The Experts below are selected from a list of 342 Experts worldwide ranked by ideXlab platform
Ruen Liu - One of the best experts on this subject based on the ideXlab platform.
-
regional metabolic and network changes in Meige Syndrome
Scientific Reports, 2021Co-Authors: Jiayu Liu, Qian Wang, Ruen Liu, Hu DingAbstract:To contribute to the understanding of the aetiology and pathogenesis of Meige Syndrome, the metabolic networks of patients with Meige Syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed and unmedicated primary Meige Syndrome patients enrolled between September 2017 and September 2020 at the Department of Neurosurgery, Peking University People’s Hospital, and 50 age- and sex-matched healthy control subjects participated in the study. Metabolic connectivity and graph theory analysis were used to investigate metabolic network differences based on 18F-FDG-PET images. Glucose hypometabolism was detected in the left internal globus pallidus and parietal lobe, right frontal lobe and postcentral gyrus, and bilateral thalamus and cerebellum of patients with Meige Syndrome. Clustering coefficients (Cps) (density threshold: 16–28%; P < 0.05) and shortest path lengths (Lps) (density threshold: 10–15%; P < 0.05) were higher in Meige Syndrome patients than in healthy controls. Small-worldness was lower in Meige Syndrome patients than in healthy controls, and centrality was significantly lower in the right superior occipital gyrus and pallidum and higher in the right thalamus. Hypometabolism in the globus pallidus and thalamus may indicate basal ganglia-thalamocortical motor circuit abnormalities as a pathogenic mechanism of Meige Syndrome, providing a possible explanation for the efficacy of deep brain stimulation (DBS) in improving symptoms. Meige Syndrome patients had abnormal small-world properties. Centrality changes in the right pallidus and thalamus verified the important roles of these regions in the pathogenesis of Meige Syndrome.
-
pallidal versus subthalamic deep brain stimulation for Meige Syndrome a retrospective study
Scientific Reports, 2021Co-Authors: Jiayu Liu, Ruen Liu, Hu Ding, Dongliang Wang, Zhi Liu, Jia Ouyang, Zeyu MiaoAbstract:Deep-brain stimulation (DBS) is an effective treatment for patients with Meige Syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are accepted targets for this treatment. We compared 12-month outcomes for patients who had undergone bilateral stimulation of the GPi or STN. Forty-two Asian patients with primary Meige Syndrome who underwent GPi or STN neurostimulation were recruited between September 2017 and September 2019 at the Department of Neurosurgery, Peking University People’s Hospital. The primary outcome was the change in motor function, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) at 3 days before DBS (baseline) surgery and 1, 3, 6, and 12 months after surgery. Secondary outcomes included health-related quality of life, sleep quality status, depression severity, and anxiety severity at 3 days before and 12 months after DBS surgery. Adverse events during the 12 months were also recorded. Changes in BFMDRS-M and BFMDRS-D scores at 1, 3, 6, and 12 months with DBS and without medication did not significantly differ based on the stimulation target. There were also no significant differences in the changes in health-related quality of life (36-Item Short-Form General Health Survey) and sleep quality status (Pittsburgh Sleep Quality Index) at 12 months. However, there were larger improvements in the STN than the GPi group in mean score changes on the 17-item Hamilton depression rating scale (− 3.38 vs. − 0.33 points; P = 0.014) and 14-item Hamilton anxiety rating scale (− 3.43 vs. − 0.19 points; P < 0.001). There were no significant between-group differences in the frequency or type of serious adverse events. Patients with Meige Syndrome had similar improvements in motor function, quality of life and sleep after either pallidal or subthalamic stimulation. Depression and anxiety factors may reasonably be included during the selection of DBS targets for Meige Syndrome.
