum of 6 months. In Cox proportional-hazards models adjusted for age and village cluster, we compared the survival of children vaccinated with MV early ( 12+ months) with the survival of Measles-unvaccinated children. Among Measles-vaccinated children, we modelled the effect of age at Measles Vaccination linearly to assess mortality changes per month increase in Vaccination age. From 1999 to 2006, 14,813 children (31,725 observations) were included. Children vaccinated with MV had a Hazard Ratio (HR) of 0.76 (95% CI: 0.63–0.91) compared with Measles-unvaccinated children; censoring Measles deaths did not change the results (HR = 0.79 (0.65–0.95)). For early MV the HR was 0.68 (0.53–0.87), for MV as recommended the HR was 0.77 (0.62–0.96) and for late MV the HR was 0.86 (0.67–1.11). Limiting the analysis to Measles-vaccinated children, age at Measles Vaccination was associated with a 2.6% (0.4–5.1%) increase in mortality per month increase in Vaccination age. Early MV was associated with a large survival advantage. The current policy to increase Vaccination age, when Measles control improves, may not optimize the impact of MV on child survival.
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Additional file 1: of Is early Measles Vaccination associated with stronger survival benefits than later Measles Vaccination?
2018Co-Authors: Jesper Hansen, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Ane FiskerAbstract:Supplementary Results. Table S1. List of Vaccination campaigns in Guinea-Bissau 1999â2006. Table S2. Mortality of children with and without Measles vaccine with information on potential confounders. Stratified by age of Vaccination. Table S3. Characteristics at the beginning of an observation period for children by age at entry into the analyses. Table S4. Mortality of children with and without Measles vaccine with deaths due to Measles censored. Stratified by age of Vaccination and by sex. Table S5. Mortality before meningitis and Measles Vaccinations campaigns. Stratified by age at Measles Vaccination and by sex. Table S6. Mortality of Measles-vaccinated children with MV as most recent vaccine, and Measles-unvaccinated children with DTP as most recent vaccine. Stratified by age at Measles Vaccination and by sex. Table S7. Mortality of children with and without Measles vaccine. Children with no vaccines at all are excluded. Stratified by age at Measles Vaccination and by sex. (DOCX 45 kb
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A general Measles Vaccination campaign in urban Guinea-Bissau: Comparing child mortality among participants and non-participants
Vaccine, 2016Co-Authors: Stine Byberg, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Peter Aaby, Christine Stabell Benn, Claudina Cabral, M. Careme, Ane FiskerAbstract:Abstract Background Measles Vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of Measles vaccine. We compared mortality one year after the December 2012 Measles Vaccination campaign in Bissau city for children who received campaign Measles vaccine with children who did not receive campaign Measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project’s study area who received Measles Vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign Measles Vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing Measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine Measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving Measles vaccine during the 2012 campaign, especially for girls and children with previous routine Measles Vaccination. Measles Vaccination campaigns may be an effective way of improving child survival.
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Household experience and costs of seeking Measles Vaccination in rural Guinea-Bissau.
Tropical medicine & international health : TM & IH, 2016Co-Authors: Stine Byberg, Amabelia Rodrigues, Ane Fisker, Ibriama Balde, Ulrika Enemark, Peter Aaby, Christine Stabell Benn, Ulla K. GriffithsAbstract:: Children younger than 12 months of age are eligible for childhood vaccines through the public health system in Guinea-Bissau. To limit open vial wastage, a restrictive vial opening policy has been implemented; 10-dose Measles vaccine vials are only opened if six or more children aged 9-11 months are present at the Vaccination post. Consequently, mothers who bring their child for Measles Vaccination can be told to return another day. We aimed to describe the household experience and estimate household costs of seeking Measles Vaccination in rural Guinea-Bissau. : Within a national sample of village clusters under demographic surveillance, we interviewed mothers of children aged 9-21 months about their experience with seeking Measles Vaccination. From information about time and money spent, we calculated household costs of seeking Measles Vaccination. : We interviewed mothers of 1308 children of whom 1043 (80%) had sought Measles Vaccination at least once. Measles Vaccination coverage was 70% (910/1308). Coverage decreased with increasing distance to the health centre. On average, mothers who had taken their child for Vaccination took their child 1.4 times. Mean costs of achieving 70% coverage were 2.04 USD (SD 3.86) per child taken for Vaccination. Half of the mothers spent more than 2 h seeking Vaccination and 11% spent money on transportation. : We found several indications of missed opportunities for Measles Vaccination resulting in suboptimal coverage. The household costs comprised 3.3% of the average monthly income and should be taken into account when assessing the costs of delivering Vaccinations.
Julie D. Cantor - One of the best experts on this subject based on the ideXlab platform.
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Mandatory Measles Vaccination in New York City — Reflections on a Bold Experiment
The New England journal of medicine, 2019Co-Authors: Julie D. CantorAbstract:Mandatory Measles Vaccination in New York City In the face of Measles outbreaks, New York City mandated Vaccination in four Brooklyn ZIP Codes, raising legal, ethical, and practical concerns. Law s...
