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Richard A. Santucci - One of the best experts on this subject based on the ideXlab platform.
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Successful management of stuttering priapism using home self-injections of the alpha-agonist Metaraminol
International braz j urol, 2004Co-Authors: Michael Mcdonald, Richard A. SantucciAbstract:Low-flow priapism can result in impotence if treatment is delayed, yet patients with recurrent priapism often suffer delay before therapy. We describe management of recurrent priapism using self-administered injections of intracavernosal Metaraminol (Aramine, Merck), a long-acting vasoconstricting amine that is considered safer than epinephrine. The patient injects as often as once daily using 5-10 mg of drug. Our patient reports rapid detumescence and has not required emergency room visits since starting injections. He denies complications. Treatment of priapism using Metaraminol has been suggested in the hospital setting; however, this is the first report of successful home self-administration of the drug.
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Successful Management of Stuttering Priapism Using Home Self-Injections D
2004Co-Authors: Michael Mcdonald, Richard A. SantucciAbstract:Low-flow priapism can result in impotence if treatment is delayed, yet patients with recurrent priapism often suffer delay before therapy. We describe management of recurrent priapism using self-administered injections of intracavernosal Metaraminol (Aramine, Merck), a long-acting vasoconstricting amine that is considered safer than epinephrine. The patient injects as often as once daily using 5-10 mg of drug. Our patient reports rapid detumescence and has not required emergency room visits since starting injections. He denies complications. Treatment of priapism using Metaraminol has been suggested in the hospital setting; however, this is the first report of successful home self-administration of the drug
Rahal, Sheila Canevese - One of the best experts on this subject based on the ideXlab platform.
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Emprego do Metaraminol no bloqueio da hipotensão produzida pelo uso da levomepromazina em cães
'Universidade de Sao Paulo Agencia USP de Gestao da Informacao Academica (AGUIA)', 1995Co-Authors: Nunes Newton, Pompermayer, Luiz Gonzaga, Pirolo Josmari, Rahal, Sheila CaneveseAbstract:Avaliou-se a possibilidade do uso do bitartarato de Metaraminol, visando o bloqueio da hipotensão produzida pelo cloridrato de levomepromazina em cães. Foram empregados 20 cães, machos e fêmeas, adultos, com pesos compreendidos entre 8 e 12 kg. Os animais foram divididos em dois grupos iguais (GI e GII). Aos cães do GI foi administrada, por via intravenosa, levomepromazina na dose de 2 mg/kg, seguida, 15 minutos após, de 0,5 ml de solução salina 0,9%. A pressão arterial sistólica (PAS), frequências cardíaca (FC) e respiratória (FR), temperatura retal (T) e avaliação eletrocardiográfica na derivação DII foram observadas antes da aplicação da levomepromazina e após a mesma, em intervalos de 15 minutos durante 60 minutos. Aos cães do GII foi aplicada a mesma metodologia, substituindo-se, porém, a solução salina pelo Metaraminol na dose de 0,1 mg/kg, pela via intravenosa. Os valores obtidos foram submetidos à avaliação estatística pelo método de Análise de Perfil. Os resultados mostraram que o Metaraminol produziu um aumento da PAS e diminuição da FC, além de promover menor queda da T e melhora dos valores de FR. Não foram observadas alterações na eletrocardiografia que pudessem ser atribuídas aos fármacos empregados. Concluiu-se que o Metaraminol é seguro e indicado quando se emprega a levomepromazina, em cães.The aim of this work was evaluate the possibility of the use of the Metaraminol bitartarate to blockade the decrease of the blood pressure produced by levomepromazine HCL in dogs. To this 20 crossbreed adult dogs, males and females, with average weight from 8 to 12 kg, were separated in two groups with 10 dogs each (GI and G1I). To the GI was administered, intravenously, 2 mg/kg of levomepromazine. Fifteen minutes after was administered, by the same way, 0.5 ml of saline solution (0.9%). The systolic blood pressure (PA), heart rate (FC), respiratory frequency (FR), body temperature (T) and eletrocardiographic analysis (Dll) was evaluated before and after the administration of the levomepromazine at 15 minutes of intervals, during 60 minutes. To the GII was applied the same method but the saline solution was replaced by the Metaraminol at 0.1 mg/kg, administered by the intravenous way. The numeric data was evaluated by the profile analysis as statistic method. The results showed that the Metaraminol increase the blood pressure and decrease the heart rate. The respiration and the body temperature were not changed with the use of Metaraminol and the drugs administered did not produce eletrocardiographic alterations. The conclusion is that the use of Metaraminol is indicated after the use of levomepromazine in dogs
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Emprego do Metaraminol no bloqueio da hipotensão produzida pelo uso da levomepromazina em cães
Brazilian Journal of Veterinary Research and Animal Science, 1994Co-Authors: Pompermayer, Luiz Gonzaga, Nunes Newton, Pirolo Josmari, Rahal, Sheila CaneveseAbstract:Avaliou-se a possibilidade do uso do bitartarato de metaram inol, visando o bloqueio da hipotensão produzida pelo cloridrato de levomepromazina em cães. Foram em pregados 20 cães, machos e fêmeas, adultos, com pesos com preendidos entre 8 e 12 kg. Os animais foram divididos em dois grupos iguais (GI e GII). Aos cães do GI foi administrada, por via intravenosa, levom epromazina na dose de 2 mg/kg, seguida, 15 minutos após, de 0,5 ml de solução salina 0,9%. A pressão arterial sistólica (PAS), freqüências cardíaca (FC) e respiratória (FR), temperatura retal (T) e avaliação eletrocardiográficana derivação DII foram observadas antes da aplicação da levomepromazina e após a mesma, em intervalos de 15 minutos durante 60 minutos. Aos cães do GII foi aplicada a mesma metodologia, substituindo-se, porém, a solução salina pelo Metaraminol na dose de 0,1 mg/kg, pela via intravenosa. Os valores obtidos foram submetidos à avaliação estatística pelo método de Análise de Perfil. Os resultados mostraram que o Metaraminol produziu um aumento da PAS e diminuição da FC, além de prom over m enor queda da T e m elhora dos valores de FR. Não foram observadas alterações na eletrocardiografia que pudessem ser atribuídas aos fármacos empregados. Concluiu-se que o Metaraminol é seguro e indicado quando se emprega a levom eprom azina, em cães
Ya-li Wang - One of the best experts on this subject based on the ideXlab platform.
