The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Eric L. Cole - One of the best experts on this subject based on the ideXlab platform.

  • Microcystic Adnexal Carcinoma reconstruction of a large centrofacial defect
    Plastic and reconstructive surgery. Global open, 2014
    Co-Authors: Mariela Lopez, Eric L. Cole
    Abstract:

    Microcystic Adnexal Carcinoma (MAC) is a rare, malignant tumor of the skin that is commonly classified as a low-grade sweat gland Carcinoma. Goldstein et al1 first described the tumor in 1982. The tumor arises in the skin adnexa from a pluripotent Adnexal keratinocyte. Histologically, it is well differentiated and appears as small, keratinized cysts with well-defined ducts.2 The Surveillance, Epidemiology and End Results database was able to identify a total of 273 reported cases from 1973 to 2004.3 Yu et al3 concluded that MAC is a locally invasive tumor that rarely metastasizes and has a predilection for the head and neck skin. The clinical presentation is typically a firm, flesh-colored nodule or plaque.4 Kirkland et al5 reported that the tumor often requires extensive surgical resection. Outcome studies of tumors treated with Mohs micrographic surgery (MMS) show that MMS allows for tissue conservation and an increased likelihood of long-term cure with one study reporting a 2-year success rate of 89.7%.4,6 Limited data exist regarding the role of radiation therapy, but a recent study showed promising outcomes.7 The purpose of our case report is to add to the limited treatment experience of this rare tumor.

  • Microcystic Adnexal Carcinoma: Reconstruction of a Large Centrofacial Defect
    Wolters Kluwer, 2014
    Co-Authors: Mariela Lopez, Eric L. Cole
    Abstract:

    Summary: We report a rare case of a large facial Microcystic Adnexal Carcinoma in an elderly patient who underwent several rounds of excision. The patient was left with a large facial defect and remaining positive margins. The decision was made to stop further excision and proceed with reconstructive surgery. We show that the patient’s function and quality of life were not impeded despite reconstruction in light of positive margins for tumor. We believe that this case will draw the surgeon’s attention to the possibility of palliative reconstruction in the treatment of a patient with large debilitating facial defects after Microcystic Adnexal Carcinoma excision

Richard H Greiner - One of the best experts on this subject based on the ideXlab platform.

  • a Microcystic Adnexal Carcinoma in the auditory canal 15 years after radiotherapy of a 12 year old boy with nasopharynx Carcinoma
    Strahlentherapie Und Onkologie, 2005
    Co-Authors: Karl T Beer, Sabine S Buhler, Primus Mullis, Hubert R Laeng, Richard H Greiner
    Abstract:

    Background: Radiogenic malignancies require cure of the primary disease and a prolonged survival. The introduction of high-volt technology in the 1950s and 1960s made radical radiotherapy feasible and successful in terms of higher cure rates and longer survival. We are already in a time when a higher number of patients with radiogenic secondary malignancies must be expected. Case Report: A 12-year-old boy is reported who suffered from an advanced nasopharynx Carcinoma and was treated with radical irradiation in 1983. 15 years later he developed a rare Microcystic Adnexal Carcinoma of the auditory canal inside the volume of the target dose. The secondary malignant neoplasm was resected and required another radiation treatment (1 Gy b.i.d.) due to involved margins. Discussion and Literature Review: The entity of Microcystic Carcinoma is discussed with a review of the literature on biology, diagnosis, and treatment.

  • a Microcystic Adnexal Carcinoma in the auditory canal 15 years after radiotherapy of a 12 year old boy with nasopharynx Carcinoma
    Strahlentherapie Und Onkologie, 2005
    Co-Authors: Karl T Beer, Sabine S Buhler, Primus Mullis, Hubert R Laeng, Richard H Greiner
    Abstract:

    Radiogenic malignancies require cure of the primary disease and a prolonged survival. The introduction of high-volt technology in the 1950s and 1960s made radical radiotherapy feasible and successful in terms of higher cure rates and longer survival. We are already in a time when a higher number of patients with radiogenic secondary malignancies must be expected. A 12-year-old boy is reported who suffered from an advanced nasopharynx Carcinoma and was treated with radical irradiation in 1983. 15 years later he developed a rare Microcystic Adnexal Carcinoma of the auditory canal inside the volume of the target dose. The secondary malignant neoplasm was resected and required another radiation treatment (1 Gy b.i.d.) due to involved margins. The entity of Microcystic Carcinoma is discussed with a review of the literature on biology, diagnosis, and treatment.

Mariela Lopez - One of the best experts on this subject based on the ideXlab platform.

  • Microcystic Adnexal Carcinoma reconstruction of a large centrofacial defect
    Plastic and reconstructive surgery. Global open, 2014
    Co-Authors: Mariela Lopez, Eric L. Cole
    Abstract:

    Microcystic Adnexal Carcinoma (MAC) is a rare, malignant tumor of the skin that is commonly classified as a low-grade sweat gland Carcinoma. Goldstein et al1 first described the tumor in 1982. The tumor arises in the skin adnexa from a pluripotent Adnexal keratinocyte. Histologically, it is well differentiated and appears as small, keratinized cysts with well-defined ducts.2 The Surveillance, Epidemiology and End Results database was able to identify a total of 273 reported cases from 1973 to 2004.3 Yu et al3 concluded that MAC is a locally invasive tumor that rarely metastasizes and has a predilection for the head and neck skin. The clinical presentation is typically a firm, flesh-colored nodule or plaque.4 Kirkland et al5 reported that the tumor often requires extensive surgical resection. Outcome studies of tumors treated with Mohs micrographic surgery (MMS) show that MMS allows for tissue conservation and an increased likelihood of long-term cure with one study reporting a 2-year success rate of 89.7%.4,6 Limited data exist regarding the role of radiation therapy, but a recent study showed promising outcomes.7 The purpose of our case report is to add to the limited treatment experience of this rare tumor.

