The Experts below are selected from a list of 57450 Experts worldwide ranked by ideXlab platform
George M. Whitesides - One of the best experts on this subject based on the ideXlab platform.
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Three-dimensional Microfluidic Devices fabricated in layered paper and tape.
Proceedings of the National Academy of Sciences of the United States of America, 2008Co-Authors: Andres W. Martinez, Scott T. Phillips, George M. WhitesidesAbstract:This article describes a method for fabricating 3D Microfluidic Devices by stacking layers of patterned paper and double-sided adhesive tape. Paper-based 3D Microfluidic Devices have capabilities in Microfluidics that are difficult to achieve using conventional open-channel microsystems made from glass or polymers. In particular, 3D paper-based Devices wick fluids and distribute microliter volumes of samples from single inlet points into arrays of detection zones (with numbers up to thousands). This capability makes it possible to carry out a range of new analytical protocols simply and inexpensively (all on a piece of paper) without external pumps. We demonstrate a prototype 3D device that tests 4 different samples for up to 4 different analytes and displays the results of the assays in a side-by-side configuration for easy comparison. Three-dimensional paper-based Microfluidic Devices are especially appropriate for use in distributed healthcare in the developing world and in environmental monitoring and water analysis.
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flash a rapid method for prototyping paper based Microfluidic Devices
Lab on a Chip, 2008Co-Authors: Andres W. Martinez, Scott T. Phillips, Benjamin J Wiley, Malancha Gupta, George M. WhitesidesAbstract:This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of Microfluidic Devices in paper. Paper-based Microfluidic Devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 µm in width and 70 µm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based Microfluidic Devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based Microfluidic Devices in regions where the technological support for conventional photolithography is not available.
Andres W. Martinez - One of the best experts on this subject based on the ideXlab platform.
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Three-dimensional Microfluidic Devices fabricated in layered paper and tape.
Proceedings of the National Academy of Sciences of the United States of America, 2008Co-Authors: Andres W. Martinez, Scott T. Phillips, George M. WhitesidesAbstract:This article describes a method for fabricating 3D Microfluidic Devices by stacking layers of patterned paper and double-sided adhesive tape. Paper-based 3D Microfluidic Devices have capabilities in Microfluidics that are difficult to achieve using conventional open-channel microsystems made from glass or polymers. In particular, 3D paper-based Devices wick fluids and distribute microliter volumes of samples from single inlet points into arrays of detection zones (with numbers up to thousands). This capability makes it possible to carry out a range of new analytical protocols simply and inexpensively (all on a piece of paper) without external pumps. We demonstrate a prototype 3D device that tests 4 different samples for up to 4 different analytes and displays the results of the assays in a side-by-side configuration for easy comparison. Three-dimensional paper-based Microfluidic Devices are especially appropriate for use in distributed healthcare in the developing world and in environmental monitoring and water analysis.
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flash a rapid method for prototyping paper based Microfluidic Devices
Lab on a Chip, 2008Co-Authors: Andres W. Martinez, Scott T. Phillips, Benjamin J Wiley, Malancha Gupta, George M. WhitesidesAbstract:This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of Microfluidic Devices in paper. Paper-based Microfluidic Devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 µm in width and 70 µm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based Microfluidic Devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based Microfluidic Devices in regions where the technological support for conventional photolithography is not available.
Po Ki Yuen - One of the best experts on this subject based on the ideXlab platform.
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Three-dimensional interconnected microporous poly(dimethylsiloxane) Microfluidic Devices.
Lab on a chip, 2011Co-Authors: Po Ki Yuen, Vasiliy Nikolaevich Goral, Katherine A. FinkAbstract:This technical note presents a fabrication method and applications of three-dimensional (3D) interconnected microporous poly(dimethylsiloxane) (PDMS) Microfluidic Devices. Based on soft lithography, the microporous PDMS Microfluidic Devices were fabricated by molding a mixture of PDMS pre-polymer and sugar particles in a microstructured mold. After curing and demolding, the sugar particles were dissolved and washed away from the microstructured PDMS replica revealing 3D interconnected microporous structures. Other than introducing microporous structures into the PDMS replica, different sizes of sugar particles can be used to alter the surface wettability of the microporous PDMS replica. Oxygen plasma assisted bonding was used to enclose the microstructured microporous PDMS replica using a non-porous PDMS with inlet and outlet holes. A gas absorption reaction using carbon dioxide (CO2) gas acidified water was used to demonstrate the advantages and potential applications of the microporous PDMS Microfluidic Devices. We demonstrated that the acidification rate in the microporous PDMS Microfluidic device was approximately 10 times faster than the non-porous PDMS Microfluidic device under similar experimental conditions. The microporous PDMS Microfluidic Devices can also be used in cell culture applications where gas perfusion can improve cell survival and functions.