-
subthalamic nucleus deep brain stimulation in primary Meige Syndrome a 1 year follow up study
Neuromodulation, 2021Co-Authors: Jia Ouyang, Hu Ding, Dongliang Wang, Qingpei Hao, Runze Zhu, Ruen LiuAbstract:OBJECTIVE To investigate the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Meige Syndrome. MATERIALS AND METHODS Fifteen consecutive patients who underwent STN-DBS at the Peking University People's Hospital between September 2017 and June 2018 were included in this study. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score and the BFMDRS disability score were obtained prior to surgery, and at specific time points after surgery. Patients' sleep status was also assessed before and after surgery. RESULTS The BFMDRS movement scores decreased from 15.3 ± 4.6 to 5.2 ± 6.2 after STN-DBS, with a mean improvement of 68.6% (p < 0.05). The BFMDRS disability scores were also significantly decreased, from 6.9 ± 3.3 to 3.5 ± 2.9, with a mean improvement of 51.7% (p < 0.05). The eye, mouth, speech, and swallowing movement scores also decreased significantly after STN-DBS compared to baseline (p < 0.05). The sleep quality of the patients was also improved after surgery. CONCLUSIONS These findings demonstrate that the STN is an effective brain target for the treatment of patients with Meige Syndrome. STN-DBS was not only able to improve patients' motor symptoms, but also their sleep status.
-
Regional metabolic and network changes in Meige Syndrome
'Springer Science and Business Media LLC', 2021Co-Authors: Jiayu Liu, Qian Wang, Ruen Liu, Hu DingAbstract:Abstract To contribute to the understanding of the aetiology and pathogenesis of Meige Syndrome, the metabolic networks of patients with Meige Syndrome were investigated using 18F-fluoro-D-glucose positron emission tomography (18F-FDG-PET) imaging of cerebral glucose metabolism. Fifty right-handed and unmedicated primary Meige Syndrome patients enrolled between September 2017 and September 2020 at the Department of Neurosurgery, Peking University People’s Hospital, and 50 age- and sex-matched healthy control subjects participated in the study. Metabolic connectivity and graph theory analysis were used to investigate metabolic network differences based on 18F-FDG-PET images. Glucose hypometabolism was detected in the left internal globus pallidus and parietal lobe, right frontal lobe and postcentral gyrus, and bilateral thalamus and cerebellum of patients with Meige Syndrome. Clustering coefficients (Cps) (density threshold: 16–28%; P
-
pallidal deep brain stimulation in primary Meige Syndrome clinical outcomes and psychiatric features
Journal of Neurology Neurosurgery and Psychiatry, 2020Co-Authors: Qingpei Hao, Hu Ding, Dongliang Wang, Zhi Liu, Jia Ouyang, Ruen LiuAbstract:Objectives To study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige Syndrome (MS) and evaluate the psychiatric disorders before and after surgery. Methods Twenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed before surgery and after continuous neurostimulation. Before surgery, patients were assessed by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Self-Rating Depression Scale, Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and Pittsburgh Sleep Quality Index (PQSI), which corresponded to motor symptoms, depressive state, quality of life and sleep quality, respectively. The implantable pulse generator of each patient was activated at 1 month after surgery. At 1 month, 3 months, 6 months and 12 months after continuous neurostimulation, all patients were evaluated by the same scales above. Results The BFMDRS movement scores decreased from 15.0±5.3 before surgery to 3.5±4.5 at 12 months after neurostimulation, with a mean improvement of 78% (p Conclusions Bilateral pallidal neurostimulation is a beneficial therapeutic option for refractory MS, which could improve the motor symptoms except for depression and sleep quality.
Jia Ouyang - One of the best experts on this subject based on the ideXlab platform.
-
pallidal versus subthalamic deep brain stimulation for Meige Syndrome a retrospective study
Scientific Reports, 2021Co-Authors: Jiayu Liu, Ruen Liu, Hu Ding, Dongliang Wang, Zhi Liu, Jia Ouyang, Zeyu MiaoAbstract:Deep-brain stimulation (DBS) is an effective treatment for patients with Meige Syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are accepted targets for this treatment. We compared 12-month outcomes for patients who had undergone bilateral stimulation of the GPi or STN. Forty-two Asian patients with primary Meige Syndrome who underwent GPi or STN neurostimulation were recruited between September 2017 and September 2019 at the Department of Neurosurgery, Peking University People’s Hospital. The primary outcome was the change in motor function, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) at 3 days before DBS (baseline) surgery and 1, 3, 6, and 12 months after surgery. Secondary outcomes included health-related quality of life, sleep quality status, depression severity, and anxiety severity at 3 days before and 12 months after DBS surgery. Adverse events during the 12 months were also recorded. Changes in BFMDRS-M and BFMDRS-D scores at 1, 3, 6, and 12 months with DBS and without medication did not significantly differ based on the stimulation target. There were also no significant differences in the changes in health-related quality of life (36-Item Short-Form General Health Survey) and sleep quality status (Pittsburgh Sleep Quality Index) at 12 months. However, there were larger improvements in the STN than the GPi group in mean score changes on the 17-item Hamilton depression rating scale (− 3.38 vs. − 0.33 points; P = 0.014) and 14-item Hamilton anxiety rating scale (− 3.43 vs. − 0.19 points; P < 0.001). There were no significant between-group differences in the frequency or type of serious adverse events. Patients with Meige Syndrome had similar improvements in motor function, quality of life and sleep after either pallidal or subthalamic stimulation. Depression and anxiety factors may reasonably be included during the selection of DBS targets for Meige Syndrome.
