The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Gyorgy Buzsaki - One of the best experts on this subject based on the ideXlab platform.

  • behavior dependent short term assembly dynamics in the Medial Prefrontal Cortex
    Nature Neuroscience, 2008
    Co-Authors: Shigeyoshi Fujisawa, Asohan Amarasingham, Matthew T Harrison, Gyorgy Buzsaki
    Abstract:

    Fujisawa and colleagues report that during a working memory task, firing patterns in ensembles of rat Medial Prefrontal Cortex neurons reflect behavioral outcomes on coarser time scales and short-term synaptic plasticity on finer time scales. These results suggest that short-term plasticity plays a role in the neural computations guiding behavior.

  • behavior dependent short term assembly dynamics in the Medial Prefrontal Cortex
    Nature Neuroscience, 2008
    Co-Authors: Shigeyoshi Fujisawa, Asohan Amarasingham, Matthew T Harrison, Gyorgy Buzsaki
    Abstract:

    Although short-term plasticity is believed to play a fundamental role in cortical computation, empirical evidence bearing on its role during behavior is scarce. Here we looked for the signature of short-term plasticity in the fine-timescale spiking relationships of a simultaneously recorded population of physiologically identified pyramidal cells and interneurons, in the Medial Prefrontal Cortex of the rat, in a working memory task. On broader timescales, sequentially organized and transiently active neurons reliably differentiated between different trajectories of the rat in the maze. On finer timescales, putative monosynaptic interactions reflected short-term plasticity in their dynamic and predictable modulation across various aspects of the task, beyond a statistical accounting for the effect of the neurons' co-varying firing rates. Seeking potential mechanisms for such effects, we found evidence for both firing pattern-dependent facilitation and depression, as well as for a supralinear effect of presynaptic coincidence on the firing of postsynaptic targets.

Bruce L Mcnaughton - One of the best experts on this subject based on the ideXlab platform.

  • the role of Medial Prefrontal Cortex in memory and decision making
    Neuron, 2012
    Co-Authors: David R Euston, Aaron J Gruber, Bruce L Mcnaughton
    Abstract:

    Some have claimed that the Medial Prefrontal Cortex (mPFC) mediates decision making. Others suggest mPFC is selectively involved in the retrieval of remote long-term memory. Yet others suggests mPFC supports memory and consolidation on time scales ranging from seconds to days. How can all these roles be reconciled? We propose that the function of the mPFC is to learn associations between context, locations, events, and corresponding adaptive responses, particularly emotional responses. Thus, the ubiquitous involvement of mPFC in both memory and decision making may be due to the fact that almost all such tasks entail the ability to recall the best action or emotional response to specific events in a particular place and time. An interaction between multiple memory systems may explain the changing importance of mPFC to different types of memories over time. In particular, mPFC likely relies on the hippocampus to support rapid learning and memory consolidation.

  • selective delay activity in the Medial Prefrontal Cortex of the rat contribution of sensorimotor information and contingency
    Journal of Neurophysiology, 2007
    Co-Authors: Stephen L Cowen, Bruce L Mcnaughton
    Abstract:

    The Medial Prefrontal Cortex (mPFC) plays a critical role in the organization of goal-directed behaviors and in the learning of reinforcement contingencies. Given these observations, it was hypothe...

Shigeyoshi Fujisawa - One of the best experts on this subject based on the ideXlab platform.

  • behavior dependent short term assembly dynamics in the Medial Prefrontal Cortex
    Nature Neuroscience, 2008
    Co-Authors: Shigeyoshi Fujisawa, Asohan Amarasingham, Matthew T Harrison, Gyorgy Buzsaki
    Abstract:

    Fujisawa and colleagues report that during a working memory task, firing patterns in ensembles of rat Medial Prefrontal Cortex neurons reflect behavioral outcomes on coarser time scales and short-term synaptic plasticity on finer time scales. These results suggest that short-term plasticity plays a role in the neural computations guiding behavior.

