Methanesulfonate

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Xuejun Dong - One of the best experts on this subject based on the ideXlab platform.

  • Feedback regulation of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 via ATM/Chk2 pathway contributes to the resistance of MCF-7 breast cancer cells to cisplatin.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017
    Co-Authors: Ying Qian, Xuejun Dong
    Abstract:

    The methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 protein is a structure-specific nuclease that plays important roles in DNA replication and repair. Knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 has been found to sensitize cancer cells to chemotherapy. However, the underlying molecular mechanism is not well understood. We found that methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 was upregulated and the ATM/Chk2 pathway was activated at the same time when MCF-7 cells were treated with cisplatin. By using lentivirus targeting methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 gene, we showed that knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 enhanced cell apoptosis and inhibited cell proliferation in MCF-7 cells under cisplatin treatment. Abrogation of ATM/Chk2 pathway inhibited cell viability in MCF-7 cells in response to cisplatin. Importantly, we revealed that ATM/Chk2 was required for the upregulation of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81, and knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 resulted in inactivation of ATM/Chk2 pathway in response to cisplatin. Meanwhile, knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 activated the p53/Bcl-2 pathway in response to cisplatin. These data suggest that the ATM/Chk2 may promote the repair of DNA damage caused by cisplatin by sustaining methyl Methanesulfonate and ultraviolet-sensitive gene clone 81, and the double-strand breaks generated by methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 may activate the ATM/Chk2 pathway in turn, which provide a novel mechanism of how methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 modulates DNA damage response and repair.

  • feedback regulation of methyl Methanesulfonate and ultraviolet sensitive gene clone 81 via atm chk2 pathway contributes to the resistance of mcf 7 breast cancer cells to cisplatin
    Tumor Biology, 2017
    Co-Authors: Ying Qian, Xuejun Dong
    Abstract:

    The methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 protein is a structure-specific nuclease that plays important roles in DNA replication and repair. Knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 has been found to sensitize cancer cells to chemotherapy. However, the underlying molecular mechanism is not well understood. We found that methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 was upregulated and the ATM/Chk2 pathway was activated at the same time when MCF-7 cells were treated with cisplatin. By using lentivirus targeting methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 gene, we showed that knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 enhanced cell apoptosis and inhibited cell proliferation in MCF-7 cells under cisplatin treatment. Abrogation of ATM/Chk2 pathway inhibited cell viability in MCF-7 cells in response to cisplatin. Importantly, we revealed that ATM/Chk2 was required for the upregulation of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81, and knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 resulted in inactivation of ATM/Chk2 pathway in response to cisplatin. Meanwhile, knockdown of methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 activated the p53/Bcl-2 pathway in response to cisplatin. These data suggest that the ATM/Chk2 may promote the repair of DNA damage caused by cisplatin by sustaining methyl Methanesulfonate and ultraviolet-sensitive gene clone 81, and the double-strand breaks generated by methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 may activate the ATM/Chk2 pathway in turn, which provide a novel mechanism of how methyl Methanesulfonate and ultraviolet-sensitive gene clone 81 modulates DNA damage response and repair.

Feng Zheng - One of the best experts on this subject based on the ideXlab platform.

  • determination of methyl Methanesulfonate and ethyl Methanesulfonate in methanesulfonic acid by derivatization followed by high performance liquid chromatography with ultraviolet detection
    IEEE Journal of Solid-state Circuits, 2017
    Co-Authors: Jie Zhou, Xiangyuan Zheng, Wenyuan Liu, Feng Zheng
    Abstract:

    Methanesulfonic acid is routinely used in pharmaceuticals but can contain potentially genotoxic impurities such as methyl Methanesulfonate and ethyl Methanesulfonate. The aim of this study was to develop a simple high-performance liquid chromatography with ultraviolet detection method for determining methyl Methanesulfonate and ethyl Methanesulfonate in methanesulfonic acid. Samples (250 mg) in water/acetonitrile (200 μL) were first combined with 10.0 mol/L sodium hydroxide solution (270 μL). Then they were mixed with 2.0 mg/mL N,N-diethyldithiocarbamate (500 μL), diluted to 5 mL with N,N-dimethylacetamide and allowed to react at 80°C for 1 h. The derivatives were analyzed using gradient high-performance liquid chromatography with ultraviolet detection (277 nm) and structurally elucidated by liquid chromatography with mass spectrometry. With acetonitrile/5 mmol/L ammonium acetate solution as the eluent and 1 mL/min as the flow rate on a C18 column, the derivatives were eluted at 10.6 and 14.8 min. Good linearity (correlation coefficients > 0.999) and low limits of quantitation (0.6 ppm) were obtained. The recoveries were in the range of 80-115% with relative standard deviation < 5.0%. Finally, the established method was successfully used for the determination of methyl Methanesulfonate and ethyl Methanesulfonate in methanesulfonic acid.