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mandatory Measles Vaccination in new york city reflections on a bold experiment
The New England Journal of Medicine, 2019Co-Authors: Julie D. CantorAbstract:Mandatory Measles Vaccination in New York City In the face of Measles outbreaks, New York City mandated Vaccination in four Brooklyn ZIP Codes, raising legal, ethical, and practical concerns. Law s...
Peter Aaby - One of the best experts on this subject based on the ideXlab platform.
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A general Measles Vaccination campaign in urban Guinea-Bissau: Comparing child mortality among participants and non-participants
Vaccine, 2016Co-Authors: Stine Byberg, Sanne Thysen, Amabelia Rodrigues, Cesario Martins, Peter Aaby, Christine Stabell Benn, Claudina Cabral, M. Careme, Ane FiskerAbstract:Abstract Background Measles Vaccination campaigns targeting children aged 9–59 months are conducted every three years in Guinea-Bissau. Studies have demonstrated beneficial non-specific effects of Measles vaccine. We compared mortality one year after the December 2012 Measles Vaccination campaign in Bissau city for children who received campaign Measles vaccine with children who did not receive campaign Measles vaccine. Methods Field workers from Bandim Health Project registered all children living in the Bandim Health Project’s study area who received Measles Vaccination at the campaign posts. Children not seen during the campaign were visited at home and campaign participation status was assessed. We compared mortality rates of participants vs. non-participants in Cox regression models. Results 5633 children aged 9–59 months (85%) received campaign Measles Vaccination and 1006 (15%) did not. During the subsequent year 16 children died. Adjusted for background factors, the hazard ratio (HR) comparing Measles vaccinated versus unvaccinated was 0.28 (95% CI: 0.10–0.77). The benefit was larger for girls (HR: 0.17 (0.05–0.59)) and for children who had received routine Measles vaccine before the campaign (HR: 0.15 (0.04–0.63)). Conclusions We found indications of strong beneficial non-specific effects of receiving Measles vaccine during the 2012 campaign, especially for girls and children with previous routine Measles Vaccination. Measles Vaccination campaigns may be an effective way of improving child survival.
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Household experience and costs of seeking Measles Vaccination in rural Guinea-Bissau.
Tropical medicine & international health : TM & IH, 2016Co-Authors: Stine Byberg, Amabelia Rodrigues, Ane Fisker, Ibriama Balde, Ulrika Enemark, Peter Aaby, Christine Stabell Benn, Ulla K. GriffithsAbstract:: Children younger than 12 months of age are eligible for childhood vaccines through the public health system in Guinea-Bissau. To limit open vial wastage, a restrictive vial opening policy has been implemented; 10-dose Measles vaccine vials are only opened if six or more children aged 9-11 months are present at the Vaccination post. Consequently, mothers who bring their child for Measles Vaccination can be told to return another day. We aimed to describe the household experience and estimate household costs of seeking Measles Vaccination in rural Guinea-Bissau. : Within a national sample of village clusters under demographic surveillance, we interviewed mothers of children aged 9-21 months about their experience with seeking Measles Vaccination. From information about time and money spent, we calculated household costs of seeking Measles Vaccination. : We interviewed mothers of 1308 children of whom 1043 (80%) had sought Measles Vaccination at least once. Measles Vaccination coverage was 70% (910/1308). Coverage decreased with increasing distance to the health centre. On average, mothers who had taken their child for Vaccination took their child 1.4 times. Mean costs of achieving 70% coverage were 2.04 USD (SD 3.86) per child taken for Vaccination. Half of the mothers spent more than 2 h seeking Vaccination and 11% spent money on transportation. : We found several indications of missed opportunities for Measles Vaccination resulting in suboptimal coverage. The household costs comprised 3.3% of the average monthly income and should be taken into account when assessing the costs of delivering Vaccinations.
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Risk factors for Measles in young infants in an urban African area with high Measles Vaccination coverage.
The Pediatric infectious disease journal, 2011Co-Authors: Carlito Balé, Cesario Martins, May-lill Garly, Jens Nielsen, Hilton Whittle, Peter AabyAbstract:BACKGROUND: We examined risk factors for Measles infection before Measles Vaccination at 9 months of age in Guinea-Bissau. METHODS: Among 1524 children enrolled in a trial of early Measles Vaccination at 4.5 months of age we assessed the relative risk (RR) of Measles before enrollment and the incidence rate ratio between 4.5 and 9 months of age for different groups. RESULTS: The incidence was high with 4% having Measles before 4.5 months and 10% having Measles between 4.5 and 9 months of age. The main risk factor was the age of the mother; children of young mothers (age 15-24 years) had lower antibody titers and higher risk of Measles than children of older mothers both before 4.5 months (RR = 1.74 [1.02-2.96]) and between 4.5 and 9 months of age (incidence rate ratio = 1.59 [1.05-2.41]). Having no Bacillus Calmette-Guerin scar was associated with a higher risk of Measles before 4.5 months of age (RR = 2.61 [1.54-4.45]). Children who were not breast-fed and had fever or respiratory infection at enrollment had a 2- to 4-fold higher risk of Measles between 4.5 and 9 months of age. INTERPRETATION: Young mothers transmit lower titers of antibodies to their children and an increasing proportion of infants become susceptible to Measles before the age of Measles Vaccination.