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low cost rapid prototyping of flexible Microfluidic Devices using a desktop digital craft cutter
Lab on a Chip, 2010Co-Authors: Po Ki Yuen, Vasiliy N GoralAbstract:Low-cost and straight forward rapid prototyping of flexible Microfluidic Devices using a desktop digital craft cutter is presented. This rapid prototyping method can consistently achieve microchannels as thin as 200 µm in width and can be used to fabricate three-dimensional (3D) Microfluidic Devices using only double-sided pressure sensitive adhesive (PSA) tape and laser printer transparency film. Various functional Microfluidic Devices are demonstrated with this rapid prototyping method. The complete fabrication process from device design concept to working device can be completed in minutes without the need of expensive equipment.
Scott T. Phillips - One of the best experts on this subject based on the ideXlab platform.
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Three-dimensional Microfluidic Devices fabricated in layered paper and tape.
Proceedings of the National Academy of Sciences of the United States of America, 2008Co-Authors: Andres W. Martinez, Scott T. Phillips, George M. WhitesidesAbstract:This article describes a method for fabricating 3D Microfluidic Devices by stacking layers of patterned paper and double-sided adhesive tape. Paper-based 3D Microfluidic Devices have capabilities in Microfluidics that are difficult to achieve using conventional open-channel microsystems made from glass or polymers. In particular, 3D paper-based Devices wick fluids and distribute microliter volumes of samples from single inlet points into arrays of detection zones (with numbers up to thousands). This capability makes it possible to carry out a range of new analytical protocols simply and inexpensively (all on a piece of paper) without external pumps. We demonstrate a prototype 3D device that tests 4 different samples for up to 4 different analytes and displays the results of the assays in a side-by-side configuration for easy comparison. Three-dimensional paper-based Microfluidic Devices are especially appropriate for use in distributed healthcare in the developing world and in environmental monitoring and water analysis.
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flash a rapid method for prototyping paper based Microfluidic Devices
Lab on a Chip, 2008Co-Authors: Andres W. Martinez, Scott T. Phillips, Benjamin J Wiley, Malancha Gupta, George M. WhitesidesAbstract:This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of Microfluidic Devices in paper. Paper-based Microfluidic Devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 µm in width and 70 µm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based Microfluidic Devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based Microfluidic Devices in regions where the technological support for conventional photolithography is not available.
Z. Hugh Fan - One of the best experts on this subject based on the ideXlab platform.
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Mixing in Microfluidic Devices and enhancement methods
Journal of Micromechanics and Microengineering, 2015Co-Authors: Kevin Ward, Ss Han, Gs May, Bonnie Baker, R. Bonnot, Pierre Temple-boyer, Annarita Giani, Z. Hugh Fan, Frederick Mailly, Frédérique Pascal-delannoyAbstract:Mixing in Microfluidic Devices presents a challenge due to laminar flows in microchannels, which result from low Reynolds numbers determined by the channel’s hydraulic diameter, flow velocity, and solution’s kinetic viscosity. To address this challenge, novel methods of mixing enhancement within Microfluidic Devices have been explored for a variety of applications. Passive mixing methods have been created, including those using ridges or slanted wells within the microchannels, as well as their variations with improved performance by varying geometry and patterns, by changing the properties of channel surfaces, and by optimization via simulations. In addition, active mixing methods including microstirrers, acoustic mixers, and flow pulsation have been investigated and integrated into Microfluidic Devices to enhance mixing in a more controllable manner. In general, passive mixers are easy to integrate, but difficult to control externally by users after fabrication. Active mixers usually take efforts to integrate within a device and they require external components (e.g. power sources) to operate. However, they can be controlled by users to a certain degree for tuned mixing. In this article, we provide a general overview of a number of passive and active mixers, discuss their advantages and disadvantages, and make suggestions on choosing a mixing method for a specific need as well as advocate possible integration of key elements of passive and active mixers to harness the advantages of both types.
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Thermoplastic Microfluidic Devices and their applications in protein and DNA analysis
The Analyst, 2011Co-Authors: Ke Liu, Z. Hugh FanAbstract:Microfluidics is a platform technology that has been used for genomics, proteomics, chemical synthesis, environment monitoring, cellular studies, and other applications. The fabrication materials of Microfluidic Devices have traditionally included silicon and glass, but plastics have gained increasing attention in the past few years. We focus this review on thermoplastic Microfluidic Devices and their applications in protein and DNA analysis. We outline the device design and fabrication methods, followed by discussion on the strategies of surface treatment. We then concentrate on several significant advancements in applying thermoplastic Microfluidic Devices to protein separation, immunoassays, and DNA analysis. Comparison among numerous efforts, as well as the discussion on the challenges and innovation associated with detection, is presented.