  • Determination of methyl Methanesulfonate and ethyl Methanesulfonate in methanesulfonic acid by derivatization followed by high‐performance liquid chromatography with ultraviolet detection
    Journal of separation science, 2017
    Co-Authors: Jie Zhou, Xiangyuan Zheng, Wenyuan Liu, Feng Zheng
    Abstract:

    Methanesulfonic acid is routinely used in pharmaceuticals but can contain potentially genotoxic impurities such as methyl Methanesulfonate and ethyl Methanesulfonate. The aim of this study was to develop a simple high-performance liquid chromatography with ultraviolet detection method for determining methyl Methanesulfonate and ethyl Methanesulfonate in methanesulfonic acid. Samples (250 mg) in water/acetonitrile (200 μL) were first combined with 10.0 mol/L sodium hydroxide solution (270 μL). Then they were mixed with 2.0 mg/mL N,N-diethyldithiocarbamate (500 μL), diluted to 5 mL with N,N-dimethylacetamide and allowed to react at 80°C for 1 h. The derivatives were analyzed using gradient high-performance liquid chromatography with ultraviolet detection (277 nm) and structurally elucidated by liquid chromatography with mass spectrometry. With acetonitrile/5 mmol/L ammonium acetate solution as the eluent and 1 mL/min as the flow rate on a C18 column, the derivatives were eluted at 10.6 and 14.8 min. Good linearity (correlation coefficients > 0.999) and low limits of quantitation (0.6 ppm) were obtained. The recoveries were in the range of 80-115% with relative standard deviation < 5.0%. Finally, the established method was successfully used for the determination of methyl Methanesulfonate and ethyl Methanesulfonate in methanesulfonic acid.

Heng Jiang - One of the best experts on this subject based on the ideXlab platform.

  • Solvent-free tetrahydropyranylation of alcohols catalyzed by amine Methanesulfonates
    Research on Chemical Intermediates, 2010
    Co-Authors: Rui Wang, Mingzhu Sun, Heng Jiang
    Abstract:

    A comparative study of tetrahydropyranylation of alcohols under various solvents or solvent-free conditions using different amine Methanesulfonates as catalysts shows that tetrahydropyranyl ethers of alcohols are obtained under solvent-free conditions in good yields using catalytic amounts of triethylenediamine Methanesulfonate, 1,6-hexanediamine Methanesulfonate, diethylenetriamine Methanesulfonate and pyridine Methanesulfonate, respectively. The reaction occurs readily in short times at room temperature catalyzed by these catalysts, especially triethylenediamine Methanesulfonate. Some of the major advantages of this procedure are that the catalysts are environmentally friendly, highly effective, and easy to prepare and handle. The reaction is also clean and needs no solvent, and the work-up is very simple.

  • ferrous Methanesulfonate as an efficient and recyclable catalyst for chemoselective synthesis of 1 1 diacetate from aldehydes
    ChemInform, 2010
    Co-Authors: Min Wang, Gui Fu Tian, Zhi Guo Song, Heng Jiang
    Abstract:

    Abstract Ferrous Methanesulfonate catalysing the conversion of aromatic, heteroaromatic, unsaturated, and aliphatic aldehydes to 1,1-diacetates at room temperature under solvent-free condition has been developed. The catalytic activity of seventeen metal Methanesulfonates was compared under the same condition, ferrous methanesufonate proved to be the best. It can be easily recovered and reused for several times without distinct deterioration in catalytic activity. During the competitive protection between a ketone and an aldehyde group with Ac 2 O, 1,1-diacetate formed exclusively with the aldehyde group.

