The Experts below are selected from a list of 300 Experts worldwide ranked by ideXlab platform
Metin Ozdemirli - One of the best experts on this subject based on the ideXlab platform.
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Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinoma.
Archives of pathology & laboratory medicine, 2004Co-Authors: C. Alexander Ewing, Mohammed Kalan, Francis Chucker, Metin OzdemirliAbstract:Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although Melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge the presence of identical pigment in macrophages of pericolonic lymph nodes has been reported in only 4 other patients in the English literature. We report the case of a patient who underwent a left hemicolectomy for colonic adenocarcinoma and was found incidentally to have Melanosis coli associated with long-term use of the herbal laxative Swiss Kriss, not only in his colonic mucosa, but also in the colonic submucosa and in his pericolonic lymph nodes.
C. Alexander Ewing - One of the best experts on this subject based on the ideXlab platform.
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Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinoma.
Archives of pathology & laboratory medicine, 2004Co-Authors: C. Alexander Ewing, Mohammed Kalan, Francis Chucker, Metin OzdemirliAbstract:Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although Melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge the presence of identical pigment in macrophages of pericolonic lymph nodes has been reported in only 4 other patients in the English literature. We report the case of a patient who underwent a left hemicolectomy for colonic adenocarcinoma and was found incidentally to have Melanosis coli associated with long-term use of the herbal laxative Swiss Kriss, not only in his colonic mucosa, but also in the colonic submucosa and in his pericolonic lymph nodes.
X U Guanghu - One of the best experts on this subject based on the ideXlab platform.
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clinical application of endoscopic findings and expression of oncogene in Melanosis coli
Hainan Medical Journal, 2013Co-Authors: X U GuanghuAbstract:Objective To study the endoscopic findings of Melanosis coli(MC) and the rules of the expres- sion of oncogene APC, Bcl-2, K-ras, Ki-67 and Cox-2 in MC, and to explore the relationship between the severity of MC and the risks of cancer. Methods One hundred and eight patients of MC selected by colonoscopy, histopatholo- gy and special staining confirmed were enrolled in the study(MC group). Besides, 50 subjects of normal colorectal mucosa were selected as the control group. Immunohistochemistry method was used to examine the expression of APC, Bcl-2, K-ras, Ki-67 and Cox-2 in MC group and the control group. Results Compared with the control group, the MC endoscopic varying degrees was correlated to the positive expression rate of Bcl-2, K-ras, Ki-67 and Cox-2. The severer the MC endoscopic varying degrees, the lower the positive expression rate of APC and the higher the positive expression rate of Bcl-2, K-ras, Ki-67, Cox-2, with statistically significant difference(P0.05). The posi- tive expression rate of Bcl-2, K-ras, Ki-67, Cox-2 was the highest in MC with cancer subgroup, followed by MC with polyps subgroup, MC Ⅰ~Ⅲsubgroup, and the control group(P0.05). The positive expression rate of APC was the highest in the control group and MC Ⅰ ~ Ⅱ subgroup, followed by MC Ⅲ subgroup and MC with polyps sub- group, MC with cancer and(P0.05). Conclusion As the severity of MC increased, the risk of cancer might be high- er. For the patients with MC Ⅲ and MC with polyps, combined examination of endoscopic findings and expression of oncogene is practical and can improve the level of the diagnosis and treatment of early colorectal carcinoma in prima- ry hospital.
Mohammed Kalan - One of the best experts on this subject based on the ideXlab platform.
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Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinoma.
Archives of pathology & laboratory medicine, 2004Co-Authors: C. Alexander Ewing, Mohammed Kalan, Francis Chucker, Metin OzdemirliAbstract:Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although Melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge the presence of identical pigment in macrophages of pericolonic lymph nodes has been reported in only 4 other patients in the English literature. We report the case of a patient who underwent a left hemicolectomy for colonic adenocarcinoma and was found incidentally to have Melanosis coli associated with long-term use of the herbal laxative Swiss Kriss, not only in his colonic mucosa, but also in the colonic submucosa and in his pericolonic lymph nodes.
Francis Chucker - One of the best experts on this subject based on the ideXlab platform.
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Melanosis coli involving pericolonic lymph nodes associated with the herbal laxative Swiss Kriss: a rare and incidental finding in a patient with colonic adenocarcinoma.
Archives of pathology & laboratory medicine, 2004Co-Authors: C. Alexander Ewing, Mohammed Kalan, Francis Chucker, Metin OzdemirliAbstract:Melanosis coli is a well-known condition in which macrophages filled with a lipofuscin-like pigment are found in the colonic lamina propria. The condition has been associated with the ingestion of anthracene laxatives and is believed to be caused by increased epithelial apoptosis. Although Melanosis coli is a frequent finding in colonic biopsies and resection specimens, to our knowledge the presence of identical pigment in macrophages of pericolonic lymph nodes has been reported in only 4 other patients in the English literature. We report the case of a patient who underwent a left hemicolectomy for colonic adenocarcinoma and was found incidentally to have Melanosis coli associated with long-term use of the herbal laxative Swiss Kriss, not only in his colonic mucosa, but also in the colonic submucosa and in his pericolonic lymph nodes.