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Effect of dopamine and Metaraminol on the renal function of patients with septic shock.
Chinese Medical Journal, 2007Co-Authors: Lichao Hou, Lize Xiong, Shaoyang Chen, Min Chen, Xijing Zhang, Ting-ting Huo, Qiang Wang, Ya-li WangAbstract:Background Vasoactive drugs are often necessary for reversing hypotension in patients with severe infection. The standard for evaluating effects of vasoactive drugs should not only be based on the increase of arterial blood pressure, but also on the blood flow perfusion of internal organs. The effects of dopamine and Metaraminol on the renal function of the patients with septic shock were investigated retrospectively in this study. Methods Ninety-eight patients with septic shock were divided into three groups according to the highest infusing rate of Metaraminol, with the lightest infusing rate of (0.1 - 0.5, 0.6 - 1.0, > 1.0) microgxkg(-1)xmin(-1) in group A, B and C respectively. Urine output, mean arterial blood pressure (MAP), heart rate (HR), urine output, blood urea nitrogen (BUN), creatinine (CRE), urine albumin (U-ALB), urine beta(2)-microglubulin (Ubeta(2)-MG) and Apache III scores were recorded. Results Before antishock therapy, hypotension, tachycardia and oliguria occurred to all the 98 patients with septic shock and CRE, BUN, U-ALB, Ubeta(2)-MG and Apache III scoring were abnormal in most cases. With the antishock therapy, MAP, HR, urine output, BUN and CRE in all patients returned gradually to normal (P 0.05). Conclusion Dopamine and Metaraminol when applied to the patients with septic shock could effectively maintain the circulatory stability and promote restoration of renal function.
Michael Mcdonald - One of the best experts on this subject based on the ideXlab platform.
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Successful management of stuttering priapism using home self-injections of the alpha-agonist Metaraminol
International braz j urol, 2004Co-Authors: Michael Mcdonald, Richard A. SantucciAbstract:Low-flow priapism can result in impotence if treatment is delayed, yet patients with recurrent priapism often suffer delay before therapy. We describe management of recurrent priapism using self-administered injections of intracavernosal Metaraminol (Aramine, Merck), a long-acting vasoconstricting amine that is considered safer than epinephrine. The patient injects as often as once daily using 5-10 mg of drug. Our patient reports rapid detumescence and has not required emergency room visits since starting injections. He denies complications. Treatment of priapism using Metaraminol has been suggested in the hospital setting; however, this is the first report of successful home self-administration of the drug.
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Successful Management of Stuttering Priapism Using Home Self-Injections D
2004Co-Authors: Michael Mcdonald, Richard A. SantucciAbstract:Low-flow priapism can result in impotence if treatment is delayed, yet patients with recurrent priapism often suffer delay before therapy. We describe management of recurrent priapism using self-administered injections of intracavernosal Metaraminol (Aramine, Merck), a long-acting vasoconstricting amine that is considered safer than epinephrine. The patient injects as often as once daily using 5-10 mg of drug. Our patient reports rapid detumescence and has not required emergency room visits since starting injections. He denies complications. Treatment of priapism using Metaraminol has been suggested in the hospital setting; however, this is the first report of successful home self-administration of the drug
Hu Wen-neng - One of the best experts on this subject based on the ideXlab platform.
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Effect of Metaraminol on arterial blood pressure and renal function in patients with septic shock
Chinese Heart Journal, 2007Co-Authors: Hu Wen-nengAbstract:AIM To study the effect of Metaraminol on the renal function in the patients with septic shock.METHODS Seventy patients with septic shock,who had been admitted into ICU of Department of Anesthesiology,Xijing Hospital since 1995 were enrolled in this study.The dosage of Metaraminol had been adjusted to maintain the stability of arterial blood pressure for all the patients with septic shock according to the changes in their conditions.Based on the dosage of Metaraminol used clinically and our experiences,all the patients were divided into three groups:Group A had 23 cases with the biggest infusing rate of 0.5~5 μg/(kg·min)during anti-shock therapy,Group B had 23 cases with the biggest infusing rate of 6~10 μg/(kg·min),and Group C had 24 cases with the biggest infusing rate of 11 μg/(kg·min).APACHE III scoring was made for all the patients before the anti-shock therapy,and the changes in arterial blood pressure,heart rate(HR),urinary output,blood urea nitrogen(BUN),creatinine(CRE),urinary albumin(ALB)and β_2-microglobulin(β_2-MG)were recorded.RESULTS Before the anti-shock therapy,the APACHE III scoring in Group B was higher than that in Group A,but lower than that in Group C(P0.01).The levels of BUN,CRE,urine ALB and β_2-MG output were abnormally high in all the patients,but with no statistical significance among the three groups.After the anti-shock therapy,the urine output,BUN,CRE,urine ALB and β_2-MG output gradually decreased compared with those before treatment(P0.01)but with no statistical significance among the three groups.CONCLUSION Metaraminol promotes the restoration of the abnormal renal function in patients with septic shock,which is related to the hemodynamic stability and not the dosage of Metaraminol used.