-
subthalamic nucleus deep brain stimulation in primary Meige Syndrome a 1 year follow up study
Neuromodulation, 2021Co-Authors: Jia Ouyang, Hu Ding, Dongliang Wang, Qingpei Hao, Runze Zhu, Ruen LiuAbstract:OBJECTIVE To investigate the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Meige Syndrome. MATERIALS AND METHODS Fifteen consecutive patients who underwent STN-DBS at the Peking University People's Hospital between September 2017 and June 2018 were included in this study. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score and the BFMDRS disability score were obtained prior to surgery, and at specific time points after surgery. Patients' sleep status was also assessed before and after surgery. RESULTS The BFMDRS movement scores decreased from 15.3 ± 4.6 to 5.2 ± 6.2 after STN-DBS, with a mean improvement of 68.6% (p < 0.05). The BFMDRS disability scores were also significantly decreased, from 6.9 ± 3.3 to 3.5 ± 2.9, with a mean improvement of 51.7% (p < 0.05). The eye, mouth, speech, and swallowing movement scores also decreased significantly after STN-DBS compared to baseline (p < 0.05). The sleep quality of the patients was also improved after surgery. CONCLUSIONS These findings demonstrate that the STN is an effective brain target for the treatment of patients with Meige Syndrome. STN-DBS was not only able to improve patients' motor symptoms, but also their sleep status.
-
pallidal deep brain stimulation in primary Meige Syndrome clinical outcomes and psychiatric features
Journal of Neurology Neurosurgery and Psychiatry, 2020Co-Authors: Qingpei Hao, Hu Ding, Dongliang Wang, Zhi Liu, Jia Ouyang, Ruen LiuAbstract:Objectives To study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige Syndrome (MS) and evaluate the psychiatric disorders before and after surgery. Methods Twenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed before surgery and after continuous neurostimulation. Before surgery, patients were assessed by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Self-Rating Depression Scale, Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and Pittsburgh Sleep Quality Index (PQSI), which corresponded to motor symptoms, depressive state, quality of life and sleep quality, respectively. The implantable pulse generator of each patient was activated at 1 month after surgery. At 1 month, 3 months, 6 months and 12 months after continuous neurostimulation, all patients were evaluated by the same scales above. Results The BFMDRS movement scores decreased from 15.0±5.3 before surgery to 3.5±4.5 at 12 months after neurostimulation, with a mean improvement of 78% (p Conclusions Bilateral pallidal neurostimulation is a beneficial therapeutic option for refractory MS, which could improve the motor symptoms except for depression and sleep quality.
-
grey matter changes in Meige Syndrome a voxel based morphology analysis
Scientific Reports, 2020Co-Authors: Jiayu Liu, Ruen Liu, Lei Chen, Yongan Jiang, Jixia Fang, Dongliang Wang, Zhi Liu, Jia OuyangAbstract:To investigate the changes and clinical significance of brain structural abnormalities in patients with Meige Syndrome and related depressive symptoms. We retrospectively analysed clinical data, imaging examinations, and Hamilton Depression Rating scale scores in 46 patients with Meige Syndrome from January 2017 to January 2019. We compared the Meige Syndrome group with the healthy control group, and the definite depression group with the non-definite depression group. Voxel-based morphometry (VBM) was used to compare grey matter (GM) volumes. We conducted two-sample t-tests corrected for subject age and gender. We tested at a level of significance of p 50 voxels) in the left hemisphere in the middle frontal orbital gyrus, temporal pole (superior temporal gyrus) and insula and in the right hemisphere in the temporal pole (middle temporal gyrus), precuneus, inferior parietal, inferior temporal and olfactory cortices in the Meige Syndrome group. Comparing VBM-MRI measures in Meige Syndrome patients with and without depression, decreased GM volume was found in the left hemisphere in the cuneus and hippocampus and in the right hemisphere in the angular gyrus, middle frontal gyrus and middle occipital gyrus in the definite depression group. Unlike other dystonia studies that have suggested an involvement of the basal ganglia and motor cortex in the pathophysiology of the disorder , we believe that the precuneus is involved in the development of Meige Syndrome. Additionally, our findings suggest that the hippocampus plays a role in the pathogenesis of depression in patients with Meige Syndrome.