  • Thermal decomposition of metal Methanesulfonates in air
    Journal of Thermal Analysis and Calorimetry, 2009
    Co-Authors: Min Wang, Heng Jiang, Zhi Guo Song, Hong Gong
    Abstract:

    The thermal decompositions of dehydrated or anhydrous bivalent transition metal (Mn, Fe, Co, Ni, Cu, Zn, Cd) and alkali rare metal (Mg, Ca, Sr, Ba) Methanesulfonates were studied by TG/DTG, IR and XRD techniques in dynamic Air at 250–850 °C. The initial decomposition temperatures were calculated from TG curves for each compound, which show the onsets of mass loss of Methanesulfonates were above 400 °C. For transition metal Methanesulfonates, the pyrolysis products at 850 °C were metal oxides. For alkali rare metal Methanesulfonates, the pyrolysis products at 850 °C of Sr and Ba Methanesulfonates were sulphates, while those of Mg and Ca Methanesulfonate were mixtures of sulphate and oxide.

  • Acetic Acid Assisted Cobalt Methanesulfonate Catalysed Chemoselective Diacetylation of Aldehydes
    Chinese Chemical Letters, 2008
    Co-Authors: Min Wang, Hong Gong, Zhi Guo Song, Heng Jiang
    Abstract:

    Cobalt Methanesulfonate in combination with acetic acid catalysed the chemoselective diacetylation of aldehyde with acetic anhydride at room temperature under solvent free conditions. After reaction, cobalt Methanesulfonate can be easily recovered and reused many times. The reaction was mild and efficient with good to high yields.

  • Thermal decomposition and dehydration kinetic studies on hydrated Co(II) Methanesulfonate
    Thermochimica Acta, 2005
    Co-Authors: Heng Jiang, Hong Gong
    Abstract:

    Abstract The synthesis, characterization and thermal decomposition studies of Co(II) Methanesulfonate are reported. The prepared salt was characterized by Fourier transform infrared (FTIR). The thermal decomposition process was studied using thermogravimetry (TG) and differential scanning calorimetry (DSC) techniques. It can be verified that Co(II) Methanesulfonate contains four molecules of crystallization water, which eliminates in two steps. Under heating Co(II) Methanesulfonate suffers three main processes: dehydration, thermal degradation and oxide formation. During thermal degradation, the anhydrous salt decomposes to the mixture of CoSO 4 , Co 3 O 4 and CoO in the range of 365–480 °C. At about 800 °C, the decomposed residue was identified as Co 3 O 4 by X-ray powder diffraction (XRD). The dehydration kinetics of hydrated Co(II) Methanesulfonate was studied by TG technology. The activation energies E α of two stages dehydration were estimated by isoconversional methods of Friedman, Ozawa and KAS.

Hong Gong - One of the best experts on this subject based on the ideXlab platform.

  • Thermal decomposition of metal Methanesulfonates in air
    Journal of Thermal Analysis and Calorimetry, 2009
    Co-Authors: Min Wang, Heng Jiang, Zhi Guo Song, Hong Gong
    Abstract:

    The thermal decompositions of dehydrated or anhydrous bivalent transition metal (Mn, Fe, Co, Ni, Cu, Zn, Cd) and alkali rare metal (Mg, Ca, Sr, Ba) Methanesulfonates were studied by TG/DTG, IR and XRD techniques in dynamic Air at 250–850 °C. The initial decomposition temperatures were calculated from TG curves for each compound, which show the onsets of mass loss of Methanesulfonates were above 400 °C. For transition metal Methanesulfonates, the pyrolysis products at 850 °C were metal oxides. For alkali rare metal Methanesulfonates, the pyrolysis products at 850 °C of Sr and Ba Methanesulfonates were sulphates, while those of Mg and Ca Methanesulfonate were mixtures of sulphate and oxide.

  • Acetic Acid Assisted Cobalt Methanesulfonate Catalysed Chemoselective Diacetylation of Aldehydes
    Chinese Chemical Letters, 2008
    Co-Authors: Min Wang, Hong Gong, Zhi Guo Song, Heng Jiang
    Abstract:

    Cobalt Methanesulfonate in combination with acetic acid catalysed the chemoselective diacetylation of aldehyde with acetic anhydride at room temperature under solvent free conditions. After reaction, cobalt Methanesulfonate can be easily recovered and reused many times. The reaction was mild and efficient with good to high yields.

