The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Michael X Cohen - One of the best experts on this subject based on the ideXlab platform.
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top down directed synchrony from medial frontal cortex to Nucleus Accumbens during reward anticipation
Human Brain Mapping, 2012Co-Authors: Michael X Cohen, L J Bour, Mariska Mantione, Martijn Figee, Matthijs Vink, Marina A J Tijssen, Annefleur Van Rootselaar, Pepijn Van Den Munckhof, Richard P SchuurmanAbstract:The Nucleus Accumbens and medial frontal cortex (MFC) are part of a loop involved in modu- lating behavior according to anticipated rewards. However, the precise temporal landscape of their elec- trophysiological interactions in humans remains unknown because it is not possible to record neural activity from the Nucleus Accumbens using noninvasive techniques. We recorded electrophysiological ac- tivity simultaneously from the Nucleus Accumbens and cortex (via surface EEG) in humans who had elec- trodes implanted as part of deep-brain-stimulation treatment for obsessive-compulsive disorder. Patients performed a simple reward motivation task previously shown to activate the ventral striatum. Spectral Granger causality analyses were applied to dissociate ''top-down'' (cortex ! Nucleus Accumbens)- from ''bottom-up'' (Nucleus Accumbens ! cortex)-directed synchronization (functional connectivity). ''Top- down''-directed synchrony from cortex to Nucleus Accumbens was maximal over medial frontal sites and was significantly stronger when rewards were anticipated. These findings provide direct electrophysio- logical evidence for a role of the MFC in modulating Nucleus Accumbens reward-related processing and may be relevant to understanding the mechanisms of deep-brain stimulation and its beneficial effects on psychiatric conditions. Hum Brain Mapp 00:000-000, 2011. V C 2011 Wiley-Liss, Inc.
Alberto Oliverio - One of the best experts on this subject based on the ideXlab platform.
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Spatial memory, plasticity and Nucleus Accumbens
Reviews in The Neurosciences, 2012Co-Authors: Arianna Rinaldi, Alberto Oliverio, Andrea MeleAbstract:Research on the function of the Nucleus Accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the Nucleus Accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-Nucleus Accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the Nucleus Accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit.
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Nucleus Accumbens dopamine receptors in the consolidation of spatial memory.
Behavioural Pharmacology, 2004Co-Authors: Andrea Mele, M. Avena, P. Roullet, E. De Leonibus, S. Mandillo, F. Sargolini, R. Coccurello, Alberto OliverioAbstract:Nucleus Accumbens dopamine is known to play an important role in motor activity and in behaviours governed by drugs and natural reinforcers, as well as in non-associative forms of learning. At the same time, activation of D1 and D2 dopamine receptors has been suggested to promote intracellular events related to neural plasticity. Therefore, in this study we wished to investigate the role of the two classes of dopamine receptors within the Nucleus Accumbens on the consolidation of spatial information. On day 1, CD1 male mice were placed in an open field containing five different objects and, immediately after three sessions of habituation, the animals were focally injected within the Nucleus Accumbens with either the D1 antagonist SCH 23390 (12.5, 25 or 50 ng/side), or the D2 antagonist sulpiride (25, 50, 75 or 100 ng/side). Twenty-four hours later the ability of mice to discriminate an object displacement was assessed. Both the D1 and the D2 antagonists impaired the ability of mice to detect the spatial change. If the highest doses of the two antagonists were injected 2 h after the end of the last of the habituation sessions, no effect was observed in the reactivity to spatial change examined 24 h later. These data demonstrate that activation of both D1 and D2 receptors within the Accumbens is necessary in the early stages of the consolidation of spatial information. The data are discussed in terms of involvement of Nucleus Accumbens dopamine in information processing in the absence of explicit reinforcers.
Andrea Mele - One of the best experts on this subject based on the ideXlab platform.
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Spatial memory, plasticity and Nucleus Accumbens
Reviews in The Neurosciences, 2012Co-Authors: Arianna Rinaldi, Alberto Oliverio, Andrea MeleAbstract:Research on the function of the Nucleus Accumbens, the most ventral component of the striatal complex, has traditionally focused on locomotor activity, reward, motivation and addiction. However, based on the existence of projections to the Nucleus Accumbens from the allocortical regions involved in spatial navigation, it has been suggested that this structure plays a role in spatial learning and memory. Lesion and neuropharmacological studies confirm this view, also revealing the complex dynamics of the receptors involved in these processes. Moreover, the effects of post-training intra-Nucleus Accumbens drug administrations demonstrate the necessity of off-line neural activity within this structure in order to consolidate spatial memory. Blockade of molecular processes implicated in synaptic plasticity, such as cAMP response element-binding protein (CREB)-induced transcription or extracellular matrix remodeling, provides further experimental support to this hypothesis. These observations imply that experience-dependent synaptic plasticity responsible for long-term stabilization of spatial information might occur within the Nucleus Accumbens, similarly to what has been observed in the hippocampus. This suggests that a comprehensive understanding of spatial memory processing should be viewed in the context of a wider neural circuit.
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Nucleus Accumbens dopamine receptors in the consolidation of spatial memory.