Satoshi Goto - One of the best experts on this subject based on the ideXlab platform.
-
A Short Commentary on Globus Pallidus Internus Deep Brain Stimulation inPrimary Meige Syndrome
Journal of Neurology and Neurophysiology, 2016Co-Authors: Ryoma Morigaki, Satoshi GotoAbstract:Meige Syndrome is a type of segmental dystonia that manifests a combination of blepharospasm and oromandibular dystonia and is often associated with other types of craniocervical dystonia. Although the precise pathogenesis of primary Meige Syndrome remains to be elucidated, it has been suggested that this movement disorder might be a basal ganglia disorder. Multiple single case reports and open-labelled small case series have shown that globus pallidus internus deep brain stimulation (GPi-DBS) could result in therapeutic benefits in patients with severe Meige Syndrome. However, randomized and controlled trials are necessary to accurately assess the safety and therapeutic efficacy of GPi-DBS in treating patients with Meige Syndrome. This short commentary introduces the current use of GPi-DBS in the treatment of medically refractory Meige Syndrome.
-
Bilateral pallidal deep brain stimulation in primary Meige Syndrome.
Parkinsonism & Related Disorders, 2010Co-Authors: Wataru Sako, Ryoma Morigaki, Yoshifumi Mizobuchi, Takashi Tsuzuki, Yukitaka Ushio, Shinji Nagahiro, Ryuji Kaji, Satoshi GotoAbstract:Abstract Primary Meige Syndrome is an idiopathic movement disorder that manifests as craniofacial and often cervical dystonias. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) has emerged as a powerful surgical option in the treatment of primary generalized or segmental dystonia. However, the experience with GPi-DBS in Meige Syndrome is limited. We followed 5 patients with disabling Meige Syndrome treated by bilateral GPi-DBS for 49 ± 43.7 (mean ± SD) months. All patients were assessed before surgery and at the last follow-up after surgery using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) which includes both the movement and disability scales. Bilateral GPi-DBS produced a sustained and long-lasting improvement in dystonia symptoms associated with Meige Syndrome. At the last follow-up, the mean scores of BFMDRS movement and disability scales improved significantly by 84 ± 6.8% (range, 75–94%) and 89 ± 8.1% (range, 80–100%), respectively. Bilateral pallidal stimulation is a beneficial therapeutic option for long-term relief of the disabling dystonia symptoms in Meige Syndrome.
-
bilateral pallidal stimulation for idiopathic segmental axial dystonia advanced from Meige Syndrome refractory to bilateral thalamotomy
Movement Disorders, 2001Co-Authors: Daisuke Muta, Shigeyuki Nishikawa, Tadashi Hamasaki, Nobuhiro Inoue, Yukitaka Ushio, Satoshi Goto, Shuji MitaAbstract:Meige Syndrome is an adult-onset dystonic movement disorder that predominantly involves facial muscles, while some patients with this Syndrome develop spasmodic dysphonia and dystonia of the neck, trunk, arms, and legs. We report that all dystonic symptoms that had been refractory to both pharmacotherapy and bilateral thalamotomy were markedly alleviated by bilateral pallidal stimulation in a patient with segmental axial dystonia advanced from Meige Syndrome.
Dongliang Wang - One of the best experts on this subject based on the ideXlab platform.