  • Thermal decomposition and dehydration kinetic studies on hydrated Co(II) Methanesulfonate
    Thermochimica Acta, 2005
    Co-Authors: Heng Jiang, Hong Gong
    Abstract:

    Abstract The synthesis, characterization and thermal decomposition studies of Co(II) Methanesulfonate are reported. The prepared salt was characterized by Fourier transform infrared (FTIR). The thermal decomposition process was studied using thermogravimetry (TG) and differential scanning calorimetry (DSC) techniques. It can be verified that Co(II) Methanesulfonate contains four molecules of crystallization water, which eliminates in two steps. Under heating Co(II) Methanesulfonate suffers three main processes: dehydration, thermal degradation and oxide formation. During thermal degradation, the anhydrous salt decomposes to the mixture of CoSO 4 , Co 3 O 4 and CoO in the range of 365–480 °C. At about 800 °C, the decomposed residue was identified as Co 3 O 4 by X-ray powder diffraction (XRD). The dehydration kinetics of hydrated Co(II) Methanesulfonate was studied by TG technology. The activation energies E α of two stages dehydration were estimated by isoconversional methods of Friedman, Ozawa and KAS.

  • Research of thermal decomposition of hydrated Methanesulfonates
    Journal of Thermal Analysis and Calorimetry, 2004
    Co-Authors: J. Tian, Heng Jiang, Hong Gong, Z. Sun
    Abstract:

    Hydrated Methanesulfonates Ln(CH3SO3)3·nH2O (Ln=La, Ce, Pr, Nd and Yb) and Zn(CH3SO3)2·nH2O were synthesized. The effect of atmosphere on thermal decomposition products of these Methanesulfonates was investigated. Thermal decomposition products in air atmosphere of these compounds were characterized by infrared spectrometry, the content of metallic ion in thermal decomposition products were determined by complexometric titration. The results show that the thermal decomposition atmosphere has evident effect on decomposition products of hydrated La(III), Pr(III) and Nd(III) Methanesulfonates, and no effect on that of hydrated Ce(III), Yb(III) and Zn(II) Methanesulfonates.

Irina A. Uspenskaya - One of the best experts on this subject based on the ideXlab platform.

  • Solid-liquid phase equilibrium in the water–Zn(II) Methanesulfonate and water–Cu(II) Methanesulfonate systems
    Thermochimica Acta, 2018
    Co-Authors: Ekaterina V. Belova, Vladimir S. Krasnov, Andrey B. Ilyukhin, Irina A. Uspenskaya
    Abstract:

    Abstract Fragments of M(CH3SO3)2-H2O (M = Zn,Cu) phase diagrams from subsolidus temperatures up to 70 °C (343.15 K) were obtained. Melting parameters of anhydrous zinc Methanesulfonate (Tm = 566.2 ± 0.3 K, ΔmH = 33.4 ± 0.6 kJ/mol) were clarified. New dodecahydrate zinc Methanesulfonate and octahydrate copper Methanesulfonate were revealed and characterized. Space group (R-3), lattice parameters (a = 9.1711(2), c = 21.4910(5)) and structure of Zn(CH3SO3)2∙12H2O were determined. The dodecahydrate melts congruently at Tm = 299.4 ± 0.1 K, with the enthalpy of fusion ΔmH = 78.9 ± 0.1 kJ/mol. The octahydrate Cu(CH3SO3)2∙8H2O melts incongruently at 254.9 ± 0.1 K.

  • Experimental investigation of the solid – Liquid phase equilibria in the water – Ammonium Methanesulfonate and in the water – Sodium Methanesulfonate systems
    Fluid Phase Equilibria, 2017
    Co-Authors: Daria A. Kosova, Tsimafei I. Navalayeu, Aleksey I. Maksimov, Tatiana S. Babkina, Irina A. Uspenskaya
    Abstract:

    Abstract The thermal stability of ammonium and sodium Methanesulfonates was investigated under inert atmosphere by thermogravimetry. Temperatures and enthalpies of phase transitions were determined for these salts by means of differential scanning calorimetry (DSC). It was shown that sodium salt melts congruently. Solid – liquid phase equilibria in the binary water – salt systems were studied. It was found that hydrate is formed in the water – sodium Methanesulfonate system. Melting parameters and composition of this hydrate (NaSO 3 CH 3 ·8H 2 O) were evaluated with the help of DSC. The data on the density of the Methanesulfonates aqueous solutions in a wide range of concentrations at 25.00 °C were obtained.