The Experts below are selected from a list of 1113 Experts worldwide ranked by ideXlab platform
Ren Zhao - One of the best experts on this subject based on the ideXlab platform.
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Palladium-Catalyzed β-Mesylation of Simple Amide via Primary sp3 C-H Activation.
Organic letters, 2017Co-Authors: Ren ZhaoAbstract:A β-Mesylation of primary sp3 C–H bonds from simple amides with methanesulfonic anhydride (Ms2O) has been established successfully at 80 °C in a Pd(OAc)2 (catalyst)/K2S2O8 (oxidant)/CF3CH2OH (solvent) system. These amide substrates involve N-monosubstituted linear, branch, or cyclic alkanes, and electron-deficient benzyl compounds. The β-mesylated amide products can be converted easily to β-fluoroamides or β-lactams through inter- or intramolecular SN2 processes.
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Palladium-Catalyzed β‑Mesylation of Simple Amide via Primary sp3 C–H Activation
2017Co-Authors: Ren ZhaoAbstract:A β-Mesylation of primary sp3 C–H bonds from simple amides with methanesulfonic anhydride (Ms2O) has been established successfully at 80 °C in a Pd(OAc)2 (catalyst)/K2S2O8 (oxidant)/CF3CH2OH (solvent) system. These amide substrates involve N-monosubstituted linear, branch, or cyclic alkanes, and electron-deficient benzyl compounds. The β-mesylated amide products can be converted easily to β-fluoroamides or β-lactams through inter- or intramolecular SN2 processes
Radovan Šebesta - One of the best experts on this subject based on the ideXlab platform.
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a practical three step synthesis of vinylferrocene
Synthesis, 2017Co-Authors: Kristina Plevova, Brigita Mudrakova, Radovan ŠebestaAbstract:An improved, short and efficient synthesis of vinylferrocene is reported. This three-step synthesis includes Friedel–Crafts acylation, reduction, and a one-pot Mesylation/elimination step to afford the target compound in 62% yield over three steps.
Yaghoub Abedi - One of the best experts on this subject based on the ideXlab platform.
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a novel synthesis of aryl mesylatesvia one pot demethylation Mesylation of aryl methyl ethersusing a mixture of phosphorus pentoxide in methane sulfonicacid
Synthesis, 2009Co-Authors: Babak Kaboudin, Yaghoub AbediAbstract:A simple, efficient, and new method has been developed for the synthesis of aryl mesylates via one-pot demethylation-Mesylation of aryl methyl ethers. Treatment of a variety of aryl methyl ethers with a mixture of phosphorus pentoxide in methanesulfonic acid as an efficient reagent proceeded effectively to afford the corresponding aryl mesylates in good yields. This method is easy, rapid, and good-yielding for the synthesis of aryl mesylates from aryl methyl ethers.
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A Novel Synthesis of Aryl Mesylatesvia One-Pot Demethylation-Mesylation of Aryl Methyl EthersUsing a Mixture of Phosphorus Pentoxide in MethanesulfonicAcid
Synthesis, 2009Co-Authors: Babak Kaboudin, Yaghoub AbediAbstract:A simple, efficient, and new method has been developed for the synthesis of aryl mesylates via one-pot demethylation-Mesylation of aryl methyl ethers. Treatment of a variety of aryl methyl ethers with a mixture of phosphorus pentoxide in methanesulfonic acid as an efficient reagent proceeded effectively to afford the corresponding aryl mesylates in good yields. This method is easy, rapid, and good-yielding for the synthesis of aryl mesylates from aryl methyl ethers.
Bruce Ganem - One of the best experts on this subject based on the ideXlab platform.
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Reductive deoxygenation using hydridozirconium enolates: A new synthesis of α,β-unsaturated esters
Tetrahedron Letters, 1992Co-Authors: Alexander G. Godfrey, Bruce GanemAbstract:An unusual new reaction of Cp2ZrHCl transforms β-ketoesters into α,β-unsaturated esters in one step and provides a useful alternative to the traditional, three-step process of reduction, Mesylation/tosylation, and elimination.
Guncheol Kim - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric and diastereodivergent approach to key intermediates for the synthesis of homopumiliotoxin 223G and epiquinamide isomer
Tetrahedron Letters, 2010Co-Authors: Le Anh Tuan, Hyeyoung Pyeon, Guncheol KimAbstract:A stereoselective reaction followed by a sequential cyclization route has been used in the divergent synthesis of 1-hydroxyquinolizidione isomers. Sharpless asymmetric dihydroxylation afforded hydroxyl lactone and the following Mesylation provided the required precursor for cyclization.
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One-pot inversion of d-mannono-1,4-lactone for the practical synthesis of l-ribose
Tetrahedron Letters, 2003Co-Authors: Myung Joon Seo, Jae Hak Shim, Guncheol KimAbstract:l-Ribose was synthesized in a concise manner from d-mannono-1,4-lactone using one-pot inversion conditions. Treatment of d-mannono-1,4-lactone with piperidine, followed by Mesylation-induced SN2-type O-alkylation, afforded the desired one-pot inversion in an optimum yield, and the following straightforward transformations provided l-ribose in good yields.