-
pallidal versus subthalamic deep brain stimulation for Meige Syndrome a retrospective study
Scientific Reports, 2021Co-Authors: Jiayu Liu, Ruen Liu, Hu Ding, Dongliang Wang, Zhi Liu, Jia Ouyang, Zeyu MiaoAbstract:Deep-brain stimulation (DBS) is an effective treatment for patients with Meige Syndrome. The globus pallidus interna (GPi) and the subthalamic nucleus (STN) are accepted targets for this treatment. We compared 12-month outcomes for patients who had undergone bilateral stimulation of the GPi or STN. Forty-two Asian patients with primary Meige Syndrome who underwent GPi or STN neurostimulation were recruited between September 2017 and September 2019 at the Department of Neurosurgery, Peking University People’s Hospital. The primary outcome was the change in motor function, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) at 3 days before DBS (baseline) surgery and 1, 3, 6, and 12 months after surgery. Secondary outcomes included health-related quality of life, sleep quality status, depression severity, and anxiety severity at 3 days before and 12 months after DBS surgery. Adverse events during the 12 months were also recorded. Changes in BFMDRS-M and BFMDRS-D scores at 1, 3, 6, and 12 months with DBS and without medication did not significantly differ based on the stimulation target. There were also no significant differences in the changes in health-related quality of life (36-Item Short-Form General Health Survey) and sleep quality status (Pittsburgh Sleep Quality Index) at 12 months. However, there were larger improvements in the STN than the GPi group in mean score changes on the 17-item Hamilton depression rating scale (− 3.38 vs. − 0.33 points; P = 0.014) and 14-item Hamilton anxiety rating scale (− 3.43 vs. − 0.19 points; P < 0.001). There were no significant between-group differences in the frequency or type of serious adverse events. Patients with Meige Syndrome had similar improvements in motor function, quality of life and sleep after either pallidal or subthalamic stimulation. Depression and anxiety factors may reasonably be included during the selection of DBS targets for Meige Syndrome.
-
subthalamic nucleus deep brain stimulation in primary Meige Syndrome a 1 year follow up study
Neuromodulation, 2021Co-Authors: Jia Ouyang, Hu Ding, Dongliang Wang, Qingpei Hao, Runze Zhu, Ruen LiuAbstract:OBJECTIVE To investigate the efficacy of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Meige Syndrome. MATERIALS AND METHODS Fifteen consecutive patients who underwent STN-DBS at the Peking University People's Hospital between September 2017 and June 2018 were included in this study. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score and the BFMDRS disability score were obtained prior to surgery, and at specific time points after surgery. Patients' sleep status was also assessed before and after surgery. RESULTS The BFMDRS movement scores decreased from 15.3 ± 4.6 to 5.2 ± 6.2 after STN-DBS, with a mean improvement of 68.6% (p < 0.05). The BFMDRS disability scores were also significantly decreased, from 6.9 ± 3.3 to 3.5 ± 2.9, with a mean improvement of 51.7% (p < 0.05). The eye, mouth, speech, and swallowing movement scores also decreased significantly after STN-DBS compared to baseline (p < 0.05). The sleep quality of the patients was also improved after surgery. CONCLUSIONS These findings demonstrate that the STN is an effective brain target for the treatment of patients with Meige Syndrome. STN-DBS was not only able to improve patients' motor symptoms, but also their sleep status.
-
pallidal deep brain stimulation in primary Meige Syndrome clinical outcomes and psychiatric features
Journal of Neurology Neurosurgery and Psychiatry, 2020Co-Authors: Qingpei Hao, Hu Ding, Dongliang Wang, Zhi Liu, Jia Ouyang, Ruen LiuAbstract:Objectives To study the efficacy and safety of bilateral globus pallidus internus deep brain stimulation (GPi-DBS) in refractory Meige Syndrome (MS) and evaluate the psychiatric disorders before and after surgery. Methods Twenty-two patients with MS treated with bilateral GPi-DBS were retrospectively analysed before surgery and after continuous neurostimulation. Before surgery, patients were assessed by the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS), Self-Rating Depression Scale, Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36) and Pittsburgh Sleep Quality Index (PQSI), which corresponded to motor symptoms, depressive state, quality of life and sleep quality, respectively. The implantable pulse generator of each patient was activated at 1 month after surgery. At 1 month, 3 months, 6 months and 12 months after continuous neurostimulation, all patients were evaluated by the same scales above. Results The BFMDRS movement scores decreased from 15.0±5.3 before surgery to 3.5±4.5 at 12 months after neurostimulation, with a mean improvement of 78% (p Conclusions Bilateral pallidal neurostimulation is a beneficial therapeutic option for refractory MS, which could improve the motor symptoms except for depression and sleep quality.