  • Microcystic Adnexal Carcinoma: Reconstruction of a Large Centrofacial Defect
    Wolters Kluwer, 2014
    Co-Authors: Mariela Lopez, Eric L. Cole
    Abstract:

    Summary: We report a rare case of a large facial Microcystic Adnexal Carcinoma in an elderly patient who underwent several rounds of excision. The patient was left with a large facial defect and remaining positive margins. The decision was made to stop further excision and proceed with reconstructive surgery. We show that the patient’s function and quality of life were not impeded despite reconstruction in light of positive margins for tumor. We believe that this case will draw the surgeon’s attention to the possibility of palliative reconstruction in the treatment of a patient with large debilitating facial defects after Microcystic Adnexal Carcinoma excision

Robert Paver - One of the best experts on this subject based on the ideXlab platform.

  • periocular Microcystic Adnexal Carcinoma management and outcome with mohs micrographic surgery
    Ophthalmologica, 2006
    Co-Authors: Igal Leibovitch, Shyamala C Huilgol, Shawn Richards, Robert Paver, Dinesh Selva
    Abstract:

    Purpose: To report a series of patients with periocular Microcystic Adnexal Carcinoma (MAC) treated with Mohs’ micrographic surgery (MMS). Design: Prospective, in

  • Microcystic Adnexal Carcinoma treatment with mohs micrographic surgery
    Journal of The American Academy of Dermatology, 2005
    Co-Authors: Igal Leibovitch, Shyamala C Huilgol, Shawn Richards, Dinesh Selva, Robert Paver
    Abstract:

    Background Microcystic Adnexal Carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision. Objective To report a large series of patients with MAC treated with Mohs micrographic surgery (MMS). Methods This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002. Results There were 44 cases; most of them (90.9%) were located in the head and neck area. In 31.8% of cases it was a recurrent tumor. In 32.5% of cases the tumor was initially misdiagnosed as basal cell Carcinoma or squamous cell Carcinoma. Perineural invasion was recorded in 17.5% of cases; most of them (85.7%) were previously recurrent tumors. There was only one case of recurrence (5%) out of 20 patients who completed a 5 year follow-up period after MMS. Conclusion The low 5-year recurrence rate of MAC with MMS emphasizes the importance of margin-controlled excision.

Karl T Beer - One of the best experts on this subject based on the ideXlab platform.

  • a Microcystic Adnexal Carcinoma in the auditory canal 15 years after radiotherapy of a 12 year old boy with nasopharynx Carcinoma
    Strahlentherapie Und Onkologie, 2005
    Co-Authors: Karl T Beer, Sabine S Buhler, Primus Mullis, Hubert R Laeng, Richard H Greiner
    Abstract:

    Background: Radiogenic malignancies require cure of the primary disease and a prolonged survival. The introduction of high-volt technology in the 1950s and 1960s made radical radiotherapy feasible and successful in terms of higher cure rates and longer survival. We are already in a time when a higher number of patients with radiogenic secondary malignancies must be expected. Case Report: A 12-year-old boy is reported who suffered from an advanced nasopharynx Carcinoma and was treated with radical irradiation in 1983. 15 years later he developed a rare Microcystic Adnexal Carcinoma of the auditory canal inside the volume of the target dose. The secondary malignant neoplasm was resected and required another radiation treatment (1 Gy b.i.d.) due to involved margins. Discussion and Literature Review: The entity of Microcystic Carcinoma is discussed with a review of the literature on biology, diagnosis, and treatment.

  • a Microcystic Adnexal Carcinoma in the auditory canal 15 years after radiotherapy of a 12 year old boy with nasopharynx Carcinoma
    Strahlentherapie Und Onkologie, 2005
    Co-Authors: Karl T Beer, Sabine S Buhler, Primus Mullis, Hubert R Laeng, Richard H Greiner
    Abstract:

    Radiogenic malignancies require cure of the primary disease and a prolonged survival. The introduction of high-volt technology in the 1950s and 1960s made radical radiotherapy feasible and successful in terms of higher cure rates and longer survival. We are already in a time when a higher number of patients with radiogenic secondary malignancies must be expected. A 12-year-old boy is reported who suffered from an advanced nasopharynx Carcinoma and was treated with radical irradiation in 1983. 15 years later he developed a rare Microcystic Adnexal Carcinoma of the auditory canal inside the volume of the target dose. The secondary malignant neoplasm was resected and required another radiation treatment (1 Gy b.i.d.) due to involved margins. The entity of Microcystic Carcinoma is discussed with a review of the literature on biology, diagnosis, and treatment.