  • behavior dependent short term assembly dynamics in the Medial Prefrontal Cortex
    Nature Neuroscience, 2008
    Co-Authors: Shigeyoshi Fujisawa, Asohan Amarasingham, Matthew T Harrison, Gyorgy Buzsaki
    Abstract:

    Although short-term plasticity is believed to play a fundamental role in cortical computation, empirical evidence bearing on its role during behavior is scarce. Here we looked for the signature of short-term plasticity in the fine-timescale spiking relationships of a simultaneously recorded population of physiologically identified pyramidal cells and interneurons, in the Medial Prefrontal Cortex of the rat, in a working memory task. On broader timescales, sequentially organized and transiently active neurons reliably differentiated between different trajectories of the rat in the maze. On finer timescales, putative monosynaptic interactions reflected short-term plasticity in their dynamic and predictable modulation across various aspects of the task, beyond a statistical accounting for the effect of the neurons' co-varying firing rates. Seeking potential mechanisms for such effects, we found evidence for both firing pattern-dependent facilitation and depression, as well as for a supralinear effect of presynaptic coincidence on the firing of postsynaptic targets.

Antonio Argiolas - One of the best experts on this subject based on the ideXlab platform.

  • dopamine noradrenaline and differences in sexual behavior between roman high and low avoidance male rats a microdialysis study in the Medial Prefrontal Cortex
    Frontiers in Behavioral Neuroscience, 2017
    Co-Authors: Fabrizio Sanna, Jessica Bratzu, Maria Antonietta Piludu, Maria Giuseppa Corda, Maria Rosaria Melis, Osvaldo Giorgi, Antonio Argiolas
    Abstract:

    Roman High- (RHA) and Low-Avoidance (RLA) outbred rats, which differ for a respectively rapid vs. poor acquisition of the active avoidance response in the shuttle-box, display differences in sexual activity when put in the presence of a sexually receptive female rat. Indeed RHA rats show higher levels of sexual motivation and copulatory performance than RLA rats, which persist also after repeated sexual activity. These differences have been correlated to a higher tone of the mesolimbic dopaminergic system of RHA rats vs. RLA rats, revealed by the higher increase of dopamine found in the dialysate obtained from the nucleus accumbens of RHA than RLA rats during sexual activity. This work shows that extracellular dopamine and noradrenaline also, increase in the dialysate from the Medial Prefrontal Cortex of male RHA and RLA rats put in the presence of an inaccessible female rat and more markedly during direct sexual interaction. Such increases in dopamine (and its main metabolite DOPAC) and noradrenaline were found in both sexually naive and experienced animals, but they were higher i) in RHA than in RLA rats and ii) in sexually experienced RHA and RLA rats than in their naive counterparts. Finally, the differences in dopamine and noradrenaline in the Medial Prefrontal Cortex occurred concomitantly to those in sexual activity, as RHA rats displayed higher levels of sexual motivation and copulatory performance than RLA rats in both the sexually naive and experienced conditions. These results suggest that a higher dopaminergic tone also occurs in the Medial Prefrontal Cortex, together with an increased noradrenergic tone, which may be involved in the different copulatory patterns found in RHA and RLA rats, as suggested for the mesolimbic dopaminergic system.

Lique M Coole - One of the best experts on this subject based on the ideXlab platform.

  • lesions of the Medial Prefrontal Cortex cause maladaptive sexual behavior in male rats
    Biological Psychiatry, 2010
    Co-Authors: Jo F Davis, Maarte Loos, Andrea R Di Sebastiano, Michael N Lehma, Lique M Coole
    Abstract:

    Background An inability to inhibit behaviors once they become maladaptive is a component of several psychiatric illnesses, and the Medial Prefrontal Cortex (mPFC) was identified as a potential mediator of behavioral inhibition. The current study tested if the mPFC is involved in inhibition of sexual behavior when associated with aversive outcomes. Methods Using male rats, effects of lesions of the infralimbic and prelimbic areas of the mPFC on expression of sexual behavior and ability to inhibit mating were tested using a paradigm of copulation-contingent aversion. Results Medial Prefrontal Cortex lesions did not alter expression of sexual behavior. In contrast, mPFC lesions completely blocked the acquisition of sex-aversion conditioning and lesioned animals continued to mate, in contrast to the robust behavioral inhibition toward copulation in mPFC intact male animals, resulting in only 22% of intact male animals continuing to mate. However, rats with mPFC lesions were capable of forming a conditioned place preference to sexual reward and conditioned place aversion for lithium chloride, suggesting that these lesions did not alter associative learning or sensitivity for lithium chloride. Conclusions The current study indicates that animals with mPFC lesions are likely capable of forming the associations with aversive outcomes of their behavior but lack the ability to suppress seeking of sexual reward in the face of aversive consequences. These data may contribute to a better understanding of a common pathology underlying impulse control disorders, as compulsive sexual behavior has a high prevalence of comorbidity with psychiatric disorders and Parkinson's disease.