Behavioural Pharmacology, 2004Co-Authors: Andrea Mele, M. Avena, P. Roullet, E. De Leonibus, S. Mandillo, F. Sargolini, R. Coccurello, Alberto OliverioAbstract:Nucleus Accumbens dopamine is known to play an important role in motor activity and in behaviours governed by drugs and natural reinforcers, as well as in non-associative forms of learning. At the same time, activation of D1 and D2 dopamine receptors has been suggested to promote intracellular events related to neural plasticity. Therefore, in this study we wished to investigate the role of the two classes of dopamine receptors within the Nucleus Accumbens on the consolidation of spatial information. On day 1, CD1 male mice were placed in an open field containing five different objects and, immediately after three sessions of habituation, the animals were focally injected within the Nucleus Accumbens with either the D1 antagonist SCH 23390 (12.5, 25 or 50 ng/side), or the D2 antagonist sulpiride (25, 50, 75 or 100 ng/side). Twenty-four hours later the ability of mice to discriminate an object displacement was assessed. Both the D1 and the D2 antagonists impaired the ability of mice to detect the spatial change. If the highest doses of the two antagonists were injected 2 h after the end of the last of the habituation sessions, no effect was observed in the reactivity to spatial change examined 24 h later. These data demonstrate that activation of both D1 and D2 receptors within the Accumbens is necessary in the early stages of the consolidation of spatial information. The data are discussed in terms of involvement of Nucleus Accumbens dopamine in information processing in the absence of explicit reinforcers.
Robert C Malenka - One of the best experts on this subject based on the ideXlab platform.
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5-HT release in Nucleus Accumbens rescues social deficits in mouse autism model
Nature, 2018Co-Authors: Jessica J Walsh, Daniel J Christoffel, Boris D Heifets, Gabriel A Bendor, Aslihan Selimbeyoglu, Lin W Hung, Karl Deisseroth, Robert C MalenkaAbstract:Dysfunction in prosocial interactions is a core symptom of autism spectrum disorder. However, the neural mechanisms that underlie sociability are poorly understood, limiting the rational development of therapies to treat social deficits. Here we show in mice that bidirectional modulation of the release of serotonin (5-HT) from dorsal raphe neurons in the Nucleus Accumbens bidirectionally modifies sociability. In a mouse model of a common genetic cause of autism spectrum disorder—a copy number variation on chromosome 16p11.2—genetic deletion of the syntenic region from 5-HT neurons induces deficits in social behaviour and decreases dorsal raphe 5-HT neuronal activity. These sociability deficits can be rescued by optogenetic activation of dorsal raphe 5-HT neurons, an effect requiring and mimicked by activation of 5-HT1b receptors in the Nucleus Accumbens. These results demonstrate an unexpected role for 5-HT action in the Nucleus Accumbens in social behaviours, and suggest that targeting this mechanism may prove therapeutically beneficial.Stimulating the release of serotonin (5-HT) in the Nucleus Accumbens in wild-type mice promotes sociability, and rescues deficits in social behaviours in a mouse model of autism.
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Social reward requires coordinated activity of Nucleus Accumbens oxytocin and serotonin
Nature, 2013Co-Authors: Gül Dölen, Ayeh Darvishzadeh, Kee Wui Huang, Robert C MalenkaAbstract:Social behaviours in species as diverse as honey bees and humans promote group survival but often come at some cost to the individual. Although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviours, the neural mechanisms by which social reward is encoded by the brain are largely unknown. Here we demonstrate that in mice oxytocin acts as a social reinforcement signal within the Nucleus Accumbens core, where it elicits a presynaptically expressed long-term depression of excitatory synaptic transmission in medium spiny neurons. Although the Nucleus Accumbens receives oxytocin-receptor-containing inputs from several brain regions, genetic deletion of these receptors specifically from dorsal raphe Nucleus, which provides serotonergic (5-hydroxytryptamine; 5-HT) innervation to the Nucleus Accumbens, abolishes the reinforcing properties of social interaction. Furthermore, oxytocin-induced synaptic plasticity requires activation of Nucleus Accumbens 5-HT1B receptors, the blockade of which prevents social reward. These results demonstrate that the rewarding properties of social interaction in mice require the coordinated activity of oxytocin and 5-HT in the Nucleus Accumbens, a mechanistic insight with implications for understanding the pathogenesis of social dysfunction in neuropsychiatric disorders such as autism.
Richard P Schuurman - One of the best experts on this subject based on the ideXlab platform.
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top down directed synchrony from medial frontal cortex to Nucleus Accumbens during reward anticipation
Human Brain Mapping, 2012Co-Authors: Michael X Cohen, L J Bour, Mariska Mantione, Martijn Figee, Matthijs Vink, Marina A J Tijssen, Annefleur Van Rootselaar, Pepijn Van Den Munckhof, Richard P SchuurmanAbstract:The Nucleus Accumbens and medial frontal cortex (MFC) are part of a loop involved in modu- lating behavior according to anticipated rewards. However, the precise temporal landscape of their elec- trophysiological interactions in humans remains unknown because it is not possible to record neural activity from the Nucleus Accumbens using noninvasive techniques. We recorded electrophysiological ac- tivity simultaneously from the Nucleus Accumbens and cortex (via surface EEG) in humans who had elec- trodes implanted as part of deep-brain-stimulation treatment for obsessive-compulsive disorder. Patients performed a simple reward motivation task previously shown to activate the ventral striatum. Spectral Granger causality analyses were applied to dissociate ''top-down'' (cortex ! Nucleus Accumbens)- from ''bottom-up'' (Nucleus Accumbens ! cortex)-directed synchronization (functional connectivity). ''Top- down''-directed synchrony from cortex to Nucleus Accumbens was maximal over medial frontal sites and was significantly stronger when rewards were anticipated. These findings provide direct electrophysio- logical evidence for a role of the MFC in modulating Nucleus Accumbens reward-related processing and may be relevant to understanding the mechanisms of deep-brain stimulation and its beneficial effects on psychiatric conditions. Hum Brain Mapp 00:000-000, 2011. V C 2011 Wiley-Liss, Inc.