-
grey matter changes in Meige Syndrome a voxel based morphology analysis
Scientific Reports, 2020Co-Authors: Jiayu Liu, Ruen Liu, Lei Chen, Yongan Jiang, Jixia Fang, Dongliang Wang, Zhi Liu, Jia OuyangAbstract:To investigate the changes and clinical significance of brain structural abnormalities in patients with Meige Syndrome and related depressive symptoms. We retrospectively analysed clinical data, imaging examinations, and Hamilton Depression Rating scale scores in 46 patients with Meige Syndrome from January 2017 to January 2019. We compared the Meige Syndrome group with the healthy control group, and the definite depression group with the non-definite depression group. Voxel-based morphometry (VBM) was used to compare grey matter (GM) volumes. We conducted two-sample t-tests corrected for subject age and gender. We tested at a level of significance of p 50 voxels) in the left hemisphere in the middle frontal orbital gyrus, temporal pole (superior temporal gyrus) and insula and in the right hemisphere in the temporal pole (middle temporal gyrus), precuneus, inferior parietal, inferior temporal and olfactory cortices in the Meige Syndrome group. Comparing VBM-MRI measures in Meige Syndrome patients with and without depression, decreased GM volume was found in the left hemisphere in the cuneus and hippocampus and in the right hemisphere in the angular gyrus, middle frontal gyrus and middle occipital gyrus in the definite depression group. Unlike other dystonia studies that have suggested an involvement of the basal ganglia and motor cortex in the pathophysiology of the disorder , we believe that the precuneus is involved in the development of Meige Syndrome. Additionally, our findings suggest that the hippocampus plays a role in the pathogenesis of depression in patients with Meige Syndrome.
Fangang Meng - One of the best experts on this subject based on the ideXlab platform.
-
stimulation induced dyskinesia after subthalamic nucleus deep brain stimulation in patients with Meige Syndrome
Neuromodulation, 2021Co-Authors: Ning Wang, Lin Wang, Kailiang Wang, Qiao Wang, Shiying Fan, Feng Zhang, Fangang MengAbstract:OBJECTIVES Deep brain stimulation of the subthalamic nucleus (STN-DBS) is increasingly used to treat Meige Syndrome (MS) and markedly improves symptoms. Stimulation-induced dyskinesia (SID), which adversely affects surgical outcomes and patient satisfaction, may, however, occur in some patients. This study attempts to explore possible causes of SID. MATERIALS AND METHODS Retrospectively collected clinical data on 32 patients who underwent STN-DBS between October 2016 and April 2019 were analyzed. Clinical outcomes were assessed pre- and post-surgery, using the Burke-Fahn-Marsden dystonia rating scale (BFMDRS). Patients were divided into a dyskinesia group and a non-dyskinesia group, according to whether or not they experienced persistent SID during follow-up. The coordinates of the active contacts were calculated from post-operative computerized tomography or magnetic resonance imaging, using the inter-commissural line as a reference. At final follow-up, the main stimulatory parameters for further study included pulse width, voltage, and frequency. RESULTS At final follow-up (mean = 16.3 ± 7.2 months), MS patients had improved BFMDRS total scores compared with pre-surgical scores (mean improvement = 79.0%, p < 0.0001). The mean improvement in BFMDRS total scores in the dyskinesia (n = 10) and non-dyskinesia (n = 22) groups were 81.6 ± 8.8% and 77.9 ± 14.2%, respectively. The mean minimum voltage to induce dyskinesia was 1.7 ± 0.3 V. The programmed parameters of both groups were similar. When compared with the non-dyskinesia group, active stimulatory contact coordinates in the dyskinesia group were inferior (mean left side: z = -2.3 ± 1.7 mm vs. z = -1.2 ± 1.5 mm; p = 0.0282; mean right side: z = -2.7 ± 1.9 mm vs. z = -2.3 ± 1.7 mm; p = 0.0256). The x and y coordinates were similar. CONCLUSION STN-DBS is an effective intervention for MS, providing marked improvements in clinical symptoms; SID may, however occur in the subsequent programming control process. Comparing patients with/without dyskinesia, the active contacts were located closer to the inferior part of the STN in patients with dyskinesia, which may provide an explanation for the dyskinesia.