The Experts below are selected from a list of 111 Experts worldwide ranked by ideXlab platform
Peter C. Doherty - One of the best experts on this subject based on the ideXlab platform.
-
Cell Mediated Immunity in Virus Infections
Bioscience Reports, 1997Co-Authors: Peter C. DohertyAbstract:The discovery of the molecular nature of T cell-Mediated Immunity is reviewed in a historical context. Current approaches to understanding virus-induced inflammatory processes are described.
Rawleigh Rowe - One of the best experts on this subject based on the ideXlab platform.
-
Cell-Mediated Immunity in Trachomatous Scarring: Evidence from a Leprosy Population
Ophthalmology, 1993Co-Authors: Paul Courtright, Susan Lewallen, Rawleigh RoweAbstract:Background: There is limited understanding of the mechanisms that mediate Immunity after infection by Chlamydia trachomatis . Since it is known that the clinical course of leprosy is related to cell-Mediated Immunity and that such Immunity contributes to the development of trachomatous conjunctival scarring, the authors examined patients to determine if there might be an association between leprosy status and trachomatous conjunctival scarring. Methods: Leprosy patients registered at Shashemane Hospital were interviewed, examined, and patients with siblings residing in the vicinity were asked to return for further clinical examination. A subsample of sibships was selected for laboratory evaluation of cell-Mediated Immunity, measured by lymphocyte proliferative responses in vitro to stimulation by mycobacterial antigens. Results: Conjunctival scarring was less severe in multibacillary leprosy patients (with suppressed cell-Mediated Immunity) than in their healthy siblings and more severe in paucibacillary leprosy patients (with enhanced cell-Mediated Immunity) than in their healthy siblings. The mean lymphocyte proliferative responses to mycobacterial antigens were greater, in the sibling (whether leprous or healthy) with more severe conjunctival scarring, regardless of type of leprosy. Conclusion: The specific cellular immune responses to Mycobacterium leprae and p65 antigen in patients with increased conjunctival scarring provide evidence that early in the course of infection with C. trachomatis , factors related to an individual's cellular response are crucial to the development of conjunctival scarring. A delayed-type hypersensitivity reaction ("reversal reaction") found in paucibacillary leprosy patients could contribute to the increased trachomatous conjunctival scarring in these patients.
Myron J. Levin - One of the best experts on this subject based on the ideXlab platform.
-
VZV T Cell-Mediated Immunity
Current topics in microbiology and immunology, 2010Co-Authors: Adriana Weinberg, Myron J. LevinAbstract:Primary varicella-zoster virus (VZV) infection (varicella) induces VZV-specific antibody and VZV-specific T cell-Mediated Immunity. T cell-Mediated Immunity, which is detected within 1–2 weeks after appearance of rash, and consists of both CD4 and CD8 effector and memory T cells, is essential for recovery from varicella. Administration of a varicella vaccine also generates VZV-specific humoral and cellular immune responses. The memory cell responses that develop during varicella or after vaccination contribute to protection following re-exposure to VZV. These responses are subsequently boosted either by endogenous re-exposure (silent reactivation of latent virus) or exogenous re-exposure (environmental). VZV-specific T cell-Mediated Immunity is also necessary to maintain latent VZV in a subclinical state in sensory ganglia. When these responses decline, as occurs with aging or iatrogenic immune suppression, reactivation of VZV leads to herpes zoster. Similarly, the magnitude of these responses early after the onset of herpes zoster correlates with the extent of zoster-associated pain. These essential immune responses are boosted by the VZV vaccine developed to prevent herpes zoster.
Baik Hwan Cho - One of the best experts on this subject based on the ideXlab platform.
-
Effect of radiofrequency ablation of the liver on cell-Mediated Immunity in rats.
World journal of surgery, 2005Co-Authors: Jang Il Moon, Zhe-wu Jin, Dae Yung Lee, Chan Young Kim, Chang Ho Song, Baik Hwan ChoAbstract:We investigated the effect of radiofrequency ablation (RFA) of the liver on cell-Mediated Immunity in rats. Sprague-Dawley rats were divided into five groups: control group that did not have any procedure, a sham-operation group that underwent laparotomy, a lobectomy group that had left lateral lobectomy of the liver, a one-lobe RFA group that had RFA on the left lateral lobe of the liver, and a two-lobe RFA group that had RFA on the left lateral and left median lobe of the liver. Delayed-type hypersensitivity (DTH) was induced by challenging the ears of previously sensitized rats with 2,4-dinitro-1-fluorobenzene. Cell-Mediated Immunity was evaluated by direct measurement of the ear thickness and quantitative analysis of leukocytic infiltration of the tissue. The increased ear thickness was 42.0%, 69.2%, 61.8%, 46.7%, and 39.8% from the baseline one day after each procedure, and the mean leukocytic infiltration into the ear tissue was 3136.7, 3895.0, 3913.3, 2803.3, and 2316.7/mm2 seven days after each procedure in the control, sham-operation, lobectomy, one-lobe RFA, and two-lobe RFA groups, respectively. In conclusion, RFA of the liver tissue can partially abolish the augmentation of DTH and leukocytic infiltration those were seen in the hepatic lobectomy and sham-operation groups. The procedure had a negative effect on cell-Mediated Immunity in rats, and the intensity of RFA showed a reverse correlation with cell-Mediated Immunity.
Paul Courtright - One of the best experts on this subject based on the ideXlab platform.
-
Cell-Mediated Immunity in Trachomatous Scarring: Evidence from a Leprosy Population
Ophthalmology, 1993Co-Authors: Paul Courtright, Susan Lewallen, Rawleigh RoweAbstract:Background: There is limited understanding of the mechanisms that mediate Immunity after infection by Chlamydia trachomatis . Since it is known that the clinical course of leprosy is related to cell-Mediated Immunity and that such Immunity contributes to the development of trachomatous conjunctival scarring, the authors examined patients to determine if there might be an association between leprosy status and trachomatous conjunctival scarring. Methods: Leprosy patients registered at Shashemane Hospital were interviewed, examined, and patients with siblings residing in the vicinity were asked to return for further clinical examination. A subsample of sibships was selected for laboratory evaluation of cell-Mediated Immunity, measured by lymphocyte proliferative responses in vitro to stimulation by mycobacterial antigens. Results: Conjunctival scarring was less severe in multibacillary leprosy patients (with suppressed cell-Mediated Immunity) than in their healthy siblings and more severe in paucibacillary leprosy patients (with enhanced cell-Mediated Immunity) than in their healthy siblings. The mean lymphocyte proliferative responses to mycobacterial antigens were greater, in the sibling (whether leprous or healthy) with more severe conjunctival scarring, regardless of type of leprosy. Conclusion: The specific cellular immune responses to Mycobacterium leprae and p65 antigen in patients with increased conjunctival scarring provide evidence that early in the course of infection with C. trachomatis , factors related to an individual's cellular response are crucial to the development of conjunctival scarring. A delayed-type hypersensitivity reaction ("reversal reaction") found in paucibacillary leprosy patients could contribute to the increased trachomatous conjunctival scarring in these patients.
