The Experts below are selected from a list of 26481 Experts worldwide ranked by ideXlab platform
Webster S. S. Jee - One of the best experts on this subject based on the ideXlab platform.
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Bone mechanics
Clinical Biomechanics, 2001Co-Authors: Webster S. S. JeeAbstract:This informative volume summarizes what is known about bone mechanics. It describes the methods used to acquire that knowledge and suggests the nature of future research on this topic. This easy-to-read book keeps mathematical notation simple and minimal and presents data in summary form. Bone Mechanics is concerned with the Mechanical behavior and functional stress adaptation of whole bones as structural elements, the Mechanical behavior and functional adaptation of bone tissue as material, and the physiological significance of the Mechanical properties of bone and the biological response of bone to applied stress. Orthopaedic surgeons, dentists, anatomists, biologists, biomedical engineers and physiologists are among those who will find this volume to be of interest.
Jj Telega - One of the best experts on this subject based on the ideXlab platform.
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Bone Mechanics Handbook, 2nd Edition. -
Applied Mechanics Reviews, 2003Co-Authors: Stephen C. Cowin, Jj TelegaAbstract:This text summarizes the understanding of bone mechanics with comprehensive coverage of the histology, physiology, and the cell and molecular biology of the bone. It covers Mechanical techniques, Mechanical properties of cortical and cancellous bone, bone adaptation, and clincally related issues.
Ning Wang - One of the best experts on this subject based on the ideXlab platform.
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Cell Mechanics: Mechanical Response, Cell Adhesion, and Molecular Deformation
Annual Review of Biomedical Engineering, 2002Co-Authors: Cheng Zhu, Ning WangAbstract:As the basic unit of life, the cell is a biologically complex system, the understanding of which requires a combination of various approaches including biomechanics. With recent progress in cell and molecular biology, the field of cell mechanics has grown rapidly over the last few years. This review synthesizes some of these recent developments to foster new concepts and approaches, and it emphasizes molecular-level understanding. The focuses are on the common themes and interconnections in three related areas: (a) the responses of cells to Mechanical forces, (b) the mechanics and kinetics of cell adhesion, and (c) the deformation of biomolecules. Specific examples are also given to illustrate the quantitative modeling used in analyzing biological processes and physiological functions.
W T Yang - One of the best experts on this subject based on the ideXlab platform.
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Reaction path potential for complex systems derived from combined ab initio quantum Mechanical and molecular Mechanical calculations
Journal of Chemical Physics, 2004Co-Authors: Z Y Lu, W T YangAbstract:Combined ab initio quantum Mechanical and molecular Mechanical calculations have been widely used for modeling chemical reactions in complex systems such as enzymes, with most applications being based on the determination of a minimum energy path connecting the reactant through the transition state to the product in the enzyme environment. However, statistical mechanics sampling and reaction dynamics calculations with a combined ab initio quantum Mechanical (QM) and molecular Mechanical (MM) potential are still not feasible because of the computational costs associated mainly with the ab initio quantum Mechanical calculations for the QM subsystem. To address this issue, a reaction path potential energy surface is developed here for statistical mechanics and dynamics simulation of chemical reactions in enzymes and other complex systems. The reaction path potential follows the ideas from the reaction path Hamiltonian of Miller, Handy and Adams for gas phase chemical reactions but is designed specifically for large systems that are described with combined ab initio quantum Mechanical and molecular Mechanical methods. The reaction path potential is an analytical energy expression of the combined quantum Mechanical and molecular Mechanical potential energy along the minimum energy path. An expansion around the minimum energy path is made in both the nuclear and the electronic degrees of freedom for the QM subsystem internal energy, while the energy of the subsystem described with MM remains unchanged from that in the combined quantum Mechanical and molecular Mechanical expression and the electrostatic interaction between the QM and MM subsystems is described as the interaction of the MM charges with the QM charges. The QM charges are polarizable in response to the changes in both the MM and the QM degrees of freedom through a new response kernel developed in the present work. The input data for constructing the reaction path potential are energies, vibrational frequencies, and electron density response properties of the QM subsystem along the minimum energy path, all of which can be obtained from the combined quantum Mechanical and molecular Mechanical calculations. Once constructed, it costs much less for its evaluation. Thus, the reaction path potential provides a potential energy surface for rigorous statistical mechanics and reaction dynamics calculations of complex systems. As an example, the method is applied to the statistical Mechanical calculations for the potential of mean force of the chemical reaction in triosephosphate isomerase. (C) 2004 American Institute of Physics.
Josef Guttmann - One of the best experts on this subject based on the ideXlab platform.
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Determination of expiratory lung mechanics using cardiogenic oscillations during decelerated expiration
Critical Care, 2008Co-Authors: Alexander Wahl, Michael Lichtwarck-aschoff, Knut Möller, Stefan Schumann, Josef GuttmannAbstract:Mechanical energy from the beating heart is transferred to the lung, inducing variations in the airway pressure signal called cardiogenic oscillations (COS), which we hypothesize reflect intratidal nonlinear lung mechanics. However, during high flow rate, as characteristic for passive expiration, the analysis of lung mechanics is impractical since COS are almost suppressed and the quantity is low.
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dynamic versus static respiratory mechanics in acute lung injury and acute respiratory distress syndrome
Critical Care Medicine, 2006Co-Authors: C Stahl, Knut Möller, S Schumann, Ralf Kuhlen, M Sydow, Christian Putensen, Josef GuttmannAbstract:Objectives:It is not clear whether the Mechanical properties of the respiratory system assessed under the dynamic condition of Mechanical ventilation are equivalent to those assessed under static conditions. We hypothesized that the analyses of dynamic and static respiratory mechanics provide differ
